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Items: 35


Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire.

Zelazowska MA, Dong Q, Plummer JB, Zhong Y, Liu B, Krug LT, McBride KM.

Life Sci Alliance. 2020 Feb 6;3(3). pii: e201900526. doi: 10.26508/lsa.201900526. Print 2020 Mar.


A role of hypoxia-inducible factor 1 alpha in Murine Gammaherpesvirus 68 (MHV68) lytic replication and reactivation from latency.

López-Rodríguez DM, Kirillov V, Krug LT, Mesri EA, Andreansky S.

PLoS Pathog. 2019 Dec 6;15(12):e1008192. doi: 10.1371/journal.ppat.1008192. eCollection 2019 Dec.


Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome.

Dong Q, Smith KR, Oldenburg DG, Shapiro M, Schutt WR, Malik L, Plummer JB, Mu Y, MacCarthy T, White DW, McBride KM, Krug LT.

mBio. 2018 Oct 30;9(5). pii: e01831-18. doi: 10.1128/mBio.01831-18.


Correction: Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.

Van Skike ND, Minkah NK, Hogan CH, Wu G, Benziger PT, Oldenburg DG, Kara M, Kim-Holzapfel DM, White DW, Tibbetts SA, French JB, Krug LT.

PLoS Pathog. 2018 Sep 25;14(9):e1007319. doi: 10.1371/journal.ppat.1007319. eCollection 2018 Sep.


Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.

Van Skike ND, Minkah NK, Hogan CH, Wu G, Benziger PT, Oldenburg DG, Kara M, Kim-Holzapfel DM, White DW, Tibbetts SA, French JB, Krug LT.

PLoS Pathog. 2018 Feb 1;14(2):e1006843. doi: 10.1371/journal.ppat.1006843. eCollection 2018 Feb. Erratum in: PLoS Pathog. 2018 Sep 25;14(9):e1007319.


The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expression.

Foreman HC, Armstrong J, Santana AL, Krug LT, Reich NC.

J Biol Chem. 2017 Sep 29;292(39):16257-16266. doi: 10.1074/jbc.M117.786970. Epub 2017 Aug 15.


A codon-shuffling method to prevent reversion during production of replication-defective herpesvirus stocks: Implications for herpesvirus vaccines.

Li G, Ward C, Yeasmin R, Skiena S, Krug LT, Forrest JC.

Sci Rep. 2017 Mar 13;7:44404. doi: 10.1038/srep44404.


RTA Occupancy of the Origin of Lytic Replication during Murine Gammaherpesvirus 68 Reactivation from B Cell Latency.

Santana AL, Oldenburg DG, Kirillov V, Malik L, Dong Q, Sinayev R, Marcu KB, White DW, Krug LT.

Pathogens. 2017 Feb 16;6(1). pii: E9. doi: 10.3390/pathogens6010009.


Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host.

Cieniewicz B, Santana AL, Minkah N, Krug LT.

Front Microbiol. 2016 Aug 17;7:1202. doi: 10.3389/fmicb.2016.01202. eCollection 2016. Review.


Ablation of STAT3 in the B Cell Compartment Restricts Gammaherpesvirus Latency In Vivo.

Reddy SS, Foreman HC, Sioux TO, Park GH, Poli V, Reich NC, Krug LT.

mBio. 2016 Aug 2;7(4). pii: e00723-16. doi: 10.1128/mBio.00723-16.


Impact of Adenovirus E4-ORF3 Oligomerization and Protein Localization on Cellular Gene Expression.

Vink EI, Zheng Y, Yeasmin R, Stamminger T, Krug LT, Hearing P.

Viruses. 2015 May 13;7(5):2428-49. doi: 10.3390/v7052428.


Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1β Production upon Extrinsic Stimulation in Culture.

Cieniewicz B, Dong Q, Li G, Forrest JC, Mounce BC, Tarakanova VL, van der Velden A, Krug LT.

J Virol. 2015 Jul;89(13):6562-74. doi: 10.1128/JVI.00658-15. Epub 2015 Apr 8.


Absence of the uracil DNA glycosylase of murine gammaherpesvirus 68 impairs replication and delays the establishment of latency in vivo.

Minkah N, Macaluso M, Oldenburg DG, Paden CR, White DW, McBride KM, Krug LT.

J Virol. 2015 Mar;89(6):3366-79. doi: 10.1128/JVI.03111-14. Epub 2015 Jan 14.


Editorial overview: Roseoloviruses: stopping to smell the roses--the Roseoloviruses have come of age as human pathogens.

Krug LT.

Curr Opin Virol. 2014 Dec;9:vi-vii. doi: 10.1016/j.coviro.2014.11.001. Epub 2014 Nov 17. No abstract available.


Roseoloviruses: unmet needs and research priorities: perspective.

Caserta MT, Krug LT, Pellett PE.

Curr Opin Virol. 2014 Dec;9:167-9. doi: 10.1016/j.coviro.2014.10.005. Epub 2014 Nov 14. Review.


Roseolovirus molecular biology: recent advances.

Krug LT, Pellett PE.

Curr Opin Virol. 2014 Dec;9:170-7. doi: 10.1016/j.coviro.2014.10.004. Epub 2014 Nov 27. Review.


Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.

Minkah N, Chavez K, Shah P, Maccarthy T, Chen H, Landau N, Krug LT.

Virology. 2014 Apr;454-455:215-26. doi: 10.1016/j.virol.2014.02.022. Epub 2014 Mar 13.


Enhanced response of T cells from murine gammaherpesvirus 68-infected mice lacking the suppressor of T cell receptor signaling molecules Sts-1 and Sts-2.

Cieniewicz B, Carpino N, Krug LT.

PLoS One. 2014 Feb 28;9(2):e90196. doi: 10.1371/journal.pone.0090196. eCollection 2014.


Gammaherpesviral gene expression and virion composition are broadly controlled by accelerated mRNA degradation.

Abernathy E, Clyde K, Yeasmin R, Krug LT, Burlingame A, Coscoy L, Glaunsinger B.

PLoS Pathog. 2014 Jan;10(1):e1003882. doi: 10.1371/journal.ppat.1003882. Epub 2014 Jan 16.


Complexities of gammaherpesvirus transcription revealed by microarrays and RNAseq.

Krug LT.

Curr Opin Virol. 2013 Jun;3(3):276-84. doi: 10.1016/j.coviro.2013.04.006. Epub 2013 May 16. Review.


The absence of M1 leads to increased establishment of murine gammaherpesvirus 68 latency in IgD-negative B cells.

Krug LT, Evans AG, Gargano LM, Paden CR, Speck SH.

J Virol. 2013 Mar;87(6):3597-604. doi: 10.1128/JVI.01953-12. Epub 2013 Jan 9.


Tiled microarray identification of novel viral transcript structures and distinct transcriptional profiles during two modes of productive murine gammaherpesvirus 68 infection.

Cheng BY, Zhi J, Santana A, Khan S, Salinas E, Forrest JC, Zheng Y, Jaggi S, Leatherwood J, Krug LT.

J Virol. 2012 Apr;86(8):4340-57. doi: 10.1128/JVI.05892-11. Epub 2012 Feb 8.


Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis.

Torres-González E, Bueno M, Tanaka A, Krug LT, Cheng DS, Polosukhin VV, Sorescu D, Lawson WE, Blackwell TS, Rojas M, Mora AL.

Am J Respir Cell Mol Biol. 2012 Jun;46(6):748-56. doi: 10.1165/rcmb.2011-0224OC. Epub 2012 Jan 6.


Inhibition of NF-kappaB signaling reduces virus load and gammaherpesvirus-induced pulmonary fibrosis.

Krug LT, Torres-González E, Qin Q, Sorescu D, Rojas M, Stecenko A, Speck SH, Mora AL.

Am J Pathol. 2010 Aug;177(2):608-21. doi: 10.2353/ajpath.2010.091122. Epub 2010 Jun 21.


NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency.

Krug LT, Collins CM, Gargano LM, Speck SH.

J Virol. 2009 May;83(10):4732-48. doi: 10.1128/JVI.00111-09. Epub 2009 Mar 4.


A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology.

Evans AG, Moser JM, Krug LT, Pozharskaya V, Mora AL, Speck SH.

J Exp Med. 2008 Mar 17;205(3):669-84. doi: 10.1084/jem.20071135. Epub 2008 Mar 10.


Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency.

Krug LT, Moser JM, Dickerson SM, Speck SH.

PLoS Pathog. 2007 Jan;3(1):e11.


Variable methylation of the Epstein-Barr virus Wp EBNA gene promoter in B-lymphoblastoid cell lines.

Elliott J, Goodhew EB, Krug LT, Shakhnovsky N, Yoo L, Speck SH.

J Virol. 2004 Dec;78(24):14062-5.


Short duration of elevated vIRF-1 expression during lytic replication of human herpesvirus 8 limits its ability to block antiviral responses induced by alpha interferon in BCBL-1 cells.

Pozharskaya VP, Weakland LL, Zimring JC, Krug LT, Unger ER, Neisch A, Joshi H, Inoue N, Offermann MK.

J Virol. 2004 Jun;78(12):6621-35.


Differences in DNA binding specificity among Roseolovirus origin binding proteins.

Krug LT, Inoue N, Pellett PE.

Virology. 2001 Sep 15;288(1):145-53.

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