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Items: 1 to 50 of 132

1.

Interaction of circulating GLP-1 and the response of the dorsolateral prefrontal cortex to food-cues predicts body weight development.

Maurer L, Mai K, Krude H, Haynes JD, Weygandt M, Spranger J.

Mol Metab. 2019 Nov;29:136-144. doi: 10.1016/j.molmet.2019.08.014. Epub 2019 Aug 21.

2.

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective.

Heyder N, Kleinau G, Szczepek M, Kwiatkowski D, Speck D, Soletto L, Cerdá-Reverter JM, Krude H, Kühnen P, Biebermann H, Scheerer P.

Front Endocrinol (Lausanne). 2019 Jul 31;10:515. doi: 10.3389/fendo.2019.00515. eCollection 2019.

3.

Effectiveness and safety of the tri-iodothyronine analogue Triac in children and adults with MCT8 deficiency: an international, single-arm, open-label, phase 2 trial.

Groeneweg S, Peeters RP, Moran C, Stoupa A, Auriol F, Tonduti D, Dica A, Paone L, Rozenkova K, Malikova J, van der Walt A, de Coo IFM, McGowan A, Lyons G, Aarsen FK, Barca D, van Beynum IM, van der Knoop MM, Jansen J, Manshande M, Lunsing RJ, Nowak S, den Uil CA, Zillikens MC, Visser FE, Vrijmoeth P, de Wit MCY, Wolf NI, Zandstra A, Ambegaonkar G, Singh Y, de Rijke YB, Medici M, Bertini ES, Depoorter S, Lebl J, Cappa M, De Meirleir L, Krude H, Craiu D, Zibordi F, Oliver Petit I, Polak M, Chatterjee K, Visser TJ, Visser WE.

Lancet Diabetes Endocrinol. 2019 Sep;7(9):695-706. doi: 10.1016/S2213-8587(19)30155-X. Epub 2019 Jul 31.

PMID:
31377265
4.

Evaluation of a rare glucose-dependent insulinotropic polypeptide receptor variant in a patient with diabetes.

Jacobi SF, Khajavi N, Kleinau G, Teumer A, Scheerer P, Homuth G, Völzke H, Wiegand S, Kühnen P, Krude H, Gong M, Raile K, Biebermann H.

Diabetes Obes Metab. 2019 May;21(5):1168-1176. doi: 10.1111/dom.13634. Epub 2019 Feb 19.

PMID:
30784161
5.

Melanocortin-4 Receptor Signalling: Importance for Weight Regulation and Obesity Treatment.

Kühnen P, Krude H, Biebermann H.

Trends Mol Med. 2019 Feb;25(2):136-148. doi: 10.1016/j.molmed.2018.12.002. Epub 2019 Jan 11. Review.

PMID:
30642682
6.

An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance.

Mai K, Li L, Wiegand S, Brachs M, Leupelt V, Ernert A, Kühnen P, Hübner N, Robinson P, Chen W, Krude H, Spranger J.

Diabetes. 2019 Jan;68(1):57-65. doi: 10.2337/db18-0440. Epub 2018 Nov 2.

7.

A New Multisystem Disorder Caused by the Gαs Mutation p.F376V.

Biebermann H, Kleinau G, Schnabel D, Bockenhauer D, Wilson LC, Tully I, Kiff S, Scheerer P, Reyes M, Paisdzior S, Gregory JW, Allgrove J, Krude H, Mannstadt M, Gardella TJ, Dattani M, Jüppner H, Grüters A.

J Clin Endocrinol Metab. 2019 Apr 1;104(4):1079-1089. doi: 10.1210/jc.2018-01250.

8.

An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation.

Khajavi N, Finan B, Kluth O, Müller TD, Mergler S, Schulz A, Kleinau G, Scheerer P, Schürmann A, Gudermann T, Tschöp MH, Krude H, DiMarchi RD, Biebermann H.

Cell Signal. 2018 Nov;51:13-22. doi: 10.1016/j.cellsig.2018.07.006. Epub 2018 Jul 25.

PMID:
30055232
9.

[Update of the S2k guidelines : Surgical treatment of benign thyroid diseases].

Musholt TJ, Bockisch A, Clerici T, Dotzenrath C, Dralle H, Goretzki PE, Hermann M, Holzer K, Karges W, Krude H, Kussmann J, Lorenz K, Luster M, Niederle B, Nies C, Riss P, Schabram J, Schabram P, Schmid KW, Simon D, Spitzweg C, Steinmüller T, Trupka A, Vorländer C, Weber T, Bartsch DK; Leitliniengruppe der CAEK.

Chirurg. 2018 Sep;89(9):699-709. doi: 10.1007/s00104-018-0653-y. Review. German.

PMID:
29876616
10.

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.

Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P.

Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7.

PMID:
29736023
11.

Effects of a combined dietary, exercise and behavioral intervention and sympathetic system on body weight maintenance after intended weight loss: Results of a randomized controlled trial.

Mai K, Brachs M, Leupelt V, Jumpertz-von Schwartzenberg R, Maurer L, Grüters-Kieslich A, Ernert A, Bobbert T, Krude H, Spranger J.

Metabolism. 2018 Jun;83:60-67. doi: 10.1016/j.metabol.2018.01.003. Epub 2018 Jan 31.

PMID:
29360493
12.

Mean High-Dose l-Thyroxine Treatment Is Efficient and Safe to Achieve a Normal IQ in Young Adult Patients With Congenital Hypothyroidism.

Aleksander PE, Brückner-Spieler M, Stoehr AM, Lankes E, Kühnen P, Schnabel D, Ernert A, Stäblein W, Craig ME, Blankenstein O, Grüters A, Krude H.

J Clin Endocrinol Metab. 2018 Apr 1;103(4):1459-1469. doi: 10.1210/jc.2017-01937.

PMID:
29325045
13.

Life-Limiting Conditions at a University Pediatric Tertiary Care Center: A Cross-Sectional Study.

Bösch A, Wager J, Zernikow B, Thalemann R, Frenzel H, Krude H, Reindl T.

J Palliat Med. 2018 Feb;21(2):169-176. doi: 10.1089/jpm.2017.0020. Epub 2018 Jan 3.

PMID:
29297749
14.

Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level.

Fischer J, Kleinau G, Rutz C, Zwanziger D, Khajavi N, Müller A, Rehders M, Brix K, Worth CL, Führer D, Krude H, Wiesner B, Schülein R, Biebermann H.

Cell Mol Life Sci. 2018 Jun;75(12):2227-2239. doi: 10.1007/s00018-017-2728-1. Epub 2017 Dec 30.

PMID:
29290039
15.

Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1.

Mühlhaus J, Dinter J, Jyrch S, Teumer A, Jacobi SF, Homuth G, Kühnen P, Wiegand S, Grüters A, Völzke H, Raile K, Kleinau G, Krude H, Biebermann H.

Front Pharmacol. 2017 Nov 24;8:807. doi: 10.3389/fphar.2017.00807. eCollection 2017.

16.

Absorption and tolerability of taste-masked hydrocortisone granules in neonates, infants and children under 6 years of age with adrenal insufficiency.

Neumann U, Whitaker MJ, Wiegand S, Krude H, Porter J, Davies M, Digweed D, Voet B, Ross RJ, Blankenstein O.

Clin Endocrinol (Oxf). 2018 Jan;88(1):21-29. doi: 10.1111/cen.13447. Epub 2017 Sep 7.

17.

Weight Loss Partially Restores Glucose-Driven Betatrophin Response in Humans.

Maurer L, Brachs S, Decker AM, Brachs M, Leupelt V, Jumpertz von Schwartzenberg R, Ernert A, Bobbert T, Krude H, Spranger J, Mai K.

J Clin Endocrinol Metab. 2016 Nov;101(11):4014-4020. Epub 2016 Jul 26.

PMID:
27459526
18.

Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity.

Kühnen P, Handke D, Waterland RA, Hennig BJ, Silver M, Fulford AJ, Dominguez-Salas P, Moore SE, Prentice AM, Spranger J, Hinney A, Hebebrand J, Heppner FL, Walzer L, Grötzinger C, Gromoll J, Wiegand S, Grüters A, Krude H.

Cell Metab. 2016 Sep 13;24(3):502-509. doi: 10.1016/j.cmet.2016.08.001. Epub 2016 Aug 25.

19.

Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling.

Müller A, Niederstadt L, Jonas W, Yi CX, Meyer F, Wiedmer P, Fischer J, Grötzinger C, Schürmann A, Tschöp M, Kleinau G, Grüters A, Krude H, Biebermann H.

Front Endocrinol (Lausanne). 2016 Aug 8;7:109. doi: 10.3389/fendo.2016.00109. eCollection 2016.

20.

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist.

Kühnen P, Clément K, Wiegand S, Blankenstein O, Gottesdiener K, Martini LL, Mai K, Blume-Peytavi U, Grüters A, Krude H.

N Engl J Med. 2016 Jul 21;375(3):240-6. doi: 10.1056/NEJMoa1512693.

21.

Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort.

Löf C, Patyra K, Kuulasmaa T, Vangipurapu J, Undeutsch H, Jaeschke H, Pajunen T, Kero A, Krude H, Biebermann H, Kleinau G, Kühnen P, Rantakari K, Miettinen P, Kirjavainen T, Pursiheimo JP, Mustila T, Jääskeläinen J, Ojaniemi M, Toppari J, Ignatius J, Laakso M, Kero J.

Thyroid. 2016 Sep;26(9):1215-24. doi: 10.1089/thy.2016.0016. Epub 2016 Aug 2.

22.
23.

ANP system activity predicts variability of fat mass reduction and insulin sensitivity during weight loss.

Brachs M, Wiegand S, Leupelt V, Ernert A, Kintscher U, Jumpertz von Schwarzenberg R, Decker AM, Bobbert T, Hübner N, Chen W, Krude H, Spranger J, Mai K.

Metabolism. 2016 Jun;65(6):935-43. doi: 10.1016/j.metabol.2016.03.013. Epub 2016 Apr 7.

PMID:
27173472
24.

Surfactant proteins in pediatric interstitial lung disease.

Griese M, Lorenz E, Hengst M, Schams A, Wesselak T, Rauch D, Wittmann T, Kirchberger V, Escribano A, Schaible T, Baden W, Schulze J, Krude H, Aslanidis C, Schwerk N, Kappler M, Hartl D, Lohse P, Zarbock R.

Pediatr Res. 2016 Jan;79(1-1):34-41. doi: 10.1038/pr.2015.173. Epub 2015 Sep 16.

PMID:
26375475
25.

NKX2.1-Related Disorders: a novel mutation with mild clinical presentation.

Monti S, Nicoletti A, Cantasano A, Krude H, Cassio A.

Ital J Pediatr. 2015 Jun 24;41:45. doi: 10.1186/s13052-015-0150-6.

26.

Treatment of congenital thyroid dysfunction: Achievements and challenges.

Krude H, Kühnen P, Biebermann H.

Best Pract Res Clin Endocrinol Metab. 2015 Jun;29(3):399-413. doi: 10.1016/j.beem.2015.04.004. Epub 2015 Apr 26. Review.

PMID:
26051299
27.

3-iodothyronamine differentially modulates α-2A-adrenergic receptor-mediated signaling.

Dinter J, Mühlhaus J, Jacobi SF, Wienchol CL, Cöster M, Meister J, Hoefig CS, Müller A, Köhrle J, Grüters A, Krude H, Mittag J, Schöneberg T, Kleinau G, Biebermann H.

J Mol Endocrinol. 2015 Jun;54(3):205-16. doi: 10.1530/JME-15-0003. Epub 2015 Apr 15.

PMID:
25878061
28.

Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.

Dinter J, Mühlhaus J, Wienchol CL, Yi CX, Nürnberg D, Morin S, Grüters A, Köhrle J, Schöneberg T, Tschöp M, Krude H, Kleinau G, Biebermann H.

PLoS One. 2015 Feb 23;10(2):e0117774. doi: 10.1371/journal.pone.0117774. eCollection 2015.

29.

A novel hemizygous mutation of MAMLD1 in a patient with 46,XY complete gonadal dysgenesis.

Ruiz-Arana IL, Hübner A, Cetingdag C, Krude H, Grüters A, Fukami M, Biebermann H, Köhler B.

Sex Dev. 2015;9(2):80-5. doi: 10.1159/000371603. Epub 2015 Feb 3.

PMID:
25660412
30.

Development and testing in healthy adults of oral hydrocortisone granules with taste masking for the treatment of neonates and infants with adrenal insufficiency.

Whitaker MJ, Spielmann S, Digweed D, Huatan H, Eckland D, Johnson TN, Tucker G, Krude H, Blankenstein O, Ross RJ.

J Clin Endocrinol Metab. 2015 Apr;100(4):1681-8. doi: 10.1210/jc.2014-4060. Epub 2015 Feb 3.

PMID:
25646792
31.

[Monogenic and syndromic symptoms of morbid obesity. Rare but important].

Wiegand S, Krude H.

Internist (Berl). 2015 Feb;56(2):111-2, 114-20. doi: 10.1007/s00108-014-3532-8. German.

PMID:
25630806
32.

Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.

Fischer J, Kleinau G, Müller A, Kühnen P, Zwanziger D, Kinne A, Rehders M, Moeller LC, Führer D, Grüters A, Krude H, Brix K, Biebermann H.

J Mol Endocrinol. 2015 Feb;54(1):39-50. doi: 10.1530/JME-14-0272.

PMID:
25527620
33.

[Thyroid dysfunction in pregnancy].

Führer D, Mann K, Feldkamp J, Krude H, Spitzweg C, Kratzsch J, Schott M.

Dtsch Med Wochenschr. 2014 Oct;139(42):2148-52. doi: 10.1055/s-0034-1387300. Epub 2014 Oct 7. Review. German.

PMID:
25289925
34.

Evolution, child development and the thyroid: a phylogenetic and ontogenetic introduction to normal thyroid function.

Krude H.

Endocr Dev. 2014;26:1-16. doi: 10.1159/000363151. Epub 2014 Aug 29. Review.

PMID:
25231440
35.

Comprehensive genotyping and clinical characterisation reveal 27 novel NKX2-1 mutations and expand the phenotypic spectrum.

Thorwarth A, Schnittert-Hübener S, Schrumpf P, Müller I, Jyrch S, Dame C, Biebermann H, Kleinau G, Katchanov J, Schuelke M, Ebert G, Steininger A, Bönnemann C, Brockmann K, Christen HJ, Crock P, deZegher F, Griese M, Hewitt J, Ivarsson S, Hübner C, Kapelari K, Plecko B, Rating D, Stoeva I, Ropers HH, Grüters A, Ullmann R, Krude H.

J Med Genet. 2014 Jun;51(6):375-87. doi: 10.1136/jmedgenet-2013-102248. Epub 2014 Apr 8.

36.

European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism.

Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G, Polak M, Butler G; ESPE-PES-SLEP-JSPE-APEG-APPES-ISPAE; Congenital Hypothyroidism Consensus Conference Group.

Horm Res Paediatr. 2014;81(2):80-103. doi: 10.1159/000358198. Epub 2014 Jan 21.

37.

Analysis of the gene coding for steroidogenic factor 1 (SF1, NR5A1) in a cohort of 50 Egyptian patients with 46,XY disorders of sex development.

Tantawy S, Mazen I, Soliman H, Anwar G, Atef A, El-Gammal M, El-Kotoury A, Mekkawy M, Torky A, Rudolf A, Schrumpf P, Grüters A, Krude H, Dumargne MC, Astudillo R, Bashamboo A, Biebermann H, Köhler B.

Eur J Endocrinol. 2014 Apr 10;170(5):759-67. doi: 10.1530/EJE-13-0965. Print 2014 May.

PMID:
24591553
38.

European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism.

Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G, Polak M, Butler G; ESPE-PES-SLEP-JSPE-APEG-APPES-ISPAE; Congenital Hypothyroidism Consensus Conference Group.

J Clin Endocrinol Metab. 2014 Feb;99(2):363-84. doi: 10.1210/jc.2013-1891. Epub 2014 Jan 21.

39.

Identification of PENDRIN (SLC26A4) mutations in patients with congenital hypothyroidism and "apparent" thyroid dysgenesis.

Kühnen P, Turan S, Fröhler S, Güran T, Abali S, Biebermann H, Bereket A, Grüters A, Chen W, Krude H.

J Clin Endocrinol Metab. 2014 Jan;99(1):E169-76. doi: 10.1210/jc.2013-2619. Epub 2013 Dec 20.

PMID:
24248179
40.

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.

Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH.

Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968.

41.

Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2.

Piechowski CL, Rediger A, Lagemann C, Mühlhaus J, Müller A, Pratzka J, Tarnow P, Grüters A, Krude H, Kleinau G, Biebermann H.

J Mol Endocrinol. 2013 Jun 29;51(1):109-18. doi: 10.1530/JME-13-0061. Print 2013.

PMID:
23674133
42.

Novel insights on thyroid-stimulating hormone receptor signal transduction.

Kleinau G, Neumann S, Grüters A, Krude H, Biebermann H.

Endocr Rev. 2013 Oct;34(5):691-724. doi: 10.1210/er.2012-1072. Epub 2013 May 3. Review.

43.

G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.

Müller A, Kleinau G, Piechowski CL, Müller TD, Finan B, Pratzka J, Grüters A, Krude H, Tschöp M, Biebermann H.

PLoS One. 2013;8(1):e53347. doi: 10.1371/journal.pone.0053347. Epub 2013 Jan 15.

44.

Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.

Volckmar AL, Bolze F, Jarick I, Knoll N, Scherag A, Reinehr T, Illig T, Grallert H, Wichmann HE, Wiegand S, Biebermann H, Krude H, Fischer-Posovszky P, Rief W, Wabitsch M, Klingenspor M, Hebebrand J, Hinney A.

BMC Med Genomics. 2012 Dec 27;5:65. doi: 10.1186/1755-8794-5-65.

45.

Alu elements and human common diseases like obesity.

Kuehnen P, Krude H.

Mob Genet Elements. 2012 Jul 1;2(4):197-201.

46.

Differences in taste sensitivity between obese and non-obese children and adolescents.

Overberg J, Hummel T, Krude H, Wiegand S.

Arch Dis Child. 2012 Dec;97(12):1048-52. doi: 10.1136/archdischild-2011-301189. Epub 2012 Sep 20.

PMID:
22995095
47.

Do common variants separate between obese melanocortin-4 receptor gene mutation carriers and non-carriers? The impact of cryptic relatedness.

Mühlhaus J, Pütter C, Brumm H, Grallert H, Illig T, Scherag S, Reinehr T, Pott W, Albayrak Ö, Wang HJ, Bau AM, Wiegand S, Grüters A, Krude H, Hebebrand J, Hinney A, Biebermann H, Scherag A.

Horm Res Paediatr. 2012;77(6):358-68. doi: 10.1159/000338999. Epub 2012 Jun 9.

48.

The paediatric Confusion Assessment Method for the Intensive Care Unit (pCAM-ICU): translation and cognitive debriefing for the German-speaking area.

de Grahl C, Luetz A, Gratopp A, Gensel D, Mueller J, Smith H, Ely EW, Krude H, Spies C.

Ger Med Sci. 2012;10:Doc07. doi: 10.3205/000158. Epub 2012 Apr 17.

49.

Testosterone production during puberty in two 46,XY patients with disorders of sex development and novel NR5A1 (SF-1) mutations.

Tantawy S, Lin L, Akkurt I, Borck G, Klingmüller D, Hauffa BP, Krude H, Biebermann H, Achermann JC, Köhler B.

Eur J Endocrinol. 2012 Jul;167(1):125-30. doi: 10.1530/EJE-11-0944. Epub 2012 Apr 3.

50.

An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity.

Kuehnen P, Mischke M, Wiegand S, Sers C, Horsthemke B, Lau S, Keil T, Lee YA, Grueters A, Krude H.

PLoS Genet. 2012;8(3):e1002543. doi: 10.1371/journal.pgen.1002543. Epub 2012 Mar 15.

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