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Items: 28


Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate.

Krucinska J, Lombardo MN, Erlandsen H, Hazeen A, Duay SS, Pattis JG, Robinson VL, May ER, Wright DL.

Sci Rep. 2019 Nov 19;9(1):17106. doi: 10.1038/s41598-019-53301-3.


Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus.

Reeve SM, Si D, Krucinska J, Yan Y, Viswanathan K, Wang S, Holt GT, Frenkel MS, Ojewole AA, Estrada A, Agabiti SS, Alverson JB, Gibson ND, Priestley ND, Wiemer AJ, Donald BR, Wright DL.

ACS Infect Dis. 2019 Nov 8;5(11):1896-1906. doi: 10.1021/acsinfecdis.9b00222. Epub 2019 Oct 15.


Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.

Hajian B, Scocchera E, Shoen C, Krucinska J, Viswanathan K, G-Dayanandan N, Erlandsen H, Estrada A, Mikušová K, Korduláková J, Cynamon M, Wright D.

Cell Chem Biol. 2019 Jun 20;26(6):781-791.e6. doi: 10.1016/j.chembiol.2019.02.013. Epub 2019 Mar 28.


Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens.

Krucinska J, Falcone E, Erlandsen H, Hazeen A, Lombardo MN, Estrada A, Robinson VL, Anderson AC, Wright DL.

Biochemistry. 2019 Mar 5;58(9):1188-1197. doi: 10.1021/acs.biochem.8b01298. Epub 2019 Feb 15.


Separation and identification of lipids in the photosynthetic cousins of Apicomplexa Chromera velia and Vitrella brassicaformis.

Tomčala A, Kyselová V, Schneedorferová I, Opekarová I, Moos M, Urajová P, Kručinská J, Oborník M.

J Sep Sci. 2017 Sep;40(17):3402-3413. doi: 10.1002/jssc.201700171. Epub 2017 Aug 14.


Budding of the Alveolate Alga Vitrella brassicaformis Resembles Sexual and Asexual Processes in Apicomplexan Parasites.

Füssy Z, Masařová P, Kručinská J, Esson HJ, Oborník M.

Protist. 2017 Feb;168(1):80-91. doi: 10.1016/j.protis.2016.12.001. Epub 2016 Dec 13.


MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.

Reeve SM, Scocchera EW, G-Dayanadan N, Keshipeddy S, Krucinska J, Hajian B, Ferreira J, Nailor M, Aeschlimann J, Wright DL, Anderson AC.

Cell Chem Biol. 2016 Dec 22;23(12):1458-1467. doi: 10.1016/j.chembiol.2016.11.007. Epub 2016 Dec 8.


Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.

Hajian B, Scocchera E, Keshipeddy S, G-Dayanandan N, Shoen C, Krucinska J, Reeve S, Cynamon M, Anderson AC, Wright DL.

PLoS One. 2016 Aug 31;11(8):e0161740. doi: 10.1371/journal.pone.0161740. eCollection 2016.


Structural characterization of nitrosomonas europaea cytochrome c-552 variants with marked differences in electronic structure.

Can M, Krucinska J, Zoppellaro G, Andersen NH, Wedekind JE, Hersleth HP, Andersson KK, Bren KL.

Chembiochem. 2013 Sep 23;14(14):1828-38. doi: 10.1002/cbic.201300118. Epub 2013 Jul 31.


Structure of a class II preQ1 riboswitch reveals ligand recognition by a new fold.

Liberman JA, Salim M, Krucinska J, Wedekind JE.

Nat Chem Biol. 2013 Jun;9(6):353-5. doi: 10.1038/nchembio.1231. Epub 2013 Apr 14.


A transition-state interaction shifts nucleobase ionization toward neutrality to facilitate small ribozyme catalysis.

Liberman JA, Guo M, Jenkins JL, Krucinska J, Chen Y, Carey PR, Wedekind JE.

J Am Chem Soc. 2012 Oct 17;134(41):16933-6. doi: 10.1021/ja3070528. Epub 2012 Oct 3.


Crystallographic analysis of small ribozymes and riboswitches.

Lippa GM, Liberman JA, Jenkins JL, Krucinska J, Salim M, Wedekind JE.

Methods Mol Biol. 2012;848:159-84. doi: 10.1007/978-1-61779-545-9_11.


Comparison of a preQ1 riboswitch aptamer in metabolite-bound and free states with implications for gene regulation.

Jenkins JL, Krucinska J, McCarty RM, Bandarian V, Wedekind JE.

J Biol Chem. 2011 Jul 15;286(28):24626-37. doi: 10.1074/jbc.M111.230375. Epub 2011 May 18.


APOBEC-1 complementation factor (ACF) forms RNA-dependent multimers.

Galloway CA, Kumar A, Krucinska J, Smith HC.

Biochem Biophys Res Commun. 2010 Jul 16;398(1):38-43. doi: 10.1016/j.bbrc.2010.06.021. Epub 2010 Jun 10.


A hydrodynamic analysis of APOBEC3G reveals a monomer-dimer-tetramer self-association that has implications for anti-HIV function.

Salter JD, Krucinska J, Raina J, Smith HC, Wedekind JE.

Biochemistry. 2009 Nov 17;48(45):10685-7. doi: 10.1021/bi901642c.


Direct Raman measurement of an elevated base pKa in the active site of a small ribozyme in a precatalytic conformation.

Guo M, Spitale RC, Volpini R, Krucinska J, Cristalli G, Carey PR, Wedekind JE.

J Am Chem Soc. 2009 Sep 16;131(36):12908-9. doi: 10.1021/ja9060883.


Single-atom imino substitutions at A9 and A10 reveal distinct effects on the fold and function of the hairpin ribozyme catalytic core.

Spitale RC, Volpini R, Mungillo MV, Krucinska J, Cristalli G, Wedekind JE.

Biochemistry. 2009 Aug 25;48(33):7777-9. doi: 10.1021/bi9011622.


Identification of an imino group indispensable for cleavage by a small ribozyme.

Spitale RC, Volpini R, Heller MG, Krucinska J, Cristalli G, Wedekind JE.

J Am Chem Soc. 2009 May 6;131(17):6093-5. doi: 10.1021/ja900450h.


The structural basis for recognition of the PreQ0 metabolite by an unusually small riboswitch aptamer domain.

Spitale RC, Torelli AT, Krucinska J, Bandarian V, Wedekind JE.

J Biol Chem. 2009 Apr 24;284(17):11012-6. doi: 10.1074/jbc.C900024200. Epub 2009 Mar 4.


Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme.

MacElrevey C, Salter JD, Krucinska J, Wedekind JE.

RNA. 2008 Aug;14(8):1600-16. doi: 10.1261/rna.1055308. Epub 2008 Jul 2.


Shared traits on the reaction coordinates of ribonuclease and an RNA enzyme.

Torelli AT, Spitale RC, Krucinska J, Wedekind JE.

Biochem Biophys Res Commun. 2008 Jun 20;371(1):154-8. doi: 10.1016/j.bbrc.2008.04.036. Epub 2008 Apr 16.


A posteriori design of crystal contacts to improve the X-ray diffraction properties of a small RNA enzyme.

MacElrevey C, Spitale RC, Krucinska J, Wedekind JE.

Acta Crystallogr D Biol Crystallogr. 2007 Jul;63(Pt 7):812-25. Epub 2007 Jun 15.


Nanostructures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits.

Wedekind JE, Gillilan R, Janda A, Krucinska J, Salter JD, Bennett RP, Raina J, Smith HC.

J Biol Chem. 2006 Dec 15;281(50):38122-6. Epub 2006 Oct 31.


Water in the active site of an all-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transfer.

Salter J, Krucinska J, Alam S, Grum-Tokars V, Wedekind JE.

Biochemistry. 2006 Jan 24;45(3):686-700.


Conformational heterogeneity at position U37 of an all-RNA hairpin ribozyme with implications for metal binding and the catalytic structure of the S-turn.

Alam S, Grum-Tokars V, Krucinska J, Kundracik ML, Wedekind JE.

Biochemistry. 2005 Nov 8;44(44):14396-408.


[Splenectomy in the light of personal observations].

Miklaszewska J, Kusionowicz J, Krucińska J, Król J.

Pol Tyg Lek. 1970 Apr 20;25(16):577-9. Polish. No abstract available.


[Hypoglycemia as sequelae of increased tension of the parasympathetic system during cholelithiasis].

Miklaszewska J, Krucińska J.

Przegl Lek. 1969 Jun 24;25(6):490-2. Polish. No abstract available.


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