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Cobalamin-Dependent Apparent Intramolecular Methyl Transfer for Biocatalytic Constitutional Isomerization of Catechol Monomethyl Ethers.

Farnberger JE, Hiebler K, Bierbaumer S, Skibar W, Zepeck F, Kroutil W.

ACS Catal. 2019 May 3;9(5):3900-3905. doi: 10.1021/acscatal.8b05072. Epub 2019 Apr 3.


Chemoenzymatic Total Synthesis of Deoxy-, epi-, and Podophyllotoxin and a Biocatalytic Kinetic Resolution of Dibenzylbutyrolactones.

Lazzarotto M, Hammerer L, Hetmann M, Borg A, Schmermund L, Steiner L, Hartmann P, Belaj F, Kroutil W, Gruber K, Fuchs M.

Angew Chem Int Ed Engl. 2019 Jun 11;58(24):8226-8230. doi: 10.1002/anie.201900926. Epub 2019 May 8.


Cu and Hydroquinone for the Trifluoromethylation of Unprotected Phenols.

Pletz J, Koeberl C, Fuchs M, Steiner O, Goessler W, Kroutil W.

European J Org Chem. 2019 Jan 31;2019(4):682-690. doi: 10.1002/ejoc.201801111. Epub 2018 Oct 8.


Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities.

Unterhauser K, Pöltl L, Schneditz G, Kienesberger S, Glabonjat RA, Kitsera M, Pletz J, Josa-Prado F, Dornisch E, Lembacher-Fadum C, Roier S, Gorkiewicz G, Lucena D, Barasoain I, Kroutil W, Wiedner M, Loizou JI, Breinbauer R, Díaz JF, Schild S, Högenauer C, Zechner EL.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3774-3783. doi: 10.1073/pnas.1819154116. Epub 2019 Feb 11.


Mechanistic Studies of Fatty Acid Activation by CYP152 Peroxygenases Reveal Unexpected Desaturase Activity.

Pickl M, Kurakin S, Cantú Reinhard FG, Schmid P, Pöcheim A, Winkler CK, Kroutil W, de Visser SP, Faber K.

ACS Catal. 2019 Jan 4;9(1):565-577. doi: 10.1021/acscatal.8b03733. Epub 2018 Dec 6.


Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase.

Pavkov-Keller T, Schmidt NG, Żądło-Dobrowolska A, Kroutil W, Gruber K.

Chembiochem. 2019 Jan 2;20(1):88-95. doi: 10.1002/cbic.201800462. Epub 2018 Nov 26.


Biosynthesis and isolation of selenoneine from genetically modified fission yeast.

Turrini NG, Kroepfl N, Jensen KB, Reiter TC, Francesconi KA, Schwerdtle T, Kroutil W, Kuehnelt D.

Metallomics. 2018 Oct 17;10(10):1532-1538. doi: 10.1039/c8mt00200b. Epub 2018 Sep 24.


Sequence-Based In-silico Discovery, Characterisation, and Biocatalytic Application of a Set of Imine Reductases.

Velikogne S, Resch V, Dertnig C, Schrittwieser JH, Kroutil W.

ChemCatChem. 2018 Aug 13;10(15):3236-3246. doi: 10.1002/cctc.201800607. Epub 2018 Jul 17.


Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family.

Lahham M, Pavkov-Keller T, Fuchs M, Niederhauser J, Chalhoub G, Daniel B, Kroutil W, Gruber K, Macheroux P.

J Biol Chem. 2018 Nov 2;293(44):17021-17032. doi: 10.1074/jbc.RA118.004227. Epub 2018 Sep 7.


Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases.

Marx L, Ríos-Lombardía N, Farnberger JF, Kroutil W, Benítez-Mateos AI, López-Gallego F, Morís F, González-Sabín J, Berglund P.

Adv Synth Catal. 2018 Jun 5;360(11):2157-2165. doi: 10.1002/adsc.201701485. Epub 2018 Feb 28.


Asymmetric Synthesis of (R)-1-Alkyl-Substituted Tetrahydro-ß-carbolines Catalyzed by Strictosidine Synthases.

Pressnitz D, Fischereder EM, Pletz J, Kofler C, Hammerer L, Hiebler K, Lechner H, Richter N, Eger E, Kroutil W.

Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10683-10687. doi: 10.1002/anie.201803372. Epub 2018 Jun 21.


Molecular cloning, expression, and characterization of acyltransferase from Pseudomonas protegens.

Schmidt NG, Żądło-Dobrowolska A, Ruppert V, Höflehner C, Wiltschi B, Kroutil W.

Appl Microbiol Biotechnol. 2018 Jul;102(14):6057-6068. doi: 10.1007/s00253-018-9052-z. Epub 2018 May 12.


Promiscuous activity of C-acyltransferase from Pseudomonas protegens: synthesis of acetanilides in aqueous buffer.

Żądło-Dobrowolska A, Schmidt NG, Kroutil W.

Chem Commun (Camb). 2018 Mar 29;54(27):3387-3390. doi: 10.1039/C8CC00290H.


Library of Norcoclaurine Synthases and Their Immobilization for Biocatalytic Transformations.

Lechner H, Soriano P, Poschner R, Hailes HC, Ward JM, Kroutil W.

Biotechnol J. 2018 Mar;13(3):e1700542. doi: 10.1002/biot.201700542. Epub 2017 Dec 4.


Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline.

Dornisch E, Pletz J, Glabonjat RA, Martin F, Lembacher-Fadum C, Neger M, Högenauer C, Francesconi K, Kroutil W, Zangger K, Breinbauer R, Zechner EL.

Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14753-14757. doi: 10.1002/anie.201707737. Epub 2017 Oct 18.


In vivo plug-and-play: a modular multi-enzyme single-cell catalyst for the asymmetric amination of ketoacids and ketones.

Farnberger JE, Lorenz E, Richter N, Wendisch VF, Kroutil W.

Microb Cell Fact. 2017 Jul 28;16(1):132. doi: 10.1186/s12934-017-0750-5.


Enzymatic and Chemoenzymatic Three-Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines.

Erdmann V, Lichman BR, Zhao J, Simon RC, Kroutil W, Ward JM, Hailes HC, Rother D.

Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12503-12507. doi: 10.1002/anie.201705855. Epub 2017 Sep 6.


Biocatalytic Friedel-Crafts Acylation and Fries Reaction.

Schmidt NG, Pavkov-Keller T, Richter N, Wiltschi B, Gruber K, Kroutil W.

Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7615-7619. doi: 10.1002/anie.201703270. Epub 2017 May 23.


Artificial Biocatalytic Linear Cascades for Preparation of Organic Molecules.

Schrittwieser JH, Velikogne S, Hall M, Kroutil W.

Chem Rev. 2018 Jan 10;118(1):270-348. doi: 10.1021/acs.chemrev.7b00033. Epub 2017 May 8. Review.


Biocatalytic trifluoromethylation of unprotected phenols.

Simon RC, Busto E, Richter N, Resch V, Houk KN, Kroutil W.

Nat Commun. 2016 Nov 11;7:13323. doi: 10.1038/ncomms13323.


Building Bridges: Biocatalytic C-C-Bond Formation toward Multifunctional Products.

Schmidt NG, Eger E, Kroutil W.

ACS Catal. 2016 Jul 1;6(7):4286-4311. Epub 2016 Jun 8. Review.


Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched β-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination.

Cuetos A, García-Ramos M, Fischereder EM, Díaz-Rodríguez A, Grogan G, Gotor V, Kroutil W, Lavandera I.

Angew Chem Int Ed Engl. 2016 Feb 24;55(9):3144-7. doi: 10.1002/anie.201510554. Epub 2016 Feb 2.


The Industrial Age of Biocatalytic Transamination.

Fuchs M, Farnberger JE, Kroutil W.

European J Org Chem. 2015 Nov;2015(32):6965-6982. Epub 2015 Sep 23.


Enantioselective Oxidative Aerobic Dealkylation of N-Ethyl Benzylisoquinolines by Employing the Berberine Bridge Enzyme.

Gandomkar S, Fischereder EM, Schrittwieser JH, Wallner S, Habibi Z, Macheroux P, Kroutil W.

Angew Chem Int Ed Engl. 2015 Dec 7;54(50):15051-4. doi: 10.1002/anie.201507970. Epub 2015 Oct 21.


Vinylation of Unprotected Phenols Using a Biocatalytic System.

Busto E, Simon RC, Kroutil W.

Angew Chem Int Ed Engl. 2015 Sep 7;54(37):10899-902. doi: 10.1002/anie.201505696. Epub 2015 Jul 29.


ω-Transaminases for the amination of functionalised cyclic ketones.

Richter N, Simon RC, Lechner H, Kroutil W, Ward JM, Hailes HC.

Org Biomol Chem. 2015 Sep 7;13(33):8843-51. doi: 10.1039/c5ob01204j. Epub 2015 Jul 21.


Investigation of Structural Determinants for the Substrate Specificity in the Zinc-Dependent Alcohol Dehydrogenase CPCR2 from Candida parapsilosis.

Loderer C, Dhoke GV, Davari MD, Kroutil W, Schwaneberg U, Bocola M, Ansorge-Schumacher MB.

Chembiochem. 2015 Jul 6;16(10):1512-9. doi: 10.1002/cbic.201500100. Epub 2015 Jun 10.


Asymmetric Biocatalytic Amination of Ketones at the Expense of NH3 and Molecular Hydrogen.

Holzer AK, Hiebler K, Mutti FG, Simon RC, Lauterbach L, Lenz O, Kroutil W.

Org Lett. 2015 May 15;17(10):2431-3. doi: 10.1021/acs.orglett.5b01154. Epub 2015 May 6.


Cobalamin-dependent enzymatic O-, N-, and S-demethylation.

Richter N, Zepeck F, Kroutil W.

Trends Biotechnol. 2015 Jul;33(7):371-3. doi: 10.1016/j.tibtech.2015.03.011. Epub 2015 Apr 14.


Biocatalysts for the formation of three- to six-membered carbo- and heterocycles.

Lechner H, Pressnitz D, Kroutil W.

Biotechnol Adv. 2015 Sep-Oct;33(5):457-80. doi: 10.1016/j.biotechadv.2015.01.012. Epub 2015 Feb 14. Review.


A synthetic biology approach for the transformation of l-α-amino acids to the corresponding enantiopure (R)- or (S)-α-hydroxy acids.

Gourinchas G, Busto E, Killinger M, Richter N, Wiltschi B, Kroutil W.

Chem Commun (Camb). 2015 Feb 18;51(14):2828-31. doi: 10.1039/c4cc08286a.


Continuous flow synthesis of chiral amines in organic solvents: immobilization of E. coli cells containing both ω-transaminase and PLP.

Andrade LH, Kroutil W, Jamison TF.

Org Lett. 2014 Dec 5;16(23):6092-5. doi: 10.1021/ol502712v. Epub 2014 Nov 13.


Phenotyping the quality of complex medium components by simple online-monitored shake flask experiments.

Diederichs S, Korona A, Staaden A, Kroutil W, Honda K, Ohtake H, Büchs J.

Microb Cell Fact. 2014 Nov 7;13:149. doi: 10.1186/s12934-014-0149-5.


Introducing an in situ capping strategy in systems biocatalysis to access 6-aminohexanoic acid.

Sattler JH, Fuchs M, Mutti FG, Grischek B, Engel P, Pfeffer J, Woodley JM, Kroutil W.

Angew Chem Int Ed Engl. 2014 Dec 15;53(51):14153-7. doi: 10.1002/anie.201409227. Epub 2014 Nov 3.


Stereoselective synthesis of γ-hydroxynorvaline through combination of organo- and biocatalysis.

Simon RC, Busto E, Schrittwieser JH, Sattler JH, Pietruszka J, Faber K, Kroutil W.

Chem Commun (Camb). 2014 Dec 25;50(99):15669-72. doi: 10.1039/c4cc06230b. Epub 2014 Sep 24.


Minireactor-based high-throughput temperature profiling for the optimization of microbial and enzymatic processes.

Kunze M, Lattermann C, Diederichs S, Kroutil W, Büchs J.

J Biol Eng. 2014 Aug 4;8:22. doi: 10.1186/1754-1611-8-22. eCollection 2014.


Biocontrolled formal inversion or retention of L-α-amino acids to enantiopure (R)- or (S)-hydroxyacids.

Busto E, Richter N, Grischek B, Kroutil W.

Chemistry. 2014 Aug 25;20(35):11225-8. doi: 10.1002/chem.201403195. Epub 2014 Jul 22.


Engineering strictosidine synthase: rational design of a small, focused circular permutation library of the β-propeller fold enzyme.

Fischereder E, Pressnitz D, Kroutil W, Lutz S.

Bioorg Med Chem. 2014 Oct 15;22(20):5633-7. doi: 10.1016/j.bmc.2014.06.023. Epub 2014 Jun 19.


Synthesis of (R)- or (S)-valinol using ω-transaminases in aqueous and organic media.

Fuchs CS, Simon RC, Riethorst W, Zepeck F, Kroutil W.

Bioorg Med Chem. 2014 Oct 15;22(20):5558-62. doi: 10.1016/j.bmc.2014.05.055. Epub 2014 Jun 5.


Nitrile as Activating Group in the Asymmetric Bioreduction of β-Cyanoacrylic Acids Catalyzed by Ene-Reductases.

Winkler CK, Clay D, Turrini NG, Lechner H, Kroutil W, Davies S, Debarge S, O'Neill P, Steflik J, Karmilowicz M, Wong JW, Faber K.

Adv Synth Catal. 2014 May 26;356(8):1878-1882. Epub 2014 Apr 9.


Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion.

Schrittwieser JH, Groenendaal B, Resch V, Ghislieri D, Wallner S, Fischereder EM, Fuchs E, Grischek B, Sattler JH, Macheroux P, Turner NJ, Kroutil W.

Angew Chem Int Ed Engl. 2014 Apr 1;53(14):3731-4. doi: 10.1002/anie.201400027. Epub 2014 Feb 24.


Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase.

Richter N, Simon RC, Kroutil W, Ward JM, Hailes HC.

Chem Commun (Camb). 2014 Jun 11;50(46):6098-100. doi: 10.1039/c3cc49080g.


Enzymatic aerobic alkene cleavage catalyzed by a Mn(3+) -dependent proteinase a homologue.

Rajagopalan A, Schober M, Emmerstorfer A, Hammerer L, Migglautsch A, Seisser B, Glueck SM, Niehaus F, Eck J, Pichler H, Gruber K, Kroutil W.

Chembiochem. 2013 Dec 16;14(18):2427-30. doi: 10.1002/cbic.201300601. Epub 2013 Nov 4. No abstract available.


Steric vs. electronic effects in the Lactobacillus brevis ADH-catalyzed bioreduction of ketones.

Rodríguez C, Borzęcka W, Sattler JH, Kroutil W, Lavandera I, Gotor V.

Org Biomol Chem. 2014 Jan 28;12(4):673-81. doi: 10.1039/c3ob42057d.


Biocatalytic synthesis of enantiopure building blocks for pharmaceuticals.

Simon RC, Mutti FG, Kroutil W.

Drug Discov Today Technol. 2013 Spring;10(1):e37-44. doi: 10.1016/j.ddtec.2012.08.002. Review.


Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts.

Kroutil W, Fischereder EM, Fuchs CS, Lechner H, Mutti FG, Pressnitz D, Rajagopalan A, Sattler JH, Simon RC, Siirola E.

Org Process Res Dev. 2013 May 17;17(5):751-759. Epub 2013 Apr 22.


Concise Chemoenzymatic Three Step Total Synthesis of Isosolenopsin Through Medium Engineering.

Simon RC, Fuchs CS, Lechner H, Zepeck F, Kroutil W.

European J Org Chem. 2013 Jun 1;2013(16):3397-3402.


Biochemical characterization of an alcohol dehydrogenase from Ralstonia sp.

Kulig J, Frese A, Kroutil W, Pohl M, Rother D.

Biotechnol Bioeng. 2013 Jul;110(7):1838-48. doi: 10.1002/bit.24857. Epub 2013 Feb 22.


Artificial multi-enzyme networks for the asymmetric amination of sec-alcohols.

Tauber K, Fuchs M, Sattler JH, Pitzer J, Pressnitz D, Koszelewski D, Faber K, Pfeffer J, Haas T, Kroutil W.

Chemistry. 2013 Mar 18;19(12):4030-5. doi: 10.1002/chem.201202666. Epub 2013 Jan 22.


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