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Items: 1 to 50 of 80

1.

Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia.

Chung W, Kelly AD, Kropf P, Fung H, Jelinek J, Su XY, Roboz GJ, Kantarjian HM, Azab M, Issa JJ.

Clin Epigenetics. 2019 Jul 22;11(1):106. doi: 10.1186/s13148-019-0704-3.

2.

Guadecitabine (SGI-110) in patients with intermediate or high-risk myelodysplastic syndromes: phase 2 results from a multicentre, open-label, randomised, phase 1/2 trial.

Garcia-Manero G, Roboz G, Walsh K, Kantarjian H, Ritchie E, Kropf P, O'Connell C, Tibes R, Lunin S, Rosenblat T, Yee K, Stock W, Griffiths E, Mace J, Podoltsev N, Berdeja J, Jabbour E, Issa JJ, Hao Y, Keer HN, Azab M, Savona MR.

Lancet Haematol. 2019 Jun;6(6):e317-e327. doi: 10.1016/S2352-3026(19)30029-8. Epub 2019 May 3.

PMID:
31060979
3.

Functional genomic landscape of acute myeloid leukaemia.

Tyner JW, Tognon CE, Bottomly D, Wilmot B, Kurtz SE, Savage SL, Long N, Schultz AR, Traer E, Abel M, Agarwal A, Blucher A, Borate U, Bryant J, Burke R, Carlos A, Carpenter R, Carroll J, Chang BH, Coblentz C, d'Almeida A, Cook R, Danilov A, Dao KT, Degnin M, Devine D, Dibb J, Edwards DK 5th, Eide CA, English I, Glover J, Henson R, Ho H, Jemal A, Johnson K, Johnson R, Junio B, Kaempf A, Leonard J, Lin C, Liu SQ, Lo P, Loriaux MM, Luty S, Macey T, MacManiman J, Martinez J, Mori M, Nelson D, Nichols C, Peters J, Ramsdill J, Rofelty A, Schuff R, Searles R, Segerdell E, Smith RL, Spurgeon SE, Sweeney T, Thapa A, Visser C, Wagner J, Watanabe-Smith K, Werth K, Wolf J, White L, Yates A, Zhang H, Cogle CR, Collins RH, Connolly DC, Deininger MW, Drusbosky L, Hourigan CS, Jordan CT, Kropf P, Lin TL, Martinez ME, Medeiros BC, Pallapati RR, Pollyea DA, Swords RT, Watts JM, Weir SJ, Wiest DL, Winters RM, McWeeney SK, Druker BJ.

Nature. 2018 Oct;562(7728):526-531. doi: 10.1038/s41586-018-0623-z. Epub 2018 Oct 17.

4.

Chimeric Antigen Receptor T-Cell Therapy.

Ogba N, Arwood NM, Bartlett NL, Bloom M, Brown P, Brown C, Budde EL, Carlson R, Farnia S, Fry TJ, Garber M, Gardner RA, Gurschick L, Kropf P, Reitan JJ, Sauter C, Shah B, Shpall EJ, Rosen ST.

J Natl Compr Canc Netw. 2018 Sep;16(9):1092-1106. doi: 10.6004/jnccn.2018.0073.

PMID:
30181421
5.

A phase-1 study of dasatinib plus all-trans retinoic acid in acute myeloid leukemia.

Redner RL, Beumer JH, Kropf P, Agha M, Boyiadzis M, Dorritie K, Farah R, Hou JZ, Im A, Lim SH, Raptis A, Sehgal A, Christner SM, Normolle D, Johnson DE.

Leuk Lymphoma. 2018 Nov;59(11):2595-2601. doi: 10.1080/10428194.2018.1443330. Epub 2018 Apr 4.

PMID:
29616864
6.

Demethylator phenotypes in acute myeloid leukemia.

Kelly AD, Madzo J, Madireddi P, Kropf P, Good CR, Jelinek J, Issa JJ.

Leukemia. 2018 Oct;32(10):2178-2188. doi: 10.1038/s41375-018-0084-2. Epub 2018 Mar 7.

7.

Dose, schedule, safety, and efficacy of guadecitabine in relapsed or refractory acute myeloid leukemia.

Roboz GJ, Kantarjian HM, Yee KWL, Kropf PL, O'Connell CL, Griffiths EA, Stock W, Daver NG, Jabbour E, Ritchie EK, Walsh KJ, Rizzieri D, Lunin SD, Curio T, Chung W, Hao Y, Lowder JN, Azab M, Issa JJ.

Cancer. 2018 Jan 15;124(2):325-334. doi: 10.1002/cncr.31138. Epub 2017 Dec 6.

8.

Guadecitabine (SGI-110) in treatment-naive patients with acute myeloid leukaemia: phase 2 results from a multicentre, randomised, phase 1/2 trial.

Kantarjian HM, Roboz GJ, Kropf PL, Yee KWL, O'Connell CL, Tibes R, Walsh KJ, Podoltsev NA, Griffiths EA, Jabbour E, Garcia-Manero G, Rizzieri D, Stock W, Savona MR, Rosenblat TL, Berdeja JG, Ravandi F, Rock EP, Hao Y, Azab M, Issa JJ.

Lancet Oncol. 2017 Oct;18(10):1317-1326. doi: 10.1016/S1470-2045(17)30576-4. Epub 2017 Aug 24.

9.

Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites.

Tajebe F, Getahun M, Adem E, Hailu A, Lemma M, Fikre H, Raynes J, Tamiru A, Mulugeta Z, Diro E, Toulza F, Shkedy Z, Ayele T, Modolell M, Munder M, Müller I, Takele Y, Kropf P.

PLoS Negl Trop Dis. 2017 Jul 21;11(7):e0005727. doi: 10.1371/journal.pntd.0005727. eCollection 2017 Jul.

10.

A novel non-invasive diagnostic sampling technique for cutaneous leishmaniasis.

Taslimi Y, Sadeghipour P, Habibzadeh S, Mashayekhi V, Mortazavi H, Müller I, Lane ME, Kropf P, Rafati S.

PLoS Negl Trop Dis. 2017 Jul 13;11(7):e0005750. doi: 10.1371/journal.pntd.0005750. eCollection 2017 Jul.

11.

Acute Myeloid Leukemia, Version 3.2017, NCCN Clinical Practice Guidelines in Oncology.

O'Donnell MR, Tallman MS, Abboud CN, Altman JK, Appelbaum FR, Arber DA, Bhatt V, Bixby D, Blum W, Coutre SE, De Lima M, Fathi AT, Fiorella M, Foran JM, Gore SD, Hall AC, Kropf P, Lancet J, Maness LJ, Marcucci G, Martin MG, Moore JO, Olin R, Peker D, Pollyea DA, Pratz K, Ravandi F, Shami PJ, Stone RM, Strickland SA, Wang ES, Wieduwilt M, Gregory K, Ogba N.

J Natl Compr Canc Netw. 2017 Jul;15(7):926-957. doi: 10.6004/jnccn.2017.0116.

PMID:
28687581
12.

DNA Hypomethylating Drugs in Cancer Therapy.

Sato T, Issa JJ, Kropf P.

Cold Spring Harb Perspect Med. 2017 May 1;7(5). pii: a026948. doi: 10.1101/cshperspect.a026948. Review.

13.

Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation.

Lecrux C, Sandoe CH, Neupane S, Kropf P, Toussay X, Tong XK, Lacalle-Aurioles M, Shmuel A, Hamel E.

J Neurosci. 2017 Feb 8;37(6):1518-1531. doi: 10.1523/JNEUROSCI.1784-16.2016. Epub 2017 Jan 9.

14.

Splenic irradiation for splenomegaly: A systematic review.

Zaorsky NG, Williams GR, Barta SK, Esnaola NF, Kropf PL, Hayes SB, Meyer JE.

Cancer Treat Rev. 2017 Feb;53:47-52. doi: 10.1016/j.ctrv.2016.11.016. Epub 2016 Dec 22. Review.

PMID:
28063304
15.

Visceral Leishmaniasis Patients Display Altered Composition and Maturity of Neutrophils as well as Impaired Neutrophil Effector Functions.

Yizengaw E, Getahun M, Tajebe F, Cruz Cervera E, Adem E, Mesfin G, Hailu A, Van der Auwera G, Yardley V, Lemma M, Skhedy Z, Diro E, Yeshanew A, Melkamu R, Mengesha B, Modolell M, Munder M, Müller I, Takele Y, Kropf P.

Front Immunol. 2016 Nov 29;7:517. eCollection 2016.

16.

Myeloproliferative Neoplasms, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.

Mesa R, Jamieson C, Bhatia R, Deininger MW, Gerds AT, Gojo I, Gotlib J, Gundabolu K, Hobbs G, Klisovic RB, Kropf P, Mohan SR, Oh S, Padron E, Podoltsev N, Pollyea DA, Rampal R, Rein LA, Scott B, Snyder DS, Stein BL, Verstovsek S, Wadleigh M, Wang ES, Bergman MA, Gregory KM, Sundar H.

J Natl Compr Canc Netw. 2016 Dec;14(12):1572-1611.

PMID:
27956542
17.

NCCN Guidelines Insights: Chronic Myeloid Leukemia, Version 1.2017.

Pallera A, Altman JK, Berman E, Abboud CN, Bhatnagar B, Curtin P, DeAngelo DJ, Gotlib J, Hagelstrom RT, Hobbs G, Jagasia M, Kantarjian HM, Kropf P, Metheny L, Moore JO, Ontiveros E, Purev E, Quiery A, Reddy VV, Rose MG, Shah NP, Smith BD, Snyder DS, Sweet KL, Tibes R, Yang DT, Gregory K, Sundar H, Deininger M, Radich JP.

J Natl Compr Canc Netw. 2016 Dec;14(12):1505-1512.

PMID:
27956535
18.

Malnutrition in Healthy Individuals Results in Increased Mixed Cytokine Profiles, Altered Neutrophil Subsets and Function.

Takele Y, Adem E, Getahun M, Tajebe F, Kiflie A, Hailu A, Raynes J, Mengesha B, Ayele TA, Shkedy Z, Lemma M, Diro E, Toulza F, Modolell M, Munder M, Müller I, Kropf P.

PLoS One. 2016 Aug 22;11(8):e0157919. doi: 10.1371/journal.pone.0157919. eCollection 2016.

19.

Comparing acute and chronic human cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica focusing on arginase activity.

Mortazavi H, Sadeghipour P, Taslimi Y, Habibzadeh S, Zali F, Zahedifard F, Rahmati J, Kamyab K, Ghandi N, Zamanian A, Reza Tohidinik H, Muller I, Kropf P, Rafati S.

J Eur Acad Dermatol Venereol. 2016 Dec;30(12):2118-2121. doi: 10.1111/jdv.13838. Epub 2016 Jul 21.

20.
21.

Successful Treatment of Human Visceral Leishmaniasis Restores Antigen-Specific IFN-γ, but not IL-10 Production.

Adem E, Tajebe F, Getahun M, Kiflie A, Diro E, Hailu A, Shkedy Z, Mengesha B, Mulaw T, Atnafu S, Deressa T, Mathewos B, Abate E, Modolell M, Munder M, Müller I, Takele Y, Kropf P.

PLoS Negl Trop Dis. 2016 Mar 10;10(3):e0004468. doi: 10.1371/journal.pntd.0004468. eCollection 2016 Mar.

22.

Laminar Distribution of Phase-Amplitude Coupling of Spontaneous Current Sources and Sinks.

Sotero RC, Bortel A, Naaman S, Mocanu VM, Kropf P, Villeneuve MY, Shmuel A.

Front Neurosci. 2015 Dec 22;9:454. doi: 10.3389/fnins.2015.00454. eCollection 2015.

23.

Donor Lymphocyte Infusion in Hematologic Malignancies--Good to be Fresh?

Hossain NM, Klumpp T, Ulicny J, Garner M, Kropf PL, Mangan KF, Barta SK, Fung HC, Martin ME.

Clin Lymphoma Myeloma Leuk. 2016 Feb;16(2):111-5. doi: 10.1016/j.clml.2015.10.004. Epub 2015 Nov 3.

PMID:
26632076
24.

Healthcare utilization and costs associated with tyrosine kinase inhibitor switching in patients with chronic myeloid leukemia.

Kropf P, Barnes G, Tang B, Pathak A, Issa JP.

Leuk Lymphoma. 2016;57(4):935-41. doi: 10.3109/10428194.2015.1088654. Epub 2015 Nov 20.

PMID:
26480922
25.

Historical views, conventional approaches, and evolving management strategies for myeloproliferative neoplasms.

Stein BL, Gotlib J, Arcasoy M, Nguyen MH, Shah N, Moliterno A, Jamieson C, Pollyea DA, Scott B, Wadleigh M, Levine R, Komrokji R, Klisovic R, Gundabolu K, Kropf P, Wetzler M, Oh ST, Ribeiro R, Paschal R, Mohan S, Podoltsev N, Prchal J, Talpaz M, Snyder D, Verstovsek S, Mesa RA.

J Natl Compr Canc Netw. 2015 Apr;13(4):424-34. Review.

PMID:
25870379
26.

Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis.

Jarvis JN, Meintjes G, Bicanic T, Buffa V, Hogan L, Mo S, Tomlinson G, Kropf P, Noursadeghi M, Harrison TS.

PLoS Pathog. 2015 Apr 8;11(4):e1004754. doi: 10.1371/journal.ppat.1004754. eCollection 2015 Apr.

27.

Protein energy malnutrition increases arginase activity in monocytes and macrophages.

Corware K, Yardley V, Mack C, Schuster S, Al-Hassi H, Herath S, Bergin P, Modolell M, Munder M, Müller I, Kropf P.

Nutr Metab (Lond). 2014 Oct 24;11(1):51. doi: 10.1186/1743-7075-11-51. eCollection 2014.

28.

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages.

Rath M, Müller I, Kropf P, Closs EI, Munder M.

Front Immunol. 2014 Oct 27;5:532. doi: 10.3389/fimmu.2014.00532. eCollection 2014. Review.

29.

Chronic myelogenous leukemia, version 1.2015.

O'Brien S, Radich JP, Abboud CN, Akhtari M, Altman JK, Berman E, Curtin P, DeAngelo DJ, Deininger M, Devine S, Fathi AT, Gotlib J, Jagasia M, Kropf P, Moore JO, Pallera A, Reddy VV, Shah NP, Smith BD, Snyder DS, Wetzler M, Gregory K, Sundar H.

J Natl Compr Canc Netw. 2014 Nov;12(11):1590-610.

PMID:
25361806
30.

Granulocyte functions are independent of arginine availability.

Kapp K, Prüfer S, Michel CS, Habermeier A, Luckner-Minden C, Giese T, Bomalaski J, Langhans CD, Kropf P, Müller I, Closs EI, Radsak MP, Munder M.

J Leukoc Biol. 2014 Dec;96(6):1047-53. doi: 10.1189/jlb.3AB0214-082R. Epub 2014 Aug 7.

PMID:
25104794
31.

Characterization of neutrophil subsets in healthy human pregnancies.

Ssemaganda A, Kindinger L, Bergin P, Nielsen L, Mpendo J, Ssetaala A, Kiwanuka N, Munder M, Teoh TG, Kropf P, Müller I.

PLoS One. 2014 Feb 13;9(2):e85696. doi: 10.1371/journal.pone.0085696. eCollection 2014.

32.

Right ventricular mechanics using a novel comprehensive three-view echocardiographic strain analysis in a normal population.

Forsha D, Risum N, Kropf PA, Rajagopal S, Smith PB, Kanter RJ, Samad Z, Sogaard P, Barker P, Kisslo J.

J Am Soc Echocardiogr. 2014 Apr;27(4):413-22. doi: 10.1016/j.echo.2013.12.018. Epub 2014 Feb 6.

33.

Two women presenting worsening cutaneous ulcers during pregnancy: diagnosis, immune response, and follow-up.

Conceição-Silva F, Morgado FN, Pimentel MI, e Vasconcellos Ede C, Schubach AO, Valete-Rosalino CM, Kropf P, Müller I.

PLoS Negl Trop Dis. 2013 Dec 12;7(12):e2472. doi: 10.1371/journal.pntd.0002472. eCollection 2013. No abstract available.

34.

Chronic Myelogenous Leukemia, Version 1.2014.

O'Brien S, Radich JP, Abboud CN, Akhtari M, Altman JK, Berman E, DeAngelo DJ, Deininger M, Devine S, Fathi AT, Gotlib J, Jagasia M, Kropf P, Moore JO, Pallera A, Pinilla-Ibarz J, Reddy VV, Shah NP, Smith BD, Snyder DS, Wetzler M, Gregory K, Sundar H; Ntational comprehensive cancer network.

J Natl Compr Canc Netw. 2013 Nov;11(11):1327-40.

35.

Phenotypic alteration of neutrophils in the blood of HIV seropositive patients.

Cloke T, Munder M, Bergin P, Herath S, Modolell M, Taylor G, Müller I, Kropf P.

PLoS One. 2013 Sep 9;8(9):e72034. doi: 10.1371/journal.pone.0072034. eCollection 2013.

36.

Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion.

Munder M, Engelhardt M, Knies D, Medenhoff S, Wabnitz G, Luckner-Minden C, Feldmeyer N, Voss RH, Kropf P, Müller I, Conradi R, Samstag Y, Theobald M, Ho AD, Goldschmidt H, Hundemer M.

PLoS One. 2013 May 23;8(5):e63521. doi: 10.1371/journal.pone.0063521. Print 2013.

37.

Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia.

Abebe T, Takele Y, Weldegebreal T, Cloke T, Closs E, Corset C, Hailu A, Hailu W, Sisay Y, Corware K, Corset M, Modolell M, Munder M, Tacchini-Cottier F, Müller I, Kropf P.

PLoS Negl Trop Dis. 2013;7(3):e2134. doi: 10.1371/journal.pntd.0002134. Epub 2013 Mar 28.

38.

Arginase activity in the blood of patients with visceral leishmaniasis and HIV infection.

Takele Y, Abebe T, Weldegebreal T, Hailu A, Hailu W, Hurissa Z, Ali J, Diro E, Sisay Y, Cloke T, Modolell M, Munder M, Tacchini-Cottier F, Müller I, Kropf P.

PLoS Negl Trop Dis. 2013;7(1):e1977. doi: 10.1371/journal.pntd.0001977. Epub 2013 Jan 17. Erratum in: PLoS Negl Trop Dis. 2013 Jan;7(1). doi: 10.1371/annotation/9e89dee8-e2b7-4559-bd4e-933692403410.

39.

Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection.

Cloke T, Munder M, Taylor G, Müller I, Kropf P.

PLoS One. 2012;7(11):e48939. doi: 10.1371/journal.pone.0048939. Epub 2012 Nov 13.

40.

A randomised controlled pilot feasibility study of the physical and psychological effects of an integrated support programme in breast cancer.

Baker BS, Harrington JE, Choi BS, Kropf P, Muller I, Hoffman CJ.

Complement Ther Clin Pract. 2012 Aug;18(3):182-9. doi: 10.1016/j.ctcp.2012.03.002. Epub 2012 May 3.

PMID:
22789796
41.

Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia.

Abebe T, Hailu A, Woldeyes M, Mekonen W, Bilcha K, Cloke T, Fry L, Seich Al Basatena NK, Corware K, Modolell M, Munder M, Tacchini-Cottier F, Müller I, Kropf P.

PLoS Negl Trop Dis. 2012;6(6):e1684. doi: 10.1371/journal.pntd.0001684. Epub 2012 Jun 12.

42.

Long-term results of chemoimmunotherapy with low-dose fludarabine, cyclophosphamide and high-dose rituximab as initial treatment for patients with chronic lymphocytic leukemia.

Foon KA, Mehta D, Lentzsch S, Kropf P, Marks S, Lenzner D, Pietragallo L, Sulecki M, Tarhini A, Boyiadzis M.

Blood. 2012 Mar 29;119(13):3184-5. doi: 10.1182/blood-2012-01-408047. No abstract available.

43.

Arginine deficiency leads to impaired cofilin dephosphorylation in activated human T lymphocytes.

Feldmeyer N, Wabnitz G, Leicht S, Luckner-Minden C, Schiller M, Franz T, Conradi R, Kropf P, Müller I, Ho AD, Samstag Y, Munder M.

Int Immunol. 2012 May;24(5):303-13. doi: 10.1093/intimm/dxs004. Epub 2012 Feb 16.

44.

Spontaneous graft versus host disease occurring in a patient with multiple myeloma after autologous stem cell transplant.

Fidler C, Klumpp T, Mangan K, Martin M, Sharma M, Emmons R, Lu M, Kropf P.

Am J Hematol. 2012 Feb;87(2):219-21. doi: 10.1002/ajh.22227. Epub 2011 Dec 21.

45.

Arginine depletion as a mechanism for the immune privilege of corneal allografts.

Fu H, Khan A, Coe D, Zaher S, Chai JG, Kropf P, Müller I, Larkin DF, George AJ.

Eur J Immunol. 2011 Oct;41(10):2997-3005. doi: 10.1002/eji.201141683. Epub 2011 Sep 6.

46.

Antiretroviral therapy abrogates association between arginase activity and HIV disease severity.

Cloke TE, Abebe T, Hailu A, Munder M, Taylor GP, Müller I, Kropf P.

Trans R Soc Trop Med Hyg. 2010 Nov;104(11):746-8. doi: 10.1016/j.trstmh.2010.08.004. Epub 2010 Sep 17.

47.

Increased level of arginase activity correlates with disease severity in HIV-seropositive patients.

Cloke TE, Garvey L, Choi BS, Abebe T, Hailu A, Hancock M, Kadolsky U, Bangham CR, Munder M, Müller I, Taylor GP, Kropf P.

J Infect Dis. 2010 Aug 15;202(3):374-85. doi: 10.1086/653736.

48.

Human eosinophil granulocytes do not express the enzyme arginase.

Luckner-Minden C, Fischer I, Langhans CD, Schiller M, Kropf P, Müller I, Hohlfeld JM, Ho AD, Munder M.

J Leukoc Biol. 2010 Jun;87(6):1125-32. doi: 10.1189/jlb.1109741. Epub 2010 Mar 3.

PMID:
20200399
49.

Dasatinib promotes ATRA-induced differentiation of AML cells.

Kropf PL, Wang L, Zang Y, Redner RL, Johnson DE.

Leukemia. 2010 Mar;24(3):663-5. doi: 10.1038/leu.2009.267. Epub 2009 Dec 24. No abstract available.

PMID:
20033056
50.

Polymorphonuclear neutrophils and T lymphocytes: strange bedfellows or brothers in arms?

Müller I, Munder M, Kropf P, Hänsch GM.

Trends Immunol. 2009 Nov;30(11):522-30. doi: 10.1016/j.it.2009.07.007. Epub 2009 Sep 21. Review.

PMID:
19775938

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