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Items: 1 to 50 of 165

1.

Hydrophobic Interactions Drive Binding between Vascular Endothelial Growth Factor-A (VEGFA) and Polyphenolic Inhibitors.

Perez-Moral N, Needs PW, Moyle CWA, Kroon PA.

Molecules. 2019 Jul 31;24(15). pii: E2785. doi: 10.3390/molecules24152785.

2.

Correction: Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells.

Wu Q, Needs PW, Lu Y, Kroon PA, Ren D, Yang X.

Food Funct. 2019 Jul 17;10(7):4452-4453. doi: 10.1039/c9fo90027f.

PMID:
31179472
3.

Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme.

Mohos V, Pánovics A, Fliszár-Nyúl E, Schilli G, Hetényi C, Mladěnka P, Needs PW, Kroon PA, Pethő G, Poór M.

Int J Mol Sci. 2019 May 31;20(11). pii: E2681. doi: 10.3390/ijms20112681.

4.

Exploring the Molecular Pathways Behind the Effects of Nutrients and Dietary Polyphenols on Gut Microbiota and Intestinal Permeability: A Perspective on the Potential of Metabolomics and Future Clinical Applications.

Peron G, Hidalgo-Liberona N, González-Domínguez R, Garcia-Aloy M, Guglielmetti S, Bernardi S, Kirkup B, Kroon PA, Cherubini A, Riso P, Andrés-Lacueva C.

J Agric Food Chem. 2019 May 28. doi: 10.1021/acs.jafc.9b01687. [Epub ahead of print]

PMID:
31083905
5.

Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics.

González-Domínguez R, Urpi-Sarda M, Jáuregui O, Needs PW, Kroon PA, Andrés-Lacueva C.

J Agric Food Chem. 2019 Mar 1. doi: 10.1021/acs.jafc.8b07023. [Epub ahead of print]

PMID:
30799616
6.

Lack of acute or chronic effects of epicatechin-rich and procyanidin-rich apple extracts on blood pressure and cardiometabolic biomarkers in adults with moderately elevated blood pressure: a randomized, placebo-controlled crossover trial.

Hollands WJ, Tapp H, Defernez M, Perez Moral N, Winterbone MS, Philo M, Lucey AJ, Kiely ME, Kroon PA.

Am J Clin Nutr. 2018 Nov 1;108(5):1006-1014. doi: 10.1093/ajcn/nqy139.

PMID:
30475960
7.
8.

Effect of an egg ovalbumin-derived protein hydrolysate on blood pressure and cardiovascular risk in adults with a mildly elevated blood pressure: a randomized placebo-controlled crossover trial.

Lucey AJ, Heneghan C, Manning E, Kroon PA, Kiely ME.

Eur J Nutr. 2019 Oct;58(7):2823-2833. doi: 10.1007/s00394-018-1832-9. Epub 2018 Oct 3.

PMID:
30284065
9.

Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells.

Wu Q, Kroon PA, Shao H, Needs PW, Yang X.

J Agric Food Chem. 2018 Jul 11;66(27):7181-7189. doi: 10.1021/acs.jafc.8b02420. Epub 2018 Jun 28.

PMID:
29905475
10.

Validation of control genes and a standardised protocol for quantifying gene expression in the livers of C57BL/6 and ApoE-/- mice.

Day PEL, Chambers KF, Winterbone MS, García-Blanco T, Vauzour D, Kroon PA.

Sci Rep. 2018 May 24;8(1):8081. doi: 10.1038/s41598-018-26431-3.

11.

4-Week consumption of anthocyanin-rich blood orange juice does not affect LDL-cholesterol or other biomarkers of CVD risk and glycaemia compared with standard orange juice: a randomised controlled trial.

Hollands WJ, Armah CN, Doleman JF, Perez-Moral N, Winterbone MS, Kroon PA.

Br J Nutr. 2018 Feb;119(4):415-421. doi: 10.1017/S0007114517003865.

PMID:
29498348
12.

Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells.

Wu Q, Needs PW, Lu Y, Kroon PA, Ren D, Yang X.

Food Funct. 2018 Mar 1;9(3):1736-1746. doi: 10.1039/c7fo01964e. Epub 2018 Mar 2. Erratum in: Food Funct. 2019 Jul 17;10(7):4452-4453.

PMID:
29497723
13.

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.

García-Conesa MT, Chambers K, Combet E, Pinto P, Garcia-Aloy M, Andrés-Lacueva C, de Pascual-Teresa S, Mena P, Konic Ristic A, Hollands WJ, Kroon PA, Rodríguez-Mateos A, Istas G, Kontogiorgis CA, Rai DK, Gibney ER, Morand C, Espín JC, González-Sarrías A.

Int J Mol Sci. 2018 Feb 28;19(3). pii: E694. doi: 10.3390/ijms19030694. Review.

14.

Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries.

Van Rymenant E, Grootaert C, Beerens K, Needs PW, Kroon PA, Kerimi A, Williamson G, García-Villalba R, González-Sarrías A, Tomas-Barberan F, Van Camp J, Van de Voorde J.

Food Funct. 2017 Dec 13;8(12):4331-4335. doi: 10.1039/c7fo01273j.

PMID:
29138782
15.

Acute Consumption of Flavan-3-ol-Enriched Dark Chocolate Affects Human Endogenous Metabolism.

Ostertag LM, Philo M, Colquhoun IJ, Tapp HS, Saha S, Duthie GG, Kemsley EK, de Roos B, Kroon PA, Le Gall G.

J Proteome Res. 2017 Jul 7;16(7):2516-2526. doi: 10.1021/acs.jproteome.7b00089. Epub 2017 Jun 15.

PMID:
28585834
16.

Development, validation and evaluation of an analytical method for the determination of monomeric and oligomeric procyanidins in apple extracts.

Hollands WJ, Voorspoels S, Jacobs G, Aaby K, Meisland A, Garcia-Villalba R, Tomas-Barberan F, Piskula MK, Mawson D, Vovk I, Needs PW, Kroon PA.

J Chromatogr A. 2017 Apr 28;1495:46-56. doi: 10.1016/j.chroma.2017.03.030. Epub 2017 Mar 18.

17.

Towards an Understanding of the Low Bioavailability of Quercetin: A Study of Its Interaction with Intestinal Lipids.

Rich GT, Buchweitz M, Winterbone MS, Kroon PA, Wilde PJ.

Nutrients. 2017 Feb 5;9(2). pii: E111. doi: 10.3390/nu9020111.

18.

Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies.

Kardum N, Konic Ristic A, Zec M, Kojadinovic M, Petrovic-Oggiano G, Zekovic M, Kroon PA, Glibetić M.

Int J Food Sci Nutr. 2017 Sep;68(6):742-749. doi: 10.1080/09637486.2017.1283682. Epub 2017 Feb 1.

19.

Interaction of quercetin and its metabolites with warfarin: Displacement of warfarin from serum albumin and inhibition of CYP2C9 enzyme.

Poór M, Boda G, Needs PW, Kroon PA, Lemli B, Bencsik T.

Biomed Pharmacother. 2017 Apr;88:574-581. doi: 10.1016/j.biopha.2017.01.092. Epub 2017 Jan 27.

PMID:
28135601
20.

Does epicatechin contribute to the acute vascular function effects of dark chocolate? A randomized, crossover study.

Dower JI, Geleijnse JM, Kroon PA, Philo M, Mensink M, Kromhout D, Hollman PC.

Mol Nutr Food Res. 2016 Nov;60(11):2379-2386. doi: 10.1002/mnfr.201600045. Epub 2016 Jul 26.

PMID:
27329037
21.

Quercetin solubilisation in bile salts: A comparison with sodium dodecyl sulphate.

Buchweitz M, Kroon PA, Rich GT, Wilde PJ.

Food Chem. 2016 Nov 15;211:356-64. doi: 10.1016/j.foodchem.2016.05.034. Epub 2016 May 7.

22.

Molecular structure-function relationship of dietary polyphenols for inhibiting VEGF-induced VEGFR-2 activity.

Cerezo AB, Winterbone MS, Moyle CW, Needs PW, Kroon PA.

Mol Nutr Food Res. 2015 Nov;59(11):2119-31. doi: 10.1002/mnfr.201500407. Epub 2015 Sep 8.

23.

Validated Method for the Characterization and Quantification of Extractable and Nonextractable Ellagitannins after Acid Hydrolysis in Pomegranate Fruits, Juices, and Extracts.

García-Villalba R, Espín JC, Aaby K, Alasalvar C, Heinonen M, Jacobs G, Voorspoels S, Koivumäki T, Kroon PA, Pelvan E, Saha S, Tomás-Barberán FA.

J Agric Food Chem. 2015 Jul 29;63(29):6555-66. doi: 10.1021/acs.jafc.5b02062. Epub 2015 Jul 17.

PMID:
26158321
24.

MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux.

Barrington RD, Needs PW, Williamson G, Kroon PA.

Biochem Pharmacol. 2015 Jun 1;95(3):193-200. doi: 10.1016/j.bcp.2015.03.005. Epub 2015 Mar 20.

25.

Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: relevance to angiogenesis.

Moyle CW, Cerezo AB, Winterbone MS, Hollands WJ, Alexeev Y, Needs PW, Kroon PA.

Mol Nutr Food Res. 2015 Mar;59(3):401-12. doi: 10.1002/mnfr.201400478. Epub 2015 Jan 22.

26.

Mixed pro- and anti-oxidative effects of pomegranate polyphenols in cultured cells.

Danesi F, Kroon PA, Saha S, de Biase D, D'Antuono LF, Bordoni A.

Int J Mol Sci. 2014 Oct 27;15(11):19458-71. doi: 10.3390/ijms151119458.

27.

Consumption of both low and high (-)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: a randomized controlled trial.

Gasper A, Hollands W, Casgrain A, Saha S, Teucher B, Dainty JR, Venema DP, Hollman PC, Rein MJ, Nelson R, Williamson G, Kroon PA.

Arch Biochem Biophys. 2014 Oct 1;559:29-37. doi: 10.1016/j.abb.2014.05.026. Epub 2014 Jun 12.

28.

Methods for isolating, identifying, and quantifying anthocyanin metabolites in clinical samples.

de Ferrars RM, Czank C, Saha S, Needs PW, Zhang Q, Raheem KS, Botting NP, Kroon PA, Kay CD.

Anal Chem. 2014 Oct 21;86(20):10052-8. doi: 10.1021/ac500565a. Epub 2014 Oct 10.

PMID:
24828315
29.

The pharmacokinetics of anthocyanins and their metabolites in humans.

de Ferrars RM, Czank C, Zhang Q, Botting NP, Kroon PA, Cassidy A, Kay CD.

Br J Pharmacol. 2014 Jul;171(13):3268-82. doi: 10.1111/bph.12676.

30.

Special issue: Traditional foods: from culture, ecology and diversity, to human health and potential for exploitation.

Kroon PA, D'Antuono LF.

J Sci Food Agric. 2013 Nov;93(14):3403-5. doi: 10.1002/jsfa.6357. No abstract available.

PMID:
24129978
31.

Human metabolic transformation of quercetin blocks its capacity to decrease endothelial nitric oxide synthase (eNOS) expression and endothelin-1 secretion by human endothelial cells.

Tribolo S, Lodi F, Winterbone MS, Saha S, Needs PW, Hughes DA, Kroon PA.

J Agric Food Chem. 2013 Sep 11;61(36):8589-96. doi: 10.1021/jf402511c. Epub 2013 Aug 28.

PMID:
23947593
32.

Effects of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on arachidonic acid induced markers of platelet activation and aggregation.

Konić-Ristić A, Srdić-Rajić T, Kardum N, Aleksić-Veličković V, Kroon PA, Hollands WJ, Needs PW, Boyko N, Hayran O, Jorjadze M, Glibetić M.

J Sci Food Agric. 2013 Nov;93(14):3581-7. doi: 10.1002/jsfa.6328. Epub 2013 Sep 4.

PMID:
23900938
33.

Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells.

Woodcock ME, Hollands WJ, Konic-Ristic A, Glibetic M, Boyko N, Koçaoglu B, Kroon PA.

J Sci Food Agric. 2013 Nov;93(14):3574-80. doi: 10.1002/jsfa.6251. Epub 2013 Jul 5.

PMID:
23744813
34.

Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress.

Danesi F, Saha S, Kroon PA, Glibetić M, Konić-Ristić A, D'Antuono LF, Bordoni A.

J Sci Food Agric. 2013 Nov;93(14):3558-64. doi: 10.1002/jsfa.6214. Epub 2013 Jun 7.

PMID:
23649594
35.

Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function.

Hollands WJ, Saha S, Hayran O, Boyko N, Glibetic M, Konic-Ristic A, Jorjadze M, Kroon PA.

J Sci Food Agric. 2013 Nov;93(14):3588-94. doi: 10.1002/jsfa.6213. Epub 2013 Jun 12.

PMID:
23649552
36.

Bioavailability of epicatechin and effects on nitric oxide metabolites of an apple flavanol-rich extract supplemented beverage compared to a whole apple puree: a randomized, placebo-controlled, crossover trial.

Hollands WJ, Hart DJ, Dainty JR, Hasselwander O, Tiihonen K, Wood R, Kroon PA.

Mol Nutr Food Res. 2013 Jul;57(7):1209-17. doi: 10.1002/mnfr.201200663. Epub 2013 Apr 23.

PMID:
23610075
37.

Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study.

Czank C, Cassidy A, Zhang Q, Morrison DJ, Preston T, Kroon PA, Botting NP, Kay CD.

Am J Clin Nutr. 2013 May;97(5):995-1003. doi: 10.3945/ajcn.112.049247.

PMID:
23604435
38.

Vascular function and atherosclerosis progression after 1 y of flavonoid intake in statin-treated postmenopausal women with type 2 diabetes: a double-blind randomized controlled trial.

Curtis PJ, Potter J, Kroon PA, Wilson P, Dhatariya K, Sampson M, Cassidy A.

Am J Clin Nutr. 2013 May;97(5):936-42. doi: 10.3945/ajcn.112.043745. Epub 2013 Apr 3.

PMID:
23553151
39.

Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells.

Mateos R, Pereira-Caro G, Bacon JR, Bongaerts R, Sarriá B, Bravo L, Kroon PA.

J Agric Food Chem. 2013 Apr 3;61(13):3264-9. doi: 10.1021/jf305158q. Epub 2013 Mar 20.

PMID:
23452288
40.

Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol.

Pereira-Caro G, Mateos R, Traka MH, Bacon JR, Bongaerts R, Sarriá B, Bravo L, Kroon PA.

Food Chem. 2013 Jun 1;138(2-3):1172-82. doi: 10.1016/j.foodchem.2012.11.118. Epub 2012 Dec 5.

PMID:
23411228
41.

Flavan-3-ol-enriched dark chocolate and white chocolate improve acute measures of platelet function in a gender-specific way--a randomized-controlled human intervention trial.

Ostertag LM, Kroon PA, Wood S, Horgan GW, Cienfuegos-Jovellanos E, Saha S, Duthie GG, de Roos B.

Mol Nutr Food Res. 2013 Feb;57(2):191-202. doi: 10.1002/mnfr.201200283. Epub 2012 Nov 8.

PMID:
23136121
42.

Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli.

Saha S, Hollands W, Teucher B, Needs PW, Narbad A, Ortori CA, Barrett DA, Rossiter JT, Mithen RF, Kroon PA.

Mol Nutr Food Res. 2012 Dec;56(12):1906-16. doi: 10.1002/mnfr.201200225. Epub 2012 Oct 27.

PMID:
23109475
43.

Comparison between single-cell cultures and tissue cultures as model systems for evaluating the modulation of gene expression by food bioactives.

Boschetti E, Bacon JR, Meyer F, Tugnoli V, Bordoni A, Kroon PA.

Int J Food Sci Nutr. 2013 Mar;64(2):194-201. doi: 10.3109/09637486.2012.728200. Epub 2012 Oct 2.

PMID:
23025340
44.

Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food products.

Kay CD, Hooper L, Kroon PA, Rimm EB, Cassidy A.

Mol Nutr Food Res. 2012 Nov;56(11):1605-16. doi: 10.1002/mnfr.201200363. Epub 2012 Sep 19.

PMID:
22996837
45.

Human quercetin conjugated metabolites attenuate TNF-α-induced changes in vasomodulatory molecules in an HUASMCs/HUVECs co-culture model.

Lodi F, Winterbone MS, Tribolo S, Needs PW, Hughes DA, Kroon PA.

Planta Med. 2012 Sep;78(14):1571-3. Epub 2012 Aug 3.

PMID:
22864987
46.

Human O-sulfated metabolites of (-)-epicatechin and methyl-(-)-epicatechin are poor substrates for commercial aryl-sulfatases: implications for studies concerned with quantifying epicatechin bioavailability.

Saha S, Hollands W, Needs PW, Ostertag LM, de Roos B, Duthie GG, Kroon PA.

Pharmacol Res. 2012 Jun;65(6):592-602. doi: 10.1016/j.phrs.2012.02.005. Epub 2012 Feb 25.

PMID:
22373658
47.

Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials.

Hooper L, Kay C, Abdelhamid A, Kroon PA, Cohn JS, Rimm EB, Cassidy A.

Am J Clin Nutr. 2012 Mar;95(3):740-51. doi: 10.3945/ajcn.111.023457. Epub 2012 Feb 1. Review.

PMID:
22301923
49.

In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations.

Ostertag LM, O'Kennedy N, Horgan GW, Kroon PA, Duthie GG, de Roos B.

Mol Nutr Food Res. 2011 Nov;55(11):1624-36. doi: 10.1002/mnfr.201100135. Epub 2011 Sep 5.

PMID:
21898791
50.

Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery.

Al-Shalmani S, Suri S, Hughes DA, Kroon PA, Needs PW, Taylor MA, Tribolo S, Wilson VG.

Br J Pharmacol. 2011 Apr;162(7):1485-97. doi: 10.1111/j.1476-5381.2010.00919.x.

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