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Items: 1 to 50 of 123

1.

Transcripts and tumors: regulatory and metabolic programming during biotrophic phytopathogenesis.

Schmitz L, McCotter S, Kretschmer M, Kronstad JW, Heimel K.

F1000Res. 2018 Nov 19;7. pii: F1000 Faculty Rev-1812. doi: 10.12688/f1000research.16404.1. eCollection 2018. Review.

2.

The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans.

Attarian R, Hu G, Sánchez-León E, Caza M, Croll D, Do E, Bach H, Missall T, Lodge J, Jung WH, Kronstad JW.

MBio. 2018 Dec 4;9(6). pii: e02377-18. doi: 10.1128/mBio.02377-18.

3.

A chemical genetic screen reveals a role for proteostasis in capsule and biofilm formation by Cryptococcus neoformans.

Mayer FL, Sánchez-León E, Kronstad JW.

Microb Cell. 2018 Oct 31;5(11):495-510. doi: 10.15698/mic2018.11.656.

4.

The Sec1/Munc18 (SM) protein Vps45 is involved in iron uptake, mitochondrial function and virulence in the pathogenic fungus Cryptococcus neoformans.

Caza M, Hu G, Nielson ED, Cho M, Jung WH, Kronstad JW.

PLoS Pathog. 2018 Aug 2;14(8):e1007220. doi: 10.1371/journal.ppat.1007220. eCollection 2018 Aug.

5.

ATG Genes Influence the Virulence of Cryptococcus neoformans through Contributions beyond Core Autophagy Functions.

Ding H, Caza M, Dong Y, Arif AA, Horianopoulos LC, Hu G, Johnson P, Kronstad JW.

Infect Immun. 2018 Aug 22;86(9). pii: e00069-18. doi: 10.1128/IAI.00069-18. Print 2018 Sep.

PMID:
29986893
6.

The mitochondrial ABC transporter Atm1 plays a role in iron metabolism and virulence in the human fungal pathogen Cryptococcus neoformans.

Do E, Park S, Li MH, Wang JM, Ding C, Kronstad JW, Jung WH.

Med Mycol. 2018 Jun 1;56(4):458-468. doi: 10.1093/mmy/myx073.

PMID:
29420779
7.

Vacuolar zinc transporter Zrc1 is required for detoxification of excess intracellular zinc in the human fungal pathogen Cryptococcus neoformans.

Cho M, Hu G, Caza M, Horianopoulos LC, Kronstad JW, Jung WH.

J Microbiol. 2018 Jan;56(1):65-71. doi: 10.1007/s12275-018-7475-y. Epub 2018 Jan 4.

PMID:
29299844
8.

The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans.

Rizzo J, Colombo AC, Zamith-Miranda D, Silva VKA, Allegood JC, Casadevall A, Del Poeta M, Nosanchuk JD, Kronstad JW, Rodrigues ML.

Biochim Biophys Acta Mol Cell Res. 2018 Mar;1865(3):532-541. doi: 10.1016/j.bbamcr.2017.12.007. Epub 2017 Dec 29.

9.

Acetate provokes mitochondrial stress and cell death in Ustilago maydis.

Kretschmer M, Lambie S, Croll D, Kronstad JW.

Mol Microbiol. 2018 Feb;107(4):488-507. doi: 10.1111/mmi.13894. Epub 2018 Jan 3.

PMID:
29235175
10.

Breaking the bad: Bacillus blocks fungal virulence factors.

Mayer FL, Kronstad JW.

Microb Cell. 2017 Oct 30;4(11):384-386. doi: 10.15698/mic2017.11.599.

11.
12.

Discovery of a Novel Antifungal Agent in the Pathogen Box.

Mayer FL, Kronstad JW.

mSphere. 2017 Apr 12;2(2). pii: e00120-17. doi: 10.1128/mSphere.00120-17. eCollection 2017 Mar-Apr.

13.

Phosphorus-rich structures and capsular architecture in Cryptococcus neoformans.

Ramos CL, Gomes FM, Girard-Dias W, Almeida FP, Albuquerque PC, Kretschmer M, Kronstad JW, Frases S, de Souza W, Rodrigues ML, Miranda K.

Future Microbiol. 2017 Mar;12:227-238. doi: 10.2217/fmb-2017-0060. Epub 2017 Feb 20.

PMID:
28262043
14.

Iron acquisition in fungal pathogens of humans.

Bairwa G, Hee Jung W, Kronstad JW.

Metallomics. 2017 Mar 22;9(3):215-227. doi: 10.1039/c6mt00301j. Review.

15.

The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis.

Kwon-Chung KJ, Bennett JE, Wickes BL, Meyer W, Cuomo CA, Wollenburg KR, Bicanic TA, Castañeda E, Chang YC, Chen J, Cogliati M, Dromer F, Ellis D, Filler SG, Fisher MC, Harrison TS, Holland SM, Kohno S, Kronstad JW, Lazera M, Levitz SM, Lionakis MS, May RC, Ngamskulrongroj P, Pappas PG, Perfect JR, Rickerts V, Sorrell TC, Walsh TJ, Williamson PR, Xu J, Zelazny AM, Casadevall A.

mSphere. 2017 Jan 11;2(1). pii: e00357-16. doi: 10.1128/mSphere.00357-16. eCollection 2017 Jan-Feb.

16.

Maize susceptibility to Ustilago maydis is influenced by genetic and chemical perturbation of carbohydrate allocation.

Kretschmer M, Croll D, Kronstad JW.

Mol Plant Pathol. 2017 Dec;18(9):1222-1237. doi: 10.1111/mpp.12486. Epub 2016 Nov 14.

PMID:
27564861
17.

Chloroplast-associated metabolic functions influence the susceptibility of maize to Ustilago maydis.

Kretschmer M, Croll D, Kronstad JW.

Mol Plant Pathol. 2017 Dec;18(9):1210-1221. doi: 10.1111/mpp.12485. Epub 2016 Nov 14.

PMID:
27564650
18.

Networks of fibers and factors: regulation of capsule formation in Cryptococcus neoformans.

Ding H, Mayer FL, Sánchez-León E, de S Araújo GR, Frases S, Kronstad JW.

F1000Res. 2016 Jul 22;5. pii: F1000 Faculty Rev-1786. doi: 10.12688/f1000research.8854.1. eCollection 2016. Review.

19.

The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans.

Do E, Park M, Hu G, Caza M, Kronstad JW, Jung WH.

Biochem Biophys Res Commun. 2016 Sep 2;477(4):706-711. doi: 10.1016/j.bbrc.2016.06.123. Epub 2016 Jun 25.

20.

The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans.

Caza M, Hu G, Price M, Perfect JR, Kronstad JW.

mSphere. 2016 Jan 13;1(1). pii: e00080-15. doi: 10.1128/mSphere.00080-15. eCollection 2016 Jan-Feb.

21.

The ZIP family zinc transporters support the virulence of Cryptococcus neoformans.

Do E, Hu G, Caza M, Kronstad JW, Jung WH.

Med Mycol. 2016 Aug 1;54(6):605-15. doi: 10.1093/mmy/myw013. Epub 2016 Apr 26.

22.

Correction: Iron Regulation of the Major Virulence Factors in the AIDS-Associated Pathogen Cryptococcus neoformans.

Jung WH, Sham A, White R, Kronstad JW.

PLoS Biol. 2016 Mar 8;14(3):e1002410. doi: 10.1371/journal.pbio.1002410. eCollection 2016 Mar. No abstract available.

23.

The putative phospholipase Lip2 counteracts oxidative damage and influences the virulence of Ustilago maydis.

Lambie SC, Kretschmer M, Croll D, Haslam TM, Kunst L, Klose J, Kronstad JW.

Mol Plant Pathol. 2017 Feb;18(2):210-221. doi: 10.1111/mpp.12391. Epub 2016 Apr 21.

PMID:
26950180
24.

Regulation of the fungal secretome.

McCotter SW, Horianopoulos LC, Kronstad JW.

Curr Genet. 2016 Aug;62(3):533-45. doi: 10.1007/s00294-016-0578-2. Epub 2016 Feb 15. Review.

PMID:
26879194
25.

Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation.

Geddes JM, Caza M, Croll D, Stoynov N, Foster LJ, Kronstad JW.

MBio. 2016 Jan 12;7(1):e01862-15. doi: 10.1128/mBio.01862-15.

26.

Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A.

Geddes JM, Croll D, Caza M, Stoynov N, Foster LJ, Kronstad JW.

BMC Microbiol. 2015 Oct 9;15:206. doi: 10.1186/s12866-015-0532-3.

27.

The cAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis.

Choi J, Jung WH, Kronstad JW.

J Microbiol. 2015 Sep;53(9):579-87. doi: 10.1007/s12275-015-5247-5. Epub 2015 Aug 1. Review.

28.

The endosomal sorting complex required for transport machinery influences haem uptake and capsule elaboration in Cryptococcus neoformans.

Hu G, Caza M, Cadieux B, Bakkeren E, Do E, Jung WH, Kronstad JW.

Mol Microbiol. 2015 Jun;96(5):973-92. doi: 10.1111/mmi.12985. Epub 2015 Mar 28.

29.

Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans.

Do E, Hu G, Caza M, Oliveira D, Kronstad JW, Jung WH.

Fungal Genet Biol. 2015 Feb;75:11-9. doi: 10.1016/j.fgb.2014.12.006. Epub 2014 Dec 29.

30.

Highly recombinant VGII Cryptococcus gattii population develops clonal outbreak clusters through both sexual macroevolution and asexual microevolution.

Billmyre RB, Croll D, Li W, Mieczkowski P, Carter DA, Cuomo CA, Kronstad JW, Heitman J.

MBio. 2014 Jul 29;5(4):e01494-14. doi: 10.1128/mBio.01494-14.

31.

Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.

Janbon G, Ormerod KL, Paulet D, Byrnes EJ 3rd, Yadav V, Chatterjee G, Mullapudi N, Hon CC, Billmyre RB, Brunel F, Bahn YS, Chen W, Chen Y, Chow EW, Coppée JY, Floyd-Averette A, Gaillardin C, Gerik KJ, Goldberg J, Gonzalez-Hilarion S, Gujja S, Hamlin JL, Hsueh YP, Ianiri G, Jones S, Kodira CD, Kozubowski L, Lam W, Marra M, Mesner LD, Mieczkowski PA, Moyrand F, Nielsen K, Proux C, Rossignol T, Schein JE, Sun S, Wollschlaeger C, Wood IA, Zeng Q, Neuvéglise C, Newlon CS, Perfect JR, Lodge JK, Idnurm A, Stajich JE, Kronstad JW, Sanyal K, Heitman J, Fraser JA, Cuomo CA, Dietrich FS.

PLoS Genet. 2014 Apr 17;10(4):e1004261. doi: 10.1371/journal.pgen.1004261. eCollection 2014 Apr.

32.

Defects in phosphate acquisition and storage influence virulence of Cryptococcus neoformans.

Kretschmer M, Reiner E, Hu G, Tam N, Oliveira DL, Caza M, Yeon JH, Kim J, Kastrup CJ, Jung WH, Kronstad JW.

Infect Immun. 2014 Jul;82(7):2697-712. doi: 10.1128/IAI.01607-14. Epub 2014 Apr 7.

33.

Role of the Apt1 protein in polysaccharide secretion by Cryptococcus neoformans.

Rizzo J, Oliveira DL, Joffe LS, Hu G, Gazos-Lopes F, Fonseca FL, Almeida IC, Frases S, Kronstad JW, Rodrigues ML.

Eukaryot Cell. 2014 Jun;13(6):715-26. doi: 10.1128/EC.00273-13. Epub 2013 Dec 13.

34.

Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans.

Caza M, Kronstad JW.

Front Cell Infect Microbiol. 2013 Nov 19;3:80. doi: 10.3389/fcimb.2013.00080. eCollection 2013. Review.

35.

Iron in eukaryotic microbes: regulation, trafficking and theft.

Kronstad JW.

Curr Opin Microbiol. 2013 Dec;16(6):659-61. doi: 10.1016/j.mib.2013.08.009. Epub 2013 Sep 25. No abstract available.

PMID:
24074556
36.

Pathogenic yeasts deploy cell surface receptors to acquire iron in vertebrate hosts.

Kronstad JW, Cadieux B, Jung WH.

PLoS Pathog. 2013;9(8):e1003498. doi: 10.1371/journal.ppat.1003498. Epub 2013 Aug 29. No abstract available.

37.

An encapsulation of iron homeostasis and virulence in Cryptococcus neoformans.

Kronstad JW, Hu G, Jung WH.

Trends Microbiol. 2013 Sep;21(9):457-65. doi: 10.1016/j.tim.2013.05.007. Epub 2013 Jun 25. Review.

38.

Altered immune response differentially enhances susceptibility to Cryptococcus neoformans and Cryptococcus gattii infection in mice expressing the HIV-1 transgene.

Leongson K, Cousineau-Côté V, Goupil M, Aumont F, Sénéchal S, Gaboury L, Jolicoeur P, Kronstad JW, de Repentigny L.

Infect Immun. 2013 Apr;81(4):1100-13. doi: 10.1128/IAI.01339-12. Epub 2013 Jan 22.

39.

The Mannoprotein Cig1 supports iron acquisition from heme and virulence in the pathogenic fungus Cryptococcus neoformans.

Cadieux B, Lian T, Hu G, Wang J, Biondo C, Teti G, Liu V, Murphy ME, Creagh AL, Kronstad JW.

J Infect Dis. 2013 Apr 15;207(8):1339-47. doi: 10.1093/infdis/jit029. Epub 2013 Jan 15.

40.

Aimless mutants of Cryptococcus neoformans: failure to disseminate.

Griffiths EJ, Kretschmer M, Kronstad JW.

Fungal Biol Rev. 2012 Oct 1;26(2-3):61-72. Epub 2012 Mar 30.

41.

A defect in ATP-citrate lyase links acetyl-CoA production, virulence factor elaboration and virulence in Cryptococcus neoformans.

Griffiths EJ, Hu G, Fries B, Caza M, Wang J, Gsponer J, Gates-Hollingsworth MA, Kozel TR, De Repentigny L, Kronstad JW.

Mol Microbiol. 2012 Dec;86(6):1404-23. doi: 10.1111/mmi.12065. Epub 2012 Nov 1.

42.

A defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs.

Kim J, Cho YJ, Do E, Choi J, Hu G, Cadieux B, Chun J, Lee Y, Kronstad JW, Jung WH.

Fungal Genet Biol. 2012 Nov;49(11):955-66. doi: 10.1016/j.fgb.2012.08.006. Epub 2012 Sep 4.

43.

The cAMP/Protein Kinase A Pathway and Virulence in Cryptococcus neoformans.

Kronstad JW, Hu G, Choi J.

Mycobiology. 2011 Sep;39(3):143-50. doi: 10.5941/MYCO.2011.39.3.143. Epub 2011 Sep 27.

44.

Regulated expression of cyclic AMP-dependent protein kinase A reveals an influence on cell size and the secretion of virulence factors in Cryptococcus neoformans.

Choi J, Vogl AW, Kronstad JW.

Mol Microbiol. 2012 Aug;85(4):700-15. doi: 10.1111/j.1365-2958.2012.08134.x. Epub 2012 Jul 13.

45.

Peroxisomal and mitochondrial β-oxidation pathways influence the virulence of the pathogenic fungus Cryptococcus neoformans.

Kretschmer M, Wang J, Kronstad JW.

Eukaryot Cell. 2012 Aug;11(8):1042-54. doi: 10.1128/EC.00128-12. Epub 2012 Jun 15.

46.

Defects in mitochondrial and peroxisomal β-oxidation influence virulence in the maize pathogen Ustilago maydis.

Kretschmer M, Klose J, Kronstad JW.

Eukaryot Cell. 2012 Aug;11(8):1055-66. doi: 10.1128/EC.00129-12. Epub 2012 Jun 15.

47.

Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.

Hu G, Wang J, Choi J, Jung WH, Liu I, Litvintseva AP, Bicanic T, Aurora R, Mitchell TG, Perfect JR, Kronstad JW.

BMC Genomics. 2011 Oct 27;12:526. doi: 10.1186/1471-2164-12-526.

48.

Iron influences the abundance of the iron regulatory protein Cir1 in the fungal pathogen Cryptococcus neoformans.

Jung WH, Kronstad JW.

FEBS Lett. 2011 Oct 20;585(20):3342-7. doi: 10.1016/j.febslet.2011.09.025. Epub 2011 Sep 29.

49.

Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host.

Price MS, Betancourt-Quiroz M, Price JL, Toffaletti DL, Vora H, Hu G, Kronstad JW, Perfect JR.

MBio. 2011 Jun 7;2(3):e00103-11. doi: 10.1128/mBio.00103-11. Print 2011.

50.

Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box.

Kronstad JW, Attarian R, Cadieux B, Choi J, D'Souza CA, Griffiths EJ, Geddes JM, Hu G, Jung WH, Kretschmer M, Saikia S, Wang J.

Nat Rev Microbiol. 2011 Mar;9(3):193-203. doi: 10.1038/nrmicro2522. Review.

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