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Items: 1 to 50 of 72

1.

Brain signatures of threat-safety discrimination in adolescent chronic pain.

Heathcote LC, Timmers I, Kronman CA, Mahmud F, Hernandez JM, Bentley J, Youssef AM, Pine DS, Borsook D, Simons LE.

Pain. 2019 Nov 20. doi: 10.1097/j.pain.0000000000001753. [Epub ahead of print]

PMID:
31764389
2.

Cardiorespiratory fitness predicts effective connectivity between the hippocampus and default mode network nodes in young adults.

Kronman CA, Kern KL, Nauer RK, Dunne MF, Storer TW, Schon K.

Hippocampus. 2019 Oct 24. doi: 10.1002/hipo.23169. [Epub ahead of print]

PMID:
31647603
3.

Intramuscular Ricin Poisoning of Mice Leads to Widespread Damage in the Heart, Spleen, and Bone Marrow.

Sapoznikov A, Rosner A, Falach R, Gal Y, Aftalion M, Evgy Y, Israeli O, Sabo T, Kronman C.

Toxins (Basel). 2019 Jun 16;11(6). pii: E344. doi: 10.3390/toxins11060344.

4.

Pain neuroscience education on YouTube.

Heathcote LC, Pate JW, Park AL, Leake HB, Moseley GL, Kronman CA, Fischer M, Timmers I, Simons LE.

PeerJ. 2019 Mar 22;7:e6603. doi: 10.7717/peerj.6603. eCollection 2019.

5.

Is Empathy for Pain Unique in Its Neural Correlates? A Meta-Analysis of Neuroimaging Studies of Empathy.

Timmers I, Park AL, Fischer MD, Kronman CA, Heathcote LC, Hernandez JM, Simons LE.

Front Behav Neurosci. 2018 Nov 27;12:289. doi: 10.3389/fnbeh.2018.00289. eCollection 2018.

6.

Generation of Highly Efficient Equine-Derived Antibodies for Post-Exposure Treatment of Ricin Intoxications by Vaccination with Monomerized Ricin.

Falach R, Sapoznikov A, Alcalay R, Aftalion M, Ehrlich S, Makovitzki A, Agami A, Mimran A, Rosner A, Sabo T, Kronman C, Gal Y.

Toxins (Basel). 2018 Nov 12;10(11). pii: E466. doi: 10.3390/toxins10110466.

7.

Early disruption of the alveolar-capillary barrier in a ricin-induced ARDS mouse model: neutrophil-dependent and -independent impairment of junction proteins.

Sapoznikov A, Gal Y, Falach R, Sagi I, Ehrlich S, Lerer E, Makovitzki A, Aloshin A, Kronman C, Sabo T.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L255-L268. doi: 10.1152/ajplung.00300.2018. Epub 2018 Nov 1.

PMID:
30382767
8.

Feeling the Pressure to Be Perfect: Effect on Pain-Related Distress and Dysfunction in Youth With Chronic Pain.

Randall ET, Smith KR, Kronman CA, Conroy C, Smith AM, Simons LE.

J Pain. 2018 Apr;19(4):418-429. doi: 10.1016/j.jpain.2017.11.012. Epub 2017 Dec 14.

PMID:
29248510
9.

Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects.

Gal Y, Mazor O, Falach R, Sapoznikov A, Kronman C, Sabo T.

Toxins (Basel). 2017 Oct 3;9(10). pii: E311. doi: 10.3390/toxins9100311. Review.

10.

Total Body Irradiation Mitigates Inflammation and Extends the Therapeutic Time Window for Anti-Ricin Antibody Treatment against Pulmonary Ricinosis in Mice.

Gal Y, Sapoznikov A, Falach R, Ehrlich S, Aftalion M, Kronman C, Sabo T.

Toxins (Basel). 2017 Sep 11;9(9). pii: E278. doi: 10.3390/toxins9090278.

11.

Improved antibody-based ricin neutralization by affinity maturation is correlated with slower off-rate values.

Rosenfeld R, Alcalay R, Mechaly A, Lapidoth G, Epstein E, Kronman C, J Fleishman S, Mazor O.

Protein Eng Des Sel. 2017 Sep 1;30(9):611-617. doi: 10.1093/protein/gzx028.

PMID:
28472478
12.

Extended therapeutic window for post-exposure treatment of ricin intoxication conferred by the use of high-affinity antibodies.

Noy-Porat T, Alcalay R, Epstein E, Sabo T, Kronman C, Mazor O.

Toxicon. 2017 Mar 1;127:100-105. doi: 10.1016/j.toxicon.2017.01.009. Epub 2017 Jan 12.

PMID:
28089771
13.

A novel swine model of ricin-induced acute respiratory distress syndrome.

Katalan S, Falach R, Rosner A, Goldvaser M, Brosh-Nissimov T, Dvir A, Mizrachi A, Goren O, Cohen B, Gal Y, Sapoznikov A, Ehrlich S, Sabo T, Kronman C.

Dis Model Mech. 2017 Feb 1;10(2):173-183. doi: 10.1242/dmm.027847. Epub 2017 Jan 6.

14.

Potent Antiedematous and Protective Effects of Ciprofloxacin in Pulmonary Ricinosis.

Gal Y, Sapoznikov A, Falach R, Ehrlich S, Aftalion M, Sabo T, Kronman C.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7153-7158. Print 2016 Dec.

15.

Quantitative profiling of the in vivo enzymatic activity of ricin reveals disparate depurination of different pulmonary cell types.

Falach R, Sapoznikov A, Gal Y, Israeli O, Leitner M, Seliger N, Ehrlich S, Kronman C, Sabo T.

Toxicol Lett. 2016 Sep 6;258:11-19. doi: 10.1016/j.toxlet.2016.06.003. Epub 2016 Jun 11.

PMID:
27298272
16.

Ricin-Holotoxin-Based Vaccines: Induction of Potent Ricin-Neutralizing Antibodies.

Sabo T, Kronman C, Mazor O.

Methods Mol Biol. 2016;1403:683-94. doi: 10.1007/978-1-4939-3387-7_38.

PMID:
27076160
17.

Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates.

Noy-Porat T, Rosenfeld R, Ariel N, Epstein E, Alcalay R, Zvi A, Kronman C, Ordentlich A, Mazor O.

Toxins (Basel). 2016 Mar 3;8(3). pii: E64. doi: 10.3390/toxins8030064.

18.

Diverse profiles of ricin-cell interactions in the lung following intranasal exposure to ricin.

Sapoznikov A, Falach R, Mazor O, Alcalay R, Gal Y, Seliger N, Sabo T, Kronman C.

Toxins (Basel). 2015 Nov 17;7(11):4817-31. doi: 10.3390/toxins7114817.

19.

Antibody treatment against pulmonary exposure to abrin confers significantly higher levels of protection than treatment against ricin intoxication.

Sabo T, Gal Y, Elhanany E, Sapoznikov A, Falach R, Mazor O, Kronman C.

Toxicol Lett. 2015 Sep 2;237(2):72-8. doi: 10.1016/j.toxlet.2015.06.003. Epub 2015 Jun 5.

PMID:
26051443
20.

Rapid assessment of antibody-induced ricin neutralization by employing a novel functional cell-based assay.

Gal Y, Alcalay R, Sabo T, Noy-Porat T, Epstein E, Kronman C, Mazor O.

J Immunol Methods. 2015 Sep;424:136-9. doi: 10.1016/j.jim.2015.05.005. Epub 2015 May 21.

PMID:
26003675
21.

Characterization and epitope mapping of the polyclonal antibody repertoire elicited by ricin holotoxin-based vaccination.

Cohen O, Mechaly A, Sabo T, Alcalay R, Aloni-Grinstein R, Seliger N, Kronman C, Mazor O.

Clin Vaccine Immunol. 2014 Nov;21(11):1534-40. doi: 10.1128/CVI.00510-14. Epub 2014 Sep 10.

22.

Antibody/doxycycline combined therapy for pulmonary ricinosis: Attenuation of inflammation improves survival of ricin-intoxicated mice.

Gal Y, Mazor O, Alcalay R, Seliger N, Aftalion M, Sapoznikov A, Falach R, Kronman C, Sabo T.

Toxicol Rep. 2014 Aug 1;1:496-504. doi: 10.1016/j.toxrep.2014.07.013. eCollection 2014.

23.

Next generation OP-bioscavengers: a circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics.

Kronman C, Cohen O, Mazor O, Ordentlich A, Raveh L, Velan B, Shafferman A.

Chem Biol Interact. 2010 Sep 6;187(1-3):253-8. doi: 10.1016/j.cbi.2009.12.004. Epub 2009 Dec 11.

PMID:
20005217
24.

Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase.

Mazor O, Cohen O, Kronman C, Raveh L, Stein D, Ordentlich A, Shafferman A.

Mol Pharmacol. 2008 Sep;74(3):755-63. doi: 10.1124/mol.108.047449. Epub 2008 Jun 3.

PMID:
18523134
25.

Flexibility versus "rigidity" of the functional architecture of AChE active center.

Shafferman A, Barak D, Stein D, Kronman C, Velan B, Greig NH, Ordentlich A.

Chem Biol Interact. 2008 Sep 25;175(1-3):166-72. doi: 10.1016/j.cbi.2008.03.013. Epub 2008 Apr 8.

26.

Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants.

Cohen O, Kronman C, Lazar A, Velan B, Shafferman A.

J Biol Chem. 2007 Dec 7;282(49):35491-501. Epub 2007 Oct 11.

27.

Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication.

Kronman C, Cohen O, Raveh L, Mazor O, Ordentlich A, Shafferman A.

Toxicology. 2007 Apr 20;233(1-3):40-6. Epub 2006 Sep 1.

PMID:
17045722
28.

Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds.

Cohen O, Kronman C, Raveh L, Mazor O, Ordentlich A, Shafferman A.

Mol Pharmacol. 2006 Sep;70(3):1121-31. Epub 2006 Jun 26.

PMID:
16801396
29.

Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents.

Barak D, Ordentlich A, Kaplan D, Kronman C, Velan B, Shafferman A.

Chem Biol Interact. 2005 Dec 15;157-158:219-26. Epub 2005 Nov 11.

PMID:
16289124
30.

Host-regulated disposition of mammalian AChEs.

Kronman C, Cohen O, Velan B, Shafferman A.

Chem Biol Interact. 2005 Dec 15;157-158:51-5. Epub 2005 Nov 9.

PMID:
16289063
31.

The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers.

Ordentlich A, Barak D, Sod-Moriah G, Kaplan D, Mizrahi D, Segall Y, Kronman C, Karton Y, Lazar A, Marcus D, Velan B, Shafferman A.

Chem Biol Interact. 2005 Dec 15;157-158:191-8. Epub 2005 Nov 10.

PMID:
16289014
32.

Functional requirements for the optimal catalytic configuration of the AChE active center.

Shafferman A, Barak D, Kaplan D, Ordentlich A, Kronman C, Velan B.

Chem Biol Interact. 2005 Dec 15;157-158:123-31. Epub 2005 Oct 27.

PMID:
16256968
33.

Efficacious, nontoxigenic Bacillus anthracis spore vaccines based on strains expressing mutant variants of lethal toxin components.

Mendelson I, Gat O, Aloni-Grinstein R, Altboum Z, Inbar I, Kronman C, Bar-Haim E, Cohen S, Velan B, Shafferman A.

Vaccine. 2005 Dec 1;23(48-49):5688-97. Epub 2005 Feb 5.

PMID:
16039760
34.

Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE.

Ordentlich A, Barak D, Sod-Moriah G, Kaplan D, Mizrahi D, Segall Y, Kronman C, Karton Y, Lazar A, Marcus D, Velan B, Shafferman A.

Biochemistry. 2004 Sep 7;43(35):11255-65.

PMID:
15366935
35.

Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase?

Kaplan D, Barak D, Ordentlich A, Kronman C, Velan B, Shafferman A.

Biochemistry. 2004 Mar 23;43(11):3129-36.

PMID:
15023064
36.
37.

Use of a promoter trap system in Bacillus anthracis and Bacillus subtilis for the development of recombinant protective antigen-based vaccines.

Gat O, Inbar I, Aloni-Grinstein R, Zahavy E, Kronman C, Mendelson I, Cohen S, Velan B, Shafferman A.

Infect Immun. 2003 Feb;71(2):801-13.

38.

Effective protective immunity to Yersinia pestis infection conferred by DNA vaccine coding for derivatives of the F1 capsular antigen.

Grosfeld H, Cohen S, Bino T, Flashner Y, Ber R, Mamroud E, Kronman C, Shafferman A, Velan B.

Infect Immun. 2003 Jan;71(1):374-83.

39.
40.

Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity.

Cohen O, Kronman C, Chitlaru T, Ordentlich A, Velan B, Shafferman A.

Biochem J. 2001 Aug 1;357(Pt 3):795-802.

41.
42.

Effect of human acetylcholinesterase subunit assembly on its circulatory residence.

Chitlaru T, Kronman C, Velan B, Shafferman A.

Biochem J. 2001 Mar 15;354(Pt 3):613-25.

43.

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.

Kryger G, Harel M, Giles K, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL.

Acta Crystallogr D Biol Crystallogr. 2000 Nov;56(Pt 11):1385-94.

PMID:
11053835
44.

Attenuated nontoxinogenic and nonencapsulated recombinant Bacillus anthracis spore vaccines protect against anthrax.

Cohen S, Mendelson I, Altboum Z, Kobiler D, Elhanany E, Bino T, Leitner M, Inbar I, Rosenberg H, Gozes Y, Barak R, Fisher M, Kronman C, Velan B, Shafferman A.

Infect Immun. 2000 Aug;68(8):4549-58.

46.

Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase.

Barak D, Ordentlich A, Kaplan D, Barak R, Mizrahi D, Kronman C, Segall Y, Velan B, Shafferman A.

Biochemistry. 2000 Feb 8;39(5):1156-61.

PMID:
10653663
47.

Theoretical and experimental investigations of electrostatic effects on acetylcholinesterase catalysis and inhibition.

Malany S, Baker N, Verweyst M, Medhekar R, Quinn DM, Velan B, Kronman C, Shafferman A.

Chem Biol Interact. 1999 May 14;119-120:99-110.

PMID:
10421443
48.

Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers.

Ordentlich A, Barak D, Kronman C, Benschop HP, De Jong LP, Ariel N, Barak R, Segall Y, Velan B, Shafferman A.

Biochemistry. 1999 Mar 9;38(10):3055-66.

PMID:
10074358
49.

Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels.

Chitlaru T, Kronman C, Zeevi M, Kam M, Harel A, Ordentlich A, Velan B, Shafferman A.

Biochem J. 1998 Dec 15;336 ( Pt 3):647-58.

50.

Bovine acetylcholinesterase: cloning, expression and characterization.

Mendelson I, Kronman C, Ariel N, Shafferman A, Velan B.

Biochem J. 1998 Aug 15;334 ( Pt 1):251-9.

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