Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 217


PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy.

Nishimori S, Lai F, Shiraishi M, Kobayashi T, Kozhemyakina E, Yao TP, Lassar AB, Kronenberg HM.

JCI Insight. 2019 Mar 7;4(5). pii: 97903. doi: 10.1172/jci.insight.97903. eCollection 2019 Mar 7.


Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential: (Trends Endocrinol. Metab. 29, 723-735, 2018).

Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM.

Trends Endocrinol Metab. 2019 Mar 2. pii: S1043-2760(19)30024-4. doi: 10.1016/j.tem.2019.01.009. [Epub ahead of print] No abstract available.


Autocrine regulation of mesenchymal progenitor cell fates orchestrates tooth eruption.

Takahashi A, Nagata M, Gupta A, Matsushita Y, Yamaguchi T, Mizuhashi K, Maki K, Ruellas AC, Cevidanes LS, Kronenberg HM, Ono N, Ono W.

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):575-580. doi: 10.1073/pnas.1810200115. Epub 2018 Dec 3.


Resting zone of the growth plate houses a unique class of skeletal stem cells.

Mizuhashi K, Ono W, Matsushita Y, Sakagami N, Takahashi A, Saunders TL, Nagasawa T, Kronenberg HM, Ono N.

Nature. 2018 Nov;563(7730):254-258. doi: 10.1038/s41586-018-0662-5. Epub 2018 Oct 31.


Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential.

Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM.

Trends Endocrinol Metab. 2018 Oct;29(10):723-735. doi: 10.1016/j.tem.2018.08.004. Epub 2018 Aug 24. Review. Erratum in: Trends Endocrinol Metab. 2019 Mar 2;:.


Withdrawal of parathyroid hormone after prolonged administration leads to adipogenic differentiation of mesenchymal precursors in vivo.

Balani DH, Kronenberg HM.

Bone. 2019 Jan;118:16-19. doi: 10.1016/j.bone.2018.05.024. Epub 2018 May 22.


Msx2 Marks Spatially Restricted Populations of Mesenchymal Precursors.

Sakagami N, Matsushita Y, Syklawer-Howle S, Kronenberg HM, Ono W, Ono N.

J Dent Res. 2018 Oct;97(11):1260-1267. doi: 10.1177/0022034518771014. Epub 2018 May 10.


[Differential effects on bone and mesenchymal stem cells caused by intermittent and continuous PTH administration].

Zhang LX, Balani YM, Trinh S, Kronenberg HM, Mu Y.

Zhonghua Yi Xue Za Zhi. 2018 Mar 13;98(10):781-787. doi: 10.3760/cma.j.issn.0376-2491.2018.10.014. Chinese.


Regulation of Bone Remodeling by Parathyroid Hormone.

Wein MN, Kronenberg HM.

Cold Spring Harb Perspect Med. 2018 Aug 1;8(8). pii: a031237. doi: 10.1101/cshperspect.a031237. Review.


Intravital imaging of osteocytes in mouse calvaria using third harmonic generation microscopy.

Tokarz D, Cisek R, Wein MN, Turcotte R, Haase C, Yeh SA, Bharadwaj S, Raphael AP, Paudel H, Alt C, Liu TM, Kronenberg HM, Lin CP.

PLoS One. 2017 Oct 24;12(10):e0186846. doi: 10.1371/journal.pone.0186846. eCollection 2017.


Parathyroid hormone regulates fates of murine osteoblast precursors in vivo.

Balani DH, Ono N, Kronenberg HM.

J Clin Invest. 2017 Sep 1;127(9):3327-3338. doi: 10.1172/JCI91699. Epub 2017 Jul 31.


Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow.

Greenbaum A, Chan KY, Dobreva T, Brown D, Balani DH, Boyce R, Kronenberg HM, McBride HJ, Gradinaru V.

Sci Transl Med. 2017 Apr 26;9(387). pii: eaah6518. doi: 10.1126/scitranslmed.aah6518.


Corrigendum: SIKs control osteocyte responses to parathyroid hormone.

Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM.

Nat Commun. 2017 Feb 22;8:14745. doi: 10.1038/ncomms14745. No abstract available.


Sclerostin Antibody Administration Converts Bone Lining Cells Into Active Osteoblasts.

Kim SW, Lu Y, Williams EA, Lai F, Lee JY, Enishi T, Balani DH, Ominsky MS, Ke HZ, Kronenberg HM, Wein MN.

J Bone Miner Res. 2017 May;32(5):892-901. doi: 10.1002/jbmr.3038. Epub 2017 Jan 30.


SIKs control osteocyte responses to parathyroid hormone.

Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM.

Nat Commun. 2016 Oct 19;7:13176. doi: 10.1038/ncomms13176.


Bone repair and stem cells.

Ono N, Kronenberg HM.

Curr Opin Genet Dev. 2016 Oct;40:103-107. doi: 10.1016/j.gde.2016.06.012. Epub 2016 Jul 9. Review.


Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation.

Ono W, Sakagami N, Nishimori S, Ono N, Kronenberg HM.

Nat Commun. 2016 Apr 12;7:11277. doi: 10.1038/ncomms11277.


Bone and Mineral Metabolism: Where Are We, Where Are We Going, and How Will We Get There?

Kronenberg HM.

J Clin Endocrinol Metab. 2016 Mar;101(3):795-8. doi: 10.1210/jc.2015-3607. Epub 2016 Feb 23.


Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease.

Eda H, Santo L, Wein MN, Hu DZ, Cirstea DD, Nemani N, Tai YT, Raines SE, Kuhstoss SA, Munshi NC, Kronenberg HM, Raje NS.

J Bone Miner Res. 2016 Jun;31(6):1225-34. doi: 10.1002/jbmr.2789. Epub 2016 Feb 19.


Loss of Gsα in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy.

Sinha P, Aarnisalo P, Chubb R, Poulton IJ, Guo J, Nachtrab G, Kimura T, Swami S, Saeed H, Chen M, Weinstein LS, Schipani E, Sims NA, Kronenberg HM, Wu JY.

J Biol Chem. 2016 Jan 22;291(4):1631-42. doi: 10.1074/jbc.M115.679753. Epub 2015 Nov 23.


Mesenchymal progenitor cells for the osteogenic lineage.

Ono N, Kronenberg HM.

Curr Mol Biol Rep. 2015 Sep;1(3):95-100. Epub 2015 Jul 16.


Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis.

Hirai T, Kobayashi T, Nishimori S, Karaplis AC, Goltzman D, Kronenberg HM.

Endocrinology. 2015 Aug;156(8):2774-80. doi: 10.1210/en.2014-1835. Epub 2015 Jun 8.


The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro.

Spatz JM, Wein MN, Gooi JH, Qu Y, Garr JL, Liu S, Barry KJ, Uda Y, Lai F, Dedic C, Balcells-Camps M, Kronenberg HM, Babij P, Pajevic PD.

J Biol Chem. 2015 Jul 3;290(27):16744-58. doi: 10.1074/jbc.M114.628313. Epub 2015 May 7.


Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.

Yu VW, Saez B, Cook C, Lotinun S, Pardo-Saganta A, Wang YH, Lymperi S, Ferraro F, Raaijmakers MH, Wu JY, Zhou L, Rajagopal J, Kronenberg HM, Baron R, Scadden DT.

J Exp Med. 2015 May 4;212(5):759-74. doi: 10.1084/jem.20141843. Epub 2015 Apr 27.


Tribute to Stephen M. Krane.

Dayer JM, Goldring MB, Goldring SR, Kronenberg HM, Martin TJ, Russell RG.

J Bone Miner Res. 2015 May;30(5):751-2. doi: 10.1002/jbmr.2477. No abstract available.


A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones.

Ono N, Ono W, Nagasawa T, Kronenberg HM.

Nat Cell Biol. 2014 Dec;16(12):1157-67. doi: 10.1038/ncb3067. Epub 2014 Nov 24.


HDAC5 controls MEF2C-driven sclerostin expression in osteocytes.

Wein MN, Spatz J, Nishimori S, Doench J, Root D, Babij P, Nagano K, Baron R, Brooks D, Bouxsein M, Pajevic PD, Kronenberg HM.

J Bone Miner Res. 2015 Mar;30(3):400-11. doi: 10.1002/jbmr.2381.


Role of G-proteins in the differentiation of epiphyseal chondrocytes.

Chagin AS, Kronenberg HM.

J Mol Endocrinol. 2014 Oct;53(2):R39-45. doi: 10.1530/JME-14-0093. Epub 2014 Jun 30. Review.


Reproducibility of results in preclinical studies: a perspective from the bone field.

Manolagas SC, Kronenberg HM.

J Bone Miner Res. 2014 Oct;29(10):2131-40. doi: 10.1002/jbmr.2293.


Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development.

Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, Ono N, Kronenberg HM, Frenette PS.

Dev Cell. 2014 May 12;29(3):340-9. doi: 10.1016/j.devcel.2014.03.013.


Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage.

Ono N, Ono W, Mizoguchi T, Nagasawa T, Frenette PS, Kronenberg HM.

Dev Cell. 2014 May 12;29(3):330-9. doi: 10.1016/j.devcel.2014.03.014.


Loss of Gsα early in the osteoblast lineage favors adipogenic differentiation of mesenchymal progenitors and committed osteoblast precursors.

Sinha P, Aarnisalo P, Chubb R, Ono N, Fulzele K, Selig M, Saeed H, Chen M, Weinstein LS, Pajevic PD, Kronenberg HM, Wu JY.

J Bone Miner Res. 2014 Nov;29(11):2414-26. doi: 10.1002/jbmr.2270.


G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.

Chagin AS, Vuppalapati KK, Kobayashi T, Guo J, Hirai T, Chen M, Offermanns S, Weinstein LS, Kronenberg HM.

Nat Commun. 2014 Apr 30;5:3673. doi: 10.1038/ncomms4673.


The PTH-Gαs-protein kinase A cascade controls αNAC localization to regulate bone mass.

Pellicelli M, Miller JA, Arabian A, Gauthier C, Akhouayri O, Wu JY, Kronenberg HM, St-Arnaud R.

Mol Cell Biol. 2014 May;34(9):1622-33. doi: 10.1128/MCB.01434-13. Epub 2014 Feb 18.


Overview of skeletal development.

Kobayashi T, Kronenberg HM.

Methods Mol Biol. 2014;1130:3-12. doi: 10.1007/978-1-62703-989-5_1. Review.


Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice.

Guo J, Song L, Liu M, Segawa H, Miyamoto K, Bringhurst FR, Kronenberg HM, Jüppner H.

Endocrinology. 2013 May;154(5):1680-9. doi: 10.1210/en.2012-2240. Epub 2013 Mar 20.


In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma.

Pozzi S, Fulciniti M, Yan H, Vallet S, Eda H, Patel K, Santo L, Cirstea D, Hideshima T, Schirtzinge L, Kuhstoss S, Anderson KC, Munshi N, Scadden D, Kronenberg HM, Raje N.

Bone. 2013 Apr;53(2):487-96. doi: 10.1016/j.bone.2013.01.012. Epub 2013 Jan 17.


Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling.

Fulzele K, Krause DS, Panaroni C, Saini V, Barry KJ, Liu X, Lotinun S, Baron R, Bonewald L, Feng JQ, Chen M, Weinstein LS, Wu JY, Kronenberg HM, Scadden DT, Divieti Pajevic P.

Blood. 2013 Feb 7;121(6):930-9. doi: 10.1182/blood-2012-06-437160. Epub 2012 Nov 16.


Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes.

Song L, Liu M, Ono N, Bringhurst FR, Kronenberg HM, Guo J.

J Bone Miner Res. 2012 Nov;27(11):2344-58. doi: 10.1002/jbmr.1694.


Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts.

Kim SW, Pajevic PD, Selig M, Barry KJ, Yang JY, Shin CS, Baek WY, Kim JE, Kronenberg HM.

J Bone Miner Res. 2012 Oct;27(10):2075-84. doi: 10.1002/jbmr.1665.


Anabolic action of parathyroid hormone regulated by the β2-adrenergic receptor.

Hanyu R, Wehbi VL, Hayata T, Moriya S, Feinstein TN, Ezura Y, Nagao M, Saita Y, Hemmi H, Notomi T, Nakamoto T, Schipani E, Takeda S, Kaneko K, Kurosawa H, Karsenty G, Kronenberg HM, Vilardaga JP, Noda M.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7433-8. doi: 10.1073/pnas.1109036109. Epub 2012 Apr 25.


Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.

Park D, Spencer JA, Koh BI, Kobayashi T, Fujisaki J, Clemens TL, Lin CP, Kronenberg HM, Scadden DT.

Cell Stem Cell. 2012 Mar 2;10(3):259-72. doi: 10.1016/j.stem.2012.02.003.


A novel population of cells expressing both hematopoietic and mesenchymal markers is present in the normal adult bone marrow and is augmented in a murine model of marrow fibrosis.

Ohishi M, Ono W, Ono N, Khatri R, Marzia M, Baker EK, Root SH, Wilson TL, Iwamoto Y, Kronenberg HM, Aguila HL, Purton LE, Schipani E.

Am J Pathol. 2012 Feb;180(2):811-8. doi: 10.1016/j.ajpath.2011.10.028. Epub 2011 Dec 5.


Constitutively active PTH/PTHrP receptor specifically expressed in osteoblasts enhances bone formation induced by bone marrow ablation.

Ono N, Nakashima K, Schipani E, Hayata T, Ezura Y, Soma K, Kronenberg HM, Noda M.

J Cell Physiol. 2012 Feb;227(2):408-15. doi: 10.1002/jcp.22986.


Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice.

Wu JY, Aarnisalo P, Bastepe M, Sinha P, Fulzele K, Selig MK, Chen M, Poulton IJ, Purton LE, Sims NA, Weinstein LS, Kronenberg HM.

J Clin Invest. 2011 Sep;121(9):3492-504. doi: 10.1172/JCI46406. Epub 2011 Aug 1.


The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification.

Moisan A, Rivera MN, Lotinun S, Akhavanfard S, Coffman EJ, Cook EB, Stoykova S, Mukherjee S, Schoonmaker JA, Burger A, Kim WJ, Kronenberg HM, Baron R, Haber DA, Bardeesy N.

Dev Cell. 2011 May 17;20(5):583-596. doi: 10.1016/j.devcel.2011.03.013. Erratum in: Dev Cell. 2012 May 15;22(5):1109-17.


Osteopontin deficiency enhances parathyroid hormone/ parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology.

Morishita M, Ono N, Miyai K, Nakagawa T, Hanyu R, Nagao M, Kamolratanakul P, Notomi T, Rittling SR, Denhardt DT, Kronenberg HM, Ezura Y, Hayata T, Nakamoto T, Noda M.

Tissue Cell. 2011 Jun;43(3):196-200. doi: 10.1016/j.tice.2011.02.003. Epub 2011 Apr 21.


Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life.

Hirai T, Chagin AS, Kobayashi T, Mackem S, Kronenberg HM.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):191-6. doi: 10.1073/pnas.1005011108. Epub 2010 Dec 20.


Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss.

Tawfeek H, Bedi B, Li JY, Adams J, Kobayashi T, Weitzmann MN, Kronenberg HM, Pacifici R.

PLoS One. 2010 Aug 20;5(8):e12290. doi: 10.1371/journal.pone.0012290.


Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.

Maes C, Kobayashi T, Selig MK, Torrekens S, Roth SI, Mackem S, Carmeliet G, Kronenberg HM.

Dev Cell. 2010 Aug 17;19(2):329-44. doi: 10.1016/j.devcel.2010.07.010.

Supplemental Content

Loading ...
Support Center