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Items: 24


Deep Mutational Scan of an SCN5A Voltage Sensor.

Glazer AM, Kroncke BM, Matreyek KA, Yang T, Wada Y, Shields T, Salem JE, Fowler DM, Roden DM.

Circ Genom Precis Med. 2020 Feb;13(1):e002786. doi: 10.1161/CIRCGEN.119.002786. Epub 2020 Jan 12.


Patient-independent human induced pluripotent stem cell model: A new tool for rapid determination of genetic variant pathogenicity in long QT syndrome.

Chavali NV, Kryshtal DO, Parikh SS, Wang L, Glazer AM, Blackwell DJ, Kroncke BM, Shoemaker MB, Knollmann BC.

Heart Rhythm. 2019 Nov;16(11):1686-1695. doi: 10.1016/j.hrthm.2019.04.031. Epub 2019 Apr 18.


Protein structure aids predicting functional perturbation of missense variants in SCN5A and KCNQ1.

Kroncke BM, Mendenhall J, Smith DK, Sanders CR, Capra JA, George AL, Blume JD, Meiler J, Roden DM.

Comput Struct Biotechnol J. 2019 Feb 1;17:206-214. doi: 10.1016/j.csbj.2019.01.008. eCollection 2019.


Multiple mechanisms underlie increased cardiac late sodium current.

Kroncke BM, Yang T, Roden DM.

Heart Rhythm. 2019 Jul;16(7):1091-1097. doi: 10.1016/j.hrthm.2019.01.018. Epub 2019 Jan 21.


SCN5A (NaV1.5) Variant Functional Perturbation and Clinical Presentation: Variants of a Certain Significance.

Kroncke BM, Glazer AM, Smith DK, Blume JD, Roden DM.

Circ Genom Precis Med. 2018 May;11(5):e002095. doi: 10.1161/CIRCGEN.118.002095.


A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.

Johnson CN, Potet F, Thompson MK, Kroncke BM, Glazer AM, Voehler MW, Knollmann BC, George AL Jr, Chazin WJ.

Structure. 2018 May 1;26(5):683-694.e3. doi: 10.1016/j.str.2018.03.005. Epub 2018 Apr 5.


Exploiting ion channel structure to assess rare variant pathogenicity.

Kroncke BM, Yang T, Kannankeril P, Shoemaker MB, Roden DM.

Heart Rhythm. 2018 Jun;15(6):890-894. doi: 10.1016/j.hrthm.2018.01.021. Epub 2018 Jan 9.


Predicting the Functional Impact of KCNQ1 Variants of Unknown Significance.

Li B, Mendenhall JL, Kroncke BM, Taylor KC, Huang H, Smith DK, Vanoye CG, Blume JD, George AL Jr, Sanders CR, Meiler J.

Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001754. doi: 10.1161/CIRCGENETICS.117.001754.


Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains.

Deatherage CL, Lu Z, Kroncke BM, Ma S, Smith JA, Voehler MW, McFeeters RL, Sanders CR.

Sci Adv. 2017 Apr 12;3(4):e1602794. doi: 10.1126/sciadv.1602794. eCollection 2017 Apr.


Structural basis for KCNE3 modulation of potassium recycling in epithelia.

Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, George AL Jr, Meiler J, Vanoye CG, Sanders CR.

Sci Adv. 2016 Sep 9;2(9):e1501228. doi: 10.1126/sciadv.1501228. eCollection 2016 Sep.


Documentation of an Imperative To Improve Methods for Predicting Membrane Protein Stability.

Kroncke BM, Duran AM, Mendenhall JL, Meiler J, Blume JD, Sanders CR.

Biochemistry. 2016 Sep 13;55(36):5002-9. doi: 10.1021/acs.biochem.6b00537. Epub 2016 Aug 30.


Probing Structural Dynamics and Topology of the KCNE1 Membrane Protein in Lipid Bilayers via Site-Directed Spin Labeling and Electron Paramagnetic Resonance Spectroscopy.

Sahu ID, Craig AF, Dunagan MM, Troxel KR, Zhang R, Meiberg AG, Harmon CN, McCarrick RM, Kroncke BM, Sanders CR, Lorigan GA.

Biochemistry. 2015 Oct 20;54(41):6402-12. doi: 10.1021/acs.biochem.5b00505. Epub 2015 Oct 7.


Personalized biochemistry and biophysics.

Kroncke BM, Vanoye CG, Meiler J, George AL Jr, Sanders CR.

Biochemistry. 2015 Apr 28;54(16):2551-9. doi: 10.1021/acs.biochem.5b00189. Epub 2015 Apr 15.


Mapping membrane protein backbone dynamics: a comparison of site-directed spin labeling with NMR 15N-relaxation measurements.

Lo RH, Kroncke BM, Solomon TL, Columbus L.

Biophys J. 2014 Oct 7;107(7):1697-702. doi: 10.1016/j.bpj.2014.08.018.


The homology model of PMP22 suggests mutations resulting in peripheral neuropathy disrupt transmembrane helix packing.

Mittendorf KF, Kroncke BM, Meiler J, Sanders CR.

Biochemistry. 2014 Oct 7;53(39):6139-41. doi: 10.1021/bi500809t. Epub 2014 Sep 25.


Structural investigation of the transmembrane domain of KCNE1 in proteoliposomes.

Sahu ID, Kroncke BM, Zhang R, Dunagan MM, Smith HJ, Craig A, McCarrick RM, Sanders CR, Lorigan GA.

Biochemistry. 2014 Oct 14;53(40):6392-401. doi: 10.1021/bi500943p. Epub 2014 Oct 3.


Structure of the Neisserial outer membrane protein Opa₆₀: loop flexibility essential to receptor recognition and bacterial engulfment.

Fox DA, Larsson P, Lo RH, Kroncke BM, Kasson PM, Columbus L.

J Am Chem Soc. 2014 Jul 16;136(28):9938-46. doi: 10.1021/ja503093y. Epub 2014 May 19.


Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channel.

Peng D, Kim JH, Kroncke BM, Law CL, Xia Y, Droege KD, Van Horn WD, Vanoye CG, Sanders CR.

Biochemistry. 2014 Apr 1;53(12):2032-42. doi: 10.1021/bi500102w. Epub 2014 Mar 18.


DEER EPR measurements for membrane protein structures via bifunctional spin labels and lipodisq nanoparticles.

Sahu ID, McCarrick RM, Troxel KR, Zhang R, Smith HJ, Dunagan MM, Swartz MS, Rajan PV, Kroncke BM, Sanders CR, Lorigan GA.

Biochemistry. 2013 Sep 24;52(38):6627-32. doi: 10.1021/bi4009984. Epub 2013 Sep 9.


Reversible folding of human peripheral myelin protein 22, a tetraspan membrane protein.

Schlebach JP, Peng D, Kroncke BM, Mittendorf KF, Narayan M, Carter BD, Sanders CR.

Biochemistry. 2013 May 14;52(19):3229-41. doi: 10.1021/bi301635f. Epub 2013 May 2.


Backbone ¹H, ¹³C and ¹⁵N resonance assignments of the α-helical membrane protein TM0026 from Thermotoga maritima.

Kroncke BM, Columbus L.

Biomol NMR Assign. 2013 Oct;7(2):203-6. doi: 10.1007/s12104-012-9410-1. Epub 2012 Jul 28.


MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation.

Johnstone SR, Kroncke BM, Straub AC, Best AK, Dunn CA, Mitchell LA, Peskova Y, Nakamoto RK, Koval M, Lo CW, Lampe PD, Columbus L, Isakson BE.

Circ Res. 2012 Jul 6;111(2):201-11. doi: 10.1161/CIRCRESAHA.112.272302. Epub 2012 May 31.


Identification and removal of nitroxide spin label contaminant: impact on PRE studies of α-helical membrane proteins in detergent.

Kroncke BM, Columbus L.

Protein Sci. 2012 Apr;21(4):589-95. doi: 10.1002/pro.2038. Epub 2012 Mar 2.


Structural origins of nitroxide side chain dynamics on membrane protein α-helical sites.

Kroncke BM, Horanyi PS, Columbus L.

Biochemistry. 2010 Nov 30;49(47):10045-60. doi: 10.1021/bi101148w. Epub 2010 Nov 8.

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