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Items: 1 to 50 of 121

1.

The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair.

Moreno NS, Liu J, Haas KM, Parker LL, Chakraborty C, Kron SJ, Hodges K, Miller LD, Langefeld C, Robinson PJ, Lelièvre SA, Vidi PA.

Nucleic Acids Res. 2019 Sep 12. pii: gkz802. doi: 10.1093/nar/gkz802. [Epub ahead of print] No abstract available.

PMID:
31511892
2.

Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer.

Ricco N, Flor A, Wolfgeher D, Efimova EV, Ramamurthy A, Appelbe OK, Brinkman J, Truman AW, Spiotto MT, Kron SJ.

Mol Oncol. 2019 Sep;13(9):1927-1943. doi: 10.1002/1878-0261.12535. Epub 2019 Jul 26.

3.

Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence.

Liu Y, Efimova EV, Ramamurthy A, Kron SJ.

J Cell Sci. 2019 Jul 1;132(13). pii: jcs229385. doi: 10.1242/jcs.229385.

PMID:
31189537
4.

Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex.

Hernández-Ortega S, Sánchez-Botet A, Quandt E, Masip N, Gasa L, Verde G, Jiménez J, Levin RS, Rutaganira FU, Burlingame AL, Wolfgeher D, Ribeiro MPC, Kron SJ, Shokat KM, Clotet J.

Exp Mol Med. 2019 Apr 16;51(4):44. doi: 10.1038/s12276-019-0242-2.

5.

A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence.

Wu D, Pepowski B, Takahashi S, Kron SJ.

BMC Genomics. 2019 Apr 15;20(1):290. doi: 10.1186/s12864-019-5653-x.

6.

Targeted antibody and cytokine cancer immunotherapies through collagen affinity.

Ishihara J, Ishihara A, Sasaki K, Lee SS, Williford JM, Yasui M, Abe H, Potin L, Hosseinchi P, Fukunaga K, Raczy MM, Gray LT, Mansurov A, Katsumata K, Fukayama M, Kron SJ, Swartz MA, Hubbell JA.

Sci Transl Med. 2019 Apr 10;11(487). pii: eaau3259. doi: 10.1126/scitranslmed.aau3259.

7.

Repurposing Drugs for Cancer Radiotherapy: Early Successes and Emerging Opportunities.

Khan MK, Nasti TH, Buchwald ZS, Weichselbaum RR, Kron SJ.

Cancer J. 2019 Mar/Apr;25(2):106-115. doi: 10.1097/PPO.0000000000000369.

PMID:
30896532
8.

O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors.

Efimova EV, Appelbe OK, Ricco N, Lee SS, Liu Y, Wolfgeher DJ, Collins TN, Flor AC, Ramamurthy A, Warrington S, Bindokas VP, Kron SJ.

Mol Cancer Res. 2019 Jun;17(6):1338-1350. doi: 10.1158/1541-7786.MCR-18-1025. Epub 2019 Mar 18.

PMID:
30885991
9.

The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair.

Salvador Moreno N, Liu J, Haas KM, Parker LL, Chakraborty C, Kron SJ, Hodges K, Miller LD, Langefeld C, Robinson PJ, Lelièvre SA, Vidi PA.

Nucleic Acids Res. 2019 Apr 8;47(6):2703-2715. doi: 10.1093/nar/gkz138.

10.

STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability.

Ranoa DRE, Widau RC, Mallon S, Parekh AD, Nicolae CM, Huang X, Bolt MJ, Arina A, Parry R, Kron SJ, Moldovan GL, Khodarev NN, Weichselbaum RR.

Cancer Res. 2019 Apr 1;79(7):1465-1479. doi: 10.1158/0008-5472.CAN-18-1972. Epub 2018 Nov 27.

PMID:
30482772
11.

Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins.

Xu J, Lee SS, Seo H, Pang L, Jun Y, Zhang RY, Zhang ZY, Kim P, Lee W, Kron SJ, Yeo Y.

Small. 2018 Dec;14(50):e1803601. doi: 10.1002/smll.201803601. Epub 2018 Nov 9.

12.

Nondestructive, multiplex three-dimensional mapping of immune infiltrates in core needle biopsy.

Lee SS, Bindokas VP, Lingen MW, Kron SJ.

Lab Invest. 2019 Sep;99(9):1400-1413. doi: 10.1038/s41374-018-0156-y. Epub 2018 Nov 6.

13.

Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment.

Lee SS, Bindokas VP, Kron SJ.

Mol Cancer Ther. 2019 Jan;18(1):213-226. doi: 10.1158/1535-7163.MCT-18-0554. Epub 2018 Oct 15.

PMID:
30322947
14.

Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection.

Cheng X, Jobin-Robitaille O, Billon P, Buisson R, Niu H, Lacoste N, Abshiru N, Côté V, Thibault P, Kron SJ, Sung P, Brandl CJ, Masson JY, Côté J.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10028-10033. doi: 10.1073/pnas.1806513115. Epub 2018 Sep 17.

15.

The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration.

Sánchez-Botet A, Gasa L, Quandt E, Hernández-Ortega S, Jiménez J, Mezquita P, Carrasco-García MÀ, Kron SJ, Vidal A, Villanueva A, Ribeiro MPC, Clotet J.

Sci Rep. 2018 Aug 7;8(1):11797. doi: 10.1038/s41598-018-30307-x.

16.

Three-Dimensional Analysis of the Human Pancreas.

Fowler JL, Lee SS, Wesner ZC, Olehnik SK, Kron SJ, Hara M.

Endocrinology. 2018 Mar 1;159(3):1393-1400. doi: 10.1210/en.2017-03076.

17.

Radiation-enhanced delivery of plasmid DNA to tumors utilizing a novel PEI polyplex.

Appelbe OK, Kim BK, Rymut N, Wang J, Kron SJ, Yeo Y.

Cancer Gene Ther. 2018 Aug;25(7-8):196-206. doi: 10.1038/s41417-017-0004-z. Epub 2017 Dec 19.

18.

Multiplex three-dimensional optical mapping of tumor immune microenvironment.

Lee SS, Bindokas VP, Kron SJ.

Sci Rep. 2017 Dec 5;7(1):17031. doi: 10.1038/s41598-017-16987-x.

19.

A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence.

Flor AC, Wolfgeher D, Wu D, Kron SJ.

Cell Death Discov. 2017 Oct 30;3:17075. doi: 10.1038/cddiscovery.2017.75. eCollection 2017.

20.

Simple strategies to enhance discovery of acetylation post-translational modifications by quadrupole-orbitrap LC-MS/MS.

Manning AJ, Lee J, Wolfgeher DJ, Kron SJ, Greenberg JT.

Biochim Biophys Acta Proteins Proteom. 2018 Feb;1866(2):224-229. doi: 10.1016/j.bbapap.2017.10.006. Epub 2017 Oct 16. Review.

PMID:
29050961
21.

HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation.

Efimova EV, Ricco N, Labay E, Mauceri HJ, Flor AC, Ramamurthy A, Sutton HG, Weichselbaum RR, Kron SJ.

Mol Cancer Ther. 2018 Feb;17(2):407-418. doi: 10.1158/1535-7163.MCT-17-0288. Epub 2017 Oct 13.

22.

Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide.

Appelbe OK, Moynihan KD, Flor A, Rymut N, Irvine DJ, Kron SJ.

J Control Release. 2017 Nov 28;266:248-255. doi: 10.1016/j.jconrel.2017.09.043. Epub 2017 Oct 5.

23.

A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer.

Gasa L, Sanchez-Botet A, Quandt E, Hernández-Ortega S, Jiménez J, Carrasco-García MA, Simonetti S, Kron SJ, Ribeiro MP, Nadal E, Villanueva A, Clotet J.

Sci Rep. 2017 Aug 31;7(1):10228. doi: 10.1038/s41598-017-10770-8.

24.

Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis.

Bar-Yosef H, Vivanco Gonzalez N, Ben-Aroya S, Kron SJ, Kornitzer D.

Sci Rep. 2017 Jul 18;7(1):5692. doi: 10.1038/s41598-017-05741-y.

25.

Differential Growth of Francisella tularensis, Which Alters Expression of Virulence Factors, Dominant Antigens, and Surface-Carbohydrate Synthases, Governs the Apparent Virulence of Ft SchuS4 to Immunized Animals.

Holland KM, Rosa SJ, Kristjansdottir K, Wolfgeher D, Franz BJ, Zarrella TM, Kumar S, Sunagar R, Singh A, Bakshi CS, Namjoshi P, Barry EM, Sellati TJ, Kron SJ, Gosselin EJ, Reed DS, Hazlett KRO.

Front Microbiol. 2017 Jun 22;8:1158. doi: 10.3389/fmicb.2017.01158. eCollection 2017.

26.

Basal Tumor Cell Isolation and Patient-Derived Xenograft Engraftment Identify High-Risk Clinical Bladder Cancers.

Skowron KB, Pitroda SP, Namm JP, Balogun O, Beckett MA, Zenner ML, Fayanju O, Huang X, Fernandez C, Zheng W, Qiao G, Chin R, Kron SJ, Khodarev NN, Posner MC, Steinberg GD, Weichselbaum RR.

Sci Rep. 2016 Oct 24;6:35854. doi: 10.1038/srep35854.

27.

Lipid-derived reactive aldehydes link oxidative stress to cell senescence.

Flor AC, Kron SJ.

Cell Death Dis. 2016 Sep 8;7(9):e2366. doi: 10.1038/cddis.2016.275. No abstract available.

28.

Image-Guided Radiotherapy Targets Macromolecules through Altering the Tumor Microenvironment.

Appelbe OK, Zhang Q, Pelizzari CA, Weichselbaum RR, Kron SJ.

Mol Pharm. 2016 Oct 3;13(10):3457-3467. Epub 2016 Sep 1.

29.

Modulation of therapy-induced senescence by reactive lipid aldehydes.

Flor AC, Doshi AP, Kron SJ.

Cell Death Discov. 2016;2. pii: 16045. Epub 2016 Jul 4.

30.

Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers.

Labay E, Mauceri HJ, Efimova EV, Flor AC, Sutton HG, Kron SJ, Weichselbaum RR.

Oncotarget. 2016 Jun 7;7(23):33919-33. doi: 10.18632/oncotarget.8984.

31.

Nanoparticle formulations of cisplatin for cancer therapy.

Duan X, He C, Kron SJ, Lin W.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Sep;8(5):776-91. doi: 10.1002/wnan.1390. Epub 2016 Feb 5. Review.

32.

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors.

Woodford MR, Truman AW, Dunn DM, Jensen SM, Cotran R, Bullard R, Abouelleil M, Beebe K, Wolfgeher D, Wierzbicki S, Post DE, Caza T, Tsutsumi S, Panaretou B, Kron SJ, Trepel JB, Landas S, Prodromou C, Shapiro O, Stetler-Stevenson WG, Bourboulia D, Neckers L, Bratslavsky G, Mollapour M.

Cell Rep. 2016 Feb 2;14(4):872-884. doi: 10.1016/j.celrep.2015.12.084. Epub 2016 Jan 21.

33.

The dynamic interactome of human Aha1 upon Y223 phosphorylation.

Wolfgeher D, Dunn DM, Woodford MR, Bourboulia D, Bratslavsky G, Mollapour M, Kron SJ, Truman AW.

Data Brief. 2015 Nov 6;5:752-5. doi: 10.1016/j.dib.2015.10.028. eCollection 2015 Dec.

34.

Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses Immunity.

Lee J, Manning AJ, Wolfgeher D, Jelenska J, Cavanaugh KA, Xu H, Fernandez SM, Michelmore RW, Kron SJ, Greenberg JT.

Cell Rep. 2015 Nov 24;13(8):1670-82. doi: 10.1016/j.celrep.2015.10.029. Epub 2015 Nov 12.

35.

Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.

Efimova EV, Takahashi S, Shamsi NA, Wu D, Labay E, Ulanovskaya OA, Weichselbaum RR, Kozmin SA, Kron SJ.

Mol Cancer Res. 2016 Feb;14(2):173-84. doi: 10.1158/1541-7786.MCR-15-0263. Epub 2015 Nov 4.

36.

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells.

Dunn DM, Woodford MR, Truman AW, Jensen SM, Schulman J, Caza T, Remillard TC, Loiselle D, Wolfgeher D, Blagg BS, Franco L, Haystead TA, Daturpalli S, Mayer MP, Trepel JB, Morgan RM, Prodromou C, Kron SJ, Panaretou B, Stetler-Stevenson WG, Landas SK, Neckers L, Bratslavsky G, Bourboulia D, Mollapour M.

Cell Rep. 2015 Aug 11;12(6):1006-18. doi: 10.1016/j.celrep.2015.07.004. Epub 2015 Jul 30.

37.

The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage.

Truman AW, Kristjansdottir K, Wolfgeher D, Ricco N, Mayampurath A, Volchenboum SL, Clotet J, Kron SJ.

Data Brief. 2014 Nov 7;2:12-5. doi: 10.1016/j.dib.2014.10.006. eCollection 2015 Mar.

38.

Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations.

Depreux FF, Puckelwartz MJ, Augustynowicz A, Wolfgeher D, Labno CM, Pierre-Louis D, Cicka D, Kron SJ, Holaska J, McNally EM.

Hum Mol Genet. 2015 Aug 1;24(15):4284-95. doi: 10.1093/hmg/ddv160. Epub 2015 May 6.

39.

Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.

Truman AW, Kristjansdottir K, Wolfgeher D, Ricco N, Mayampurath A, Volchenboum SL, Clotet J, Kron SJ.

J Proteomics. 2015 Jan 1;112:285-300. doi: 10.1016/j.jprot.2014.09.028. Epub 2014 Oct 18.

40.

DNA-directed assembly of antibody-fluorophore conjugates for quantitative multiparametric flow cytometry.

Flor AC, Williams JH, Blaine KM, Duggan RC, Sperling AI, Schwartz DA, Kron SJ.

Chembiochem. 2014 Jan 24;15(2):267-75. doi: 10.1002/cbic.201300464. Epub 2013 Dec 27.

41.

DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast.

Balogun FO, Truman AW, Kron SJ.

DNA Repair (Amst). 2013 Sep;12(9):751-60. doi: 10.1016/j.dnarep.2013.06.003. Epub 2013 Jul 6.

42.

The yin and yang of cyclin control by nutrients.

Jiménez J, Truman AW, Menoyo S, Kron SJ, Clotet J.

Cell Cycle. 2013 Mar 15;12(6):865-6. doi: 10.4161/cc.24217. Epub 2013 Mar 7. No abstract available.

43.

CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression.

Truman AW, Kristjansdottir K, Wolfgeher D, Hasin N, Polier S, Zhang H, Perrett S, Prodromou C, Jones GW, Kron SJ.

Cell. 2012 Dec 7;151(6):1308-18. doi: 10.1016/j.cell.2012.10.051.

44.

Activity assay of epidermal growth factor receptor tyrosine kinase inhibitors in triple-negative breast cancer cells using peptide-conjugated magnetic beads.

Ghosh G, Yan X, Kron SJ, Palecek SP.

Assay Drug Dev Technol. 2013 Feb;11(1):44-51. doi: 10.1089/adt.2012.454. Epub 2012 Sep 20.

45.

Photocleavable peptide-oligonucleotide conjugates for protein kinase assays by MALDI-TOF MS.

Zhou G, Khan F, Dai Q, Sylvester JE, Kron SJ.

Mol Biosyst. 2012 Sep;8(9):2395-404. Epub 2012 Jul 6.

46.

Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors.

Ghosh G, Lian X, Kron SJ, Palecek SP.

BMC Cancer. 2012 Mar 20;12:95. doi: 10.1186/1471-2407-12-95.

47.

Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.

Meng Y, Efimova EV, Hamzeh KW, Darga TE, Mauceri HJ, Fu YX, Kron SJ, Weichselbaum RR.

Mol Ther. 2012 May;20(5):1046-55. doi: 10.1038/mt.2012.19. Epub 2012 Feb 14.

48.

Annotator: postprocessing software for generating function-based signatures from quantitative mass spectrometry.

Sylvester JE, Bray TS, Kron SJ.

J Proteome Res. 2012 Mar 2;11(3):1521-36. doi: 10.1021/pr200460s. Epub 2012 Feb 3.

49.

Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.

Barreto-Andrade JC, Efimova EV, Mauceri HJ, Beckett MA, Sutton HG, Darga TE, Vokes EE, Posner MC, Kron SJ, Weichselbaum RR.

Mol Cancer Ther. 2011 Jul;10(7):1185-93. doi: 10.1158/1535-7163.MCT-11-0061. Epub 2011 May 13.

50.

Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence.

Labay E, Efimova EV, Quarshie BK, Golden DW, Weichselbaum RR, Kron SJ.

Int J High Throughput Screen. 2011 Mar;2:1-13.

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