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Items: 1 to 50 of 80

1.

A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate Carcinoma.

Anestopoulos I, Sfakianos AP, Franco R, Chlichlia K, Panayiotidis MI, Kroll DJ, Pappa A.

Molecules. 2016 Dec 31;22(1). pii: E62. doi: 10.3390/molecules22010062.

2.

Spiroscytalin, a new tetramic acid and other metabolites of mixed biogenesis from Scytalidium cuboideum.

Sy-Cordero AA, Figueroa M, Raja HA, Meza Aviña ME, Croatt MP, Adcock AF, Kroll DJ, Wani MC, Pearce CJ, Oberlies NH.

Tetrahedron. 2015 Nov 25;71(47):8899-904. doi: 10.1016/j.tet.2015.09.073.

3.

Systematically variable planktonic carbon metabolism along a land-to-lake gradient in a Great Lakes coastal zone.

Weinke AD, Kendall ST, Kroll DJ, Strickler EA, Weinert ME, Holcomb TM, Defore AA, Dila DK, Snider MJ, Gereaux LC, Biddanda BA.

J Plankton Res. 2014 Nov;36(6):1528-1542. Epub 2014 Aug 11.

4.

Waol A, trans-dihydrowaol A, and cis-dihydrowaol A: polyketide-derived γ-lactones from a Volutella species.

El-Elimat T, Figueroa M, Raja HA, Adcock AF, Kroll DJ, Swanson SM, Wani MC, Pearce CJ, Oberlies NH.

Tetrahedron Lett. 2013 Aug 7;54(32):4300-4302.

5.

Peptaibols, tetramic acid derivatives, isocoumarins, and sesquiterpenes from a Bionectria sp. (MSX 47401).

Figueroa M, Raja H, Falkinham JO 3rd, Adcock AF, Kroll DJ, Wani MC, Pearce CJ, Oberlies NH.

J Nat Prod. 2013 Jun 28;76(6):1007-15. doi: 10.1021/np3008842. Epub 2013 Jun 19.

6.

Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).

El-Elimat T, Figueroa M, Raja HA, Graf TN, Adcock AF, Kroll DJ, Day CS, Wani MC, Pearce CJ, Oberlies NH.

J Nat Prod. 2013 Mar 22;76(3):382-7. doi: 10.1021/np300749w. Epub 2013 Jan 9.

7.

Enhanced bioactivity of silybin B methylation products.

Sy-Cordero AA, Graf TN, Runyon SP, Wani MC, Kroll DJ, Agarwal R, Brantley SJ, Paine MF, Polyak SJ, Oberlies NH.

Bioorg Med Chem. 2013 Feb 1;21(3):742-7. doi: 10.1016/j.bmc.2012.11.035. Epub 2012 Dec 5.

8.

Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi.

Pearce CJ, Lantvit DD, Shen Q, Jarjoura D, Zhang X, Oberlies NH, Kroll DJ, Wani MC, Orjala J, Soejarto DD, Farnsworth NR, de Blanco EJ, Fuchs JR, Kinghorn AD, Swanson SM.

Methods Mol Biol. 2012;944:267-77. doi: 10.1007/978-1-62703-122-6_20.

PMID:
23065624
9.

Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae.

Figueroa M, Graf TN, Ayers S, Adcock AF, Kroll DJ, Yang J, Swanson SM, Munoz-Acuna U, Carcache de Blanco EJ, Agrawal R, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH.

J Antibiot (Tokyo). 2012 Nov;65(11):559-64. doi: 10.1038/ja.2012.69. Epub 2012 Sep 12.

10.

Indole alkaloids from two cultured cyanobacteria, Westiellopsis sp. and Fischerella muscicola.

Kim H, Lantvit D, Hwang CH, Kroll DJ, Swanson SM, Franzblau SG, Orjala J.

Bioorg Med Chem. 2012 Sep 1;20(17):5290-5. doi: 10.1016/j.bmc.2012.06.030. Epub 2012 Jul 5.

11.

Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities.

Ayers S, Ehrmann BM, Adcock AF, Kroll DJ, Carcache de Blanco EJ, Shen Q, Swanson SM, Falkinham JO 3rd, Wani MC, Mitchell SM, Pearce CJ, Oberlies NH.

J Pept Sci. 2012 Aug;18(8):500-10. doi: 10.1002/psc.2425. Epub 2012 Jun 29.

12.

Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales.

Ayers S, Ehrmann BM, Adcock AF, Kroll DJ, Wani MC, Pearce CJ, Oberlies NH.

Tetrahedron Lett. 2011 Nov 2;52(44):5733-5735.

13.

Nitrile-Containing Fischerindoles from the Cultured Cyanobacterium Fischerella sp.

Kim H, Krunic A, Lantvit D, Shen Q, Kroll DJ, Swanson SM, Orjala J.

Tetrahedron. 2012 Apr 15;68(15):3205-3209.

14.

Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022).

Ayers S, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Matthew S, Carcache de Blanco EJ, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH.

J Antibiot (Tokyo). 2012 Jan;65(1):3-8. doi: 10.1038/ja.2011.95. Epub 2011 Nov 9.

15.

Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.

Ayers S, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH.

Tetrahedron Lett. 2011 Oct 5;52(40):5128-5230.

16.

Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).

Sy-Cordero AA, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Wani MC, Pearce CJ, Oberlies NH.

J Nat Prod. 2011 Oct 28;74(10):2137-42. doi: 10.1021/np2004243. Epub 2011 Oct 6. Erratum in: J Nat Prod. 2012 Feb 24;75(2):307.

17.

Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships.

Ayers S, Graf TN, Adcock AF, Kroll DJ, Matthew S, Carcache de Blanco EJ, Shen Q, Swanson SM, Wani MC, Pearce CJ, Oberlies NH.

J Nat Prod. 2011 May 27;74(5):1126-31. doi: 10.1021/np200062x. Epub 2011 Apr 22.

18.

The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation.

Ngo N, Brantley SJ, Carrizosa DR, Kashuba AD, Dees EC, Kroll DJ, Oberlies NH, Paine MF.

J Exp Pharmacol. 2010 Jul;2010(2):83-91.

19.

Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling.

Deep G, Gangar SC, Oberlies NH, Kroll DJ, Agarwal R.

Mol Carcinog. 2010 Oct;49(10):902-12. doi: 10.1002/mc.20670.

20.

Dereplication of macrocyclic trichothecenes from extracts of filamentous fungi through UV and NMR profiles.

Sy-Cordero AA, Graf TN, Wani MC, Kroll DJ, Pearce CJ, Oberlies NH.

J Antibiot (Tokyo). 2010 Sep;63(9):539-44. doi: 10.1038/ja.2010.77. Epub 2010 Jul 21.

21.

Colchicinoids from Colchicum crocifolium Boiss. (Colchicaceae).

Alali FQ, Gharaibeh AA, Ghawanmeh A, Tawaha K, Qandil A, Burgess JP, Sy A, Nakanishi Y, Kroll DJ, Oberlies NH.

Nat Prod Res. 2010;24(2):152-9. doi: 10.1080/14786410902941097.

PMID:
20077308
22.

Discovery of anticancer agents of diverse natural origin.

Kinghorn AD, Carcache de Blanco EJ, Chai HB, Orjala J, Farnsworth NR, Soejarto DD, Oberlies NH, Wani MC, Kroll DJ, Pearce CJ, Swanson SM, Kramer RA, Rose WC, Fairchild CR, Vite GD, Emanuel S, Jarjoura D, Cope FO.

Pure Appl Chem. 2009 Jan 1;81(6):1051-1063.

23.

A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL).

Ladas EJ, Kroll DJ, Oberlies NH, Cheng B, Ndao DH, Rheingold SR, Kelly KM.

Cancer. 2010 Jan 15;116(2):506-13. doi: 10.1002/cncr.24723.

24.

Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.

Sy-Cordero A, Graf TN, Nakanishi Y, Wani MC, Agarwal R, Kroll DJ, Oberlies NH.

Planta Med. 2010 Apr;76(6):644-7. doi: 10.1055/s-0029-1240624. Epub 2009 Nov 25.

25.

Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.

Brantley SJ, Oberlies NH, Kroll DJ, Paine MF.

J Pharmacol Exp Ther. 2010 Mar;332(3):1081-7. doi: 10.1124/jpet.109.161927. Epub 2009 Nov 24.

26.

Bioactive constituents of the stem bark of Mitrephora glabra.

Li C, Lee D, Graf TN, Phifer SS, Nakanishi Y, Riswan S, Setyowati FM, Saribi AM, Soejarto DD, Farnsworth NR, Falkinham JO 3rd, Kroll DJ, Kinghorn AD, Wani MC, Oberlies NH.

J Nat Prod. 2009 Nov;72(11):1949-53. doi: 10.1021/np900572g.

27.

Design, synthesis, and biological evaluation of antibody-drug conjugates comprised of potent camptothecin analogues.

Burke PJ, Senter PD, Meyer DW, Miyamoto JB, Anderson M, Toki BE, Manikumar G, Wani MC, Kroll DJ, Jeffrey SC.

Bioconjug Chem. 2009 Jun;20(6):1242-50. doi: 10.1021/bc9001097.

PMID:
19469529
28.

Inhibition of paclitaxel metabolism in vitro in human hepatocytes by Ginkgo biloba preparations.

Etheridge AS, Kroll DJ, Mathews JM.

J Diet Suppl. 2009;6(2):104-10. doi: 10.1080/19390210902861817.

PMID:
22435411
29.

Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin.

Deep G, Raina K, Singh RP, Oberlies NH, Kroll DJ, Agarwal R.

Int J Cancer. 2008 Dec 15;123(12):2750-8. doi: 10.1002/ijc.23879.

30.

Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae).

Alali FQ, Tahboub YR, Ibrahim ES, Qandil AM, Tawaha K, Burgess JP, Sy A, Nakanishi Y, Kroll DJ, Oberlies NH.

Phytochemistry. 2008 Sep;69(12):2341-6. doi: 10.1016/j.phytochem.2008.06.017. Epub 2008 Aug 6.

PMID:
18691727
31.

Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.

Deep G, Oberlies NH, Kroll DJ, Agarwal R.

Int J Cancer. 2008 Jul 1;123(1):41-50. doi: 10.1002/ijc.23485.

32.

Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway.

Deep G, Oberlies NH, Kroll DJ, Agarwal R.

Oncogene. 2008 Jun 26;27(28):3986-98. doi: 10.1038/onc.2008.45. Epub 2008 Mar 10.

PMID:
18332867
33.
34.

Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma associated herpesvirus.

Nun TK, Kroll DJ, Oberlies NH, Soejarto DD, Case RJ, Piskaut P, Matainaho T, Hilscher C, Wang L, Dittmer DP, Gao SJ, Damania B.

Mol Cancer Ther. 2007 Aug;6(8):2360-70.

35.

Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.

Phifer SS, Lee D, Seo EK, Kim NC, Graf TN, Kroll DJ, Navarro HA, Izydore RA, Jiménez F, Garcia R, Rose WC, Fairchild CR, Wild R, Soejarto DD, Farnsworth NR, Kinghorn AD, Oberlies NH, Wall ME, Wani MC.

J Nat Prod. 2007 Jun;70(6):954-61. Epub 2007 Jun 7.

36.

Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies.

Kroll DJ, Shaw HS, Oberlies NH.

Integr Cancer Ther. 2007 Jun;6(2):110-9. Review.

PMID:
17548790
37.

A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII.

Trembath DG, Lal A, Kroll DJ, Oberlies NH, Riggins GJ.

Mol Cancer. 2007 Apr 16;6:30.

38.

Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells.

Deep G, Oberlies NH, Kroll DJ, Agarwal R.

Carcinogenesis. 2007 Jul;28(7):1533-42. Epub 2007 Mar 26.

PMID:
17389612
39.

Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro.

Morgan MT, Nakanishi Y, Kroll DJ, Griset AP, Carnahan MA, Wathier M, Oberlies NH, Manikumar G, Wani MC, Grinstaff MW.

Cancer Res. 2006 Dec 15;66(24):11913-21.

40.

Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): two native Jordanian meadow saffrons.

Alali FQ, Tawaha K, El-Elimat T, Qasaymeh R, Li C, Burgess J, Nakanishi Y, Kroll DJ, Wani MC, Oberlies NH.

Nat Prod Res. 2006 May 20;20(6):558-66.

PMID:
16835088
41.

A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.

Li C, Lee D, Graf TN, Phifer SS, Nakanishi Y, Burgess JP, Riswan S, Setyowati FM, Saribi AM, Soejarto DD, Farnsworth NR, Falkinham JO 3rd, Kroll DJ, Kinghorn AD, Wani MC, Oberlies NH.

Org Lett. 2005 Dec 8;7(25):5709-12.

43.

Diterpene glycosides from Egletes viscosa.

Lee D, Li C, Graf TN, Vigo JS, Graham JG, Cabieses F, Farnsworth NR, Cordell GA, Kinghorn AD, Kroll DJ, Wani MC, Oberlies NH.

Planta Med. 2005 Aug;71(8):792-4.

PMID:
16142652
44.

Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.

Davis-Searles PR, Nakanishi Y, Kim NC, Graf TN, Oberlies NH, Wani MC, Wall ME, Agarwal R, Kroll DJ.

Cancer Res. 2005 May 15;65(10):4448-57.

45.

New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.

Alali FQ, El-Elimat T, Li C, Qandil A, Alkofahi A, Tawaha K, Burgess JP, Nakanishi Y, Kroll DJ, Navarro HA, Falkinham JO 3rd, Wani MC, Oberlies NH.

J Nat Prod. 2005 Feb;68(2):173-8.

PMID:
15730238
46.

ASHP statement on the use of dietary supplements.

Kroll DJ.

Am J Health Syst Pharm. 2004 Aug 15;61(16):1707-11. No abstract available.

PMID:
15540485
47.

Delayed-type hypersensitivity reaction with iscador M given in combination with cytotoxic chemotherapy.

Shaw HS, Hobbs KB, Kroll DJ, Seewaldt VL.

J Clin Oncol. 2004 Nov 1;22(21):4432-4. No abstract available. Erratum in: J Clin Oncol. 2005 Feb 20;23(6):1337.

PMID:
15514390
48.

Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.

Gu JQ, Graf TN, Lee D, Chai HB, Mi Q, Kardono LB, Setyowati FM, Ismail R, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kroll DJ, Falkinham JO 3rd, Wall ME, Wani MC, Kinghorn AD, Oberlies NH.

J Nat Prod. 2004 Jul;67(7):1156-61.

PMID:
15270571
49.

Camptothecin and taxol: historic achievements in natural products research.

Oberlies NH, Kroll DJ.

J Nat Prod. 2004 Feb;67(2):129-35.

PMID:
14987046
50.

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