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Items: 15

1.

Control of antiviral innate immune response by protein geranylgeranylation.

Yang S, Harding AT, Sweeney C, Miao D, Swan G, Zhou C, Jiang Z, Fitzgerald KA, Hammer G, Bergo MO, Kroh HK, Lacy DB, Sun C, Glogauer M, Que LG, Heaton NS, Wang D.

Sci Adv. 2019 May 29;5(5):eaav7999. doi: 10.1126/sciadv.aav7999. eCollection 2019 May.

2.

Protein Z-dependent protease inhibitor (ZPI) is a physiologically significant inhibitor of prothrombinase function.

Huang X, Swanson R, Kroh HK, Bock PE.

J Biol Chem. 2019 May 10;294(19):7644-7657. doi: 10.1074/jbc.RA118.006787. Epub 2019 Mar 27.

PMID:
30918026
3.

A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.

Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB.

J Biol Chem. 2018 Jan 19;293(3):941-952. doi: 10.1074/jbc.M117.813428. Epub 2017 Nov 27.

4.

Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.

Gupta P, Zhang Z, Sugiman-Marangos SN, Tam J, Raman S, Julien JP, Kroh HK, Lacy DB, Murgolo N, Bekkari K, Therien AG, Hernandez LD, Melnyk RA.

J Biol Chem. 2017 Oct 20;292(42):17290-17301. doi: 10.1074/jbc.M117.806687. Epub 2017 Aug 23.

5.

Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.

Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB.

J Biol Chem. 2017 Sep 1;292(35):14401-14412. doi: 10.1074/jbc.M117.781112. Epub 2017 Jul 13.

6.

Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab.

Hernandez LD, Kroh HK, Hsieh E, Yang X, Beaumont M, Sheth PR, DiNunzio E, Rutherford SA, Ohi MD, Ermakov G, Xiao L, Secore S, Karczewski J, Racine F, Mayhood T, Fischer P, Sher X, Gupta P, Lacy DB, Therien AG.

J Mol Biol. 2017 Apr 7;429(7):1030-1044. doi: 10.1016/j.jmb.2017.02.010. Epub 2017 Feb 21.

PMID:
28232034
7.

Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.

Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E.

Infect Immun. 2016 Jan 11;84(3):856-65. doi: 10.1128/IAI.01291-15.

8.

Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein.

Kroh HK, Bock PE.

J Biol Chem. 2012 Nov 9;287(46):39149-57. doi: 10.1074/jbc.M112.415562. Epub 2012 Sep 25.

9.

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.

Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R.

Nat Med. 2011 Aug 21;17(9):1142-6. doi: 10.1038/nm.2423.

10.

Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.

Kroh HK, Panizzi P, Tchaikovski S, Baird TR, Wei N, Krishnaswamy S, Tans G, Rosing J, Furie B, Furie BC, Bock PE.

J Biol Chem. 2011 Jul 1;286(26):23345-56. doi: 10.1074/jbc.M111.230292. Epub 2011 Apr 29.

11.

Skizzle is a novel plasminogen- and plasmin-binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generation.

Wiles KG, Panizzi P, Kroh HK, Bock PE.

J Biol Chem. 2010 Jul 2;285(27):21153-64. doi: 10.1074/jbc.M110.107730. Epub 2010 Apr 30.

12.

Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin.

Kroh HK, Panizzi P, Bock PE.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):7786-91. doi: 10.1073/pnas.0811750106. Epub 2009 Apr 28.

13.

Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.

Kroh HK, Tans G, Nicolaes GA, Rosing J, Bock PE.

J Biol Chem. 2007 Jun 1;282(22):16095-104. Epub 2007 Apr 12.

14.

Solution structure of the cytoplasmic domain of erythrocyte membrane band 3 determined by site-directed spin labeling.

Zhou Z, DeSensi SC, Stein RA, Brandon S, Dixit M, McArdle EJ, Warren EM, Kroh HK, Song L, Cobb CE, Hustedt EJ, Beth AH.

Biochemistry. 2005 Nov 22;44(46):15115-28.

PMID:
16285715
15.

Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions.

Panizzi P, Friedrich R, Fuentes-Prior P, Kroh HK, Briggs J, Tans G, Bode W, Bock PE.

J Biol Chem. 2006 Jan 13;281(2):1169-78. Epub 2005 Oct 17.

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