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Items: 38

1.

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.

Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA Jr, Benovic JL, An SS, Dulin NO, Penn RB.

FASEB J. 2018 Feb;32(2):862-874. doi: 10.1096/fj.201700555R. Epub 2018 Jan 4.

PMID:
29042451
2.

In silico design of novel probes for the atypical opioid receptor MRGPRX2.

Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL.

Nat Chem Biol. 2017 May;13(5):529-536. doi: 10.1038/nchembio.2334. Epub 2017 Mar 13.

3.

Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc.

Sato S, Huang XP, Kroeze WK, Roth BL.

Mol Pharmacol. 2016 Dec;90(6):726-737. Epub 2016 Oct 17.

4.

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

Huang XP, Karpiak J, Kroeze WK, Zhu H, Chen X, Moy SS, Saddoris KA, Nikolova VD, Farrell MS, Wang S, Mangano TJ, Deshpande DA, Jiang A, Penn RB, Jin J, Koller BH, Kenakin T, Shoichet BK, Roth BL.

Nature. 2015 Nov 26;527(7579):477-83. doi: 10.1038/nature15699. Epub 2015 Nov 9.

5.

Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily.

Roth BL, Kroeze WK.

J Biol Chem. 2015 Aug 7;290(32):19471-7. doi: 10.1074/jbc.R115.654764. Epub 2015 Jun 22. Review.

6.

Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.

Vardy E, Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V, Stevens RC, Peterson RT, Roth BL.

Chem Biol. 2015 Jun 18;22(6):764-75. doi: 10.1016/j.chembiol.2015.05.012.

7.

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguère PM, Sciaky N, Roth BL.

Nat Struct Mol Biol. 2015 May;22(5):362-9. doi: 10.1038/nsmb.3014. Epub 2015 Apr 20.

8.

Tuning up the right signal: chemical and genetic approaches to study GPCR functions.

Giguere PM, Kroeze WK, Roth BL.

Curr Opin Cell Biol. 2014 Apr;27:51-5. doi: 10.1016/j.ceb.2013.11.006. Epub 2013 Dec 8. Review.

9.

Quantitative analysis of focused a-to-I RNA editing sites by ultra-high-throughput sequencing in psychiatric disorders.

Zhu H, Urban DJ, Blashka J, McPheeters MT, Kroeze WK, Mieczkowski P, Overholser JC, Jurjus GJ, Dieter L, Mahajan GJ, Rajkowska G, Wang Z, Sullivan PF, Stockmeier CA, Roth BL.

PLoS One. 2012;7(8):e43227. doi: 10.1371/journal.pone.0043227. Epub 2012 Aug 17.

10.

Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo.

Yadav PN, Kroeze WK, Farrell MS, Roth BL.

J Pharmacol Exp Ther. 2011 Oct;339(1):99-105. doi: 10.1124/jpet.111.183780. Epub 2011 Jul 7.

11.

The presynaptic component of the serotonergic system is required for clozapine's efficacy.

Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL.

Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195. Epub 2010 Nov 3.

12.

Deorphanization of novel peptides and their receptors.

Ozawa A, Lindberg I, Roth B, Kroeze WK.

AAPS J. 2010 Sep;12(3):378-84. doi: 10.1208/s12248-010-9198-9. Epub 2010 May 6. Review.

13.

Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method.

Abbas AI, Urban DJ, Jensen NH, Farrell MS, Kroeze WK, Mieczkowski P, Wang Z, Roth BL.

Nucleic Acids Res. 2010 Jun;38(10):e118. doi: 10.1093/nar/gkq107. Epub 2010 Feb 25.

14.

Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity.

Strachan RT, Sciaky N, Cronan MR, Kroeze WK, Roth BL.

Mol Pharmacol. 2010 Mar;77(3):327-38. doi: 10.1124/mol.109.061440. Epub 2009 Nov 20.

15.

Screening the receptorome.

Kroeze WK, Roth BL.

J Psychopharmacol. 2006 Jul;20(4 Suppl):41-6. Review.

PMID:
16785269
16.

Screening the receptorome yields validated molecular targets for drug discovery.

Roth BL, Kroeze WK.

Curr Pharm Des. 2006;12(14):1785-95. Review.

PMID:
16712488
17.

p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.

Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4717-22. Epub 2006 Mar 10.

18.

The human polyomavirus, JCV, uses serotonin receptors to infect cells.

Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K, Dugan A, Stanifer M, Bhatnagar A, Kroeze WK, Roth BL, Atwood WJ.

Science. 2004 Nov 19;306(5700):1380-3.

19.

Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors.

Bhatnagar A, Sheffler DJ, Kroeze WK, Compton-Toth B, Roth BL.

J Biol Chem. 2004 Aug 13;279(33):34614-23. Epub 2004 Jun 9.

20.

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia.

Roth BL, Sheffler DJ, Kroeze WK.

Nat Rev Drug Discov. 2004 Apr;3(4):353-9. Review. No abstract available.

PMID:
15060530
21.

G-protein-coupled receptors at a glance.

Kroeze WK, Sheffler DJ, Roth BL.

J Cell Sci. 2003 Dec 15;116(Pt 24):4867-9. Review. No abstract available.

22.

H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL.

Neuropsychopharmacology. 2003 Mar;28(3):519-26.

23.

Similar ultrastructural distribution of the 5-HT(2A) serotonin receptor and microtubule-associated protein MAP1A in cortical dendrites of adult rat.

Cornea-Hébert V, Watkins KC, Roth BL, Kroeze WK, Gaudreau P, Leclerc N, Descarries L.

Neuroscience. 2002;113(1):23-35.

PMID:
12123681
24.

Molecular biology of serotonin receptors structure and function at the molecular level.

Kroeze WK, Kristiansen K, Roth BL.

Curr Top Med Chem. 2002 Jun;2(6):507-28. Review.

PMID:
12052191
25.

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

Shapiro DA, Kristiansen K, Weiner DM, Kroeze WK, Roth BL.

J Biol Chem. 2002 Mar 29;277(13):11441-9. Epub 2002 Jan 18. Erratum in: J Biol Chem 2002 May 17;277(20):18244.

28.

Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation.

Roth BL, Berry SA, Kroeze WK, Willins DL, Kristiansen K.

Crit Rev Neurobiol. 1998;12(4):319-38. Review.

PMID:
10348614
29.

Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: the third intracellular loop is alpha-helical and binds purified arrestins.

Gelber EI, Kroeze WK, Willins DL, Gray JA, Sinar CA, Hyde EG, Gurevich V, Benovic J, Roth BL.

J Neurochem. 1999 May;72(5):2206-14.

30.

The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis.

Kroeze WK, Roth BL.

Biol Psychiatry. 1998 Dec 1;44(11):1128-42. Review.

PMID:
9836016
31.

5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function.

Roth BL, Willins DL, Kristiansen K, Kroeze WK.

Pharmacol Ther. 1998 Sep;79(3):231-57. Review.

PMID:
9776378
32.

G protein-coupled receptor (GPCR) trafficking in the central nervous system: relevance for drugs of abuse.

Roth BL, Willins DL, Kroeze WK.

Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):73-85. Review. No abstract available.

PMID:
9716931
33.

Brugia malayi: acquired resistance to microfilariae in BALB/c mice correlates with local Th2 responses.

Pearlman E, Kroeze WK, Hazlett FE Jr, Chen SS, Mawhorter SD, Boom WH, Kazura JW.

Exp Parasitol. 1993 Mar;76(2):200-8.

PMID:
8454029
34.
35.

Echinococcus multilocularis: susceptibility and responses to infection in inbred mice.

Kroeze WK, Tanner CE.

Int J Parasitol. 1987 Apr;17(4):873-83. No abstract available.

PMID:
3583535
36.

Echinococcus multilocularis: responses to infection in Mongolian gerbils.

Kroeze WK, Tanner CE.

Exp Parasitol. 1986 Feb;61(1):1-9.

PMID:
3943584
37.

Echinococcus multilocularis: responses to infection in cotton rats (Sigmodon hispidus).

Kroeze WK, Tanner CE.

Int J Parasitol. 1985 Jun;15(3):233-8. No abstract available.

PMID:
3897083
38.

Taenia crassiceps: fate of cysticerci following ingestion by the mouse.

Kroeze WK, Freeman RS.

Exp Parasitol. 1982 Dec;54(3):425-31. No abstract available.

PMID:
7151949

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