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Items: 1 to 50 of 100

1.

Rat Cytomegalovirus-encoded γ-chemokine vXCL1 is a highly adapted, species-specific agonist for rat XCR1+ dendritic cells.

Bauer A, Madela J, Berg C, Daugvilaite V, Gurka S, Mages HW, Kroczek RA, Rosenkilde MM, Voigt S.

J Cell Sci. 2019 Oct 24. pii: jcs.236190. doi: 10.1242/jcs.236190. [Epub ahead of print]

PMID:
31649144
2.

Structure-Function Relationship of XCL1 Used for in vivo Targeting of Antigen Into XCR1+ Dendritic Cells.

Kroczek AL, Hartung E, Gurka S, Becker M, Reeg N, Mages HW, Voigt S, Freund C, Kroczek RA.

Front Immunol. 2018 Dec 13;9:2806. doi: 10.3389/fimmu.2018.02806. eCollection 2018.

3.

ICOS Costimulation Differentially Affects T Cells in Secondary Lymphoid Organs and Inflamed Tissues.

Van DV, Bauer L, Kroczek RA, Hutloff A.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):437-447. doi: 10.1165/rcmb.2017-0309OC.

PMID:
29676593
4.

CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.

Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W.

Immunity. 2017 Feb 21;46(2):205-219. doi: 10.1016/j.immuni.2017.01.003. Epub 2017 Feb 9.

5.

Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells.

Vu Van D, Beier KC, Pietzke LJ, Al Baz MS, Feist RK, Gurka S, Hamelmann E, Kroczek RA, Hutloff A.

Nat Commun. 2016 Feb 26;7:10875. doi: 10.1038/ncomms10875.

6.

Expression analysis of surface molecules on human thymic dendritic cells with the 10th HLDA Workshop antibody panel.

Gurka S, Dirks S, Photiadis J, Kroczek RA.

Clin Transl Immunology. 2015 Oct 30;4(10):e47. doi: 10.1038/cti.2015.21. eCollection 2015 Oct.

7.

Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103- and XCR1+CD103+ dendritic cells.

Wylie B, Seppanen E, Xiao K, Zemek R, Zanker D, Prato S, Foley B, Hart PH, Kroczek RA, Chen W, Waithman J.

Oncoimmunology. 2015 Apr 2;4(8):e1019198. eCollection 2015 Aug.

8.

Mouse Conventional Dendritic Cells Can be Universally Classified Based on the Mutually Exclusive Expression of XCR1 and SIRPα.

Gurka S, Hartung E, Becker M, Kroczek RA.

Front Immunol. 2015 Feb 4;6:35. doi: 10.3389/fimmu.2015.00035. eCollection 2015. Review.

9.

ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2.

Weber JP, Fuhrmann F, Feist RK, Lahmann A, Al Baz MS, Gentz LJ, Vu Van D, Mages HW, Haftmann C, Riedel R, Grün JR, Schuh W, Kroczek RA, Radbruch A, Mashreghi MF, Hutloff A.

J Exp Med. 2015 Feb 9;212(2):217-33. doi: 10.1084/jem.20141432. Epub 2015 Feb 2.

10.

Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1.

Hartung E, Becker M, Bachem A, Reeg N, Jäkel A, Hutloff A, Weber H, Weise C, Giesecke C, Henn V, Gurka S, Anastassiadis K, Mages HW, Kroczek RA.

J Immunol. 2015 Feb 1;194(3):1069-79. doi: 10.4049/jimmunol.1401903. Epub 2014 Dec 17.

11.

Ontogenic, Phenotypic, and Functional Characterization of XCR1(+) Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPα.

Becker M, Güttler S, Bachem A, Hartung E, Mora A, Jäkel A, Hutloff A, Henn V, Mages HW, Gurka S, Kroczek RA.

Front Immunol. 2014 Jul 28;5:326. doi: 10.3389/fimmu.2014.00326. eCollection 2014.

12.

Antigen export during liver infection of the malaria parasite augments protective immunity.

Montagna GN, Beigier-Bompadre M, Becker M, Kroczek RA, Kaufmann SH, Matuschewski K.

MBio. 2014 Jul 29;5(4):e01321-14. doi: 10.1128/mBio.01321-14.

13.

Lymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells.

Cerovic V, Houston SA, Westlund J, Utriainen L, Davison ES, Scott CL, Bain CC, Joeris T, Agace WW, Kroczek RA, Mowat AM, Yrlid U, Milling SW.

Mucosal Immunol. 2015 Jan;8(1):38-48. doi: 10.1038/mi.2014.40. Epub 2014 May 21.

14.

T cell costimulation molecules CD80/86 inhibit osteoclast differentiation by inducing the IDO/tryptophan pathway.

Bozec A, Zaiss MM, Kagwiria R, Voll R, Rauh M, Chen Z, Mueller-Schmucker S, Kroczek RA, Heinzerling L, Moser M, Mellor AL, David JP, Schett G.

Sci Transl Med. 2014 May 7;6(235):235ra60. doi: 10.1126/scitranslmed.3007764.

15.

Cytomegalovirus expresses the chemokine homologue vXCL1 capable of attracting XCR1+ CD4- dendritic cells.

Geyer H, Hartung E, Mages HW, Weise C, Belužić R, Vugrek O, Jonjic S, Kroczek RA, Voigt S.

J Virol. 2014 Jan;88(1):292-302. doi: 10.1128/JVI.02330-13. Epub 2013 Oct 23.

16.

Systemic minor histocompatibility antigen expression in blood endothelial cells prevents T cell-mediated vascular immunopathology.

Caviezel-Firner S, Engeler D, Bolinger B, Onder L, Scandella E, Yu M, Kroczek RA, Ludewig B.

Eur J Immunol. 2013 Dec;43(12):3233-43. doi: 10.1002/eji.201343545. Epub 2013 Sep 6.

17.

Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens.

Gottschalk C, Damuzzo V, Gotot J, Kroczek RA, Yagita H, Murphy KM, Knolle PA, Ludwig-Portugall I, Kurts C.

J Am Soc Nephrol. 2013 Mar;24(4):543-9. doi: 10.1681/ASN.2012101022. Epub 2013 Feb 14.

18.

Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation.

Bachem A, Hartung E, Güttler S, Mora A, Zhou X, Hegemann A, Plantinga M, Mazzini E, Stoitzner P, Gurka S, Henn V, Mages HW, Kroczek RA.

Front Immunol. 2012 Jul 18;3:214. doi: 10.3389/fimmu.2012.00214. eCollection 2012.

19.

Comprehensive analysis of CD4+ T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS.

Lischke T, Hegemann A, Gurka S, Vu Van D, Burmeister Y, Lam KP, Kershaw O, Mollenkopf HJ, Mages HW, Hutloff A, Kroczek RA.

J Immunol. 2012 Jul 1;189(1):234-44. doi: 10.4049/jimmunol.1102034. Epub 2012 Jun 1.

20.

The Role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation by Murine and Human Dendritic Cells.

Kroczek RA, Henn V.

Front Immunol. 2012 Feb 10;3:14. doi: 10.3389/fimmu.2012.00014. eCollection 2012.

21.

Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation.

Bollig N, Brüstle A, Kellner K, Ackermann W, Abass E, Raifer H, Camara B, Brendel C, Giel G, Bothur E, Huber M, Paul C, Elli A, Kroczek RA, Nurieva R, Dong C, Jacob R, Mak TW, Lohoff M.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8664-9. doi: 10.1073/pnas.1205834109. Epub 2012 May 2.

22.

Highly controlled electrofusion of individually selected cells in dielectrophoretic field cages.

Kirschbaum M, Guernth-Marschner CR, Cherré S, de Pablo Peña A, Jaeger MS, Kroczek RA, Schnelle T, Mueller T, Duschl C.

Lab Chip. 2012 Feb 7;12(3):443-50. doi: 10.1039/c1lc20818g. Epub 2011 Nov 29.

PMID:
22124613
23.

Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis.

Frey O, Meisel J, Hutloff A, Bonhagen K, Bruns L, Kroczek RA, Morawietz L, Kamradt T.

Ann Rheum Dis. 2010 Aug;69(8):1495-501. doi: 10.1136/ard.2009.119164. Epub 2010 May 24.

PMID:
20498202
24.

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells.

Bachem A, Güttler S, Hartung E, Ebstein F, Schaefer M, Tannert A, Salama A, Movassaghi K, Opitz C, Mages HW, Henn V, Kloetzel PM, Gurka S, Kroczek RA.

J Exp Med. 2010 Jun 7;207(6):1273-81. doi: 10.1084/jem.20100348. Epub 2010 May 17.

25.

Dendritic cells support homeostatic expansion of Foxp3+ regulatory T cells in Foxp3.LuciDTR mice.

Suffner J, Hochweller K, Kühnle MC, Li X, Kroczek RA, Garbi N, Hämmerling GJ.

J Immunol. 2010 Feb 15;184(4):1810-20. doi: 10.4049/jimmunol.0902420. Epub 2010 Jan 18.

26.

Generation of novel anti-BTLA monoclonal antibodies for in vivo use and their functional testing at near-physiological conditions.

Gurka S, Worbs S, Kroczek RA.

Hybridoma (Larchmt). 2009 Dec;28(6):405-14. doi: 10.1089/hyb.2009.0047.

PMID:
20025499
27.

Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells.

Dorner BG, Dorner MB, Zhou X, Opitz C, Mora A, Güttler S, Hutloff A, Mages HW, Ranke K, Schaefer M, Jack RS, Henn V, Kroczek RA.

Immunity. 2009 Nov 20;31(5):823-33. doi: 10.1016/j.immuni.2009.08.027. Epub 2009 Nov 12.

28.

The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells.

Tuettenberg A, Huter E, Hubo M, Horn J, Knop J, Grimbacher B, Kroczek RA, Stoll S, Jonuleit H.

J Immunol. 2009 Mar 15;182(6):3349-56. doi: 10.4049/jimmunol.0802733.

29.

ICOS controls the pool size of effector-memory and regulatory T cells.

Burmeister Y, Lischke T, Dahler AC, Mages HW, Lam KP, Coyle AJ, Kroczek RA, Hutloff A.

J Immunol. 2008 Jan 15;180(2):774-82. Erratum in: J Immunol. 2008 Mar 1;180(5):3613.

30.

CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production.

Caccamo N, Battistini L, Bonneville M, Poccia F, Fournié JJ, Meraviglia S, Borsellino G, Kroczek RA, La Mendola C, Scotet E, Dieli F, Salerno A.

J Immunol. 2006 Oct 15;177(8):5290-5.

31.

Eminent role of ICOS costimulation for T cells interacting with plasmacytoid dendritic cells.

Janke M, Witsch EJ, Mages HW, Hutloff A, Kroczek RA.

Immunology. 2006 Jul;118(3):353-60.

32.

House dust mite-specific T cells in healthy non-atopic children.

Bullens DM, De Swerdt A, Dilissen E, Kasran A, Kroczek RA, Cadot P, Casaer P, Ceuppens JL.

Clin Exp Allergy. 2005 Dec;35(12):1535-41.

PMID:
16393318
33.

Co-stimulatory molecules as potential targets for therapeutic intervention in allergic airway disease.

Kallinich T, Beier KC, Gelfand EW, Kroczek RA, Hamelmann E.

Clin Exp Allergy. 2005 Dec;35(12):1521-34. Review.

PMID:
16393317
34.

Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1.

de Haij S, Woltman AM, Trouw LA, Bakker AC, Kamerling SW, van der Kooij SW, Chen L, Kroczek RA, Daha MR, van Kooten C.

Kidney Int. 2005 Nov;68(5):2091-102.

35.

Chemokine-receptor expression on T cells in lung compartments of challenged asthmatic patients.

Kallinich T, Schmidt S, Hamelmann E, Fischer A, Qin S, Luttmann W, Virchow JC, Kroczek RA.

Clin Exp Allergy. 2005 Jan;35(1):26-33.

PMID:
15649262
36.

Inducible costimulator-positive T cells are required for allergen-induced local B-cell infiltration and antigen-specific IgE production in lung tissue.

Beier KC, Hutloff A, Löhning M, Kallinich T, Kroczek RA, Hamelmann E.

J Allergy Clin Immunol. 2004 Oct;114(4):775-82.

PMID:
15480315
37.

Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus.

Hutloff A, Büchner K, Reiter K, Baelde HJ, Odendahl M, Jacobi A, Dörner T, Kroczek RA.

Arthritis Rheum. 2004 Oct;50(10):3211-20.

38.

Emerging paradigms of T-cell co-stimulation.

Kroczek RA, Mages HW, Hutloff A.

Curr Opin Immunol. 2004 Jun;16(3):321-7. Review.

PMID:
15134781
39.

Human T cell activation by costimulatory signal-deficient allogeneic cells induces inducible costimulator-expressing anergic T cells with regulatory cell activity.

Vermeiren J, Ceuppens JL, Van Ghelue M, Witters P, Bullens D, Mages HW, Kroczek RA, Van Gool SW.

J Immunol. 2004 May 1;172(9):5371-8.

40.

Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease.

Sato T, Kanai T, Watanabe M, Sakuraba A, Okamoto S, Nakai T, Okazawa A, Inoue N, Totsuka T, Yamazaki M, Kroczek RA, Fukushima T, Ishii H, Hibi T.

Gastroenterology. 2004 Mar;126(3):829-39.

PMID:
14988837
41.

Coordinate expression of cytokines and chemokines by NK cells during murine cytomegalovirus infection.

Dorner BG, Smith HR, French AR, Kim S, Poursine-Laurent J, Beckman DL, Pingel JT, Kroczek RA, Yokoyama WM.

J Immunol. 2004 Mar 1;172(5):3119-31.

42.

Chemokine receptor expression on neoplastic and reactive T cells in the skin at different stages of mycosis fungoides.

Kallinich T, Muche JM, Qin S, Sterry W, Audring H, Kroczek RA.

J Invest Dermatol. 2003 Nov;121(5):1045-52.

43.

CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40-CD40L signalling in atherosclerosis.

Büchner K, Henn V, Gräfe M, de Boer OJ, Becker AE, Kroczek RA.

J Pathol. 2003 Oct;201(2):288-95.

PMID:
14517846
44.

Expression of activation-induced, T cell-derived, and chemokine-related cytokine/lymphotactin and its functional role in rheumatoid arthritis.

Blaschke S, Middel P, Dorner BG, Blaschke V, Hummel KM, Kroczek RA, Reich K, Benoehr P, Koziolek M, Müller GA.

Arthritis Rheum. 2003 Jul;48(7):1858-72.

45.

ICOS+ Th cells produce distinct cytokines in different mucosal immune responses.

Bonhagen K, Liesenfeld O, Stadecker MJ, Hutloff A, Erb K, Coyle AJ, Lipp M, Kroczek RA, Kamradt T.

Eur J Immunol. 2003 Feb;33(2):392-401.

46.

Single-cell analysis of the murine chemokines MIP-1alpha, MIP-1beta, RANTES and ATAC/lymphotactin by flow cytometry.

Dorner BG, Steinbach S, Hüser MB, Kroczek RA, Scheffold A.

J Immunol Methods. 2003 Mar 1;274(1-2):83-91.

PMID:
12609535
47.

Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency.

Grimbacher B, Hutloff A, Schlesier M, Glocker E, Warnatz K, Dräger R, Eibel H, Fischer B, Schäffer AA, Mages HW, Kroczek RA, Peter HH.

Nat Immunol. 2003 Mar;4(3):261-8. Epub 2003 Feb 10.

PMID:
12577056
48.

Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10.

Löhning M, Hutloff A, Kallinich T, Mages HW, Bonhagen K, Radbruch A, Hamelmann E, Kroczek RA.

J Exp Med. 2003 Jan 20;197(2):181-93.

49.

ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells.

Witsch EJ, Peiser M, Hutloff A, Büchner K, Dorner BG, Jonuleit H, Mages HW, Kroczek RA.

Eur J Immunol. 2002 Sep;32(9):2680-6.

50.

ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells.

Khayyamian S, Hutloff A, Büchner K, Gräfe M, Henn V, Kroczek RA, Mages HW.

Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6198-203.

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