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Items: 39


Strategies targeting cellular senescence.

Ovadya Y, Krizhanovsky V.

J Clin Invest. 2018 Apr 2;128(4):1247-1254. doi: 10.1172/JCI95149. Epub 2018 Apr 2.


p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence.

Sagiv A, Bar-Shai A, Levi N, Hatzav M, Zada L, Ovadya Y, Roitman L, Manella G, Regev O, Majewska J, Vadai E, Eilam R, Feigelson SW, Tsoory M, Tauc M, Alon R, Krizhanovsky V.

Cell Rep. 2018 Mar 27;22(13):3468-3479. doi: 10.1016/j.celrep.2018.03.009.


An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors.

Mancini M, Gal H, Gaborit N, Mazzeo L, Romaniello D, Salame TM, Lindzen M, Mahlknecht G, Enuka Y, Burton DG, Roth L, Noronha A, Marrocco I, Adreka D, Altstadter RE, Bousquet E, Downward J, Maraver A, Krizhanovsky V, Yarden Y.

EMBO Mol Med. 2018 Feb;10(2):294-308. doi: 10.15252/emmm.201708076.


Senescence and Telomere Homeostasis Might Be Involved in Placenta Percreta-Preliminary Investigation.

Tzadikevitch Geffen K, Gal H, Vainer I, Markovitch O, Amiel A, Krizhanovsky V, Biron-Shental T.

Reprod Sci. 2018 Aug;25(8):1254-1260. doi: 10.1177/1933719117737852. Epub 2017 Nov 6.


The anti-aging promise of p21.

Papismadov N, Gal H, Krizhanovsky V.

Cell Cycle. 2017;16(21):1997-1998. doi: 10.1080/15384101.2017.1377500. Epub 2017 Sep 29. No abstract available.


p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.

Yosef R, Pilpel N, Papismadov N, Gal H, Ovadya Y, Vadai E, Miller S, Porat Z, Ben-Dor S, Krizhanovsky V.

EMBO J. 2017 Aug 1;36(15):2280-2295. doi: 10.15252/embj.201695553. Epub 2017 Jun 12.


Quantitative identification of senescent cells in aging and disease.

Biran A, Zada L, Abou Karam P, Vadai E, Roitman L, Ovadya Y, Porat Z, Krizhanovsky V.

Aging Cell. 2017 Aug;16(4):661-671. doi: 10.1111/acel.12592. Epub 2017 Apr 28.


Senescent cell death brings hopes to life.

Ovadya Y, Krizhanovsky V.

Cell Cycle. 2017 Jan 2;16(1):9-10. doi: 10.1080/15384101.2016.1232088. Epub 2016 Sep 16. No abstract available.


mTOR signaling orchestrates the expression of cytoprotective factors during cellular senescence.

Yosef R, Krizhanovsky V.

Oncotarget. 2016 Aug 2;7(31):48859. doi: 10.18632/oncotarget.10743. No abstract available.


Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL.

Yosef R, Pilpel N, Tokarsky-Amiel R, Biran A, Ovadya Y, Cohen S, Vadai E, Dassa L, Shahar E, Condiotti R, Ben-Porath I, Krizhanovsky V.

Nat Commun. 2016 Apr 6;7:11190. doi: 10.1038/ncomms11190.


NKG2D ligands mediate immunosurveillance of senescent cells.

Sagiv A, Burton DG, Moshayev Z, Vadai E, Wensveen F, Ben-Dor S, Golani O, Polic B, Krizhanovsky V.

Aging (Albany NY). 2016 Feb;8(2):328-44.


Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy.

Golomb L, Sagiv A, Pateras IS, Maly A, Krizhanovsky V, Gorgoulis VG, Oren M, Ben-Yehuda A.

Cell Death Differ. 2015 Nov;22(11):1764-74. doi: 10.1038/cdd.2015.21. Epub 2015 Mar 20.


A new Twist in kidney fibrosis.

Ovadya Y, Krizhanovsky V.

Nat Med. 2015 Sep;21(9):975-7. doi: 10.1038/nm.3938. No abstract available.


Senescent cells talk frankly with their neighbors.

Biran A, Krizhanovsky V.

Cell Cycle. 2015;14(14):2181-2. doi: 10.1080/15384101.2015.1056608. Epub 2015 Jun 1. No abstract available.


Senescent cells communicate via intercellular protein transfer.

Biran A, Perelmutter M, Gal H, Burton DG, Ovadya Y, Vadai E, Geiger T, Krizhanovsky V.

Genes Dev. 2015 Apr 15;29(8):791-802. doi: 10.1101/gad.259341.115. Epub 2015 Apr 8.


Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer.

George B, Horn D, Bayo P, Zaoui K, Flechtenmacher C, Grabe N, Plinkert P, Krizhanovsky V, Hess J.

Cancer Lett. 2015 Mar 28;358(2):191-199. doi: 10.1016/j.canlet.2014.12.042. Epub 2014 Dec 24.


Senescent cells: SASPected drivers of age-related pathologies.

Ovadya Y, Krizhanovsky V.

Biogerontology. 2014 Dec;15(6):627-42. doi: 10.1007/s10522-014-9529-9. Epub 2014 Sep 13. Review.


Physiological and pathological consequences of cellular senescence.

Burton DG, Krizhanovsky V.

Cell Mol Life Sci. 2014 Nov;71(22):4373-86. doi: 10.1007/s00018-014-1691-3. Epub 2014 Jul 31. Review.


Cell fusion induced senescence.

Gal H, Krizhanovsky V.

Aging (Albany NY). 2014 May;6(5):353-4. No abstract available.


Natural killer cell-dependent anti-fibrotic pathway in liver injury via Toll-like receptor-9.

Abu-Tair L, Axelrod JH, Doron S, Ovadya Y, Krizhanovsky V, Galun E, Amer J, Safadi R.

PLoS One. 2013 Dec 10;8(12):e82571. doi: 10.1371/journal.pone.0082571. eCollection 2013.


Senescence is a developmental mechanism that contributes to embryonic growth and patterning.

Storer M, Mas A, Robert-Moreno A, Pecoraro M, Ortells MC, Di Giacomo V, Yosef R, Pilpel N, Krizhanovsky V, Sharpe J, Keyes WM.

Cell. 2013 Nov 21;155(5):1119-30. doi: 10.1016/j.cell.2013.10.041. Epub 2013 Nov 14.


Cell fusion induced by ERVWE1 or measles virus causes cellular senescence.

Chuprin A, Gal H, Biron-Shental T, Biran A, Amiel A, Rozenblatt S, Krizhanovsky V.

Genes Dev. 2013 Nov 1;27(21):2356-66. doi: 10.1101/gad.227512.113.


Immunosurveillance of senescent cells: the bright side of the senescence program.

Sagiv A, Krizhanovsky V.

Biogerontology. 2013 Dec;14(6):617-28. doi: 10.1007/s10522-013-9473-0. Epub 2013 Oct 10. Review.


Non-cell-autonomous tumor suppression by p53.

Lujambio A, Akkari L, Simon J, Grace D, Tschaharganeh DF, Bolden JE, Zhao Z, Thapar V, Joyce JA, Krizhanovsky V, Lowe SW.

Cell. 2013 Apr 11;153(2):449-60. doi: 10.1016/j.cell.2013.03.020. Epub 2013 Apr 4.


Granule exocytosis mediates immune surveillance of senescent cells.

Sagiv A, Biran A, Yon M, Simon J, Lowe SW, Krizhanovsky V.

Oncogene. 2013 Apr 11;32(15):1971-7. doi: 10.1038/onc.2012.206. Epub 2012 Jul 2.


Stem cells: The promises and perils of p53.

Krizhanovsky V, Lowe SW.

Nature. 2009 Aug 27;460(7259):1085-6. doi: 10.1038/4601085a. No abstract available.


Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology.

Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe SW.

Cold Spring Harb Symp Quant Biol. 2008;73:513-22. doi: 10.1101/sqb.2008.73.048. Epub 2009 Jan 15. Review.


Senescence of activated stellate cells limits liver fibrosis.

Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW.

Cell. 2008 Aug 22;134(4):657-67. doi: 10.1016/j.cell.2008.06.049.


Tissue-specific and reversible RNA interference in transgenic mice.

Dickins RA, McJunkin K, Hernando E, Premsrirut PK, Krizhanovsky V, Burgess DJ, Kim SY, Cordon-Cardo C, Zender L, Hannon GJ, Lowe SW.

Nat Genet. 2007 Jul;39(7):914-21. Epub 2007 Jun 17.


Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas.

Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW.

Nature. 2007 Feb 8;445(7128):656-60. Epub 2007 Jan 24. Erratum in: Nature. 2011 May 26;473(7348):544.


A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation.

Narita M, Narita M, Krizhanovsky V, Nuñez S, Chicas A, Hearn SA, Myers MP, Lowe SW.

Cell. 2006 Aug 11;126(3):503-14.


Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites.

Krizhanovsky V, Soreq L, Kliminski V, Ben-Arie N.

J Mol Neurosci. 2006;28(2):211-29.


Genotype identification of Math1/LacZ knockout mice based on real-time PCR with SYBR Green I dye.

Krizhanovsky V, Golenser E, Ben-Arie N.

J Neurosci Methods. 2004 Jul 30;136(2):187-92.


Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1.

Canzoniere D, Farioli-Vecchioli S, Conti F, Ciotti MT, Tata AM, Augusti-Tocco G, Mattei E, Lakshmana MK, Krizhanovsky V, Reeves SA, Giovannoni R, Castano F, Servadio A, Ben-Arie N, Tirone F.

J Neurosci. 2004 Mar 31;24(13):3355-69.


Sucrose-stimulated subsecond transient increase in cGMP level in rat intact circumvallate taste bud cells.

Krizhanovsky V, Agamy O, Naim M.

Am J Physiol Cell Physiol. 2000 Jul;279(1):C120-5.


Rapid entry of bitter and sweet tastants into liposomes and taste cells: implications for signal transduction.

Peri I, Mamrud-Brains H, Rodin S, Krizhanovsky V, Shai Y, Nir S, Naim M.

Am J Physiol Cell Physiol. 2000 Jan;278(1):C17-25.


A novel putative neuropeptide receptor expressed in neural tissue, including sensory epithelia.

Tal M, Ammar DA, Karpuj M, Krizhanovsky V, Naim M, Thompson DA.

Biochem Biophys Res Commun. 1995 Apr 17;209(2):752-9.


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