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Items: 1 to 50 of 53

1.

Increasing cellular lifespan with a flow system in organotypic culture of the Laterodorsal Tegmentum (LDT).

Romero-Leguizamón CR, Elnagar MR, Kristiansen U, Kohlmeier KA.

Sci Rep. 2019 Feb 6;9(1):1486. doi: 10.1038/s41598-018-37606-3.

2.

The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/- mice.

von Schoubye NL, Frederiksen K, Kristiansen U, Petersen AV, Dalby NO, Grunnet M, Jensen HS, Jespersen T, Sohal VS, Perrier JF.

Neurosci Lett. 2018 Jan 1;662:29-35. doi: 10.1016/j.neulet.2017.10.004. Epub 2017 Oct 5.

PMID:
28987817
3.

Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ-subunit-containing GABAA receptors in dentate gyrus granule cells.

Simonsen C, Boddum K, von Schoubye NL, Kloppenburg A, Sønderskov K, Hansen SL, Kristiansen U.

Pharmacol Res Perspect. 2017 Aug;5(4). doi: 10.1002/prp2.322.

4.

Astrocytic GABA transporter activity modulates excitatory neurotransmission.

Boddum K, Jensen TP, Magloire V, Kristiansen U, Rusakov DA, Pavlov I, Walker MC.

Nat Commun. 2016 Nov 25;7:13572. doi: 10.1038/ncomms13572.

5.

Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 receptors.

Gasiorek A, Trattnig SM, Ahring PK, Kristiansen U, Frølund B, Frederiksen K, Jensen AA.

Biochem Pharmacol. 2016 Jun 15;110-111:92-108. doi: 10.1016/j.bcp.2016.04.004. Epub 2016 Apr 13.

PMID:
27086281
6.

GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology.

Krall J, Balle T, Krogsgaard-Larsen N, Sørensen TE, Krogsgaard-Larsen P, Kristiansen U, Frølund B.

Adv Pharmacol. 2015;72:201-27. doi: 10.1016/bs.apha.2014.10.003. Epub 2014 Dec 4. Review.

PMID:
25600372
7.

The GABAA antagonist DPP-4-PIOL selectively antagonises tonic over phasic GABAergic currents in dentate gyrus granule cells.

Boddum K, Frølund B, Kristiansen U.

Neurochem Res. 2014 Nov;39(11):2078-84. doi: 10.1007/s11064-014-1397-9. Epub 2014 Aug 8.

PMID:
25103229
8.

Hippocampal P3-like auditory event-related potentials are disrupted in a rat model of cholinergic degeneration in Alzheimer's disease: reversal by donepezil treatment.

Laursen B, Mørk A, Kristiansen U, Bastlund JF.

J Alzheimers Dis. 2014;42(4):1179-89. doi: 10.3233/JAD-131502.

PMID:
25024305
9.

Impaired hippocampal acetylcholine release parallels spatial memory deficits in Tg2576 mice subjected to basal forebrain cholinergic degeneration.

Laursen B, Mørk A, Plath N, Kristiansen U, Bastlund JF.

Brain Res. 2014 Jan 16;1543:253-62. doi: 10.1016/j.brainres.2013.10.055. Epub 2013 Nov 11.

PMID:
24231553
10.

Leukocyte infiltration in experimental stroke.

Grønberg NV, Johansen FF, Kristiansen U, Hasseldam H.

J Neuroinflammation. 2013 Sep 18;10:115. doi: 10.1186/1742-2094-10-115. Review.

11.

The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors.

Hoestgaard-Jensen K, O'Connor RM, Dalby NO, Simonsen C, Finger BC, Golubeva A, Hammer H, Bergmann ML, Kristiansen U, Krogsgaard-Larsen P, Bräuner-Osborne H, Ebert B, Frølund B, Cryan JF, Jensen AA.

Br J Pharmacol. 2013 Oct;170(4):919-32. doi: 10.1111/bph.12340.

12.

Repeated potentiation of the metabotropic glutamate receptor 5 and the alpha 7 nicotinic acetylcholine receptor modulates behavioural and GABAergic deficits induced by early postnatal phencyclidine (PCP) treatment.

Kjaerby C, Bundgaard C, Fejgin K, Kristiansen U, Dalby NO.

Neuropharmacology. 2013 Sep;72:157-68. doi: 10.1016/j.neuropharm.2013.04.041. Epub 2013 May 2.

PMID:
23643744
13.

Impaired GABAergic inhibition in the prefrontal cortex of early postnatal phencyclidine (PCP)-treated rats.

Kjaerby C, Broberg BV, Kristiansen U, Dalby NO.

Cereb Cortex. 2014 Sep;24(9):2522-32. doi: 10.1093/cercor/bht109. Epub 2013 Apr 23.

PMID:
23613110
14.

Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists.

Petersen JG, Bergmann R, Møller HA, Jørgensen CG, Nielsen B, Kehler J, Frydenvang K, Kristensen J, Balle T, Jensen AA, Kristiansen U, Frølund B.

J Med Chem. 2013 Feb 14;56(3):993-1006. doi: 10.1021/jm301473k. Epub 2013 Jan 23.

PMID:
23294161
15.

Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice.

Laursen B, Mørk A, Plath N, Kristiansen U, Bastlund JF.

Behav Brain Res. 2013 Mar 1;240:146-52. doi: 10.1016/j.bbr.2012.11.012. Epub 2012 Nov 22.

PMID:
23178660
16.

Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan.

Jeppesen AS, Kristiansen U, Soelberg J, Jäger AK.

J Ethnopharmacol. 2012 Jun 14;141(3):1077-9.

PMID:
22783554
17.

Pharmacological evidence of functional inhibitory metabotrophic glutamate receptors on mouse arousal-related cholinergic laterodorsal tegmental neurons.

Kohlmeier KA, Christensen MH, Kristensen MP, Kristiansen U.

Neuropharmacology. 2013 Mar;66:99-113. doi: 10.1016/j.neuropharm.2012.02.016. Epub 2012 Feb 21.

PMID:
22381584
18.

Does brain slices from pentylenetetrazole-kindled mice provide a more predictive screening model for antiepileptic drugs?

Hansen SL, Sterjev Z, Werngreen M, Simonsen BJ, Knudsen KE, Nielsen AH, Pedersen ME, Badolo L, Kristiansen U, Vestergaard HT.

Eur J Pharmacol. 2012 May 5;682(1-3):43-9. doi: 10.1016/j.ejphar.2012.01.044. Epub 2012 Feb 15.

PMID:
22366211
19.

Experimental study of the influence of low frequency flow modulation on the whistling behavior of a corrugated pipe.

Kristiansen UR, Mattei PO, Pinhede C, Amielh M.

J Acoust Soc Am. 2011 Oct;130(4):1851-5. doi: 10.1121/1.3628665.

PMID:
21973339
20.

Acute but not delayed amphetamine treatment improves behavioral outcome in a rat embolic stroke model.

Rasmussen RS, Overgaard K, Kristiansen U, Johansen FF.

Neurol Res. 2011 Sep;33(7):774-82. doi: 10.1179/1743132811Y.0000000009.

PMID:
21756559
21.

Uterine contraction induced by Tanzanian plants used to induce abortion.

Nikolajsen T, Nielsen F, Rasch V, Sørensen PH, Ismail F, Kristiansen U, Jäger AK.

J Ethnopharmacol. 2011 Sep 1;137(1):921-5. doi: 10.1016/j.jep.2011.05.026. Epub 2011 May 27.

PMID:
21645605
22.

GABAergic actions on cholinergic laterodorsal tegmental neurons: implications for control of behavioral state.

Kohlmeier KA, Kristiansen U.

Neuroscience. 2010 Dec 15;171(3):812-29. doi: 10.1016/j.neuroscience.2010.09.034. Epub 2010 Sep 25.

PMID:
20884335
23.

Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus.

Hansen SL, Nielsen AH, Knudsen KE, Artmann A, Petersen G, Kristiansen U, Hansen SH, Hansen HS.

Neurochem Int. 2009 Mar-Apr;54(3-4):199-204. doi: 10.1016/j.neuint.2008.10.012. Epub 2008 Nov 30.

PMID:
19100800
24.

5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.

Madsen C, Jensen AA, Liljefors T, Kristiansen U, Nielsen B, Hansen CP, Larsen M, Ebert B, Bang-Andersen B, Krogsgaard-Larsen P, Frølund B.

J Med Chem. 2007 Aug 23;50(17):4147-61. Epub 2007 Jul 26.

PMID:
17655213
25.

Experiments on sound generation in corrugated pipes with flow.

Kristiansen UR, Wiik GA.

J Acoust Soc Am. 2007 Mar;121(3):1337-44.

PMID:
17407869
26.

Probing the pharmacophore of ginkgolides as glycine receptor antagonists.

Jensen AA, Begum N, Vogensen SB, Knapp KM, Gundertofte K, Dzyuba SV, Ishii H, Nakanishi K, Kristiansen U, Strømgaard K.

J Med Chem. 2007 Apr 5;50(7):1610-7. Epub 2007 Mar 13.

PMID:
17352465
27.

Differences in kinetics of structurally related competitive GABA(A) receptor antagonists.

Vestergaard HT, Cannillo C, Frølund B, Kristiansen U.

Neuropharmacology. 2007 Mar;52(3):873-82. Epub 2006 Nov 27.

PMID:
17125806
28.

Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds.

Lolli ML, Hansen SL, Rolando B, Nielsen B, Wellendorph P, Madsen K, Larsen OM, Kristiansen U, Fruttero R, Gasco A, Johansen TN.

J Med Chem. 2006 Jul 13;49(14):4442-6.

PMID:
16821803
29.

Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.

Frølund B, Jensen LS, Guandalini L, Canillo C, Vestergaard HT, Kristiansen U, Nielsen B, Stensbøl TB, Madsen C, Krogsgaard-Larsen P, Liljefors T.

J Med Chem. 2005 Jan 27;48(2):427-39.

PMID:
15658856
30.

Direct optical detection of singlet oxygen from a single cell.

Zebger I, Snyder JW, Andersen LK, Poulsen L, Gao Z, Lambert JD, Kristiansen U, Ogilby PR.

Photochem Photobiol. 2004 Apr;79(4):319-22.

PMID:
15137507
31.
32.

Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists.

Mortensen M, Kristiansen U, Ebert B, Frølund B, Krogsgaard-Larsen P, Smart TG.

J Physiol. 2004 Jun 1;557(Pt 2):389-413. Epub 2004 Feb 27.

33.

Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA A antagonists.

Frølund B, Tagmose L, Jørgensen AT, Kristiansen U, Stensbøl TB, Liljefors T, Krogsgaard-Larsen P.

Eur J Med Chem. 2003 Apr;38(4):447-9.

PMID:
12750034
35.

GABA(A) receptor ligands and their therapeutic potentials.

Frølund B, Ebert B, Kristiansen U, Liljefors T, Krogsgaard-Larsen P.

Curr Top Med Chem. 2002 Aug;2(8):817-32. Review.

PMID:
12171573
36.

Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.

Frølund B, Jørgensen AT, Tagmose L, Stensbøl TB, Vestergaard HT, Engblom C, Kristiansen U, Sanchez C, Krogsgaard-Larsen P, Liljefors T.

J Med Chem. 2002 Jun 6;45(12):2454-68.

PMID:
12036354
39.

GABAA receptor subunit interactions important for benzodiazepine and zinc modulation: a patch-clamp and single cell RT-PCR study.

Alsbo CW, Kristiansen U, Møller F, Hansen SL, Johansen FF.

Eur J Neurosci. 2001 May;13(9):1673-82.

PMID:
11359519
40.
41.

A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology.

Frølund B, Tagmose L, Liljefors T, Stensbøl TB, Engblom C, Kristiansen U, Krogsgaard-Larsen P.

J Med Chem. 2000 Dec 28;43(26):4930-3. No abstract available.

PMID:
11150163
43.

Functional properties of glycine receptors expressed in primary cultures of mouse cerebellar granule cells.

Elster L, Banke T, Kristiansen U, Schousboe A, Wahl P.

Neuroscience. 1998 May;84(2):519-28.

PMID:
9539222
44.
45.

Partial GABAA receptor agonists. Synthesis and in vitro pharmacology of a series of nonannulated analogs of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol.

Frølund B, Kristiansen U, Brehm L, Hansen AB, Krogsgaard-Larsen P, Falch E.

J Med Chem. 1995 Aug 18;38(17):3287-96.

PMID:
7650683
46.
47.

Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships.

Kristiansen U, Hedegaard A, Herdeis C, Lund TM, Nielsen B, Hansen JJ, Falch E, Hjeds H, Krogsgaard-Larsen P.

J Neurochem. 1992 Mar;58(3):1150-9.

PMID:
1310720
48.

Electrophysiological studies of the GABAA receptor ligand, 4-PIOL, on cultured hippocampal neurones.

Kristiansen U, Lambert JD, Falch E, Krogsgaard-Larsen P.

Br J Pharmacol. 1991 Sep;104(1):85-90.

49.

Ligand structural specificity of GABAA receptors in guinea pig ileum.

Kristiansen U, Fjalland B.

Pharmacol Toxicol. 1991 May;68(5):332-9.

PMID:
1658764
50.

The effects of n-butanol vapour on respiratory rate and tidal volume.

Kristiansen U, Vinggaard AM, Nielsen GD.

Arch Toxicol. 1988 Jan;61(3):229-36.

PMID:
3355368

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