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Classic bladder exstrophy and adenocarcinoma of the bladder: Methylome analysis provide no evidence for underlying disease-mechanisms of this association.

Sharma A, Fröhlich H, Zhang R, Ebert AK, Rösch W, Reis H, Kristiansen G, Ellinger J, Reutter H.

Cancer Genet. 2019 Jun;235-236:18-20. doi: 10.1016/j.cancergen.2019.05.004. Epub 2019 May 31.


Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging.

Tolkach Y, Goltz D, Kremer A, Ahmadzadehfar H, Bergheim D, Essler M, Lam M, de Keizer B, Fischer HP, Kristiansen G.

Oncotarget. 2019 Jun 25;10(41):4149-4160. doi: 10.18632/oncotarget.27024. eCollection 2019 Jun 25.


Systematic expression analysis of the mitochondrial respiratory chain protein subunits identifies COX5B as a prognostic marker in clear cell renal cell carcinoma.

Stein J, Tenbrock J, Kristiansen G, Müller SC, Ellinger J.

Int J Urol. 2019 Jul 7. doi: 10.1111/iju.14040. [Epub ahead of print]


Combination of CCl4with alcoholic and metabolic injuries mimics human liver fibrosis.

Brol MJ, Rösch F, Schierwagen R, Magdaleno F, Uschner FE, Manekeller S, Queck A, Schwarzkopf K, Odenthal M, Drebber U, Thiele M, Lingohr P, Plamper A, Kristiansen G, Lotersztajn S, Krag A, Klein S, Rheinwalt KP, Trebicka J.

Am J Physiol Gastrointest Liver Physiol. 2019 Jun 12. doi: 10.1152/ajpgi.00361.2018. [Epub ahead of print]


Co-staining of microRNAs and their target proteins by miRNA in situ hybridization and immunohistofluorescence on prostate cancer tissue microarrays.

Eckstein M, Sailer V, Nielsen BS, Wittenberg T, Wiesmann V, Lieb V, Nolte E, Hartmann A, Kristiansen G, Wernert N, Wullich B, Taubert H, Wach S; German Prostate Cancer Consortium (DPKK).

Lab Invest. 2019 Jun 11. doi: 10.1038/s41374-019-0251-8. [Epub ahead of print]


Where is the limit of prostate cancer biomarker research? Systematic investigation of potential prognostic and diagnostic biomarkers.

Kremer A, Kremer T, Kristiansen G, Tolkach Y.

BMC Urol. 2019 Jun 6;19(1):46. doi: 10.1186/s12894-019-0479-z.


Long Term Remission and Cardiac Toxicity of a Combination of Ipilimumab and Nivolumab in a Patient With Metastatic Head and Neck Carcinoma After Progression Following Nivolumab Monotherapy.

Schwab KS, Kristiansen G, Isaak A, Held SEA, Heine A, Brossart P.

Front Oncol. 2019 May 15;9:403. doi: 10.3389/fonc.2019.00403. eCollection 2019. No abstract available.


Dataset for the reporting of prostate carcinoma in radical prostatectomy specimens: updated recommendations from the International Collaboration on Cancer Reporting.

Kench JG, Judge M, Delahunt B, Humphrey PA, Kristiansen G, Oxley J, Rasiah K, Takahashi H, Trpkov K, Varma M, Wheeler TM, Zhou M, Srigley JR, Egevad L.

Virchows Arch. 2019 May 16. doi: 10.1007/s00428-019-02574-0. [Epub ahead of print] Review.


[The 16th DPKK annual conference "Urology meets Pathology"].

Taubert H, Becker C, Füssel S, Seitz G, Kristiansen G, Wach S, Wullich B.

Urologe A. 2019 Jun;58(6):686-689. doi: 10.1007/s00120-019-0941-2. German. No abstract available.


Rare Variants in BNC2 Are Implicated in Autosomal-Dominant Congenital Lower Urinary-Tract Obstruction.

Kolvenbach CM, Dworschak GC, Frese S, Japp AS, Schuster P, Wenzlitschke N, Yilmaz Ö, Lopes FM, Pryalukhin A, Schierbaum L, van der Zanden LFM, Kause F, Schneider R, Taranta-Janusz K, Szczepańska M, Pawlaczyk K, Newman WG, Beaman GM, Stuart HM, Cervellione RM, Feitz WFJ, van Rooij IALM, Schreuder MF, Steffens M, Weber S, Merz WM, Feldkötter M, Hoppe B, Thiele H, Altmüller J, Berg C, Kristiansen G, Ludwig M, Reutter H, Woolf AS, Hildebrandt F, Grote P, Zaniew M, Odermatt B, Hilger AC.

Am J Hum Genet. 2019 May 2;104(5):994-1006. doi: 10.1016/j.ajhg.2019.03.023.


[Molecular tumor board in uro-oncology-from a pathologist's view].

Gaisa NT, Kristiansen G, Perner S.

Urologe A. 2019 Jul;58(7):747-751. doi: 10.1007/s00120-019-0934-1. Review. German.


Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors.

Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W.

Pediatr Blood Cancer. 2019 Aug;66(8):e27777. doi: 10.1002/pbc.27777. Epub 2019 May 2.


Cribriform and glomeruloid acinar adenocarcinoma of the prostate-an intratumoural intraductal carcinoma?

Tolkach Y, Kristiansen G.

Histopathology. 2019 May;74(6):804-808. doi: 10.1111/his.13821. No abstract available.


N6-Methyladenosine detected in RNA of testicular germ cell tumors is controlled by METTL3, ALKBH5, YTHDC1/F1/F2, and HNRNPC as writers, erasers, and readers.

Nettersheim D, Berger D, Jostes S, Kristiansen G, Lochnit G, Schorle H.

Andrology. 2019 Jul;7(4):498-506. doi: 10.1111/andr.12612. Epub 2019 Mar 23.


Intraductal carcinoma of the prostate: a critical re-appraisal.

Varma M, Delahunt B, Egevad L, Samaratunga H, Kristiansen G.

Virchows Arch. 2019 May;474(5):525-534. doi: 10.1007/s00428-019-02544-6. Epub 2019 Mar 1. Review.


Apelin and apelin receptor expression in renal cell carcinoma.

Tolkach Y, Ellinger J, Kremer A, Esser L, Müller SC, Stephan C, Jung K, Toma M, Kristiansen G, Hauser S.

Br J Cancer. 2019 Mar;120(6):633-639. doi: 10.1038/s41416-019-0396-7. Epub 2019 Feb 20.


Cell-Free SHOX2 DNA Methylation in Blood as a Molecular Staging Parameter for Risk Stratification in Renal Cell Carcinoma Patients: A Prospective Observational Cohort Study.

Jung M, Ellinger J, Gevensleben H, Syring I, Lüders C, de Vos L, Pützer S, Bootz F, Landsberg J, Kristiansen G, Dietrich D.

Clin Chem. 2019 Apr;65(4):559-568. doi: 10.1373/clinchem.2018.297549. Epub 2019 Jan 9.


Handling and reporting of pelvic lymphadenectomy specimens in prostate and bladder cancer: a web-based survey by the European Network of Uropathology.

Prendeville S, Berney DM, Bubendorf L, Compérat E, Egevad L, Hes O, Kristiansen G, Oxley J, van Leenders GJLH, Varma M, van der Kwast T.

Histopathology. 2019 May;74(6):844-852. doi: 10.1111/his.13818. Epub 2019 Apr 1.


An overview of translational prostate cancer cohorts for prognostic and predictive studies.

Tolkach Y, Kristiansen G.

Histopathology. 2019 Jan;74(1):161-170. doi: 10.1111/his.13770. Review.


The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension.

Uschner FE, Schueller F, Nikolova I, Klein S, Schierwagen R, Magdaleno F, Gröschl S, Loosen S, Ritz T, Roderburg C, Vucur M, Kristiansen G, Lammers T, Luedde T, Trebicka J.

Oncotarget. 2018 Nov 16;9(90):36220-36237. doi: 10.18632/oncotarget.26333. eCollection 2018 Nov 16.


Mitochondrial PIWI-interacting RNAs are novel biomarkers for clear cell renal cell carcinoma.

Zhao C, Tolkach Y, Schmidt D, Toma M, Muders MH, Kristiansen G, Müller SC, Ellinger J.

World J Urol. 2018 Nov 28. doi: 10.1007/s00345-018-2575-1. [Epub ahead of print]


Dataset for the reporting of prostate carcinoma in core needle biopsy and transurethral resection and enucleation specimens: recommendations from the International Collaboration on Cancer Reporting (ICCR).

Egevad L, Judge M, Delahunt B, Humphrey PA, Kristiansen G, Oxley J, Rasiah K, Takahashi H, Trpkov K, Varma M, Wheeler TM, Zhou M, Srigley JR, Kench JG.

Pathology. 2019 Jan;51(1):11-20. doi: 10.1016/j.pathol.2018.10.003. Epub 2018 Nov 23.


Karyopherin Alpha 2 Is an Adverse Prognostic Factor in Clear-Cell and Papillary Renal-Cell Carcinoma.

Müller T, Tolkach Y, Stahl D, Steiner S, Hauser S, Ellinger J, Rabien A, Ralla B, Jung K, Stephan C, Kristiansen G.

Clin Genitourin Cancer. 2019 Feb;17(1):e167-e175. doi: 10.1016/j.clgc.2018.10.008. Epub 2018 Oct 23.


Detailed analysis of adenosine A2a receptor (ADORA2A) and CD73 (5'-nucleotidase, ecto, NT5E) methylation and gene expression in head and neck squamous cell carcinoma patients.

Vogt TJ, Gevensleben H, Dietrich J, Kristiansen G, Bootz F, Landsberg J, Goltz D, Dietrich D.

Oncoimmunology. 2018 Apr 18;7(8):e1452579. doi: 10.1080/2162402X.2018.1452579. eCollection 2018.


tRNA-halves are prognostic biomarkers for patients with prostate cancer.

Zhao C, Tolkach Y, Schmidt D, Muders M, Kristiansen G, Müller SC, Ellinger J.

Urol Oncol. 2018 Nov;36(11):503.e1-503.e7. doi: 10.1016/j.urolonc.2018.08.003. Epub 2018 Sep 9.


The knockdown of the Mediator complex subunit MED15 restrains urothelial bladder cancer cells' malignancy.

Syring I, Weiten R, Müller T, Schmidt D, Steiner S, Kristiansen G, Müller SC, Ellinger J.

Oncol Lett. 2018 Sep;16(3):3013-3021. doi: 10.3892/ol.2018.9014. Epub 2018 Jun 25.


[Meeting Report of the Uropathology Working Group of the German Society of Pathology, 2018].

Gaisa NT, Kristiansen G, Wild PJ.

Pathologe. 2018 Dec;39(Suppl 2):344-345. doi: 10.1007/s00292-018-0482-2. German. No abstract available.


CTLA4 methylation predicts response to anti-PD-1 and anti-CTLA-4 immunotherapy in melanoma patients.

Goltz D, Gevensleben H, Vogt TJ, Dietrich J, Golletz C, Bootz F, Kristiansen G, Landsberg J, Dietrich D.

JCI Insight. 2018 Jul 12;3(13). pii: 96793. doi: 10.1172/jci.insight.96793.


Quantification of Liver Fibrosis at T1 and T2 Mapping with Extracellular Volume Fraction MRI: Preclinical Results.

Luetkens JA, Klein S, Träber F, Schmeel FC, Sprinkart AM, Kuetting DLR, Block W, Uschner FE, Schierwagen R, Hittatiya K, Kristiansen G, Gieseke J, Schild HH, Trebicka J, Kukuk GM.

Radiology. 2018 Sep;288(3):748-754. doi: 10.1148/radiol.2018180051. Epub 2018 Jun 26.


[15th annual conference of the DPKK : Molecular analysis in diagnosis and treatment].

Taubert H, Becker C, Borkowetz A, Seitz G, Kristiansen G, Wach S, Wullich B.

Urologe A. 2018 Aug;57(8):966-968. doi: 10.1007/s00120-018-0710-7. German. No abstract available.


FGF-2 is a driving force for chromosomal instability and a stromal factor associated with adverse clinico-pathological features in prostate cancer.

Pecqueux C, Arslan A, Heller M, Falkenstein M, Kaczorowski A, Tolstov Y, Sültmann H, Grüllich C, Herpel E, Duensing A, Kristiansen G, Hohenfellner M, Navone NM, Duensing S.

Urol Oncol. 2018 Aug;36(8):365.e15-365.e26. doi: 10.1016/j.urolonc.2018.05.020. Epub 2018 Jun 7.


Micropapillary urothelial carcinoma: evaluation of HER2 status and immunohistochemical characterization of the molecular subtype.

Zinnall U, Weyerer V, Compérat E, Camparo P, Gaisa NT, Knuechel-Clarke R, Perren A, Lugli A, Toma M, Baretton G, Kristiansen G, Wirtz RM, Cheng L, Wullich B, Stoehr R, Hartmann A, Bertz S.

Hum Pathol. 2018 Oct;80:55-64. doi: 10.1016/j.humpath.2018.05.022. Epub 2018 Jun 6.


Pathogenic and targetable genetic alterations in 70 urachal adenocarcinomas.

Reis H, van der Vos KE, Niedworok C, Herold T, Módos O, Szendrői A, Hager T, Ingenwerth M, Vis DJ, Behrendt MA, de Jong J, van der Heijden MS, Peyronnet B, Mathieu R, Wiesweg M, Ablat J, Okon K, Tolkach Y, Keresztes D, Nagy N, Bremmer F, Gaisa NT, Chlosta P, Kriegsmann J, Kovalszky I, Timar J, Kristiansen G, Radzun HJ, Knüchel R, Schuler M, Black PC, Rübben H, Hadaschik BA, Schmid KW, van Rhijn BWG, Nyirády P, Szarvas T.

Int J Cancer. 2018 Apr 19. doi: 10.1002/ijc.31547. [Epub ahead of print]


The knockdown of the mediator complex subunit MED30 suppresses the proliferation and migration of renal cell carcinoma cells.

Syring I, Weiten R, Müller T, Schmidt D, Steiner S, Müller SC, Kristiansen G, Ellinger J.

Ann Diagn Pathol. 2018 Jun;34:18-26. doi: 10.1016/j.anndiagpath.2017.12.008. Epub 2017 Dec 20.


Potential of quantitative SEPT9 and SHOX2 methylation in plasmatic circulating cell-free DNA as auxiliary staging parameter in colorectal cancer: a prospective observational cohort study.

Bergheim J, Semaan A, Gevensleben H, Groening S, Knoblich A, Dietrich J, Weber J, Kalff JC, Bootz F, Kristiansen G, Dietrich D.

Br J Cancer. 2018 May;118(9):1217-1228. doi: 10.1038/s41416-018-0035-8. Epub 2018 Apr 3.


Significance of PITX2 Promoter Methylation in Colorectal Carcinoma Prognosis.

Semaan A, Uhl B, Branchi V, Lingohr P, Bootz F, Kristiansen G, Kalff JC, Matthaei H, Pantelis D, Dietrich D.

Clin Colorectal Cancer. 2018 Jun;17(2):e385-e393. doi: 10.1016/j.clcc.2018.02.008. Epub 2018 Feb 23.


Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.

Roswall P, Bocci M, Bartoschek M, Li H, Kristiansen G, Jansson S, Lehn S, Sjölund J, Reid S, Larsson C, Eriksson P, Anderberg C, Cortez E, Saal LH, Orsmark-Pietras C, Cordero E, Haller BK, Häkkinen J, Burvenich IJG, Lim E, Orimo A, Höglund M, Rydén L, Moch H, Scott AM, Eriksson U, Pietras K.

Nat Med. 2018 May;24(4):463-473. doi: 10.1038/nm.4494. Epub 2018 Mar 12.


Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab.

Schwab KS, Kristiansen G, Schild HH, Held SEA, Heine A, Brossart P.

Case Rep Oncol. 2018 Jan 4;11(1):17-20. doi: 10.1159/000485562. eCollection 2018 Jan-Apr.


YRNA expression in prostate cancer patients: diagnostic and prognostic implications.

Tolkach Y, Niehoff EM, Stahl AF, Zhao C, Kristiansen G, Müller SC, Ellinger J.

World J Urol. 2018 Jul;36(7):1073-1078. doi: 10.1007/s00345-018-2250-6. Epub 2018 Feb 28.


Prostate-specific membrane antigen in breast cancer: a comprehensive evaluation of expression and a case report of radionuclide therapy.

Tolkach Y, Gevensleben H, Bundschuh R, Koyun A, Huber D, Kehrer C, Hecking T, Keyver-Paik MD, Kaiser C, Ahmadzadehfar H, Essler M, Kuhn W, Kristiansen G.

Breast Cancer Res Treat. 2018 Jun;169(3):447-455. doi: 10.1007/s10549-018-4717-y. Epub 2018 Feb 17.


Quantitative perineural invasion is a prognostic marker in prostate cancer.

Lubig S, Thiesler T, Müller S, Vorreuther R, Leipner N, Kristiansen G.

Pathology. 2018 Apr;50(3):298-304. doi: 10.1016/j.pathol.2017.09.013. Epub 2018 Feb 12.


PD-L1 (CD274) and PD-L2 (PDCD1LG2) promoter methylation is associated with HPV infection and transcriptional repression in head and neck squamous cell carcinomas.

Franzen A, Vogt TJ, Müller T, Dietrich J, Schröck A, Golletz C, Brossart P, Bootz F, Landsberg J, Kristiansen G, Dietrich D.

Oncotarget. 2017 Dec 7;9(1):641-650. doi: 10.18632/oncotarget.23080. eCollection 2018 Jan 2.


Serum miR-122-5p and miR-206 expression: non-invasive prognostic biomarkers for renal cell carcinoma.

Heinemann FG, Tolkach Y, Deng M, Schmidt D, Perner S, Kristiansen G, Müller SC, Ellinger J.

Clin Epigenetics. 2018 Jan 23;10:11. doi: 10.1186/s13148-018-0444-9. eCollection 2018.


Next-generation nuclear morphology to grade solid tumours.

Kristiansen G.

Lancet Oncol. 2018 Mar;19(3):275-277. doi: 10.1016/S1470-2045(18)30063-9. Epub 2018 Feb 3. No abstract available.


The Mediator complex subunit MED15, a promoter of tumour progression and metastatic spread in renal cell carcinoma.

Weiten R, Müller T, Schmidt D, Steiner S, Kristiansen G, Müller SC, Ellinger J, Syring I.

Cancer Biomark. 2018;21(4):839-847. doi: 10.3233/CBM-170757.


The Heterogeneity of Prostate Cancer: A Practical Approach.

Tolkach Y, Kristiansen G.

Pathobiology. 2018;85(1-2):108-116. doi: 10.1159/000477852. Epub 2018 Jan 31.


[The impact of the androgen receptor splice variant AR-V7 on the prognosis and treatment of advanced prostate cancer].

Thelen P, Taubert H, Duensing S, Kristiansen G, Merseburger AS, Cronauer MV.

Aktuelle Urol. 2018 Jan 25. doi: 10.1055/s-0043-115426. [Epub ahead of print] German.


Utility of Pathology Imagebase for standardisation of prostate cancer grading.

Egevad L, Delahunt B, Berney DM, Bostwick DG, Cheville J, Comperat E, Evans AJ, Fine SW, Grignon DJ, Humphrey PA, Hörnblad J, Iczkowski KA, Kench JG, Kristiansen G, Leite KRM, Magi-Galluzzi C, McKenney JK, Oxley J, Pan CC, Samaratunga H, Srigley JR, Takahashi H, True LD, Tsuzuki T, van der Kwast T, Varma M, Zhou M, Clements M.

Histopathology. 2018 Jul;73(1):8-18. doi: 10.1111/his.13471. Epub 2018 Mar 5.


Handling and reporting of transperineal template prostate biopsy in Europe: a web-based survey by the European Network of Uropathology (ENUP).

Kammerer-Jacquet SF, Compérat E, Egevad L, Hes O, Oxley J, Varma M, Kristiansen G, Berney DM.

Virchows Arch. 2018 Apr;472(4):599-604. doi: 10.1007/s00428-017-2265-1. Epub 2018 Jan 11.


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