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Items: 1 to 50 of 64

1.

Effects of antihistamines on the H295R steroidogenesis - Autocrine up-regulation following 3β-HSD inhibition.

Munkboel CH, Hasselstrøm SB, Kristensen DM, Styrishave B.

Toxicol In Vitro. 2018 Apr;48:302-309. doi: 10.1016/j.tiv.2018.01.026. Epub 2018 Feb 1.

PMID:
29409762
2.

Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo.

Leverrier-Penna S, Mitchell RT, Becker E, Lecante L, Ben Maamar M, Homer N, Lavoué V, Kristensen DM, Dejucq-Rainsford N, Jégou B, Mazaud-Guittot S.

Hum Reprod. 2018 Feb 2. doi: 10.1093/humrep/dex383. [Epub ahead of print]

PMID:
29408962
3.

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism.

Kristensen DM, Desdoits-Lethimonier C, Mackey AL, Dalgaard MD, De Masi F, Munkbøl CH, Styrishave B, Antignac JP, Le Bizec B, Platel C, Hay-Schmidt A, Jensen TK, Lesné L, Mazaud-Guittot S, Kristiansen K, Brunak S, Kjaer M, Juul A, Jégou B.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8. Erratum in: Proc Natl Acad Sci U S A. 2018 Apr 16;:.

4.

EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?

Arendrup FS, Mazaud-Guittot S, Jégou B, Kristensen DM.

Endocr Connect. 2018 Jan;7(1):149-158. doi: 10.1530/EC-17-0298. Epub 2018 Jan 5.

5.

Assessment of the analgesic dipyrone as a possible (anti)androgenic endocrine disruptor.

Passoni MT, Kristensen MN, Morais RN, Woitkowiak C, Boareto AC, da Silva Amaral BA, Grechi N, Dalsenter PR, Munkboel CH, Styrishave B, Kristensen DM, Gomes C, van Ravenzwaay B, Martino-Andrade AJ.

Toxicol Lett. 2018 Mar 15;285:139-147. doi: 10.1016/j.toxlet.2017.12.021. Epub 2017 Dec 28.

PMID:
29289696
6.

Microbial genome analysis: the COG approach.

Galperin MY, Kristensen DM, Makarova KS, Wolf YI, Koonin EV.

Brief Bioinform. 2017 Sep 14. doi: 10.1093/bib/bbx117. [Epub ahead of print]

PMID:
28968633
7.

Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study.

Mogensen DM, Pihl MB, Skakkebæk NE, Andersen HR, Juul A, Kyhl HB, Swan S, Kristensen DM, Andersen MS, Lind DV, Jensen TK.

Environ Health. 2017 Jun 21;16(1):68. doi: 10.1186/s12940-017-0263-z.

8.

Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour.

Hay-Schmidt A, Finkielman OTE, Jensen BAH, Høgsbro CF, Bak Holm J, Johansen KH, Jensen TK, Andrade AM, Swan SH, Bornehag CG, Brunak S, Jegou B, Kristiansen K, Kristensen DM.

Reproduction. 2017 Aug;154(2):145-152. doi: 10.1530/REP-17-0165. Epub 2017 May 30.

9.

Reconstruction of the evolution of microbial defense systems.

Puigbò P, Makarova KS, Kristensen DM, Wolf YI, Koonin EV.

BMC Evol Biol. 2017 Apr 4;17(1):94. doi: 10.1186/s12862-017-0942-y.

10.

Ibuprofen results in alterations of human fetal testis development.

Ben Maamar M, Lesné L, Hennig K, Desdoits-Lethimonier C, Kilcoyne KR, Coiffec I, Rolland AD, Chevrier C, Kristensen DM, Lavoué V, Antignac JP, Le Bizec B, Dejucq-Rainsford N, Mitchell RT, Mazaud-Guittot S, Jégou B.

Sci Rep. 2017 Mar 10;7:44184. doi: 10.1038/srep44184.

11.

Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice.

Giordano A, Perugini J, Kristensen DM, Sartini L, Frontini A, Kajimura S, Kristiansen K, Cinti S.

J Cell Physiol. 2017 Nov;232(11):2923-2928. doi: 10.1002/jcp.25858. Epub 2017 Mar 24.

PMID:
28191637
12.

ATGC database and ATGC-COGs: an updated resource for micro- and macro-evolutionary studies of prokaryotic genomes and protein family annotation.

Kristensen DM, Wolf YI, Koonin EV.

Nucleic Acids Res. 2017 Jan 4;45(D1):D210-D218. doi: 10.1093/nar/gkw934. Epub 2016 Oct 18.

13.

Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-child pairs.

Lind DV, Main KM, Kyhl HB, Kristensen DM, Toppari J, Andersen HR, Andersen MS, Skakkebæk NE, Jensen TK.

Hum Reprod. 2017 Jan;32(1):223-231. Epub 2016 Nov 16.

PMID:
27852690
14.

Evolutionary switches between two serine codon sets are driven by selection.

Rogozin IB, Belinky F, Pavlenko V, Shabalina SA, Kristensen DM, Koonin EV.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13109-13113. Epub 2016 Oct 31.

15.

Prokaryotic Virus Orthologous Groups (pVOGs): a resource for comparative genomics and protein family annotation.

Grazziotin AL, Koonin EV, Kristensen DM.

Nucleic Acids Res. 2017 Jan 4;45(D1):D491-D498. doi: 10.1093/nar/gkw975. Epub 2016 Oct 26.

16.

Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort.

Lind DV, Priskorn L, Lassen TH, Nielsen F, Kyhl HB, Kristensen DM, Christesen HT, Jørgensen JS, Grandjean P, Jensen TK.

Reprod Toxicol. 2017 Mar;68:200-206. doi: 10.1016/j.reprotox.2016.08.019. Epub 2016 Aug 31.

PMID:
27592399
17.

Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age as marker of endocrine disruption.

Lind DV, Priskorn L, Lassen TH, Nielsen F, Kyhl HB, Kristensen DM, Christesen HT, Steener J, Grandjean P, Jensen TK.

Reprod Toxicol. 2016 Jul 12. pii: S0890-6238(16)30265-9. doi: 10.1016/j.reprotox.2016.07.008. [Epub ahead of print]

PMID:
27421581
18.

Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects.

Kristensen DM, Mazaud-Guittot S, Gaudriault P, Lesné L, Serrano T, Main KM, Jégou B.

Nat Rev Endocrinol. 2016 Jul;12(7):381-93. doi: 10.1038/nrendo.2016.55. Epub 2016 May 6. Review.

PMID:
27150289
19.

Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility.

Holm JB, Mazaud-Guittot S, Danneskiold-Samsøe NB, Chalmey C, Jensen B, Nørregård MM, Hansen CH, Styrishave B, Svingen T, Vinggaard AM, Koch HM, Bowles J, Koopman P, Jégou B, Kristiansen K, Kristensen DM.

Toxicol Sci. 2016 Mar;150(1):178-89. doi: 10.1093/toxsci/kfv332. Epub 2016 Jan 5.

PMID:
26732887
20.

A census of α-helical membrane proteins in double-stranded DNA viruses infecting bacteria and archaea.

Kristensen DM, Saeed U, Frishman D, Koonin EV.

BMC Bioinformatics. 2015 Nov 10;16:380. doi: 10.1186/s12859-015-0817-4.

21.

Aniline Is Rapidly Converted Into Paracetamol Impairing Male Reproductive Development.

Holm JB, Chalmey C, Modick H, Jensen LS, Dierkes G, Weiss T, Jensen BA, Nørregård MM, Borkowski K, Styrishave B, Martin Koch H, Mazaud-Guittot S, Jegou B, Kristiansen K, Kristensen DM.

Toxicol Sci. 2015 Nov;148(1):288-98. doi: 10.1093/toxsci/kfv179. Epub 2015 Aug 10.

PMID:
26259604
22.

Evolutionary Conservation of Bacterial Essential Metabolic Genes across All Bacterial Culture Media.

Ish-Am O, Kristensen DM, Ruppin E.

PLoS One. 2015 Apr 20;10(4):e0123785. doi: 10.1371/journal.pone.0123785. eCollection 2015.

23.

No evidence of inhibition of horizontal gene transfer by CRISPR-Cas on evolutionary timescales.

Gophna U, Kristensen DM, Wolf YI, Popa O, Drevet C, Koonin EV.

ISME J. 2015 Sep;9(9):2021-7. doi: 10.1038/ismej.2015.20. Epub 2015 Feb 24.

24.

Physiological role of taurine--from organism to organelle.

Lambert IH, Kristensen DM, Holm JB, Mortensen OH.

Acta Physiol (Oxf). 2015 Jan;213(1):191-212. doi: 10.1111/apha.12365. Epub 2014 Sep 12. Review.

PMID:
25142161
25.

Genomes in turmoil: quantification of genome dynamics in prokaryote supergenomes.

Puigbò P, Lobkovsky AE, Kristensen DM, Wolf YI, Koonin EV.

BMC Biol. 2014 Aug 21;12:66. doi: 10.1186/s12915-014-0066-4.

26.

Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice.

Fjære E, Aune UL, Røen K, Keenan AH, Ma T, Borkowski K, Kristensen DM, Novotny GW, Mandrup-Poulsen T, Hudson BD, Milligan G, Xi Y, Newman JW, Haj FG, Liaset B, Kristiansen K, Madsen L.

J Biol Chem. 2014 Jun 6;289(23):16032-45. doi: 10.1074/jbc.M113.525220. Epub 2014 Apr 17.

27.

Coupling between protein level selection and codon usage optimization in the evolution of bacteria and archaea.

Ran W, Kristensen DM, Koonin EV.

MBio. 2014 Mar 25;5(2):e00956-14. doi: 10.1128/mBio.00956-14.

28.

Classification and quantification of bacteriophage taxa in human gut metagenomes.

Waller AS, Yamada T, Kristensen DM, Kultima JR, Sunagawa S, Koonin EV, Bork P.

ISME J. 2014 Jul;8(7):1391-402. doi: 10.1038/ismej.2014.30. Epub 2014 Mar 13. Erratum in: ISME J. 2014 Jul;8(7):1551-2.

29.

Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent.

Mazaud-Guittot S, Nicolas Nicolaz C, Desdoits-Lethimonier C, Coiffec I, Ben Maamar M, Balaguer P, Kristensen DM, Chevrier C, Lavoué V, Poulain P, Dejucq-Rainsford N, Jégou B.

J Clin Endocrinol Metab. 2013 Nov;98(11):E1757-67. doi: 10.1210/jc.2013-2531. Epub 2013 Sep 12.

PMID:
24030937
30.

Orthologous gene clusters and taxon signature genes for viruses of prokaryotes.

Kristensen DM, Waller AS, Yamada T, Bork P, Mushegian AR, Koonin EV.

J Bacteriol. 2013 Mar;195(5):941-50. doi: 10.1128/JB.01801-12. Epub 2012 Dec 7.

31.

Contribution of phage-derived genomic islands to the virulence of facultative bacterial pathogens.

Busby B, Kristensen DM, Koonin EV.

Environ Microbiol. 2013 Feb;15(2):307-12. doi: 10.1111/j.1462-2920.2012.02886.x. Epub 2012 Oct 4.

32.

Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis.

Kristensen DM, Lesné L, Le Fol V, Desdoits-Lethimonier C, Dejucq-Rainsford N, Leffers H, Jégou B.

Int J Androl. 2012 Jun;35(3):377-84. doi: 10.1111/j.1365-2605.2012.01282.x.

PMID:
22612476
33.

Moving beyond genome sequencing into personalized genomic medicine: biological and computing challenges.

Kristensen DM.

Genome Biol. 2011 Oct 24;12(10):308. doi: 10.1186/gb-2011-12-10-308.

34.

Computational methods for Gene Orthology inference.

Kristensen DM, Wolf YI, Mushegian AR, Koonin EV.

Brief Bioinform. 2011 Sep;12(5):379-91. doi: 10.1093/bib/bbr030. Epub 2011 Jun 19.

35.

A novel double staining strategy for improved detection of testicular carcinoma in situ cells in human semen samples.

Nielsen JE, Kristensen DM, Almstrup K, Jørgensen A, Olesen IA, Jacobsen GK, Horn T, Skakkebaek NE, Leffers H, Rajpert-De Meyts E.

Andrologia. 2012 Apr;44(2):78-85. doi: 10.1111/j.1439-0272.2010.01108.x. Epub 2011 Feb 16.

PMID:
21486421
36.

Evolutionarily conserved orthologous families in phages are relatively rare in their prokaryotic hosts.

Kristensen DM, Cai X, Mushegian A.

J Bacteriol. 2011 Apr;193(8):1806-14. doi: 10.1128/JB.01311-10. Epub 2011 Feb 11.

37.

Many putative endocrine disruptors inhibit prostaglandin synthesis.

Kristensen DM, Skalkam ML, Audouze K, Lesné L, Desdoits-Lethimonier C, Frederiksen H, Brunak S, Skakkebæk NE, Jégou B, Hansen JB, Junker S, Leffers H.

Environ Health Perspect. 2011 Apr;119(4):534-41. doi: 10.1289/ehp.1002635. Epub 2010 Nov 16.

38.

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat.

Kristensen DM, Hass U, Lesné L, Lottrup G, Jacobsen PR, Desdoits-Lethimonier C, Boberg J, Petersen JH, Toppari J, Jensen TK, Brunak S, Skakkebaek NE, Nellemann C, Main KM, Jégou B, Leffers H.

Hum Reprod. 2011 Jan;26(1):235-44. doi: 10.1093/humrep/deq323. Epub 2010 Nov 8.

PMID:
21059752
39.

A low-polynomial algorithm for assembling clusters of orthologous groups from intergenomic symmetric best matches.

Kristensen DM, Kannan L, Coleman MK, Wolf YI, Sorokin A, Koonin EV, Mushegian A.

Bioinformatics. 2010 Jun 15;26(12):1481-7. doi: 10.1093/bioinformatics/btq229. Epub 2010 May 2.

40.

Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract.

Blomberg Jensen M, Nielsen JE, Jørgensen A, Rajpert-De Meyts E, Kristensen DM, Jørgensen N, Skakkebaek NE, Juul A, Leffers H.

Hum Reprod. 2010 May;25(5):1303-11. doi: 10.1093/humrep/deq024. Epub 2010 Feb 18.

PMID:
20172873
41.

OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres.

Kristensen DM, Nielsen JE, Kalisz M, Dalgaard MD, Audouze K, Larsen ME, Jacobsen GK, Horn T, Brunak S, Skakkebaek NE, Leffers H.

Mol Hum Reprod. 2010 Nov;16(11):835-45. doi: 10.1093/molehr/gaq008. Epub 2010 Jan 31.

PMID:
20123703
42.

New dimensions of the virus world discovered through metagenomics.

Kristensen DM, Mushegian AR, Dolja VV, Koonin EV.

Trends Microbiol. 2010 Jan;18(1):11-9. doi: 10.1016/j.tim.2009.11.003. Epub 2009 Nov 26.

43.

Analysis of SOX2 expression in developing human testis and germ cell neoplasia.

Sonne SB, Perrett RM, Nielsen JE, Baxter MA, Kristensen DM, Leffers H, Hanley NA, Rajpert-De-Meyts E.

Int J Dev Biol. 2010;54(4):755-60. doi: 10.1387/ijdb.082668ss.

44.

Detection of biochemical pathways by probabilistic matching of phyletic vectors.

Li H, Kristensen DM, Coleman MK, Mushegian A.

PLoS One. 2009;4(4):e5326. doi: 10.1371/journal.pone.0005326. Epub 2009 Apr 24.

45.

Evolutionary Trace Annotation Server: automated enzyme function prediction in protein structures using 3D templates.

Ward RM, Venner E, Daines B, Murray S, Erdin S, Kristensen DM, Lichtarge O.

Bioinformatics. 2009 Jun 1;25(11):1426-7. doi: 10.1093/bioinformatics/btp160. Epub 2009 Mar 23.

46.

De-orphaning the structural proteome through reciprocal comparison of evolutionarily important structural features.

Ward RM, Erdin S, Tran TA, Kristensen DM, Lisewski AM, Lichtarge O.

PLoS One. 2008 May 7;3(5):e2136. doi: 10.1371/journal.pone.0002136.

47.

Origin of pluripotent germ cell tumours: the role of microenvironment during embryonic development.

Kristensen DM, Sonne SB, Ottesen AM, Perrett RM, Nielsen JE, Almstrup K, Skakkebaek NE, Leffers H, Rajpert-De Meyts E.

Mol Cell Endocrinol. 2008 Jun 25;288(1-2):111-8. doi: 10.1016/j.mce.2008.02.018. Epub 2008 Mar 4. Review.

PMID:
18420341
48.

Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms.

Kristensen DM, Nielsen JE, Skakkebaek NE, Graem N, Jacobsen GK, Rajpert-De Meyts E, Leffers H.

Hum Reprod. 2008 Apr;23(4):775-82. doi: 10.1093/humrep/den010. Epub 2008 Feb 15.

PMID:
18281244
49.

Testicular dysgenesis syndrome and the origin of carcinoma in situ testis.

Sonne SB, Kristensen DM, Novotny GW, Olesen IA, Nielsen JE, Skakkebaek NE, Rajpert-De Meyts E, Leffers H.

Int J Androl. 2008 Apr;31(2):275-87. doi: 10.1111/j.1365-2605.2007.00855.x. Epub 2008 Jan 16. Review.

PMID:
18205797
50.

Prediction of enzyme function based on 3D templates of evolutionarily important amino acids.

Kristensen DM, Ward RM, Lisewski AM, Erdin S, Chen BY, Fofanov VY, Kimmel M, Kavraki LE, Lichtarge O.

BMC Bioinformatics. 2008 Jan 11;9:17. doi: 10.1186/1471-2105-9-17.

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