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Modeling and Mutational Analysis of the Binding Mode for the Multimodal Antidepressant Drug Vortioxetine to the Human 5-HT3A Receptor.

Ladefoged LK, Munro L, Pedersen AJ, Lummis SCR, Bang-Andersen B, Balle T, Schiøtt B, Kristensen AS.

Mol Pharmacol. 2018 Dec;94(6):1421-1434. doi: 10.1124/mol.118.113530. Epub 2018 Sep 26.


Association between genes on chromosome 19p13.2 and panic disorder.

Gregersen NO, Buttenschøn HN, Hedemand A, Nielsen MN, Dahl HA, Kristensen AS, Johansen O, Woldbye DP, Erhardt A, Kruse TA, Wang AG, Børglum AD, Mors O.

Psychiatr Genet. 2016 Dec;26(6):287-292.


Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands.

Andersen J, Ladefoged LK, Kristensen TN, Munro L, Grouleff J, Stuhr-Hansen N, Kristensen AS, Schiøtt B, Strømgaard K.

ACS Chem Neurosci. 2016 Oct 19;7(10):1406-1417. Epub 2016 Aug 10.


Relationship Between Changes in Workplace Bullying Status and the Reporting of Personality Characteristics.

Persson R, Høgh A, Grynderup MB, Willert MV, Gullander M, Hansen ÅM, Kolstad HA, Mors O, Mikkelsen EG, Kristensen AS, Kaerlev L, Rugulies R, Bonde JP.

J Occup Environ Med. 2016 Sep;58(9):902-10. doi: 10.1097/JOM.0000000000000822.


Structural rearrangement of the intracellular domains during AMPA receptor activation.

Zachariassen LG, Katchan L, Jensen AG, Pickering DS, Plested AJ, Kristensen AS.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3950-9. doi: 10.1073/pnas.1601747113. Epub 2016 Jun 16.


Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter.

Larsen MA, Plenge P, Andersen J, Eildal JN, Kristensen AS, Bøgesø KP, Gether U, Strømgaard K, Bang-Andersen B, Loland CJ.

Br J Pharmacol. 2016 Mar;173(5):925-36. doi: 10.1111/bph.13411. Epub 2016 Feb 8.


Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.

Kristensen AS, Hansen KB, Naur P, Olsen L, Kurtkaya NL, Dravid SM, Kvist T, Yi F, Pøhlsgaard J, Clausen RP, Gajhede M, Kastrup JS, Traynelis SF.

Mol Pharmacol. 2016 Feb;89(2):253-62. doi: 10.1124/mol.115.100909. Epub 2015 Dec 10.


Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter.

Andersen J, Ringsted KB, Bang-Andersen B, Strømgaard K, Kristensen AS.

Sci Rep. 2015 Oct 27;5:15650. doi: 10.1038/srep15650.


Binding of the multimodal antidepressant drug vortioxetine to the human serotonin transporter.

Andersen J, Ladefoged LK, Wang D, Kristensen TN, Bang-Andersen B, Kristensen AS, Schiøtt B, Strømgaard K.

ACS Chem Neurosci. 2015 Nov 18;6(11):1892-900. doi: 10.1021/acschemneuro.5b00225. Epub 2015 Oct 11.


Substrate and Inhibitor-Specific Conformational Changes in the Human Serotonin Transporter Revealed by Voltage-Clamp Fluorometry.

Söderhielm PC, Andersen J, Munro L, Nielsen AT, Kristensen AS.

Mol Pharmacol. 2015 Oct;88(4):676-88. doi: 10.1124/mol.115.099911. Epub 2015 Jul 14.


Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation.

Rannversson H, Wilson P, Kristensen KB, Sinning S, Kristensen AS, Strømgaard K, Andersen J.

J Biol Chem. 2015 Jun 5;290(23):14582-94. doi: 10.1074/jbc.M114.629071. Epub 2015 Apr 22.


Targeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein family.

Nissen KB, Haugaard-Kedström LM, Wilbek TS, Nielsen LS, Åberg E, Kristensen AS, Bach A, Jemth P, Strømgaard K.

PLoS One. 2015 Feb 6;10(2):e0117668. doi: 10.1371/journal.pone.0117668. eCollection 2015.


Binding of ArgTX-636 in the NMDA receptor ion channel.

Poulsen MH, Andersen J, Christensen R, Hansen KB, Traynelis SF, Strømgaard K, Kristensen AS.

J Mol Biol. 2015 Jan 16;427(1):176-89. doi: 10.1016/j.jmb.2014.05.017. Epub 2014 May 24.


Bipolar and panic disorders may be associated with hereditary defects in the innate immune system.

Foldager L, Köhler O, Steffensen R, Thiel S, Kristensen AS, Jensenius JC, Mors O.

J Affect Disord. 2014 Aug;164:148-54. doi: 10.1016/j.jad.2014.04.017. Epub 2014 Apr 19.


Analogues of 3-hydroxyisoxazole-containing glutamate receptor ligands based on the 3-hydroxypyrazole-moiety: design, synthesis and pharmacological characterization.

Jørgensen L, Nielsen B, Pickering DS, Kristensen AS, Frydenvang K, Madsen U, Clausen RP.

Neurochem Res. 2014 Oct;39(10):1895-905. doi: 10.1007/s11064-014-1332-0. Epub 2014 May 22.


Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors.

Nørager NG, Poulsen MH, Jensen AG, Jeppesen NS, Kristensen AS, Strømgaard K.

J Med Chem. 2014 Jun 12;57(11):4940-9. doi: 10.1021/jm5004705. Epub 2014 May 29.


Inhibition of AMPA receptors by polyamine toxins is regulated by agonist efficacy and stargazin.

Poulsen MH, Lucas S, Strømgaard K, Kristensen AS.

Neurochem Res. 2014 Oct;39(10):1906-13. doi: 10.1007/s11064-014-1258-6. Epub 2014 Feb 22.


Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac).

Andersen J, Stuhr-Hansen N, Zachariassen LG, Koldsø H, Schiøtt B, Strømgaard K, Kristensen AS.

Mol Pharmacol. 2014 May;85(5):703-14. doi: 10.1124/mol.113.091249. Epub 2014 Feb 10.


Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations.

Pedersen SW, Pedersen SB, Anker L, Hultqvist G, Kristensen AS, Jemth P, Strømgaard K.

Nat Commun. 2014;5:3215. doi: 10.1038/ncomms4215.


Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites.

Sørensen L, Strømgaard K, Kristensen AS.

ACS Chem Biol. 2014 Apr 18;9(4):935-44. doi: 10.1021/cb4007198. Epub 2014 Feb 3.


Are TMEM genes potential candidate genes for panic disorder?

Gregersen NO, Buttenschøn HN, Hedemand A, Dahl HA, Kristensen AS, Clementsen B, Woldbye DP, Koefoed P, Erhardt A, Kruse TA, Wang AG, Børglum AD, Mors O.

Psychiatr Genet. 2014 Feb;24(1):37-41. doi: 10.1097/YPG.0000000000000022.


Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors.

Poulsen MH, Lucas S, Strømgaard K, Kristensen AS.

Mol Pharmacol. 2014 Feb;85(2):261-8. doi: 10.1124/mol.113.089961. Epub 2013 Nov 12.


Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons.

Nørager NG, Jensen CB, Rathje M, Andersen J, Madsen KL, Kristensen AS, Strømgaard K.

ACS Chem Biol. 2013 Sep 20;8(9):2033-41. doi: 10.1021/cb400272m. Epub 2013 Jul 24.


Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors.

Poulsen MH, Lucas S, Bach TB, Barslund AF, Wenzler C, Jensen CB, Kristensen AS, Strømgaard K.

J Med Chem. 2013 Feb 14;56(3):1171-81. doi: 10.1021/jm301602d. Epub 2013 Jan 15.


General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors.

Lucas S, Poulsen MH, Nørager NG, Barslund AF, Bach TB, Kristensen AS, Strømgaard K.

J Med Chem. 2012 Nov 26;55(22):10297-301. doi: 10.1021/jm301255m. Epub 2012 Nov 6.


Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket.

Sørensen L, Andersen J, Thomsen M, Hansen SM, Zhao X, Sandelin A, Strømgaard K, Kristensen AS.

J Biol Chem. 2012 Dec 21;287(52):43694-707. doi: 10.1074/jbc.M112.342212. Epub 2012 Oct 19.


Replication and meta-analysis of TMEM132D gene variants in panic disorder.

Erhardt A, Akula N, Schumacher J, Czamara D, Karbalai N, Müller-Myhsok B, Mors O, Borglum A, Kristensen AS, Woldbye DP, Koefoed P, Eriksson E, Maron E, Metspalu A, Nurnberger J, Philibert RA, Kennedy J, Domschke K, Reif A, Deckert J, Otowa T, Kawamura Y, Kaiya H, Okazaki Y, Tanii H, Tokunaga K, Sasaki T, Ioannidis JP, McMahon FJ, Binder EB.

Transl Psychiatry. 2012 Sep 4;2:e156. doi: 10.1038/tp.2012.85.


Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression.

Koefoed P, Woldbye DP, Hansen TV, Eplov LF, Christiansen SH, Mors O, Kessing LV, Werge T, Kaipio K, Pesonen U, Fahmy T, Mellerup E, Jakobsen KD, Hansen ES, Knudsen GM, Bukh JD, Bock C, Lindberg C, Kristensen AS, Dam H, Nordentoft M, Als TD, Wang AG, Gether U, Rehfeld JF, Bolwig TG.

Acta Neuropsychiatr. 2012 Apr;24(2):81-90. doi: 10.1111/j.1601-5215.2011.00600.x.


A heteromeric snake toxin and the molecular details of pain perception.

Strømgaard K, Kristensen AS.

Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4009-11. doi: 10.1002/anie.201200340. Epub 2012 Mar 15. No abstract available.


A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage.

Bach A, Clausen BH, Møller M, Vestergaard B, Chi CN, Round A, Sørensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundström P, Lambertsen KL, Strømgaard K.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3317-22. doi: 10.1073/pnas.1113761109. Epub 2012 Feb 17.


Small molecules from spiders used as chemical probes.

Olsen CA, Kristensen AS, Strømgaard K.

Angew Chem Int Ed Engl. 2011 Nov 25;50(48):11296-311. doi: 10.1002/anie.201101599. Epub 2011 Oct 27. Review.


A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene.

Gregersen N, Dahl HA, Buttenschøn HN, Nyegaard M, Hedemand A, Als TD, Wang AG, Joensen S, Woldbye DP, Koefoed P, Kristensen AS, Kruse TA, Børglum AD, Mors O.

Eur J Hum Genet. 2012 Jan;20(1):84-90. doi: 10.1038/ejhg.2011.148. Epub 2011 Aug 3.


SLC6 neurotransmitter transporters: structure, function, and regulation.

Kristensen AS, Andersen J, Jørgensen TN, Sørensen L, Eriksen J, Loland CJ, Strømgaard K, Gether U.

Pharmacol Rev. 2011 Sep;63(3):585-640. doi: 10.1124/pr.108.000869. Epub 2011 Jul 13. Review.


Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters.

Andersen J, Stuhr-Hansen N, Zachariassen L, Toubro S, Hansen SM, Eildal JN, Bond AD, Bøgesø KP, Bang-Andersen B, Kristensen AS, Strømgaard K.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12137-42. doi: 10.1073/pnas.1103060108. Epub 2011 Jul 5.


Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating.

Kristensen AS, Jenkins MA, Banke TG, Schousboe A, Makino Y, Johnson RC, Huganir R, Traynelis SF.

Nat Neurosci. 2011 Jun;14(6):727-35. doi: 10.1038/nn.2804. Epub 2011 Apr 24.


The genetics of panic disorder.

Schumacher J, Kristensen AS, Wendland JR, Nöthen MM, Mors O, McMahon FJ.

J Med Genet. 2011 Jun;48(6):361-8. doi: 10.1136/jmg.2010.086876. Epub 2011 Apr 14. Review.


The norepinephrine transporter gene is a candidate gene for panic disorder.

Buttenschøn HN, Kristensen AS, Buch HN, Andersen JH, Bonde JP, Grynderup M, Hansen AM, Kolstad H, Kaergaard A, Kaerlev L, Mikkelsen S, Thomsen JF, Koefoed P, Erhardt A, Woldbye DP, Børglum AD, Mors O.

J Neural Transm (Vienna). 2011 Jun;118(6):969-76. doi: 10.1007/s00702-011-0624-7. Epub 2011 Mar 18.


Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

Bach A, Eildal JN, Stuhr-Hansen N, Deeskamp R, Gottschalk M, Pedersen SW, Kristensen AS, Strømgaard K.

J Med Chem. 2011 Mar 10;54(5):1333-46. doi: 10.1021/jm1013924. Epub 2011 Feb 15.


Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata.

Barslund AF, Poulsen MH, Bach TB, Lucas S, Kristensen AS, Strømgaard K.

J Nat Prod. 2011 Mar 25;74(3):483-6. doi: 10.1021/np100746w. Epub 2010 Dec 28.


Job strain and the risk of depression: is reporting biased?

Kolstad HA, Hansen AM, Kærgaard A, Thomsen JF, Kaerlev L, Mikkelsen S, Grynderup MB, Mors O, Rugulies R, Kristensen AS, Andersen JH, Bonde JP.

Am J Epidemiol. 2011 Jan 1;173(1):94-102. doi: 10.1093/aje/kwq318. Epub 2010 Nov 11.


Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists.

Frølund S, Bella A, Kristensen AS, Ziegler HL, Witt M, Olsen CA, Strømgaard K, Franzyk H, Jaroszewski JW.

J Med Chem. 2010 Oct 28;53(20):7441-51. doi: 10.1021/jm100886h.


Stressful life events, cognitive symptoms of depression and response to antidepressants in GENDEP.

Keers R, Uher R, Gupta B, Rietschel M, Schulze TG, Hauser J, Skibinska M, Henigsberg N, Kalember P, Maier W, Zobel A, Mors O, Kristensen AS, Kozel D, Giovannini C, Mendlewicz J, Kumar S, McGuffin P, Farmer AE, Aitchison KJ.

J Affect Disord. 2010 Dec;127(1-3):337-42. doi: 10.1016/j.jad.2010.06.011. Epub 2010 Jul 6.


Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example.

Chi CN, Bach A, Gottschalk M, Kristensen AS, Strømgaard K, Jemth P.

J Biol Chem. 2010 Sep 3;285(36):28252-60. doi: 10.1074/jbc.M110.124040. Epub 2010 Jun 24.


Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction.

Bach A, Chi CN, Pang GF, Olsen L, Kristensen AS, Jemth P, Strømgaard K.

Angew Chem Int Ed Engl. 2009;48(51):9685-9. doi: 10.1002/anie.200904741. No abstract available.


Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

Andersen J, Olsen L, Hansen KB, Taboureau O, Jørgensen FS, Jørgensen AM, Bang-Andersen B, Egebjerg J, Strømgaard K, Kristensen AS.

J Biol Chem. 2010 Jan 15;285(3):2051-63. doi: 10.1074/jbc.M109.072587. Epub 2009 Nov 5.


The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.

Clausen RP, Naur P, Kristensen AS, Greenwood JR, Strange M, Bräuner-Osborne H, Jensen AA, Nielsen AS, Geneser U, Ringgaard LM, Nielsen B, Pickering DS, Brehm L, Gajhede M, Krogsgaard-Larsen P, Kastrup JS.

J Med Chem. 2009 Aug 13;52(15):4911-22. doi: 10.1021/jm900565c.


Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters.

Andersen J, Kristensen AS, Bang-Andersen B, Strømgaard K.

Chem Commun (Camb). 2009 Jul 7;(25):3677-92. doi: 10.1039/b903035m. Epub 2009 May 7. Review.


Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction.

Gottschalk M, Bach A, Hansen JL, Krogsgaard-Larsen P, Kristensen AS, Strømgaard K.

Neurochem Res. 2009 Oct;34(10):1729-37. doi: 10.1007/s11064-009-9998-4. Epub 2009 Jun 4.


Potential consumers' attitudes toward psychiatric genetic research and testing and factors influencing their intentions to test.

Laegsgaard MM, Kristensen AS, Mors O.

Genet Test Mol Biomarkers. 2009 Feb;13(1):57-65. doi: 10.1089/gtmb.2008.0022.


The structure of emotional and cognitive anxiety symptoms.

Kristensen AS, Mortensen EL, Mors O.

J Anxiety Disord. 2009 Jun;23(5):600-8. doi: 10.1016/j.janxdis.2009.01.009. Epub 2009 Jan 23.


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