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Items: 1 to 50 of 77

1.

Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis.

Flentie K, Harrison GA, Tükenmez H, Livny J, Good JAD, Sarkar S, Zhu DX, Kinsella RL, Weiss LA, Solomon SD, Schene ME, Hansen MR, Cairns AG, Kulén M, Wixe T, Lindgren AEG, Chorell E, Bengtsson C, Krishnan KS, Hultgren SJ, Larsson C, Almqvist F, Stallings CL.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10510-10517. doi: 10.1073/pnas.1818009116. Epub 2019 May 6.

2.

Thiazolino 2-Pyridone Amide Isosteres As Inhibitors of Chlamydia trachomatis Infectivity.

Good JAD, Kulén M, Silver J, Krishnan KS, Bahnan W, Núñez-Otero C, Nilsson I, Wede E, de Groot E, Gylfe Å, Bergström S, Almqvist F.

J Med Chem. 2017 Nov 22;60(22):9393-9399. doi: 10.1021/acs.jmedchem.7b00716. Epub 2017 Nov 3.

PMID:
29053275
3.

Recent Advances in the Chemistry of Pentafulvenes.

Preethalayam P, Krishnan KS, Thulasi S, Chand SS, Joseph J, Nair V, Jaroschik F, Radhakrishnan KV.

Chem Rev. 2017 Mar 8;117(5):3930-3989. doi: 10.1021/acs.chemrev.6b00210. Epub 2017 Feb 2.

PMID:
28151643
4.

Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens.

Shaffer CL, Good JA, Kumar S, Krishnan KS, Gaddy JA, Loh JT, Chappell J, Almqvist F, Cover TL, Hadjifrangiskou M.

mBio. 2016 Apr 26;7(2):e00221-16. doi: 10.1128/mBio.00221-16.

5.

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.

Good JA, Andersson C, Hansen S, Wall J, Krishnan KS, Begum A, Grundström C, Niemiec MS, Vaitkevicius K, Chorell E, Wittung-Stafshede P, Sauer UH, Sauer-Eriksson AE, Almqvist F, Johansson J.

Cell Chem Biol. 2016 Mar 17;23(3):404-14. doi: 10.1016/j.chembiol.2016.02.013.

6.

σ2-Adaptin Facilitates Basal Synaptic Transmission and Is Required for Regenerating Endo-Exo Cycling Pool Under High-Frequency Nerve Stimulation in Drosophila.

Choudhury SD, Mushtaq Z, Reddy-Alla S, Balakrishnan SS, Thakur RS, Krishnan KS, Raghu P, Ramaswami M, Kumar V.

Genetics. 2016 May;203(1):369-85. doi: 10.1534/genetics.115.183863. Epub 2016 Feb 26.

7.

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity.

Good JA, Silver J, Núñez-Otero C, Bahnan W, Krishnan KS, Salin O, Engström P, Svensson R, Artursson P, Gylfe Å, Bergström S, Almqvist F.

J Med Chem. 2016 Mar 10;59(5):2094-108. doi: 10.1021/acs.jmedchem.5b01759. Epub 2016 Feb 22.

PMID:
26849778
8.

Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation.

Singh P, Chorell E, Krishnan KS, Kindahl T, Åden J, Wittung-Stafshede P, Almqvist F.

Org Lett. 2015 Dec 18;17(24):6194-7. doi: 10.1021/acs.orglett.5b03190. Epub 2015 Dec 9.

PMID:
26650849
9.

A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis.

Engström P, Krishnan KS, Ngyuen BD, Chorell E, Normark J, Silver J, Bastidas RJ, Welch MD, Hultgren SJ, Wolf-Watz H, Valdivia RH, Almqvist F, Bergström S.

mBio. 2014 Dec 30;6(1):e02304-14. doi: 10.1128/mBio.02304-14.

10.

Synthesis of fluorescent ring-fused 2-pyridone peptidomimetics.

Krishnan KS, Bengtsson C, Good JA, Mirkhanov S, Chorell E, Johansson LB, Almqvist F.

J Org Chem. 2013 Dec 6;78(23):12207-13. doi: 10.1021/jo401844y. Epub 2013 Nov 14.

PMID:
24161000
11.

Obaid Siddiqi at 80 and neurogenetics in India.

Krishnan KS, Ramaswami M, Wu CF.

J Neurogenet. 2012 Sep;26(3-4):255-6. doi: 10.3109/01677063.2012.746168. No abstract available.

PMID:
23186110
12.

Genetic modifiers of comatose mutations in Drosophila: insights into neuronal NSF (N-ethylmaleimide-sensitive fusion factor) functions.

Sanyal S, Krishnan KS.

J Neurogenet. 2012 Sep;26(3-4):348-59. doi: 10.3109/01677063.2012.697500. Epub 2012 Jul 20. Review.

PMID:
22817636
13.

Combined electron transfer dissociation-collision-induced dissociation fragmentation in the mass spectrometric distinction of leucine, isoleucine, and hydroxyproline residues in Peptide natural products.

Gupta K, Kumar M, Chandrashekara K, Krishnan KS, Balaram P.

J Proteome Res. 2012 Feb 3;11(2):515-22. doi: 10.1021/pr200091v. Epub 2011 Dec 28.

PMID:
22111579
14.

"Entitlement, no! Gratitude, yes!".

Krishnan KS, Wu CF.

J Neurogenet. 2011 Oct;25(3):63-77. doi: 10.3109/01677063.2011.608137. Epub 2011 Aug 23. No abstract available.

PMID:
21861594
15.

Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells.

Swetha MG, Sriram V, Krishnan KS, Oorschot VM, ten Brink C, Klumperman J, Mayor S.

Traffic. 2011 Aug;12(8):1037-55. doi: 10.1111/j.1600-0854.2011.01214.x. Epub 2011 May 30.

16.

Access to enantiomerically enriched cis-2,3-disubstituted azetidines via diastereoselective hydrozirconation.

Pradhan TK, Krishnan KS, Vasse JL, Szymoniak J.

Org Lett. 2011 Apr 1;13(7):1793-5. doi: 10.1021/ol200323r. Epub 2011 Mar 8.

PMID:
21384824
17.

Synaptic vesicle recycling: genetic and cell biological studies.

Majumder R, Krishnan KS.

J Neurogenet. 2010 Sep;24(3):146-57. doi: 10.3109/01677063.2010.506229. Review.

PMID:
20807099
18.

Syndapin promotes formation of a postsynaptic membrane system in Drosophila.

Kumar V, Fricke R, Bhar D, Reddy-Alla S, Krishnan KS, Bogdan S, Ramaswami M.

Mol Biol Cell. 2009 Apr;20(8):2254-64. doi: 10.1091/mbc.E08-10-1072. Epub 2009 Feb 25.

19.

Syndapin is dispensable for synaptic vesicle endocytosis at the Drosophila larval neuromuscular junction.

Kumar V, Alla SR, Krishnan KS, Ramaswami M.

Mol Cell Neurosci. 2009 Feb;40(2):234-41. doi: 10.1016/j.mcn.2008.10.011. Epub 2008 Nov 12.

20.

Conantokin-P, an unusual conantokin with a long disulfide loop.

Gowd KH, Twede V, Watkins M, Krishnan KS, Teichert RW, Bulaj G, Olivera BM.

Toxicon. 2008 Aug 1;52(2):203-13. doi: 10.1016/j.toxicon.2008.04.178. Epub 2008 Jun 3.

21.

Probing peptide libraries from Conus achatinus using mass spectrometry and cDNA sequencing: identification of delta and omega-conotoxins.

Gowd KH, Dewan KK, Iengar P, Krishnan KS, Balaram P.

J Mass Spectrom. 2008 Jun;43(6):791-805. doi: 10.1002/jms.1377.

PMID:
18286662
22.

Identification of Conus amadis disulfide isomerase: minimum sequence length of peptide fragments necessary for protein annotation.

Gowd KH, Krishnan KS, Balaram P.

Mol Biosyst. 2007 Aug;3(8):554-66. Epub 2007 Jun 27.

PMID:
17639131
23.

Sequencing of T-superfamily conotoxins from Conus virgo: pyroglutamic acid identification and disulfide arrangement by MALDI mass spectrometry.

Mandal AK, Ramasamy MR, Sabareesh V, Openshaw ME, Krishnan KS, Balaram P.

J Am Soc Mass Spectrom. 2007 Aug;18(8):1396-404. Epub 2007 Apr 24.

25.

Solution structure of delta-Am2766: a highly hydrophobic delta-conotoxin from Conus amadis that inhibits inactivation of neuronal voltage-gated sodium channels.

Sarma SP, Kumar GS, Sudarslal S, Iengar P, Ramasamy P, Sikdar SK, Krishnan KS, Balaram P.

Chem Biodivers. 2005 Apr;2(4):535-56.

PMID:
17192003
26.

De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry.

Nair SS, Nilsson CL, Emmett MR, Schaub TM, Gowd KH, Thakur SS, Krishnan KS, Balaram P, Marshall AG.

Anal Chem. 2006 Dec 1;78(23):8082-8.

27.

Characterization of contryphans from Conus loroisii and Conus amadis that target calcium channels.

Sabareesh V, Gowd KH, Ramasamy P, Sudarslal S, Krishnan KS, Sikdar SK, Balaram P.

Peptides. 2006 Nov;27(11):2647-54. Epub 2006 Sep 1.

PMID:
16945451
28.

Novel peptides of therapeutic promise from Indian Conidae.

Gowd KH, Sabareesh V, Sudarslal S, Iengar P, Franklin B, Fernando A, Dewan K, Ramaswami M, Sarma SP, Sikdar S, Balaram P, Krishnan KS.

Ann N Y Acad Sci. 2005 Nov;1056:462-73.

PMID:
16387709
29.

Analysis of conditional paralytic mutants in Drosophila sarco-endoplasmic reticulum calcium ATPase reveals novel mechanisms for regulating membrane excitability.

Sanyal S, Consoulas C, Kuromi H, Basole A, Mukai L, Kidokoro Y, Krishnan KS, Ramaswami M.

Genetics. 2005 Feb;169(2):737-50. Epub 2004 Nov 1.

30.

A novel 13 residue acyclic peptide from the marine snail, Conus monile, targets potassium channels.

Sudarslal S, Singaravadivelan G, Ramasamy P, Ananda K, Sarma SP, Sikdar SK, Krishnan KS, Balaram P.

Biochem Biophys Res Commun. 2004 May 7;317(3):682-8.

PMID:
15081394
32.

Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail.

Sudarslal S, Majumdar S, Ramasamy P, Dhawan R, Pal PP, Ramaswami M, Lala AK, Sikdar SK, Sarma SP, Krishnan KS, Balaram P.

FEBS Lett. 2003 Oct 9;553(1-2):209-12.

33.
34.
35.

Unique biochemical and behavioral alterations in Drosophila shibire(ts1) mutants imply a conformational state affecting dynamin subcellular distribution and synaptic vesicle cycling.

Chen ML, Green D, Liu L, Lam YC, Mukai L, Rao S, Ramagiri S, Krishnan KS, Engel JE, Lin JJ, Wu CF.

J Neurobiol. 2002 Nov 15;53(3):319-29.

36.

Endophilin is critically required for synapse formation and function in Drosophila melanogaster.

Rikhy R, Kumar V, Mittal R, Krishnan KS.

J Neurosci. 2002 Sep 1;22(17):7478-84.

38.

Lethal comatose mutation in Drosophila reveals possible role for NSF in neurogenesis.

Sanyal S, Krishnan KS.

Neuroreport. 2001 May 25;12(7):1363-6.

PMID:
11388412
39.

Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling.

Krishnan KS, Rikhy R, Rao S, Shivalkar M, Mosko M, Narayanan R, Etter P, Estes PS, Ramaswami M.

Neuron. 2001 Apr;30(1):197-210.

40.

Drosophila stoned proteins regulate the rate and fidelity of synaptic vesicle internalization.

Stimson DT, Estes PS, Rao S, Krishnan KS, Kelly LE, Ramaswami M.

J Neurosci. 2001 May 1;21(9):3034-44.

41.

Genetics of anesthetic response: autosomal mutations that render Drosophila resistant to halothane.

Madhavan MC, Kumar RA, Krishnan KS.

Pharmacol Biochem Behav. 2000 Dec;67(4):749-57.

PMID:
11166065
43.
44.
45.

Alleviation of the temperature-sensitive paralytic phenotype of shibire(ts) mutants in Drosophila by sub-anesthetic concentrations of carbon dioxide.

Krishnan KS, Chakravarty S, Rao S, Raghuram V, Ramaswami M.

J Neurogenet. 1996 Sep;10(4):221-38.

PMID:
8923296
46.

Traffic of dynamin within individual Drosophila synaptic boutons relative to compartment-specific markers.

Estes PS, Roos J, van der Bliek A, Kelly RB, Krishnan KS, Ramaswami M.

J Neurosci. 1996 Sep 1;16(17):5443-56.

47.

Distinct roles for N-ethylmaleimide-sensitive fusion protein (NSF) suggested by the identification of a second Drosophila NSF homolog.

Pallanck L, Ordway RW, Ramaswami M, Chi WY, Krishnan KS, Ganetzky B.

J Biol Chem. 1995 Aug 11;270(32):18742-4.

48.

Mutations that affect ion channels change the sensitivity of Drosophila melanogaster to volatile anesthetics.

Leibovitch BA, Campbell DB, Krishnan KS, Nash HA.

J Neurogenet. 1995 Apr;10(1):1-13.

PMID:
8618174
49.
50.

Genetic studies on dynamin function in Drosophila.

Ramaswami M, Rao S, van der Bliek A, Kelly RB, Krishnan KS.

J Neurogenet. 1993 Dec;9(2):73-87.

PMID:
8126598

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