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Items: 28

1.

Dissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle.

Campbell G, Krishnan KJ, Deschauer M, Taylor RW, Turnbull DM.

Hum Mol Genet. 2014 Sep 1;23(17):4612-20. doi: 10.1093/hmg/ddu176. Epub 2014 Apr 15.

2.

Late-onset respiratory failure due to TK2 mutations causing multiple mtDNA deletions.

Alston CL, Schaefer AM, Raman P, Solaroli N, Krishnan KJ, Blakely EL, He L, Craig K, Roberts M, Vyas A, Nixon J, Horvath R, Turnbull DM, Karlsson A, Gorman GS, Taylor RW.

Neurology. 2013 Dec 3;81(23):2051-3. doi: 10.1212/01.wnl.0000436931.94291.e6. Epub 2013 Nov 6.

3.

Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis.

Campbell GR, Kraytsberg Y, Krishnan KJ, Ohno N, Ziabreva I, Reeve A, Trapp BD, Newcombe J, Reynolds R, Lassmann H, Khrapko K, Turnbull DM, Mahad DJ.

Acta Neuropathol. 2012 Aug;124(2):209-20. doi: 10.1007/s00401-012-1001-9. Epub 2012 Jun 12.

4.

Relationship between mitochondria and α-synuclein: a study of single substantia nigra neurons.

Reeve AK, Park TK, Jaros E, Campbell GR, Lax NZ, Hepplewhite PD, Krishnan KJ, Elson JL, Morris CM, McKeith IG, Turnbull DM.

Arch Neurol. 2012 Mar;69(3):385-93. doi: 10.1001/archneurol.2011.2675.

PMID:
22410447
5.

Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease.

Krishnan KJ, Ratnaike TE, De Gruyter HL, Jaros E, Turnbull DM.

Neurobiol Aging. 2012 Sep;33(9):2210-4. doi: 10.1016/j.neurobiolaging.2011.08.009. Epub 2011 Sep 16.

PMID:
21925769
6.

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis.

Campbell GR, Ziabreva I, Reeve AK, Krishnan KJ, Reynolds R, Howell O, Lassmann H, Turnbull DM, Mahad DJ.

Ann Neurol. 2011 Mar;69(3):481-92. doi: 10.1002/ana.22109. Epub 2010 Nov 8.

7.

Repeats, longevity and the sources of mtDNA deletions: evidence from 'deletional spectra'.

Guo X, Popadin KY, Markuzon N, Orlov YL, Kraytsberg Y, Krishnan KJ, Zsurka G, Turnbull DM, Kunz WS, Khrapko K.

Trends Genet. 2010 Aug;26(8):340-3. doi: 10.1016/j.tig.2010.05.006. Epub 2010 Jun 28.

8.

Mitochondrial DNA and genetic disease.

Krishnan KJ, Turnbull DM.

Essays Biochem. 2010;47:139-51. doi: 10.1042/bse0470139. Review.

PMID:
20533905
9.

Older mothers are not at risk of having grandchildren with sporadic mtDNA deletions.

Elson JL, Apabhai S, Gorman G, Whittaker RG, Krishnan KJ.

Genet Med. 2010 May;12(5):313-4. doi: 10.1097/GIM.0b013e3181da76e3.

PMID:
20474085
10.

Detection of mitochondrial DNA variation in human cells.

Krishnan KJ, Blackwood JK, Reeve AK, Turnbull DM, Taylor RW.

Methods Mol Biol. 2010;628:227-57. doi: 10.1007/978-1-60327-367-1_13.

PMID:
20238085
11.

Mitochondrial DNA defects and selective extraocular muscle involvement in CPEO.

Greaves LC, Yu-Wai-Man P, Blakely EL, Krishnan KJ, Beadle NE, Kerin J, Barron MJ, Griffiths PG, Dickinson AJ, Turnbull DM, Taylor RW.

Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3340-6. doi: 10.1167/iovs.09-4659. Epub 2010 Feb 17.

12.

The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons.

Reeve AK, Krishnan KJ, Taylor G, Elson JL, Bender A, Taylor RW, Morris CM, Turnbull DM.

Aging Cell. 2009 Aug;8(4):496-8. doi: 10.1111/j.1474-9726.2009.00492.x. Epub 2009 May 31.

13.

Alpha-synuclein pathology and Parkinsonism associated with POLG1 mutations and multiple mitochondrial DNA deletions.

Betts-Henderson J, Jaros E, Krishnan KJ, Perry RH, Reeve AK, Schaefer AM, Taylor RW, Turnbull DM.

Neuropathol Appl Neurobiol. 2009 Feb;35(1):120-4. doi: 10.1111/j.1365-2990.2008.00981.x. No abstract available.

PMID:
19187065
14.

Mitochondrial DNA mutations in disease, aging, and neurodegeneration.

Reeve AK, Krishnan KJ, Turnbull D.

Ann N Y Acad Sci. 2008 Dec;1147:21-9. doi: 10.1196/annals.1427.016. Review.

PMID:
19076427
15.

Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions.

Bender A, Schwarzkopf RM, McMillan A, Krishnan KJ, Rieder G, Neumann M, Elstner M, Turnbull DM, Klopstock T.

J Neurol. 2008 Aug;255(8):1231-5. doi: 10.1007/s00415-008-0892-9. Epub 2008 Jul 11.

PMID:
18604467
16.

Age related mitochondrial degenerative disorders in humans.

Reeve AK, Krishnan KJ, Turnbull DM.

Biotechnol J. 2008 Jun;3(6):750-6. doi: 10.1002/biot.200800066. Review.

PMID:
18512864
17.

What causes mitochondrial DNA deletions in human cells?

Krishnan KJ, Reeve AK, Samuels DC, Chinnery PF, Blackwood JK, Taylor RW, Wanrooij S, Spelbrink JN, Lightowlers RN, Turnbull DM.

Nat Genet. 2008 Mar;40(3):275-9. doi: 10.1038/ng.f.94. Review.

PMID:
18305478
18.

Nature of mitochondrial DNA deletions in substantia nigra neurons.

Reeve AK, Krishnan KJ, Elson JL, Morris CM, Bender A, Lightowlers RN, Turnbull DM.

Am J Hum Genet. 2008 Jan;82(1):228-35. doi: 10.1016/j.ajhg.2007.09.018.

19.

Do mitochondrial DNA mutations have a role in neurodegenerative disease?

Krishnan KJ, Reeve AK, Turnbull DM.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1232-5. Review.

PMID:
17956320
20.

The ageing mitochondrial genome.

Krishnan KJ, Greaves LC, Reeve AK, Turnbull D.

Nucleic Acids Res. 2007;35(22):7399-405. Epub 2007 Oct 2. Review.

21.

A multiplex real-time PCR method to detect and quantify mitochondrial DNA deletions in individual cells.

Krishnan KJ, Bender A, Taylor RW, Turnbull DM.

Anal Biochem. 2007 Nov 1;370(1):127-9. Epub 2007 Jun 21. No abstract available.

PMID:
17662684
22.

Mitochondrial DNA mutations and aging.

Krishnan KJ, Greaves LC, Reeve AK, Turnbull DM.

Ann N Y Acad Sci. 2007 Apr;1100:227-40. Review.

PMID:
17460184
23.

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease.

Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, Taylor RW, Turnbull DM.

Nat Genet. 2006 May;38(5):515-7. Epub 2006 Apr 9.

PMID:
16604074
25.

The use of a 3895 bp mitochondrial DNA deletion as a marker for sunlight exposure in human skin.

Krishnan KJ, Harbottle A, Birch-Machin MA.

J Invest Dermatol. 2004 Dec;123(6):1020-4. Erratum in: J Invest Dermatol. 2005 May;124(5):1092.

26.

Implications of using the ND1 gene as a control region for real-time PCR analysis of mitochondrial DNA deletions in human skin.

Harbottle A, Krishnan KJ, Birch-Machin MA.

J Invest Dermatol. 2004 Jun;122(6):1518-21. No abstract available.

27.

Current pitfalls in the measurement of the 4977 bp mitochondrial DNA common deletion in human skin.

Krishnan KJ, Lindsey J, Lusher M, Lowes S, Birch-Machin MA.

J Invest Dermatol. 2003 Jun;120(6):981-2. No abstract available.

PMID:
12787124
28.

Mitochondrial DNA damage in non-melanoma skin cancer.

Durham SE, Krishnan KJ, Betts J, Birch-Machin MA.

Br J Cancer. 2003 Jan 13;88(1):90-5.

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