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Items: 48


Optimized acriflavine-loaded lipid nanocapsules as a safe and effective delivery system to treat breast cancer.

Montigaud Y, Ucakar B, Krishnamachary B, Bhujwalla ZM, Feron O, Préat V, Danhier F, Gallez B, Danhier P.

Int J Pharm. 2018 Nov 15;551(1-2):322-328. doi: 10.1016/j.ijpharm.2018.09.034. Epub 2018 Sep 17.


Molecular causes of elevated phosphoethanolamine in breast and pancreatic cancer cells.

Shah T, Krishnamachary B, Wildes F, Wijnen JP, Glunde K, Bhujwalla ZM.

NMR Biomed. 2018 Aug;31(8):e3936. doi: 10.1002/nbm.3936. Epub 2018 Jun 21.


Hypoxia-Induced Reporter Genes with Different Half-Lives.

Krishnamachary B, Danhier P, Kakkad S, Bharti SK, Bhujwalla ZM.

Methods Mol Biol. 2018;1790:113-125. doi: 10.1007/978-1-4939-7860-1_9.


Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft.

Bharti SK, Mironchik Y, Wildes F, Penet MF, Goggins E, Krishnamachary B, Bhujwalla ZM.

Oncotarget. 2018 Feb 24;9(20):15326-15339. doi: 10.18632/oncotarget.24569. eCollection 2018 Mar 16.


Acid-degradable Dextran as an Image Guided siRNA Carrier for COX-2 Downregulation.

Chen Z, Krishnamachary B, Penet MF, Bhujwalla ZM.

Theranostics. 2018 Jan 1;8(1):1-12. doi: 10.7150/thno.21052. eCollection 2018.


Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts.

Goggins E, Kakkad S, Mironchik Y, Jacob D, Wildes F, Krishnamachary B, Bhujwalla ZM.

Neoplasia. 2018 Feb;20(2):131-139. doi: 10.1016/j.neo.2017.11.010. Epub 2017 Dec 13.


Delayed Progression of Lung Metastases Following Delivery of a Prodrug-activating Enzyme.

Dore-Savard L, Chen Z, Winnard PT Jr, Krishnamachary B, Raman V, Black ME, Bhujwalla ZM.

Anticancer Res. 2017 May;37(5):2195-2200.


Degradable Dextran Nanopolymer as a Carrier for Choline Kinase (ChoK) siRNA Cancer Therapy.

Chen Z, Krishnamachary B, Bhujwalla ZM.

Nanomaterials (Basel). 2016 Feb 22;6(2). pii: E34. doi: 10.3390/nano6020034.


Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts.

Krishnamachary B, Stasinopoulos I, Kakkad S, Penet MF, Jacob D, Wildes F, Mironchik Y, Pathak AP, Solaiyappan M, Bhujwalla ZM.

Oncotarget. 2017 Mar 14;8(11):17981-17994. doi: 10.18632/oncotarget.14912.


Effect of Pantethine on Ovarian Tumor Progression and Choline Metabolism.

Penet MF, Krishnamachary B, Wildes F, Mironchik Y, Mezzanzanica D, Podo F, de Reggi M, Gharib B, Bhujwalla ZM.

Front Oncol. 2016 Nov 16;6:244. eCollection 2016.


Structure and Function of a Prostate Cancer Dissemination-Permissive Extracellular Matrix.

Penet MF, Kakkad S, Pathak AP, Krishnamachary B, Mironchik Y, Raman V, Solaiyappan M, Bhujwalla ZM.

Clin Cancer Res. 2017 May 1;23(9):2245-2254. doi: 10.1158/1078-0432.CCR-16-1516. Epub 2016 Oct 31.


Collagen fibers mediate MRI-detected water diffusion and anisotropy in breast cancers.

Kakkad S, Zhang J, Akhbardeh A, Jacob D, Krishnamachary B, Solaiyappan M, Jacobs MA, Raman V, Leibfritz D, Glunde K, Bhujwalla ZM.

Neoplasia. 2016 Oct;18(10):585-593. doi: 10.1016/j.neo.2016.08.004. Epub 2016 Sep 19.


Choline Metabolism Alteration: A Focus on Ovarian Cancer.

Bagnoli M, Granata A, Nicoletti R, Krishnamachary B, Bhujwalla ZM, Canese R, Podo F, Canevari S, Iorio E, Mezzanzanica D.

Front Oncol. 2016 Jun 22;6:153. doi: 10.3389/fonc.2016.00153. eCollection 2016. Review.


Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion.

Cao MD, Cheng M, Rizwan A, Jiang L, Krishnamachary B, Bhujwalla ZM, Bathen TF, Glunde K.

NMR Biomed. 2016 Aug;29(8):1098-107. doi: 10.1002/nbm.3573. Epub 2016 Jun 30.


Phototheranostics of CD44-positive cell populations in triple negative breast cancer.

Jin J, Krishnamachary B, Mironchik Y, Kobayashi H, Bhujwalla ZM.

Sci Rep. 2016 Jun 15;6:27871. doi: 10.1038/srep27871.


PSMA-specific theranostic nanoplex for combination of TRAIL gene and 5-FC prodrug therapy of prostate cancer.

Chen Z, Penet MF, Krishnamachary B, Banerjee SR, Pomper MG, Bhujwalla ZM.

Biomaterials. 2016 Feb;80:57-67. doi: 10.1016/j.biomaterials.2015.11.048. Epub 2015 Dec 2.


Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors.

Danhier P, Krishnamachary B, Bharti S, Kakkad S, Mironchik Y, Bhujwalla ZM.

Neoplasia. 2015 Dec;17(12):871-881. doi: 10.1016/j.neo.2015.11.007.


Magnetic Resonance Spectroscopy of siRNA-Based Cancer Therapy.

Penet MF, Chen Z, Mori N, Krishnamachary B, Bhujwalla ZM.

Methods Mol Biol. 2016;1372:37-47. doi: 10.1007/978-1-4939-3148-4_3.


Breast cancer cell adhesome and degradome interact to drive metastasis.

Rizwan A, Cheng M, Bhujwalla ZM, Krishnamachary B, Jiang L, Glunde K.

NPJ Breast Cancer. 2015 Oct 28;1:15017. doi: 10.1038/npjbcancer.2015.17. eCollection 2015.


Imaging transplanted stem cells in real time using an MRI dual-contrast method.

Ngen EJ, Wang L, Kato Y, Krishnamachary B, Zhu W, Gandhi N, Smith B, Armour M, Wong J, Gabrielson K, Artemov D.

Sci Rep. 2015 Sep 2;5:13628. doi: 10.1038/srep13628.


HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets.

Shah T, Krishnamachary B, Wildes F, Mironchik Y, Kakkad SM, Jacob D, Artemov D, Bhujwalla ZM.

Oncotarget. 2015 Sep 29;6(29):28104-19. doi: 10.18632/oncotarget.4612.


Metastatic breast cancer cells in lymph nodes increase nodal collagen density.

Rizwan A, Bulte C, Kalaichelvan A, Cheng M, Krishnamachary B, Bhujwalla ZM, Jiang L, Glunde K.

Sci Rep. 2015 May 7;5:10002. doi: 10.1038/srep10002.


Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma.

Granata A, Nicoletti R, Perego P, Iorio E, Krishnamachary B, Benigni F, Ricci A, Podo F, Bhujwalla ZM, Canevari S, Bagnoli M, Mezzanzanica D.

Oncotarget. 2015 May 10;6(13):11216-30.


Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism.

Penet MF, Shah T, Bharti S, Krishnamachary B, Artemov D, Mironchik Y, Wildes F, Maitra A, Bhujwalla ZM.

Clin Cancer Res. 2015 Jan 15;21(2):386-95. doi: 10.1158/1078-0432.CCR-14-0964. Epub 2014 Nov 4.


Molecular imaging of the tumor microenvironment for precision medicine and theranostics.

Penet MF, Krishnamachary B, Chen Z, Jin J, Bhujwalla ZM.

Adv Cancer Res. 2014;124:235-56. doi: 10.1016/B978-0-12-411638-2.00007-0. Review.


Silencing of the glycerophosphocholine phosphodiesterase GDPD5 alters the phospholipid metabolite profile in a breast cancer model in vivo as monitored by (31) P MRS.

Wijnen JP, Jiang L, Greenwood TR, Cheng M, Döpkens M, Cao MD, Bhujwalla ZM, Krishnamachary B, Klomp DW, Glunde K.

NMR Biomed. 2014 Jun;27(6):692-9. doi: 10.1002/nbm.3106. Epub 2014 Apr 24.


Phospholipase D1 and choline kinase-α are interactive targets in breast cancer.

Gadiya M, Mori N, Cao MD, Mironchik Y, Kakkad S, Gribbestad IS, Glunde K, Krishnamachary B, Bhujwalla ZM.

Cancer Biol Ther. 2014 May;15(5):593-601. doi: 10.4161/cbt.28165. Epub 2014 Feb 20.


Characterization of choline kinase in human endothelial cells.

Mori N, Gadiya M, Wildes F, Krishnamachary B, Glunde K, Bhujwalla ZM.

NMR Biomed. 2013 Nov;26(11):1501-7. doi: 10.1002/nbm.2983. Epub 2013 Jun 18.


COX-2 in cancer: Gordian knot or Achilles heel?

Stasinopoulos I, Shah T, Penet MF, Krishnamachary B, Bhujwalla ZM.

Front Pharmacol. 2013 Mar 28;4:34. doi: 10.3389/fphar.2013.00034. eCollection 2013.


Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.

Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM.

PLoS One. 2012;7(8):e44078. doi: 10.1371/journal.pone.0044078. Epub 2012 Aug 28.


Scientific validation of the different purification steps involved in the preparation of an Indian Ayurvedic medicine, Lauha bhasma.

Krishnamachary B, Rajendran N, Pemiah B, Krishnaswamy S, Krishnan UM, Sethuraman S, Sekar RK.

J Ethnopharmacol. 2012 Jun 26;142(1):98-104. doi: 10.1016/j.jep.2012.04.021. Epub 2012 Apr 26.


Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer.

Cao MD, Döpkens M, Krishnamachary B, Vesuna F, Gadiya MM, Lønning PE, Bhujwalla ZM, Gribbestad IS, Glunde K.

NMR Biomed. 2012 Sep;25(9):1033-42. doi: 10.1002/nbm.2766. Epub 2012 Jan 26.


Metabolic signatures imaged in cancer-induced cachexia.

Penet MF, Gadiya MM, Krishnamachary B, Nimmagadda S, Pomper MG, Artemov D, Bhujwalla ZM.

Cancer Res. 2011 Nov 15;71(22):6948-56. doi: 10.1158/0008-5472.CAN-11-1095. Epub 2011 Sep 26.


HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.

Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT Jr, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL.

Oncogene. 2012 Apr 5;31(14):1757-70. doi: 10.1038/onc.2011.365. Epub 2011 Aug 22.


Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells.

Botlagunta M, Krishnamachary B, Vesuna F, Winnard PT Jr, Bol GM, Patel AH, Raman V.

PLoS One. 2011 Mar 23;6(3):e17563. doi: 10.1371/journal.pone.0017563.


Applications of molecular MRI and optical imaging in cancer.

Penet MF, Mikhaylova M, Li C, Krishnamachary B, Glunde K, Pathak AP, Bhujwalla ZM.

Future Med Chem. 2010 Jun;2(6):975-88. Review.


Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells.

Fijalkowska I, Xu W, Comhair SA, Janocha AJ, Mavrakis LA, Krishnamachary B, Zhen L, Mao T, Richter A, Erzurum SC, Tuder RM.

Am J Pathol. 2010 Mar;176(3):1130-8. doi: 10.2353/ajpath.2010.090832. Epub 2010 Jan 28.


Molecular and functional imaging of invasion and metastasis: windows into the metastatic cascade.

Stasinopoulos I, Penet MF, Krishnamachary B, Bhujwalla ZM.

Cancer Biomark. 2010;7(4):173-88. doi: 10.3233/CBM-2010-0188.


Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft.

Krishnamachary B, Glunde K, Wildes F, Mori N, Takagi T, Raman V, Bhujwalla ZM.

Cancer Res. 2009 Apr 15;69(8):3464-71. doi: 10.1158/0008-5472.CAN-08-4120. Epub 2009 Mar 31.


Hypoxia-induced human endonuclease G expression suppresses tumor growth in a xenograft model.

Winnard PT Jr, Botlagunta M, Kluth JB, Mukadam S, Krishnamachary B, Vesuna F, Raman V.

Cancer Gene Ther. 2008 Oct;15(10):645-54. doi: 10.1038/cgt.2008.39. Epub 2008 Jun 13.


Analysis of hypoxia-inducible factor 1alpha expression and its effects on invasion and metastasis.

Krishnamachary B, Semenza GL.

Methods Enzymol. 2007;435:347-54.


HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.

Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL.

Cancer Cell. 2007 May;11(5):407-20.


Spontaneous transformation of cultured mouse bone marrow-derived stromal cells.

Zhou YF, Bosch-Marce M, Okuyama H, Krishnamachary B, Kimura H, Zhang L, Huso DL, Semenza GL.

Cancer Res. 2006 Nov 15;66(22):10849-54.


Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.

Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL.

J Biol Chem. 2006 Jun 2;281(22):15554-63. Epub 2006 Mar 30.


Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL.

Cancer Res. 2006 Mar 1;66(5):2725-31.


OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.

Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL.

Mol Cell. 2005 Feb 18;17(4):503-12.


Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.

Krishnamachary B, Berg-Dixon S, Kelly B, Agani F, Feldser D, Ferreira G, Iyer N, LaRusch J, Pak B, Taghavi P, Semenza GL.

Cancer Res. 2003 Mar 1;63(5):1138-43.

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