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Items: 34


Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin.

Grushin K, Wang J, Coleman J, Rothman JE, Sindelar CV, Krishnakumar SS.

Nat Commun. 2019 Jun 3;10(1):2413. doi: 10.1038/s41467-019-10391-x.


Mechanisms of Neurological Dysfunction in GOSR2 Progressive Myoclonus Epilepsy, a Golgi SNAREopathy.

Jepson JEC, Praschberger R, Krishnakumar SS.

Neuroscience. 2019 Apr 4. pii: S0306-4522(19)30219-2. doi: 10.1016/j.neuroscience.2019.03.057. [Epub ahead of print] Review.


Mutations in the Neuronal Vesicular SNARE VAMP2 Affect Synaptic Membrane Fusion and Impair Human Neurodevelopment.

Salpietro V, Malintan NT, Llano-Rivas I, Spaeth CG, Efthymiou S, Striano P, Vandrovcova J, Cutrupi MC, Chimenz R, David E, Di Rosa G, Marce-Grau A, Raspall-Chaure M, Martin-Hernandez E, Zara F, Minetti C; Deciphering Developmental Disorders Study; SYNAPS Study Group, Bello OD, De Zorzi R, Fortuna S, Dauber A, Alkhawaja M, Sultan T, Mankad K, Vitobello A, Thomas Q, Mau-Them FT, Faivre L, Martinez-Azorin F, Prada CE, Macaya A, Kullmann DM, Rothman JE, Krishnakumar SS, Houlden H.

Am J Hum Genet. 2019 Apr 4;104(4):721-730. doi: 10.1016/j.ajhg.2019.02.016. Epub 2019 Mar 28.


Synaptotagmin oligomers are necessary and can be sufficient to form a Ca2+ -sensitive fusion clamp.

Ramakrishnan S, Bera M, Coleman J, Krishnakumar SS, Pincet F, Rothman JE.

FEBS Lett. 2019 Jan;593(2):154-162. doi: 10.1002/1873-3468.13317. Epub 2019 Jan 18.


Symmetrical organization of proteins under docked synaptic vesicles.

Li X, Radhakrishnan A, Grushin K, Kasula R, Chaudhuri A, Gomathinayagam S, Krishnakumar SS, Liu J, Rothman JE.

FEBS Lett. 2019 Jan;593(2):144-153. doi: 10.1002/1873-3468.13316. Epub 2019 Jan 18.


Using Nanodiscs to Probe Ca2+-Dependent Membrane Interaction of Synaptotagmin-1.

Stroeva E, Krishnakumar SS.

Methods Mol Biol. 2019;1860:221-236. doi: 10.1007/978-1-4939-8760-3_14.


Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.

Bello OD, Jouannot O, Chaudhuri A, Stroeva E, Coleman J, Volynski KE, Rothman JE, Krishnakumar SS.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7624-E7631. doi: 10.1073/pnas.1808792115. Epub 2018 Jul 23.


Synergistic control of neurotransmitter release by different members of the synaptotagmin family.

Volynski KE, Krishnakumar SS.

Curr Opin Neurobiol. 2018 Aug;51:154-162. doi: 10.1016/j.conb.2018.05.006. Epub 2018 Jun 7. Review.


Rearrangements under confinement lead to increased binding energy of Synaptotagmin-1 with anionic membranes in Mg2+ and Ca2.

Gruget C, Coleman J, Bello O, Krishnakumar SS, Perez E, Rothman JE, Pincet F, Donaldson SH Jr.

FEBS Lett. 2018 May;592(9):1497-1506. doi: 10.1002/1873-3468.13040. Epub 2018 Apr 10.


PRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex Assembly.

Coleman J, Jouannot O, Ramakrishnan SK, Zanetti MN, Wang J, Salpietro V, Houlden H, Rothman JE, Krishnakumar SS.

Cell Rep. 2018 Jan 16;22(3):820-831. doi: 10.1016/j.celrep.2017.12.056.


Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses.

Michalski N, Goutman JD, Auclair SM, Boutet de Monvel J, Tertrais M, Emptoz A, Parrin A, Nouaille S, Guillon M, Sachse M, Ciric D, Bahloul A, Hardelin JP, Sutton RB, Avan P, Krishnakumar SS, Rothman JE, Dulon D, Safieddine S, Petit C.

Elife. 2017 Nov 7;6. pii: e31013. doi: 10.7554/eLife.31013.


Hypothesis - buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission.

Rothman JE, Krishnakumar SS, Grushin K, Pincet F.

FEBS Lett. 2017 Nov;591(21):3459-3480. doi: 10.1002/1873-3468.12874. Epub 2017 Oct 31. Review.


Mutations in Membrin/GOSR2 Reveal Stringent Secretory Pathway Demands of Dendritic Growth and Synaptic Integrity.

Praschberger R, Lowe SA, Malintan NT, Giachello CNG, Patel N, Houlden H, Kullmann DM, Baines RA, Usowicz MM, Krishnakumar SS, Hodge JJL, Rothman JE, Jepson JEC.

Cell Rep. 2017 Oct 3;21(1):97-109. doi: 10.1016/j.celrep.2017.09.004.


Correction: Re-visiting the trans insertion model for complexin clamping.

Krishnakumar SS, Li F, Coleman J, Schauder CM, Kümmel D, Pincet F, Rothman JE, Reinisch KM.

Elife. 2017 Sep 7;6. pii: e31512. doi: 10.7554/eLife.31512. No abstract available.


Circular oligomerization is an intrinsic property of synaptotagmin.

Wang J, Li F, Bello OD, Sindelar CV, Pincet F, Krishnakumar SS, Rothman JE.

Elife. 2017 Aug 29;6. pii: e27441. doi: 10.7554/eLife.27441.


Dilation of fusion pores by crowding of SNARE proteins.

Wu Z, Bello OD, Thiyagarajan S, Auclair SM, Vennekate W, Krishnakumar SS, O'Shaughnessy B, Karatekin E.

Elife. 2017 Mar 27;6. pii: e22964. doi: 10.7554/eLife.22964.


Homozygous mutations in VAMP1 cause a presynaptic congenital myasthenic syndrome.

Salpietro V, Lin W, Delle Vedove A, Storbeck M, Liu Y, Efthymiou S, Manole A, Wiethoff S, Ye Q, Saggar A, McElreavey K, Krishnakumar SS; SYNAPS Study Group, Pitt M, Bello OD, Rothman JE, Basel-Vanagaite L, Hubshman MW, Aharoni S, Manzur AY, Wirth B, Houlden H.

Ann Neurol. 2017 Apr;81(4):597-603. doi: 10.1002/ana.24905. Epub 2017 Mar 29.


Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization.

Vivekananda U, Novak P, Bello OD, Korchev YE, Krishnakumar SS, Volynski KE, Kullmann DM.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2395-2400. doi: 10.1073/pnas.1608763114. Epub 2017 Feb 13.


Ring-like oligomers of Synaptotagmins and related C2 domain proteins.

Zanetti MN, Bello OD, Wang J, Coleman J, Cai Y, Sindelar CV, Rothman JE, Krishnakumar SS.

Elife. 2016 Jul 19;5. pii: e17262. doi: 10.7554/eLife.17262.


Nanodisc-cell fusion: control of fusion pore nucleation and lifetimes by SNARE protein transmembrane domains.

Wu Z, Auclair SM, Bello O, Vennekate W, Dudzinski NR, Krishnakumar SS, Karatekin E.

Sci Rep. 2016 Jun 6;6:27287. doi: 10.1038/srep27287.


Using ApoE Nanolipoprotein Particles To Analyze SNARE-Induced Fusion Pores.

Bello OD, Auclair SM, Rothman JE, Krishnakumar SS.

Langmuir. 2016 Mar 29;32(12):3015-23. doi: 10.1021/acs.langmuir.6b00245. Epub 2016 Mar 18.


Re-visiting the trans insertion model for complexin clamping.

Krishnakumar SS, Li F, Coleman J, Schauder CM, Kümmel D, Pincet F, Rothman JE, Reinisch KM.

Elife. 2015 Apr 2;4. pii: e04463. doi: 10.7554/eLife.04463. Erratum in: Elife. 2017 Sep 07;6:.


Calcium sensitive ring-like oligomers formed by synaptotagmin.

Wang J, Bello O, Auclair SM, Wang J, Coleman J, Pincet F, Krishnakumar SS, Sindelar CV, Rothman JE.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13966-71. doi: 10.1073/pnas.1415849111. Epub 2014 Sep 8.


Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin.

Krishnakumar SS, Kümmel D, Jones SJ, Radoff DT, Reinisch KM, Rothman JE.

Biophys J. 2013 Dec 3;105(11):2507-16. doi: 10.1016/j.bpj.2013.10.029.


Complexin cross-links prefusion SNAREs into a zigzag array.

Kümmel D, Krishnakumar SS, Radoff DT, Li F, Giraudo CG, Pincet F, Rothman JE, Reinisch KM.

Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33. doi: 10.1038/nsmb.2101.


A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion.

Krishnakumar SS, Radoff DT, Kümmel D, Giraudo CG, Li F, Khandan L, Baguley SW, Coleman J, Reinisch KM, Pincet F, Rothman JE.

Nat Struct Mol Biol. 2011 Jul 24;18(8):934-40. doi: 10.1038/nsmb.2103.


The control of transmembrane helix transverse position in membranes by hydrophilic residues.

Krishnakumar SS, London E.

J Mol Biol. 2007 Dec 14;374(5):1251-69. Epub 2007 Oct 17. Erratum in: J Mol Biol. 2009 Jul 24;390(4):830-3.


Effect of sequence hydrophobicity and bilayer width upon the minimum length required for the formation of transmembrane helices in membranes.

Krishnakumar SS, London E.

J Mol Biol. 2007 Nov 30;374(3):671-87. Epub 2007 Sep 20. Erratum in: J Mol Biol. 2008 Dec 19;384(3):740-1.


Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication.

Fujita K, Krishnakumar SS, Franco D, Paul AV, London E, Wimmer E.

Biochemistry. 2007 May 1;46(17):5185-99. Epub 2007 Apr 7.


Multiple-probe analysis of folding and unfolding pathways of human serum albumin. Evidence for a framework mechanism of folding.

Santra MK, Banerjee A, Krishnakumar SS, Rahaman O, Panda D.

Eur J Biochem. 2004 May;271(9):1789-97.


Glutamate-induced assembly of bacterial cell division protein FtsZ.

Beuria TK, Krishnakumar SS, Sahar S, Singh N, Gupta K, Meshram M, Panda D.

J Biol Chem. 2003 Feb 7;278(6):3735-41. Epub 2002 Nov 22.


Organisation of massive vasectomy camps--a study of the Erankulam experiment.

Krishnakumar SS.

J Indian Med Assoc. 1972 Oct 16;59(8):375-80. No abstract available.


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