Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 201


Towards reduction of SAR in scaling up in vivo pulsed EPR imaging to larger objects.

Pursley R, Enomoto A, Wu H, Brender JR, Pohida T, Subramanian S, Krishna MC, Devasahayam N.

J Magn Reson. 2019 Feb;299:42-48. doi: 10.1016/j.jmr.2018.12.011. Epub 2018 Dec 14.


Imaging Metabolic Processes to Predict Radiation Responses.

Naz S, Kishimoto S, Mitchell JB, Krishna MC.

Semin Radiat Oncol. 2019 Jan;29(1):81-89. doi: 10.1016/j.semradonc.2018.10.004. Review.


Synthesis and evaluation of 13C-labeled 5-5-dimethyl-1-pyrroline-N-oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized 13C-MRI.

Saito K, Sail D, Yamamoto K, Matsumoto S, Blackman B, Kishimoto S, Brender JR, Swenson RE, Mitchell JB, Krishna MC.

Free Radic Biol Med. 2019 Feb 1;131:18-26. doi: 10.1016/j.freeradbiomed.2018.11.013. Epub 2018 Nov 22.


A radical containing injectable in-situ-oleogel and emulgel for prolonged in-vivo oxygen measurements with CW EPR.

Lampp L, Rogozhnikova OY, Trukhin DV, Tormyshev VM, Bowman MK, Devasahayam N, Krishna MC, Mäder K, Imming P.

Free Radic Biol Med. 2019 Jan;130:120-127. doi: 10.1016/j.freeradbiomed.2018.10.442. Epub 2018 Oct 27.


Effects of oxygen challenging to tissue redox and pO2 status.

Matsumoto KI, Mitchell JB, Krishna MC.

Free Radic Biol Med. 2019 Jan;130:343-347. doi: 10.1016/j.freeradbiomed.2018.10.454. Epub 2018 Nov 2.


A Multimodal Molecular Imaging Study Evaluates Pharmacological Alteration of the Tumor Microenvironment to Improve Radiation Response.

Takakusagi Y, Naz S, Takakusagi K, Ishima M, Murata H, Ohta K, Miura M, Sugawara F, Sakaguchi K, Kishimoto S, Munasinghe JP, Mitchell JB, Krishna MC.

Cancer Res. 2018 Dec 15;78(24):6828-6837. doi: 10.1158/0008-5472.CAN-18-1654. Epub 2018 Oct 9.


Direct and indirect assessment of cancer metabolism explored by MRI.

Kishimoto S, Oshima N, Krishna MC, Gillies RJ.

NMR Biomed. 2018 Aug 31:e3966. doi: 10.1002/nbm.3966. [Epub ahead of print]


Three-dimensional alginate hydrogels for radiobiological and metabolic studies of cancer cells.

Read GH, Miura N, Carter JL, Kines KT, Yamamoto K, Devasahayam N, Cheng JY, Camphausen KA, Krishna MC, Kesarwala AH.

Colloids Surf B Biointerfaces. 2018 Nov 1;171:197-204. doi: 10.1016/j.colsurfb.2018.06.018. Epub 2018 Jun 18.


Co-imaging of the tumor oxygenation and metabolism using electron paramagnetic resonance imaging and 13-C hyperpolarized magnetic resonance imaging before and after irradiation.

Matsuo M, Kawai T, Kishimoto S, Saito K, Munasinghe J, Devasahayam N, Mitchell JB, Krishna MC.

Oncotarget. 2018 May 18;9(38):25089-25100. doi: 10.18632/oncotarget.25317. eCollection 2018 May 18.


Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice.

Matsumoto S, Kishimoto S, Saito K, Takakusagi Y, Munasinghe JP, Devasahayam N, Hart CP, Gillies RJ, Mitchell JB, Krishna MC.

Cancer Res. 2018 Jul 15;78(14):3783-3792. doi: 10.1158/0008-5472.CAN-18-0491. Epub 2018 May 23.


Wireless implantable coil with parametric amplification for in vivo electron paramagnetic resonance oximetric applications.

Enomoto A, Qian C, Devasahayam N, Kishimoto S, Oshima N, Blackman B, Swenson RE, Mitchell JB, Koretsky AP, Krishna MC.

Magn Reson Med. 2018 Nov;80(5):2288-2298. doi: 10.1002/mrm.27185. Epub 2018 Mar 30.


Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect.

Scroggins BT, Matsuo M, White AO, Saito K, Munasinghe JP, Sourbier C, Yamamoto K, Diaz V, Takakusagi Y, Ichikawa K, Mitchell JB, Krishna MC, Citrin DE.

Clin Cancer Res. 2018 Jul 1;24(13):3137-3148. doi: 10.1158/1078-0432.CCR-17-1957. Epub 2018 Mar 29.


EPR-based oximetric imaging: a combination of single point-based spatial encoding and T1 weighting.

Matsumoto KI, Kishimoto S, Devasahayam N, Chandramouli GVR, Ogawa Y, Matsumoto S, Krishna MC, Subramanian S.

Magn Reson Med. 2018 Nov;80(5):2275-2287. doi: 10.1002/mrm.27182. Epub 2018 Mar 26.


Cancer Incidence in C3H Mice Protected from Lethal Total-Body Radiation after Amifostine.

Cook JA, Naz S, Anver MR, Sowers AL, Fabre K, Krishna MC, Mitchell JB.

Radiat Res. 2018 May;189(5):490-496. doi: 10.1667/RR14987.1. Epub 2018 Mar 12.


Comparative studies with EPR and MRI on the in vivo tissue redox status estimation using redox-sensitive nitroxyl probes: influence of the choice of the region of interest.

Matsumoto KI, Mitchell JB, Krishna MC.

Free Radic Res. 2018 Feb;52(2):248-255. doi: 10.1080/10715762.2018.1427235. Epub 2018 Jan 31.


Molecular imaging of tumor photoimmunotherapy: Evidence of photosensitized tumor necrosis and hemodynamic changes.

Kishimoto S, Oshima N, Yamamoto K, Munasinghe J, Ardenkjaer-Larsen JH, Mitchell JB, Choyke PL, Krishna MC.

Free Radic Biol Med. 2018 Feb 20;116:1-10. doi: 10.1016/j.freeradbiomed.2017.12.034. Epub 2017 Dec 29.


Effect of body temperature on the pharmacokinetics of a triarylmethyl-type paramagnetic contrast agent used in EPR oximetry.

Matsumoto KI, Hyodo F, Mitchell JB, Krishna MC.

Magn Reson Med. 2018 Feb;79(2):1212-1218. doi: 10.1002/mrm.27008. Epub 2017 Nov 16.


Pulsed Electron Paramagnetic Resonance Imaging: Applications in the Studies of Tumor Physiology.

Kishimoto S, Matsumoto KI, Saito K, Enomoto A, Matsumoto S, Mitchell JB, Devasahayam N, Krishna MC.

Antioxid Redox Signal. 2018 May 20;28(15):1378-1393. doi: 10.1089/ars.2017.7391. Epub 2018 Jan 9.


Quantitative imaging of pO2 in orthotopic murine gliomas: hypoxia correlates with resistance to radiation.

Yasui H, Kawai T, Matsumoto S, Saito K, Devasahayam N, Mitchell JB, Camphausen K, Inanami O, Krishna MC.

Free Radic Res. 2017 Oct;51(9-10):861-871. doi: 10.1080/10715762.2017.1388506.


In Vivo Application of Proton-Electron Double-Resonance Imaging.

Kishimoto S, Krishna MC, Khramtsov VV, Utsumi H, Lurie DJ.

Antioxid Redox Signal. 2018 May 20;28(15):1345-1364. doi: 10.1089/ars.2017.7341. Epub 2017 Nov 13.


Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies.

Takakusagi Y, Kishimoto S, Naz S, Matsumoto S, Saito K, Hart CP, Mitchell JB, Krishna MC.

Antioxid Redox Signal. 2018 Jan 10;28(2):131-140. doi: 10.1089/ars.2017.7106. Epub 2017 Sep 8.


Effect of amifostine, a radiation-protecting drug, on oxygen concentration in tissue measured by EPR oximetry and imaging.

Ueno M, Matsumoto S, Matsumoto A, Manda S, Nakanishi I, Matsumoto KI, Mitchell JB, Krishna MC, Anzai K.

J Clin Biochem Nutr. 2017 May;60(3):151-155. doi: 10.3164/jcbn.15-130. Epub 2017 Mar 25.


Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.

Neveu MA, De Preter G, Joudiou N, Bol A, Brender JR, Saito K, Kishimoto S, Grégoire V, Jordan BF, Krishna MC, Feron O, Gallez B.

Oncotarget. 2016 Dec 6;7(49):81741-81749. doi: 10.18632/oncotarget.13176.


Accelerated electron paramagnetic resonance imaging using partial Fourier compressed sensing reconstruction.

Chou CC, Chandramouli GV, Shin T, Devasahayam N, McMillan A, Babadi B, Gullapalli R, Krishna MC, Zhuo J.

Magn Reson Imaging. 2017 Apr;37:90-99. doi: 10.1016/j.mri.2016.10.029. Epub 2016 Oct 29.


Multimodality Imaging Identifies Distinct Metabolic Profiles In Vitro and In Vivo.

Neveu MA, De Preter G, Marchand V, Bol A, Brender JR, Saito K, Kishimoto S, Porporato PE, Sonveaux P, Grégoire V, Feron O, Jordan BF, Krishna MC, Gallez B.

Neoplasia. 2016 Dec;18(12):742-752. doi: 10.1016/j.neo.2016.10.010. Epub 2016 Nov 24.


Evaluation of oxygen dependence on in vitro and in vivo cytotoxicity of photoimmunotherapy using IR-700-antibody conjugates.

Kishimoto S, Bernardo M, Saito K, Koyasu S, Mitchell JB, Choyke PL, Krishna MC.

Free Radic Biol Med. 2015 Aug;85:24-32. doi: 10.1016/j.freeradbiomed.2015.03.038. Epub 2015 Apr 8.


13C-MR Spectroscopic Imaging with Hyperpolarized [1-13C]pyruvate Detects Early Response to Radiotherapy in SCC Tumors and HT-29 Tumors.

Saito K, Matsumoto S, Takakusagi Y, Matsuo M, Morris HD, Lizak MJ, Munasinghe JP, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC.

Clin Cancer Res. 2015 Nov 15;21(22):5073-81. doi: 10.1158/1078-0432.CCR-14-1717. Epub 2015 Feb 11.


Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302.

Wojtkowiak JW, Cornnell HC, Matsumoto S, Saito K, Takakusagi Y, Dutta P, Kim M, Zhang X, Leos R, Bailey KM, Martinez G, Lloyd MC, Weber C, Mitchell JB, Lynch RM, Baker AF, Gatenby RA, Rejniak KA, Hart C, Krishna MC, Gillies RJ.

Cancer Metab. 2015 Jan 29;3(1):2. doi: 10.1186/s40170-014-0026-z. eCollection 2015.


Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.

Sourbier C, Ricketts CJ, Matsumoto S, Crooks DR, Liao PJ, Mannes PZ, Yang Y, Wei MH, Srivastava G, Ghosh S, Chen V, Vocke CD, Merino M, Srinivasan R, Krishna MC, Mitchell JB, Pendergast AM, Rouault TA, Neckers L, Linehan WM.

Cancer Cell. 2014 Dec 8;26(6):840-850. doi: 10.1016/j.ccell.2014.10.005.


Oxidative stress in oral diseases.

Kesarwala AH, Krishna MC, Mitchell JB.

Oral Dis. 2016 Jan;22(1):9-18. doi: 10.1111/odi.12300. Epub 2015 Jan 19. Review.


An efficient synthesis of 3-(N-piperidinemethyl)-2, 2, 5, 5-tetramethyl-1-oxy-3-pyrroline, a promising radioprotector for cancer radiotherapy.

Wu H, Coble V, Vasalatiy O, Swenson RE, Krishna MC, Mitchell JB.

Tetrahedron Lett. 2014 Oct 1;55(40):5570-5571.


Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.

Takakusagi Y, Matsumoto S, Saito K, Matsuo M, Kishimoto S, Wojtkowiak JW, DeGraff W, Kesarwala AH, Choudhuri R, Devasahayam N, Subramanian S, Munasinghe JP, Gillies RJ, Mitchell JB, Hart CP, Krishna MC.

PLoS One. 2014 Sep 25;9(9):e107995. doi: 10.1371/journal.pone.0107995. eCollection 2014.


Magnetic resonance imaging of the tumor microenvironment in radiotherapy: perfusion, hypoxia, and metabolism.

Matsuo M, Matsumoto S, Mitchell JB, Krishna MC, Camphausen K.

Semin Radiat Oncol. 2014 Jul;24(3):210-7. doi: 10.1016/j.semradonc.2014.02.002. Review.


Suberoylanilide hydroxamic acid radiosensitizes tumor hypoxic cells in vitro through the oxidation of nitroxyl to nitric oxide.

Samuni Y, Wink DA, Krishna MC, Mitchell JB, Goldstein S.

Free Radic Biol Med. 2014 Aug;73:291-8. doi: 10.1016/j.freeradbiomed.2014.05.019. Epub 2014 May 28.


Accelerated 4D quantitative single point EPR imaging using model-based reconstruction.

Jang H, Matsumoto S, Devasahayam N, Subramanian S, Zhuo J, Krishna MC, McMillan AB.

Magn Reson Med. 2015 Apr;73(4):1692-701. doi: 10.1002/mrm.25282. Epub 2014 May 6.


In vivo imaging of tumor physiological, metabolic, and redox changes in response to the anti-angiogenic agent sunitinib: longitudinal assessment to identify transient vascular renormalization.

Matsumoto S, Saito K, Takakusagi Y, Matsuo M, Munasinghe JP, Morris HD, Lizak MJ, Merkle H, Yasukawa K, Devasahayam N, Suburamanian S, Mitchell JB, Krishna MC.

Antioxid Redox Signal. 2014 Sep 10;21(8):1145-55. doi: 10.1089/ars.2013.5725. Epub 2014 Apr 7.


Magnetic resonance imaging of tumor oxygenation and metabolic profile.

Krishna MC, Matsumoto S, Saito K, Matsuo M, Mitchell JB, Ardenkjaer-Larsen JH.

Acta Oncol. 2013 Oct;52(7):1248-56. doi: 10.3109/0284186X.2013.819118. Epub 2013 Aug 19. Review.


Single acquisition quantitative single-point electron paramagnetic resonance imaging.

Jang H, Subramanian S, Devasahayam N, Saito K, Matsumoto S, Krishna MC, McMillan AB.

Magn Reson Med. 2013 Oct;70(4):1173-81. doi: 10.1002/mrm.24886. Epub 2013 Aug 1.


Four-channel surface coil array for 300-MHz pulsed EPR imaging: proof-of-concept experiments.

Enomoto A, Hirata H, Matsumoto S, Saito K, Subramanian S, Krishna MC, Devasahayam N.

Magn Reson Med. 2014 Feb;71(2):853-8. doi: 10.1002/mrm.24702.


Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology.

Li F, Pang X, Krausz KW, Jiang C, Chen C, Cook JA, Krishna MC, Mitchell JB, Gonzalez FJ, Patterson AD.

J Proteome Res. 2013 Mar 1;12(3):1369-76. doi: 10.1021/pr301023x. Epub 2013 Jan 31.


Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.

Saito K, Matsumoto S, Yasui H, Devasahayam N, Subramanian S, Munasinghe JP, Patel V, Gutkind JS, Mitchell JB, Krishna MC.

PLoS One. 2012;7(11):e49456. doi: 10.1371/journal.pone.0049456. Epub 2012 Nov 20.


Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma.

Sourbier C, Srivastava G, Ghosh MC, Ghosh S, Yang Y, Gupta G, Degraff W, Krishna MC, Mitchell JB, Rouault TA, Linehan WM.

Oncotarget. 2012 Nov;3(11):1472-82.


Evaluation of partial k-space strategies to speed up time-domain EPR imaging.

Subramanian S, Chandramouli GV, McMillan A, Gullapalli RP, Devasahayam N, Mitchell JB, Matsumoto S, Krishna MC.

Magn Reson Med. 2013 Sep;70(3):745-53. doi: 10.1002/mrm.24508. Epub 2012 Oct 8.


The relationship between tissue oxygenation and redox status using magnetic resonance imaging.

Hyodo F, Davis RM, Hyodo E, Matsumoto S, Krishna MC, Mitchell JB.

Int J Oncol. 2012 Dec;41(6):2103-8. doi: 10.3892/ijo.2012.1638. Epub 2012 Sep 24.


The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.

Mitchell JB, Anver MR, Sowers AL, Rosenberg PS, Figueroa M, Thetford A, Krishna MC, Albert PS, Cook JA.

Cancer Res. 2012 Sep 15;72(18):4846-55. doi: 10.1158/0008-5472.CAN-12-1879. Epub 2012 Jul 17.


EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate.

Matsumoto S, Saito K, Yasui H, Morris HD, Munasinghe JP, Lizak M, Merkle H, Ardenkjaer-Larsen JH, Choudhuri R, Devasahayam N, Subramanian S, Koretsky AP, Mitchell JB, Krishna MC.

Magn Reson Med. 2013 May;69(5):1443-50. doi: 10.1002/mrm.24355. Epub 2012 Jun 12.


Echo-based Single Point Imaging (ESPI): a novel pulsed EPR imaging modality for high spatial resolution and quantitative oximetry.

Subramanian S, Devasahayam N, Matsumoto S, Saito K, Mitchell JB, Krishna MC.

J Magn Reson. 2012 May;218:105-14. doi: 10.1016/j.jmr.2012.03.022. Epub 2012 Apr 5.


Electron paramagnetic resonance imaging of tumor pO₂.

Krishna MC, Matsumoto S, Yasui H, Saito K, Devasahayam N, Subramanian S, Mitchell JB.

Radiat Res. 2012 Apr;177(4):376-86. Epub 2012 Feb 14. Review.


Reporting of quantitative oxygen mapping in EPR imaging.

Subramanian S, Devasahayam N, McMillan A, Matsumoto S, Munasinghe JP, Saito K, Mitchell JB, Chandramouli GV, Krishna MC.

J Magn Reson. 2012 Jan;214(1):244-51. doi: 10.1016/j.jmr.2011.11.013. Epub 2011 Nov 28.


The effects of resveratrol and selected metabolites on the radiation and antioxidant response.

Fabre KM, Saito K, DeGraff W, Sowers AL, Thetford A, Cook JA, Krishna MC, Mitchell JB.

Cancer Biol Ther. 2011 Nov 15;12(10):915-23. doi: 10.4161/cbt.12.10.17714. Epub 2011 Nov 15.

Supplemental Content

Loading ...
Support Center