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Quantitation of Total and Free Thiol Angiotensinogen as a Prognostic Marker for Preeclampsia.

Qi M, Weaver JC, Rahgozar S, Giannakopoulos B, Krilis SA.

Methods Mol Biol. 2019;1967:285-293. doi: 10.1007/978-1-4939-9187-7_18.


Quantitation of Total and Free Thiol β2-Glycoprotein I Levels for Diagnostic and Prognostic Purposes in the Antiphospholipid Syndrome.

Qi M, Weaver JC, Krilis SA, Giannakopoulos B.

Methods Mol Biol. 2019;1967:275-283. doi: 10.1007/978-1-4939-9187-7_17.


Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration.

Krilis M, Qi M, Qi J, Wong JWH, Guymer R, Liew G, Hunyor AP, Madigan M, McCluskey P, Weaver J, Krilis SA, Giannakopoulos B.

Free Radic Biol Med. 2018 Dec;129:237-246. doi: 10.1016/j.freeradbiomed.2018.09.034. Epub 2018 Sep 22.


Oxidative post-translational modification of βeta 2-glycoprotein I in the pathophysiology of the anti-phospholipid syndrome.

Weaver JC, Krilis SA, Giannakopoulos B.

Free Radic Biol Med. 2018 Sep;125:98-103. doi: 10.1016/j.freeradbiomed.2018.03.048. Epub 2018 Mar 29. Review.


β2GPI exerts an anti-obesity effect in female mice by inhibiting lipogenesis and promoting lipolysis.

Dong S, Qi M, Wang Y, Chen L, Weaver JC, Krilis SA, Giannakopoulos B.

Oncotarget. 2017 Oct 4;8(54):92652-92666. doi: 10.18632/oncotarget.21536. eCollection 2017 Nov 3.


Βeta 2-glycoprotein I protects mice against gram-negative septicaemia in a sexually dimorphic manner.

El-Assaad F, Qi M, Gordon AK, Qi J, Dong S, Passam F, Weaver JC, Giannakopoulos B, Krilis SA.

Sci Rep. 2017 Aug 15;7(1):8201. doi: 10.1038/s41598-017-07945-8.


Experimental Arthritis Is Dependent on Mouse Mast Cell Protease-5.

Stevens RL, McNeil HP, Wensing LA, Shin K, Wong GW, Hansbro PM, Krilis SA.

J Biol Chem. 2017 Mar 31;292(13):5392-5404. doi: 10.1074/jbc.M116.773416. Epub 2017 Feb 13.


Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration.

Krilis M, Qi M, Madigan MC, Wong JWH, Abdelatti M, Guymer RH, Whitelock J, McCluskey P, Zhang P, Qi J, Hunyor AP, Krilis SA, Giannakopoulos B.

Oncotarget. 2017 Jul 25;8(30):49016-49032. doi: 10.18632/oncotarget.14940.


Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome.

El-Assaad F, Krilis SA, Giannakopoulos B.

Thromb J. 2016 Oct 4;14(Suppl 1):20. eCollection 2016.


Gram Negative Bacterial Inflammation Ameliorated by the Plasma Protein Beta 2-Glycoprotein I.

Zhou S, Chen G, Qi M, El-Assaad F, Wang Y, Dong S, Chen L, Yu D, Weaver JC, Beretov J, Krilis SA, Giannakopoulos B.

Sci Rep. 2016 Sep 27;6:33656. doi: 10.1038/srep33656.


The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury.

Zhang P, Weaver JC, Chen G, Beretov J, Atsumi T, Qi M, Bhindi R, Qi JC, Madigan MC, Giannakopoulos B, Krilis SA.

PLoS One. 2016 Mar 31;11(3):e0152681. doi: 10.1371/journal.pone.0152681. eCollection 2016.


CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide.

Zhou S, Tanaka K, O'Keeffe M, Qi M, El-Assaad F, Weaver JC, Chen G, Weatherall C, Wang Y, Giannakopoulos B, Chen L, Yu D, Hamilton MJ, Wensing LA, Stevens RL, Krilis SA.

PLoS One. 2016 Mar 16;11(3):e0151638. doi: 10.1371/journal.pone.0151638. eCollection 2016.


Improved Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-Control Study.

Rahgozar S, Amirian T, Qi M, Shahshahan Z, Entezar-E-Ghaem M, Ghasemi Tehrani H, Miroliaei M, Krilis SA, Giannakopoulos B.

PLoS One. 2015 Aug 27;10(8):e0135905. doi: 10.1371/journal.pone.0135905. eCollection 2015.


Do Beta 2-Glycoprotein I Disulfide Bonds Protect the Human Retina in the Setting of Age-Related Macular Degeneration?

Qi M, Abdelatti M, Krilis M, Madigan MC, Weaver J, Guymer RH, McCluskey P, Wang Y, Zhou S, Krilis SA, Giannakopoulos B.

Antioxid Redox Signal. 2016 Jan 1;24(1):32-8. doi: 10.1089/ars.2014.6052. Epub 2015 May 4.


Laboratory methods to detect antiphospholipid antibodies.

Krilis SA, Giannakopoulos B.

Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):321-8. doi: 10.1182/asheducation-2014.1.321. Epub 2014 Nov 18. Review.


Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis.

Hansbro PM, Hamilton MJ, Fricker M, Gellatly SL, Jarnicki AG, Zheng D, Frei SM, Wong GW, Hamadi S, Zhou S, Foster PS, Krilis SA, Stevens RL.

J Biol Chem. 2014 Jun 27;289(26):18214-27. doi: 10.1074/jbc.M114.548594. Epub 2014 May 12.


Deletion of the antiphospholipid syndrome autoantigen β2 -glycoprotein I potentiates the lupus autoimmune phenotype in a Toll-like receptor 7-mediated murine model.

Giannakopoulos B, Mirarabshahi P, Qi M, Weatherall C, Qi JC, Tanaka K, Millar E, Vonthethoff L, Gatto D, Spielman D, Krilis SA.

Arthritis Rheumatol. 2014 Aug;66(8):2270-80. doi: 10.1002/art.38646.


Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.

Douaiher J, Succar J, Lancerotto L, Gurish MF, Orgill DP, Hamilton MJ, Krilis SA, Stevens RL.

Adv Immunol. 2014;122:211-52. doi: 10.1016/B978-0-12-800267-4.00006-7. Review.


The pathogenesis of the antiphospholipid syndrome.

Giannakopoulos B, Krilis SA.

N Engl J Med. 2013 Mar 14;368(11):1033-44. doi: 10.1056/NEJMra1112830. Review. No abstract available.


Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis.

Giannakopoulos B, Gao L, Qi M, Wong JW, Yu DM, Vlachoyiannopoulos PG, Moutsopoulos HM, Atsumi T, Koike T, Hogg P, Qi JC, Krilis SA.

J Autoimmun. 2012 Sep;39(3):121-9. doi: 10.1016/j.jaut.2012.05.005. Epub 2012 Jun 13.


Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis.

Adachi R, Krilis SA, Nigrovic PA, Hamilton MJ, Chung K, Thakurdas SM, Boyce JA, Anderson P, Stevens RL.

J Biol Chem. 2012 Jun 8;287(24):20047-55. doi: 10.1074/jbc.M112.360388. Epub 2012 Apr 16.


Molecular pathophysiology of the antiphospholipid syndrome: the role of oxidative post-translational modification of beta 2 glycoprotein I.

Passam FH, Giannakopoulos B, Mirarabshahi P, Krilis SA.

J Thromb Haemost. 2011 Jul;9 Suppl 1:275-82. doi: 10.1111/j.1538-7836.2011.04301.x. Review.


Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen β2-glycoprotein I.

Ioannou Y, Zhang JY, Qi M, Gao L, Qi JC, Yu DM, Lau H, Sturgess AD, Vlachoyiannopoulos PG, Moutsopoulos HM, Rahman A, Pericleous C, Atsumi T, Koike T, Heritier S, Giannakopoulos B, Krilis SA.

Arthritis Rheum. 2011 Sep;63(9):2774-82. doi: 10.1002/art.30383.


Essential role for mast cell tryptase in acute experimental colitis.

Hamilton MJ, Sinnamon MJ, Lyng GD, Glickman JN, Wang X, Xing W, Krilis SA, Blumberg RS, Adachi R, Lee DM, Stevens RL.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):290-5. doi: 10.1073/pnas.1005758108. Epub 2010 Dec 20.


New insights into the biology and pathobiology of beta2-glycoprotein I.

Giannakopoulos B, Mirarabshahi P, Krilis SA.

Curr Rheumatol Rep. 2011 Feb;13(1):90-5. doi: 10.1007/s11926-010-0151-9. Review.


Redox control of β2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1.

Passam FH, Rahgozar S, Qi M, Raftery MJ, Wong JW, Tanaka K, Ioannou Y, Zhang JY, Gemmell R, Qi JC, Giannakopoulos B, Hughes WE, Hogg PJ, Krilis SA.

J Thromb Haemost. 2010 Aug;8(8):1754-62. doi: 10.1111/j.1538-7836.2010.03944.x.


Intracoronary shear-related up-regulation of platelet P-selectin and platelet-monocyte aggregation despite the use of aspirin and clopidogrel.

Yong AS, Pennings GJ, Chang M, Hamzah A, Chung T, Qi M, Brieger D, Behnia M, Krilis SA, Ng MK, Lowe HC, Kritharides L.

Blood. 2011 Jan 6;117(1):11-20. doi: 10.1182/blood-2010-04-278812. Epub 2010 Sep 27.


Beta 2 glycoprotein I is a substrate of thiol oxidoreductases.

Passam FH, Rahgozar S, Qi M, Raftery MJ, Wong JW, Tanaka K, Ioannou Y, Zhang JY, Gemmell R, Qi JC, Giannakopoulos B, Hughes WE, Hogg PJ, Krilis SA.

Blood. 2010 Sep 16;116(11):1995-7. doi: 10.1182/blood-2010-02-271494. No abstract available.


In vivo modulation of angiogenesis by beta 2 glycoprotein I.

Passam FH, Qi JC, Tanaka K, Matthaei KI, Krilis SA.

J Autoimmun. 2010 Nov;35(3):232-40. doi: 10.1016/j.jaut.2010.06.013. Epub 2010 Jul 24.


Naturally occurring free thiols within beta 2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress-induced cell injury.

Ioannou Y, Zhang JY, Passam FH, Rahgozar S, Qi JC, Giannakopoulos B, Qi M, Yu P, Yu DM, Hogg PJ, Krilis SA.

Blood. 2010 Sep 16;116(11):1961-70. doi: 10.1182/blood-2009-04-215335. Epub 2010 Jun 15.


Risk stratification and outcome of cellulitis admitted to hospital.

Figtree M, Konecny P, Jennings Z, Goh C, Krilis SA, Miyakis S.

J Infect. 2010 Jun;60(6):431-9. doi: 10.1016/j.jinf.2010.03.014. Epub 2010 Mar 25.


How I treat the antiphospholipid syndrome.

Giannakopoulos B, Krilis SA.

Blood. 2009 Sep 3;114(10):2020-30. doi: 10.1182/blood-2009-05-220756. Epub 2009 Jul 8. Review.


Ro 60 functions as a receptor for beta(2)-glycoprotein I on apoptotic cells.

Reed JH, Giannakopoulos B, Jackson MW, Krilis SA, Gordon TP.

Arthritis Rheum. 2009 Mar;60(3):860-9. doi: 10.1002/art.24361.


How we diagnose the antiphospholipid syndrome.

Giannakopoulos B, Passam F, Ioannou Y, Krilis SA.

Blood. 2009 Jan 29;113(5):985-94. doi: 10.1182/blood-2007-12-129627. Epub 2008 Aug 28. Review.


Beta2-glycoprotein I inhibits vascular endothelial growth factor and basic fibroblast growth factor induced angiogenesis through its amino terminal domain.

Yu P, Passam FH, Yu DM, Denyer G, Krilis SA.

J Thromb Haemost. 2008 Jul;6(7):1215-23. doi: 10.1111/j.1538-7836.2008.03000.x. Epub 2008 Jul 1.


Beta2-glycoprotein I protects thrombin from inhibition by heparin cofactor II: potentiation of this effect in the presence of anti-beta2-glycoprotein I autoantibodies.

Rahgozar S, Giannakopoulos B, Yan X, Wei J, Cheng Qi J, Gemmell R, Krilis SA.

Arthritis Rheum. 2008 Apr;58(4):1146-55. doi: 10.1002/art.23387.


The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2.

Katsoulotos GP, Qi M, Qi JC, Tanaka K, Hughes WE, Molloy TJ, Adachi R, Stevens RL, Krilis SA.

J Biol Chem. 2008 Jan 18;283(3):1610-21. Epub 2007 Nov 16.


Current concepts on the pathogenesis of the antiphospholipid syndrome.

Giannakopoulos B, Passam F, Rahgozar S, Krilis SA.

Blood. 2007 Jan 15;109(2):422-30. Epub 2006 Sep 19. Review.


Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V.

Shi T, Giannakopoulos B, Yan X, Yu P, Berndt MC, Andrews RK, Rivera J, Iverson GM, Cockerill KA, Linnik MD, Krilis SA.

Arthritis Rheum. 2006 Aug;54(8):2558-67.


RasGRP4 in mast cell signalling and disease susceptibility.

Stevens RL, Morokawa N, Wang J, Krilis SA.

Novartis Found Symp. 2005;271:54-68; discussion 68-77, 95-9. Review.


International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS).

Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, DE Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA.

J Thromb Haemost. 2006 Feb;4(2):295-306.


Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor.

Qi JC, Wang J, Mandadi S, Tanaka K, Roufogalis BD, Madigan MC, Lai K, Yan F, Chong BH, Stevens RL, Krilis SA.

Blood. 2006 Jan 1;107(1):135-42. Epub 2005 Sep 6.


Importance of C-reactive protein in regulating monocyte tissue factor expression in patients with inflammatory rheumatic diseases.

Cai H, Song C, Lim IG, Krilis SA, Geczy CL, McNeil HP.

J Rheumatol. 2005 Jul;32(7):1224-31.


Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.

Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL.

Blood. 2005 May 15;105(10):3893-901. Epub 2005 Feb 8.


A case of desquamating rash associated with methadone use.

Kordjian N, Donaldson AD, Murrell DF, Krilis SA.

Med J Aust. 2005 Jan 17;182(2):76-7.


Domain V of beta2-glycoprotein I binds factor XI/XIa and is cleaved at Lys317-Thr318.

Shi T, Giannakopoulos B, Iverson GM, Cockerill KA, Linnik MD, Krilis SA.

J Biol Chem. 2005 Jan 14;280(2):907-12. Epub 2004 Nov 2.


Beta 2 glycoprotein I--function in health and disease.

Miyakis S, Giannakopoulos B, Krilis SA.

Thromb Res. 2004;114(5-6):335-46. Review.


Beta-2 glycoprotein I and its role in antiphospholipid syndrome-lessons from knockout mice.

Miyakis S, Robertson SA, Krilis SA.

Clin Immunol. 2004 Aug;112(2):136-43. Review.


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