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Items: 1 to 50 of 172

1.

Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex.

Mayer S, Chen J, Velmeshev D, Mayer A, Eze UC, Bhaduri A, Cunha CE, Jung D, Arjun A, Li E, Alvarado B, Wang S, Lovegren N, Gonzales ML, Szpankowski L, Leyrat A, West JAA, Panagiotakos G, Alvarez-Buylla A, Paredes MF, Nowakowski TJ, Pollen AA, Kriegstein AR.

Neuron. 2019 Feb 7. pii: S0896-6273(19)30054-6. doi: 10.1016/j.neuron.2019.01.027. [Epub ahead of print]

PMID:
30770253
2.

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution.

Pollen AA, Bhaduri A, Andrews MG, Nowakowski TJ, Meyerson OS, Mostajo-Radji MA, Di Lullo E, Alvarado B, Bedolli M, Dougherty ML, Fiddes IT, Kronenberg ZN, Shuga J, Leyrat AA, West JA, Bershteyn M, Lowe CB, Pavlovic BJ, Salama SR, Haussler D, Eichler EE, Kriegstein AR.

Cell. 2019 Feb 7;176(4):743-756.e17. doi: 10.1016/j.cell.2019.01.017.

PMID:
30735633
3.

Shared and derived features of cellular diversity in the human cerebral cortex.

Miller DJ, Bhaduri A, Sestan N, Kriegstein A.

Curr Opin Neurobiol. 2019 Jan 21;56:117-124. doi: 10.1016/j.conb.2018.12.005. [Epub ahead of print] Review.

PMID:
30677551
4.

Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing.

Adorjan I, Tyler T, Bhaduri A, Demharter S, Finszter CK, Bako M, Sebok OM, Nowakowski TJ, Khodosevich K, Møllgård K, Kriegstein AR, Shi L, Hoerder-Suabedissen A, Ansorge O, Molnár Z.

J Anat. 2019 Jan 15. doi: 10.1111/joa.12931. [Epub ahead of print]

PMID:
30644551
5.

Does Adult Neurogenesis Persist in the Human Hippocampus?

Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A.

Cell Stem Cell. 2018 Dec 6;23(6):780-781. doi: 10.1016/j.stem.2018.11.006. No abstract available.

PMID:
30526879
6.

Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development.

Nowakowski TJ, Rani N, Golkaram M, Zhou HR, Alvarado B, Huch K, West JA, Leyrat A, Pollen AA, Kriegstein AR, Petzold LR, Kosik KS.

Nat Neurosci. 2018 Dec;21(12):1784-1792. doi: 10.1038/s41593-018-0265-3. Epub 2018 Nov 19.

PMID:
30455455
7.

Identification of cell types in a mouse brain single-cell atlas using low sampling coverage.

Bhaduri A, Nowakowski TJ, Pollen AA, Kriegstein AR.

BMC Biol. 2018 Oct 11;16(1):113. doi: 10.1186/s12915-018-0580-x.

8.

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.

Fiddes IT, Lodewijk GA, Mooring M, Bosworth CM, Ewing AD, Mantalas GL, Novak AM, van den Bout A, Bishara A, Rosenkrantz JL, Lorig-Roach R, Field AR, Haeussler M, Russo L, Bhaduri A, Nowakowski TJ, Pollen AA, Dougherty ML, Nuttle X, Addor MC, Zwolinski S, Katzman S, Kriegstein A, Eichler EE, Salama SR, Jacobs FMJ, Haussler D.

Cell. 2018 May 31;173(6):1356-1369.e22. doi: 10.1016/j.cell.2018.03.051. Epub 2018 May 31.

PMID:
29856954
9.

An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder.

Werling DM, Brand H, An JY, Stone MR, Zhu L, Glessner JT, Collins RL, Dong S, Layer RM, Markenscoff-Papadimitriou E, Farrell A, Schwartz GB, Wang HZ, Currall BB, Zhao X, Dea J, Duhn C, Erdman CA, Gilson MC, Yadav R, Handsaker RE, Kashin S, Klei L, Mandell JD, Nowakowski TJ, Liu Y, Pochareddy S, Smith L, Walker MF, Waterman MJ, He X, Kriegstein AR, Rubenstein JL, Sestan N, McCarroll SA, Neale BM, Coon H, Willsey AJ, Buxbaum JD, Daly MJ, State MW, Quinlan AR, Marth GT, Roeder K, Devlin B, Talkowski ME, Sanders SJ.

Nat Genet. 2018 May;50(5):727-736. doi: 10.1038/s41588-018-0107-y. Epub 2018 Apr 26.

10.

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.

Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A.

Nature. 2018 Mar 15;555(7696):377-381. doi: 10.1038/nature25975. Epub 2018 Mar 7.

11.

Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment.

Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A.

Genome Biol. 2017 Dec 20;18(1):234. doi: 10.1186/s13059-017-1362-4.

12.

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex.

Nowakowski TJ, Bhaduri A, Pollen AA, Alvarado B, Mostajo-Radji MA, Di Lullo E, Haeussler M, Sandoval-Espinosa C, Liu SJ, Velmeshev D, Ounadjela JR, Shuga J, Wang X, Lim DA, West JA, Leyrat AA, Kent WJ, Kriegstein AR.

Science. 2017 Dec 8;358(6368):1318-1323. doi: 10.1126/science.aap8809.

13.

The Human Cell Atlas.

Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N; Human Cell Atlas Meeting Participants.

Elife. 2017 Dec 5;6. pii: e27041. doi: 10.7554/eLife.27041.

14.

The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas.

Ecker JR, Geschwind DH, Kriegstein AR, Ngai J, Osten P, Polioudakis D, Regev A, Sestan N, Wickersham IR, Zeng H.

Neuron. 2017 Nov 1;96(3):542-557. doi: 10.1016/j.neuron.2017.10.007. Review.

15.

The use of brain organoids to investigate neural development and disease.

Di Lullo E, Kriegstein AR.

Nat Rev Neurosci. 2017 Oct;18(10):573-584. doi: 10.1038/nrn.2017.107. Epub 2017 Sep 7. Review.

16.

Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.

Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL, Oldham MC.

Cereb Cortex. 2018 Jun 1;28(6):1946-1958. doi: 10.1093/cercor/bhx101.

17.

Dynamic behaviour of human neuroepithelial cells in the developing forebrain.

Subramanian L, Bershteyn M, Paredes MF, Kriegstein AR.

Nat Commun. 2017 Jan 31;8:14167. doi: 10.1038/ncomms14167.

18.

Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia.

Bershteyn M, Nowakowski TJ, Pollen AA, Di Lullo E, Nene A, Wynshaw-Boris A, Kriegstein AR.

Cell Stem Cell. 2017 Apr 6;20(4):435-449.e4. doi: 10.1016/j.stem.2016.12.007. Epub 2017 Jan 19.

19.

oRGs and mitotic somal translocation - a role in development and disease.

Ostrem B, Di Lullo E, Kriegstein A.

Curr Opin Neurobiol. 2017 Feb;42:61-67. doi: 10.1016/j.conb.2016.11.007. Epub 2016 Dec 12. Review.

20.

Zika virus cell tropism in the developing human brain and inhibition by azithromycin.

Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, Mancia Leon WR, Krencik R, Ullian EM, Spatazza J, Pollen AA, Mandel-Brehm C, Nowakowski TJ, Kriegstein AR, DeRisi JL.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14408-14413. Epub 2016 Nov 29.

21.

Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas.

Müller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein AR, Lim DA, Diaz A.

Mol Syst Biol. 2016 Nov 25;12(11):889. doi: 10.15252/msb.20166969.

22.

Primate Neurons Flex Their Musclin.

Pollen AA, Kriegstein AR.

Neuron. 2016 Nov 23;92(4):681-683. doi: 10.1016/j.neuron.2016.11.024.

23.

Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury.

Fandel TM, Trivedi A, Nicholas CR, Zhang H, Chen J, Martinez AF, Noble-Haeusslein LJ, Kriegstein AR.

Cell Stem Cell. 2016 Oct 6;19(4):544-557. doi: 10.1016/j.stem.2016.08.020. Epub 2016 Sep 22.

24.

Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development.

Nowakowski TJ, Pollen AA, Sandoval-Espinosa C, Kriegstein AR.

Neuron. 2016 Sep 21;91(6):1219-1227. doi: 10.1016/j.neuron.2016.09.005.

25.

A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA.

Rani N, Nowakowski TJ, Zhou H, Godshalk SE, Lisi V, Kriegstein AR, Kosik KS.

Neuron. 2016 Jun 15;90(6):1174-1188. doi: 10.1016/j.neuron.2016.05.005. Epub 2016 Jun 2.

26.

SCell: integrated analysis of single-cell RNA-seq data.

Diaz A, Liu SJ, Sandoval C, Pollen A, Nowakowski TJ, Lim DA, Kriegstein A.

Bioinformatics. 2016 Jul 15;32(14):2219-20. doi: 10.1093/bioinformatics/btw201. Epub 2016 Apr 19.

27.

Single-cell analysis of long non-coding RNAs in the developing human neocortex.

Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA.

Genome Biol. 2016 Apr 14;17:67. doi: 10.1186/s13059-016-0932-1.

28.

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells.

Nowakowski TJ, Pollen AA, Di Lullo E, Sandoval-Espinosa C, Bershteyn M, Kriegstein AR.

Cell Stem Cell. 2016 May 5;18(5):591-6. doi: 10.1016/j.stem.2016.03.012. Epub 2016 Mar 30.

29.

Neuronal Migration Dynamics in the Developing Ferret Cortex.

Gertz CC, Kriegstein AR.

J Neurosci. 2015 Oct 21;35(42):14307-15. doi: 10.1523/JNEUROSCI.2198-15.2015.

30.

A GABAergic projection from the zona incerta to cortex promotes cortical neuron development.

Chen J, Kriegstein AR.

Science. 2015 Oct 30;350(6260):554-8. doi: 10.1126/science.aac6472. Epub 2015 Oct 1.

31.

Molecular identity of human outer radial glia during cortical development.

Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas CR, Shuga J, Liu SJ, Oldham MC, Diaz A, Lim DA, Leyrat AA, West JA, Kriegstein AR.

Cell. 2015 Sep 24;163(1):55-67. doi: 10.1016/j.cell.2015.09.004.

32.

Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons.

Harwell CC, Fuentealba LC, Gonzalez-Cerrillo A, Parker PR, Gertz CC, Mazzola E, Garcia MT, Alvarez-Buylla A, Cepko CL, Kriegstein AR.

Neuron. 2015 Sep 2;87(5):999-1007. doi: 10.1016/j.neuron.2015.07.030. Epub 2015 Aug 20.

33.

The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells.

Ramos AD, Andersen RE, Liu SJ, Nowakowski TJ, Hong SJ, Gertz C, Salinas RD, Zarabi H, Kriegstein AR, Lim DA.

Cell Stem Cell. 2015 Apr 2;16(4):439-447. doi: 10.1016/j.stem.2015.02.007. Epub 2015 Mar 19.

34.

Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex.

Lui JH, Nowakowski TJ, Pollen AA, Javaherian A, Kriegstein AR, Oldham MC.

Nature. 2014 Nov 13;515(7526):264-8. doi: 10.1038/nature13973.

35.

Yoshiki Sasai (1962–2014).

Kriegstein AR.

Neuron. 2014 Sep 17;83(6):1237-8. No abstract available.

36.

Yoshiki Sasai (1962–2014).

Kriegstein AR.

Cell Stem Cell. 2014 Sep 4;15(3):265-6. No abstract available.

37.

The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation.

Price JD, Park KY, Chen J, Salinas RD, Cho MJ, Kriegstein AR, Lim DA.

J Neurosci. 2014 Sep 10;34(37):12560-7. doi: 10.1523/JNEUROSCI.3159-13.2014.

38.

Control of outer radial glial stem cell mitosis in the human brain.

Ostrem BE, Lui JH, Gertz CC, Kriegstein AR.

Cell Rep. 2014 Aug 7;8(3):656-64. doi: 10.1016/j.celrep.2014.06.058. Epub 2014 Jul 31.

39.

Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.

Pollen AA, Nowakowski TJ, Shuga J, Wang X, Leyrat AA, Lui JH, Li N, Szpankowski L, Fowler B, Chen P, Ramalingam N, Sun G, Thu M, Norris M, Lebofsky R, Toppani D, Kemp DW 2nd, Wong M, Clerkson B, Jones BN, Wu S, Knutsson L, Alvarado B, Wang J, Weaver LS, May AP, Jones RC, Unger MA, Kriegstein AR, West JA.

Nat Biotechnol. 2014 Oct;32(10):1053-8. doi: 10.1038/nbt.2967. Epub 2014 Aug 3.

40.

Interneurons from embryonic development to cell-based therapy.

Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A.

Science. 2014 Apr 11;344(6180):1240622. doi: 10.1126/science.1240622. Review.

41.

Axonal control of the adult neural stem cell niche.

Tong CK, Chen J, Cebrián-Silla A, Mirzadeh Z, Obernier K, Guinto CD, Tecott LH, García-Verdugo JM, Kriegstein A, Alvarez-Buylla A.

Cell Stem Cell. 2014 Apr 3;14(4):500-11. doi: 10.1016/j.stem.2014.01.014. Epub 2014 Feb 20.

42.

Diverse behaviors of outer radial glia in developing ferret and human cortex.

Gertz CC, Lui JH, LaMonica BE, Wang X, Kriegstein AR.

J Neurosci. 2014 Feb 12;34(7):2559-70. doi: 10.1523/JNEUROSCI.2645-13.2014.

43.

Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells.

Bershteyn M, Hayashi Y, Desachy G, Hsiao EC, Sami S, Tsang KM, Weiss LA, Kriegstein AR, Yamanaka S, Wynshaw-Boris A.

Nature. 2014 Mar 6;507(7490):99-103. doi: 10.1038/nature12923. Epub 2014 Jan 12.

44.

Radial glia in the proliferative ventricular zone of the embryonic and adult turtle, Trachemys scripta elegans.

Clinton BK, Cunningham CL, Kriegstein AR, Noctor SC, Martínez-Cerdeño V.

Neurogenesis (Austin). 2014 Dec 2;1(1):e970905. doi: 10.4161/23262125.2014.970905. eCollection 2014.

45.

The dynamics of neuronal migration.

Wu Q, Liu J, Fang A, Li R, Bai Y, Kriegstein AR, Wang X.

Adv Exp Med Biol. 2014;800:25-36. doi: 10.1007/978-94-007-7687-6_2. Review.

PMID:
24243098
46.

Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences.

Hansen DV, Lui JH, Flandin P, Yoshikawa K, Rubenstein JL, Alvarez-Buylla A, Kriegstein AR.

Nat Neurosci. 2013 Nov;16(11):1576-87. doi: 10.1038/nn.3541. Epub 2013 Oct 6.

47.

Cerebral organoids in a dish: progress and prospects.

Bershteyn M, Kriegstein AR.

Cell. 2013 Sep 26;155(1):19-20. doi: 10.1016/j.cell.2013.09.010.

48.

Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons.

Chen YJ, Vogt D, Wang Y, Visel A, Silberberg SN, Nicholas CR, Danjo T, Pollack JL, Pennacchio LA, Anderson S, Sasai Y, Baraban SC, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL.

PLoS One. 2013 May 1;8(5):e61956. doi: 10.1371/journal.pone.0061956. Print 2013.

49.

Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.

Nicholas CR, Chen J, Tang Y, Southwell DG, Chalmers N, Vogt D, Arnold CM, Chen YJ, Stanley EG, Elefanty AG, Sasai Y, Alvarez-Buylla A, Rubenstein JL, Kriegstein AR.

Cell Stem Cell. 2013 May 2;12(5):573-86. doi: 10.1016/j.stem.2013.04.005.

50.

Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex.

LaMonica BE, Lui JH, Hansen DV, Kriegstein AR.

Nat Commun. 2013;4:1665. doi: 10.1038/ncomms2647.

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