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Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis.

Fox RJ, Coffey CS, Conwit R, Cudkowicz ME, Gleason T, Goodman A, Klawiter EC, Matsuda K, McGovern M, Naismith RT, Ashokkumar A, Barnes J, Ecklund D, Klingner E, Koepp M, Long JD, Natarajan S, Thornell B, Yankey J, Bermel RA, Debbins JP, Huang X, Jagodnik P, Lowe MJ, Nakamura K, Narayanan S, Sakaie KE, Thoomukuntla B, Zhou X, Krieger S, Alvarez E, Apperson M, Bashir K, Cohen BA, Coyle PK, Delgado S, Dewitt LD, Flores A, Giesser BS, Goldman MD, Jubelt B, Lava N, Lynch SG, Moses H, Ontaneda D, Perumal JS, Racke M, Repovic P, Riley CS, Severson C, Shinnar S, Suski V, Weinstock-Guttman B, Yadav V, Zabeti A; NN102/SPRINT-MS Trial Investigators.

N Engl J Med. 2018 Aug 30;379(9):846-855. doi: 10.1056/NEJMoa1803583.


Objective and subjective measures of dalfampridine efficacy in clinical practice.

Klineova S, Farber R, Friedman J, Farrell C, Lublin FD, Krieger S.

Mult Scler J Exp Transl Clin. 2018 Jul 9;4(3):2055217318786742. doi: 10.1177/2055217318786742. eCollection 2018 Jul-Sep.


Education Research: Resident education through adult learning in neurology: Implementation and impact.

Shoirah H, Ntranos A, Brandstadter R, Liu Y, Medina E, Kwan J, Krieger S.

Neurology. 2018 Jul 31;91(5):234-238. doi: 10.1212/WNL.0000000000005914.


"Location, location, location".

Krieger SC, Lublin FD.

Mult Scler. 2018 Jul 26:1352458518790385. doi: 10.1177/1352458518790385. [Epub ahead of print] No abstract available.


Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions.

Crucian BE, Choukèr A, Simpson RJ, Mehta S, Marshall G, Smith SM, Zwart SR, Heer M, Ponomarev S, Whitmire A, Frippiat JP, Douglas GL, Lorenzi H, Buchheim JI, Makedonas G, Ginsburg GS, Ott CM, Pierson DL, Krieger SS, Baecker N, Sams C.

Front Immunol. 2018 Jun 28;9:1437. doi: 10.3389/fimmu.2018.01437. eCollection 2018. Review.


Landscape of pathogenic variations in a panel of 34 genes and cancer risk estimation from 5131 HBOC families.

Castéra L, Harter V, Muller E, Krieger S, Goardon N, Ricou A, Rousselin A, Paimparay G, Legros A, Bruet O, Quesnelle C, Domin F, San C, Brault B, Fouillet R, Abadie C, Béra O, Berthet P; French Exome Project Consortium, Frébourg T, Vaur D.

Genet Med. 2018 Jul 10. doi: 10.1038/s41436-018-0005-9. [Epub ahead of print]


Matched-pair, 86Y/90Y-labeled, bivalent RGD/bombesin antagonist, [RGD-Glu-[DO3A]-6-Ahx-RM2], as a potential theranostic agent for prostate cancer.

Bandara N, Stott Reynolds TJ, Schehr R, Bandari RP, Diebolder PJ, Krieger S, Xu J, Miao Y, Rogers BE, Smith CJ.

Nucl Med Biol. 2018 Jul - Aug;62-63:71-77. doi: 10.1016/j.nucmedbio.2018.06.001. Epub 2018 Jun 8.


Adaptation of two groups of Oenococcus oeni strains to red and white wines: the role of acidity and phenolic compounds.

Breniaux M, Dutilh L, Petrel M, Gontier E, Campbell-Sills H, Deleris-Bou M, Krieger S, Teissedre PL, Jourdes M, Reguant C, Lucas P.

J Appl Microbiol. 2018 Jun 15. doi: 10.1111/jam.13946. [Epub ahead of print]


Novel diagnostic tool for prediction of variant spliceogenicity derived from a set of 395 combined in silico/in vitro studies: an international collaborative effort.

Leman R, Gaildrat P, Gac GL, Ka C, Fichou Y, Audrezet MP, Caux-Moncoutier V, Caputo SM, Boutry-Kryza N, Léone M, Mazoyer S, Bonnet-Dorion F, Sevenet N, Guillaud-Bataille M, Rouleau E, Bressac-de Paillerets B, Wappenschmidt B, Rossing M, Muller D, Bourdon V, Revillon F, Parsons MT, Rousselin A, Davy G, Castelain G, Castéra L, Sokolowska J, Coulet F, Delnatte C, Férec C, Spurdle AB, Martins A, Krieger S, Houdayer C.

Nucleic Acids Res. 2018 Sep 6;46(15):7913-7923. doi: 10.1093/nar/gky372.


12(S)-HETE induces lymph endothelial cell retraction in vitro by upregulation of SOX18.

Fristiohady A, Milovanovic D, Krieger S, Huttary N, Nguyen CH, Basilio J, Jäger W, De Martin R, Krupitza G.

Int J Oncol. 2018 Jul;53(1):307-316. doi: 10.3892/ijo.2018.4378. Epub 2018 Apr 26.


Full in-frame exon 3 skipping of BRCA2 confers high risk of breast and/or ovarian cancer.

Caputo SM, Léone M, Damiola F, Ehlen A, Carreira A, Gaidrat P, Martins A, Brandão RD, Peixoto A, Vega A, Houdayer C, Delnatte C, Bronner M, Muller D, Castera L, Guillaud-Bataille M, Søkilde I, Uhrhammer N, Demontety S, Tubeuf H, Castelain G; French COVAR group collaborators, Jensen UB, Petitalot A, Krieger S, Lefol C, Moncoutier V, Boutry-Kryza N, Nielsen HR, Sinilnikova O, Stoppa-Lyonnet D, Spurdle AB, Teixeira MR, Coulet F, Thomassen M, Rouleau E.

Oncotarget. 2018 Apr 3;9(25):17334-17348. doi: 10.18632/oncotarget.24671. eCollection 2018 Apr 3.


Technical note: Evaluation of a wireless pulse oximeter for measuring arterial oxygen saturation and pulse rate in newborn Holstein Friesian calves.

Kanz P, Krieger S, Drillich M, Iwersen M.

J Dairy Sci. 2018 Jul;101(7):6437-6442. doi: 10.3168/jds.2017-14266. Epub 2018 Apr 26.


Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro.

Hong J, Fristiohady A, Nguyen CH, Milovanovic D, Huttary N, Krieger S, Hong J, Geleff S, Birner P, Jäger W, Özmen A, Krenn L, Krupitza G.

Front Pharmacol. 2018 Mar 14;9:220. doi: 10.3389/fphar.2018.00220. eCollection 2018.


Brain microstructural injury occurs in patients with RRMS despite 'no evidence of disease activity'.

Harel A, Sperling D, Petracca M, Ntranos A, Katz-Sand I, Krieger S, Lublin F, Wang Z, Liu Y, Inglese M.

J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):977-982. doi: 10.1136/jnnp-2017-317606. Epub 2018 Mar 16.


Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers.

Golmard L, Castéra L, Krieger S, Moncoutier V, Abidallah K, Tenreiro H, Laugé A, Tarabeux J, Millot GA, Nicolas A, Laé M, Abadie C, Berthet P, Polycarpe F, Frébourg T, Elan C, de Pauw A, Gauthier-Villars M, Buecher B, Stern MH, Stoppa-Lyonnet D, Vaur D, Houdayer C.

Eur J Hum Genet. 2017 Dec;25(12):1345-1353. doi: 10.1038/s41431-017-0021-2. Epub 2017 Nov 8.


Assessment of the functional impact of germline BRCA1/2 variants located in non-coding regions in families with breast and/or ovarian cancer predisposition.

Dos Santos ES, Caputo SM, Castera L, Gendrot M, Briaux A, Breault M, Krieger S, Rogan PK, Mucaki EJ, Burke LJ; ENIGMA consortium, Bièche I, Houdayer C, Vaur D, Stoppa-Lyonnet D, Brown MA, Lallemand F, Rouleau E.

Breast Cancer Res Treat. 2018 Apr;168(2):311-325. doi: 10.1007/s10549-017-4602-0. Epub 2017 Dec 13.


New Insights into Multiple Sclerosis Clinical Course from the Topographical Model and Functional Reserve.

Krieger SC, Sumowski J.

Neurol Clin. 2018 Feb;36(1):13-25. doi: 10.1016/j.ncl.2017.08.003. Epub 2017 Oct 18. Review.


Long-term follow-up of a randomized study of combination interferon and glatiramer acetate in multiple sclerosis: Efficacy and safety results up to 7 years.

Lublin FD, Cofield SS, Cutter GR, Gustafson T, Krieger S, Narayana PA, Nelson F, Salter AR, Wolinsky JS.

Mult Scler Relat Disord. 2017 Nov;18:95-102. doi: 10.1016/j.msard.2017.09.012. Epub 2017 Sep 23.


Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro.

Holzner S, Brenner S, Atanasov AG, Senfter D, Stadler S, Nguyen CH, Fristiohady A, Milovanovic D, Huttary N, Krieger S, Bago-Horvath Z, de Wever O, Tentes I, Özmen A, Jäger W, Dolznig H, Dirsch VM, Mader RM, Krenn L, Krupitza G.

Food Chem Toxicol. 2018 Jan;111:114-124. doi: 10.1016/j.fct.2017.11.015. Epub 2017 Nov 10.


Detecting splicing patterns in genes involved in hereditary breast and ovarian cancer.

Davy G, Rousselin A, Goardon N, Castéra L, Harter V, Legros A, Muller E, Fouillet R, Brault B, Smirnova AS, Lemoine F, de la Grange P, Guillaud-Bataille M, Caux-Moncoutier V, Houdayer C, Bonnet F, Blanc-Fournier C, Gaildrat P, Frebourg T, Martins A, Vaur D, Krieger S.

Eur J Hum Genet. 2017 Oct;25(10):1147-1154. doi: 10.1038/ejhg.2017.116. Epub 2017 Jul 26.


Evaluation of 64Cu-Based Radiopharmaceuticals that Target Aβ Peptide Aggregates as Diagnostic Tools for Alzheimer's Disease.

Bandara N, Sharma AK, Krieger S, Schultz JW, Han BH, Rogers BE, Mirica LM.

J Am Chem Soc. 2017 Sep 13;139(36):12550-12558. doi: 10.1021/jacs.7b05937. Epub 2017 Aug 29.


Inpatient Admissions and Costs Associated with Persistent Use of Dalfampridine Extended-Release in Multiple Sclerosis: A Claims Database Analysis.

Guo A, Niyazov A, Macaulay D, Terasawa E, Schmerold L, Wu EQ, Krieger S.

J Manag Care Spec Pharm. 2017 Jul;23(7):771-780. doi: 10.18553/jmcp.2017.23.7.771.


DNMT3A mutant transcript levels persist in remission and do not predict outcome in patients with acute myeloid leukemia.

Gaidzik VI, Weber D, Paschka P, Kaumanns A, Krieger S, Corbacioglu A, Krönke J, Kapp-Schwoerer S, Krämer D, Horst HA, Schmidt-Wolf I, Held G, Kündgen A, Ringhoffer M, Götze K, Kindler T, Fiedler W, Wattad M, Schlenk RF, Bullinger L, Teleanu V, Schlegelberger B, Thol F, Heuser M, Ganser A, Döhner H, Döhner K; German-Austrian Acute Myeloid Leukemia Study Group (AMLSG).

Leukemia. 2018 Jan;32(1):30-37. doi: 10.1038/leu.2017.200. Epub 2017 Jun 23.


Relationship between timed 25-foot walk and diffusion tensor imaging in multiple sclerosis.

Klineova S, Farber R, Saiote C, Farrell C, Delman BN, Tanenbaum LN, Friedman J, Inglese M, Lublin FD, Krieger S.

Mult Scler J Exp Transl Clin. 2016 Jun 23;2:2055217316655365. doi: 10.1177/2055217316655365. eCollection 2016 Jan-Dec.


Transcriptomics, NF-κB Pathway, and Their Potential Spaceflight-Related Health Consequences.

Zhang Y, Moreno-Villanueva M, Krieger S, Ramesh GT, Neelam S, Wu H.

Int J Mol Sci. 2017 May 31;18(6). pii: E1166. doi: 10.3390/ijms18061166. Review.


Cerebellar volume as imaging outcome in progressive multiple sclerosis.

Inglese M, Petracca M, Mormina E, Achiron A, Straus-Farber R, Miron S, Fabian M, Krieger S, Miller A, Lublin F, Sormani MP.

PLoS One. 2017 Apr 24;12(4):e0176519. doi: 10.1371/journal.pone.0176519. eCollection 2017.


AHR/CYP1A1 interplay triggers lymphatic barrier breaching in breast cancer spheroids by inducing 12(S)-HETE synthesis.

Nguyen CH, Brenner S, Huttary N, Atanasov AG, Dirsch VM, Chatuphonprasert W, Holzner S, Stadler S, Riha J, Krieger S, de Martin R, Bago-Horvath Z, Krupitza G, Jäger W.

Hum Mol Genet. 2016 Nov 15;25(22):5006-5016. doi: 10.1093/hmg/ddw329.


Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling.

Stadler S, Nguyen CH, Schachner H, Milovanovic D, Holzner S, Brenner S, Eichsteininger J, Stadler M, Senfter D, Krenn L, Schmidt WM, Huttary N, Krieger S, Koperek O, Bago-Horvath Z, Brendel KA, Marian B, de Wever O, Mader RM, Giessrigl B, Jäger W, Dolznig H, Krupitza G.

Cell Mol Life Sci. 2017 May;74(10):1907-1921. doi: 10.1007/s00018-016-2441-5. Epub 2016 Dec 24.


OutLyzer: software for extracting low-allele-frequency tumor mutations from sequencing background noise in clinical practice.

Muller E, Goardon N, Brault B, Rousselin A, Paimparay G, Legros A, Fouillet R, Bruet O, Tranchant A, Domin F, San C, Quesnelle C, Frebourg T, Ricou A, Krieger S, Vaur D, Castera L.

Oncotarget. 2016 Nov 29;7(48):79485-79493. doi: 10.18632/oncotarget.13103.


BRCA1 allele-specific expression in genetic predisposed breast/ovarian cancer.

Jamard E, Volard B, Dugué AE, Legros A, Leconte A, Clarisse B, Davy G, Polycarpe F, Dugast C, Abadie C, Frebourg T, Tinat J, Tennevet I, Layet V, Joly F, Castéra L, Berthet P, Vaur D, Krieger S.

Fam Cancer. 2017 Apr;16(2):167-171. doi: 10.1007/s10689-016-9940-2.


BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells.

Saenz DT, Fiskus W, Manshouri T, Rajapakshe K, Krieger S, Sun B, Mill CP, DiNardo C, Pemmaraju N, Kadia T, Parmar S, Sharma S, Coarfa C, Qiu P, Verstovsek S, Bhalla KN.

Leukemia. 2017 Mar;31(3):678-687. doi: 10.1038/leu.2016.260. Epub 2016 Sep 28.


Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro.

Holzner S, Senfter D, Stadler S, Staribacher A, Nguyen CH, Gaggl A, Geleff S, Huttary N, Krieger S, Jäger W, Dolznig H, Mader RM, Krupitza G.

Oncol Rep. 2016 Nov;36(5):3065-3071. doi: 10.3892/or.2016.5114. Epub 2016 Sep 20.


Baseline EDSS proportions in MS clinical trials affect the overall outcome and power: A cautionary note.

Wang G, Cutter GR, Cofield SS, Lublin F, Wolinsky JS, Gustafson T, Krieger S, Salter A.

Mult Scler. 2017 Jun;23(7):982-987. doi: 10.1177/1352458516670733. Epub 2016 Sep 28.


The topographical model of multiple sclerosis: A dynamic visualization of disease course.

Krieger SC, Cook K, De Nino S, Fletcher M.

Neurol Neuroimmunol Neuroinflamm. 2016 Sep 7;3(5):e279. doi: 10.1212/NXI.0000000000000279. eCollection 2016 Oct. Review.


The brain-tumor related protein podoplanin regulates synaptic plasticity and hippocampus-dependent learning and memory.

Cicvaric A, Yang J, Krieger S, Khan D, Kim EJ, Dominguez-Rodriguez M, Cabatic M, Molz B, Acevedo Aguilar JP, Milicevic R, Smani T, Breuss JM, Kerjaschki D, Pollak DD, Uhrin P, Monje FJ.

Ann Med. 2016 Dec;48(8):652-668. Epub 2016 Aug 25.


SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.

Fiskus W, Coothankandaswamy V, Chen J, Ma H, Ha K, Saenz DT, Krieger SS, Mill CP, Sun B, Huang P, Mumm JS, Melnick AM, Bhalla KN.

Cancer Res. 2016 Sep 15;76(18):5467-78. doi: 10.1158/0008-5472.CAN-16-0126. Epub 2016 Aug 8.


12(S)-HETE increases intracellular Ca(2+) in lymph-endothelial cells disrupting their barrier function in vitro; stabilization by clinical drugs impairing calcium supply.

Nguyen CH, Brenner S, Huttary N, Li Y, Atanasov AG, Dirsch VM, Holzner S, Stadler S, Riha J, Krieger S, Milovanovic D, Fristiohardy A, Simonitsch-Klupp I, Dolznig H, Saiko P, Szekeres T, Giessrigl B, Jäger W, Krupitza G.

Cancer Lett. 2016 Sep 28;380(1):174-83. doi: 10.1016/j.canlet.2016.06.022. Epub 2016 Jul 4.


Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor, RHO, ROCK and MLC2 to induce lymph endothelial barrier breaching.

Nguyen CH, Stadler S, Brenner S, Huttary N, Krieger S, Jäger W, Dolznig H, Krupitza G.

Br J Cancer. 2016 Jul 26;115(3):364-70. doi: 10.1038/bjc.2016.201. Epub 2016 Jun 30.


Measurement of β-hydroxybutyrate in capillary blood obtained from an ear to detect hyperketonemia in dairy cows by using an electronic handheld device.

Süss D, Drillich M, Klein-Jöbstl D, Wagener K, Krieger S, Thiel A, Meyer L, Schwendenwein I, Iwersen M.

J Dairy Sci. 2016 Sep;99(9):7362-7369. doi: 10.3168/jds.2016-10911. Epub 2016 Jun 8.


Treatment patterns and health care resource utilization associated with dalfampridine extended release in multiple sclerosis: a retrospective claims database analysis.

Guo A, Grabner M, Palli SR, Elder J, Sidovar M, Aupperle P, Krieger S.

Clinicoecon Outcomes Res. 2016 May 12;8:177-86. doi: 10.2147/CEOR.S99750. eCollection 2016.


New Approaches to the Diagnosis, Clinical Course, and Goals of Therapy in Multiple Sclerosis and Related Disorders.

Krieger SC.

Continuum (Minneap Minn). 2016 Jun;22(3):723-9. doi: 10.1212/CON.0000000000000324. Review.


Towards a new standardized method for circulating miRNAs profiling in clinical studies: Interest of the exogenous normalization to improve miRNA signature accuracy.

Vigneron N, Meryet-Figuière M, Guttin A, Issartel JP, Lambert B, Briand M, Louis MH, Vernon M, Lebailly P, Lecluse Y, Joly F, Krieger S, Lheureux S, Clarisse B, Leconte A, Gauduchon P, Poulain L, Denoyelle C.

Mol Oncol. 2016 Aug;10(7):981-92. doi: 10.1016/j.molonc.2016.03.005. Epub 2016 Apr 2.


Retinal degeneration in primary-progressive multiple sclerosis: A role for cortical lesions?

Petracca M, Cordano C, Cellerino M, Button J, Krieger S, Vancea R, Ghassemi R, Farrell C, Miller A, Calabresi PA, Lublin F, Inglese M.

Mult Scler. 2017 Jan;23(1):43-50. doi: 10.1177/1352458516637679. Epub 2016 Jul 11.


Metabolically Stabilized (68)Ga-NOTA-Bombesin for PET Imaging of Prostate Cancer and Influence of Protease Inhibitor Phosphoramidon.

Richter S, Wuest M, Bergman CN, Krieger S, Rogers BE, Wuest F.

Mol Pharm. 2016 Apr 4;13(4):1347-57. doi: 10.1021/acs.molpharmaceut.5b00970. Epub 2016 Mar 23.


Passive frame theory: A new synthesis.

Morsella E, Godwin CA, Jantz TK, Krieger SC, Gazzaley A.

Behav Brain Sci. 2016 Jan;39:e199. doi: 10.1017/S0140525X15002812.


NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro.

Nguyen CH, Senfter D, Basilio J, Holzner S, Stadler S, Krieger S, Huttary N, Milovanovic D, Viola K, Simonitsch-Klupp I, Jäger W, de Martin R, Krupitza G.

Oncotarget. 2015 Nov 17;6(36):39262-75. doi: 10.18632/oncotarget.5741.


Association of Deep Gray Matter Damage With Cortical and Spinal Cord Degeneration in Primary Progressive Multiple Sclerosis.

Ruggieri S, Petracca M, Miller A, Krieger S, Ghassemi R, Bencosme Y, Riley C, Howard J, Lublin F, Inglese M.

JAMA Neurol. 2015 Dec;72(12):1466-74. doi: 10.1001/jamaneurol.2015.1897.


Lhermitte's Sign following VMAT-Based Head and Neck Radiation-Insights into Mechanism.

Ko HC, Powers AR, Sheu RD, Kerns SL, Rosenstein BS, Krieger SC, Mourad WF, Hu KS, Gupta V, Bakst RL.

PLoS One. 2015 Oct 8;10(10):e0139448. doi: 10.1371/journal.pone.0139448. eCollection 2015.


Inhalation exposure to ethylene induces eosinophilic rhinitis and nasal epithelial remodeling in Fischer 344 rats.

Brandenberger C, Hotchkiss JA, Krieger SM, Pottenger LH, Harkema JR.

Chem Biol Interact. 2015 Nov 5;241:66-75. doi: 10.1016/j.cbi.2015.09.001. Epub 2015 Sep 11.


Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib.

Sun B, Shah B, Fiskus W, Qi J, Rajapakshe K, Coarfa C, Li L, Devaraj SG, Sharma S, Zhang L, Wang ML, Saenz DT, Krieger S, Bradner JE, Bhalla KN.

Blood. 2015 Sep 24;126(13):1565-74. doi: 10.1182/blood-2015-04-639542. Epub 2015 Aug 7. Erratum in: Blood. 2016 Sep 29;128(13):1778.

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