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Items: 30


CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools.

Chmielewski JP, Bowlby SC, Wheeler FB, Shi L, Sui G, Davis AL, Howard TD, D'Agostino RB Jr, Miller LD, Sirintrapun SJ, Cramer SD, Kridel SJ.

Mol Cancer Res. 2018 Nov;16(11):1687-1700. doi: 10.1158/1541-7786.MCR-17-0526. Epub 2018 Aug 3.


Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells.

Souchek JJ, Davis AL, Hill TK, Holmes MB, Qi B, Singh PK, Kridel SJ, Mohs AM.

Mol Cancer Ther. 2017 Sep;16(9):1819-1830. doi: 10.1158/1535-7163.MCT-17-0013. Epub 2017 Jun 14.


Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer.

Wang J, Zhang X, Shi J, Cao P, Wan M, Zhang Q, Wang Y, Kridel SJ, Liu W, Xu J, Zhang Q, Sui G.

Oncotarget. 2016 Nov 29;7(48):78566-78576. doi: 10.18632/oncotarget.12479.


Palmitoylation regulates the intracellular trafficking and stability of c-Met.

Coleman DT, Gray AL, Kridel SJ, Cardelli JA.

Oncotarget. 2016 May 31;7(22):32664-77. doi: 10.18632/oncotarget.8706.


Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines.

Hill TK, Davis AL, Wheeler FB, Kelkar SS, Freund EC, Lowther WT, Kridel SJ, Mohs AM.

Mol Pharm. 2016 Mar 7;13(3):720-8. doi: 10.1021/acs.molpharmaceut.5b00447. Epub 2016 Feb 8.


Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation.

Zhang Q, Wan M, Shi J, Horita DA, Miller LD, Kute TE, Kridel SJ, Kulik G, Sui G.

J Mol Cell Biol. 2016 Jun;8(3):232-43. doi: 10.1093/jmcb/mjw002. Epub 2016 Jan 13.


Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE.

Ritchie MK, Johnson LC, Clodfelter JE, Pemble CW 4th, Fulp BE, Furdui CM, Kridel SJ, Lowther WT.

J Biol Chem. 2016 Feb 12;291(7):3520-30. doi: 10.1074/jbc.M115.702597. Epub 2015 Dec 9.


A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS).

Gao C, Wang N, Guo X, Ziegler JT, Taylor KD, Xiang AH, Hai Y, Kridel SJ, Nadler JL, Kandeel F, Raffel LJ, Chen YD, Norris JM, Rotter JI, Watanabe RM, Wagenknecht LE, Bowden DW, Speliotes EK, Goodarzi MO, Langefeld CD, Palmer ND.

PLoS One. 2015 Nov 24;10(11):e0134649. doi: 10.1371/journal.pone.0134649. eCollection 2015.


The potential of ¹¹C-acetate PET for monitoring the Fatty acid synthesis pathway in Tumors.

Deford-Watts LM, Mintz A, Kridel SJ.

Curr Pharm Biotechnol. 2013;14(3):300-12. Review.


Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells.

Bowlby SC, Thomas MJ, D'Agostino RB Jr, Kridel SJ.

PLoS One. 2012;7(6):e40195. doi: 10.1371/journal.pone.0040195. Epub 2012 Jun 29.


Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis.

Scott KE, Wheeler FB, Davis AL, Thomas MJ, Ntambi JM, Seals DF, Kridel SJ.

PLoS One. 2012;7(1):e29761. doi: 10.1371/journal.pone.0029761. Epub 2012 Jan 6.


Polyunsaturated fatty acid metabolism in prostate cancer.

Berquin IM, Edwards IJ, Kridel SJ, Chen YQ.

Cancer Metastasis Rev. 2011 Dec;30(3-4):295-309. doi: 10.1007/s10555-011-9299-7. Review.


Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death.

Little JL, Wheeler FB, Koumenis C, Kridel SJ.

Mol Cancer Ther. 2008 Dec;7(12):3816-24. doi: 10.1158/1535-7163.MCT-08-0558.


Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways.

Fels DR, Ye J, Segan AT, Kridel SJ, Spiotto M, Olson M, Koong AC, Koumenis C.

Cancer Res. 2008 Nov 15;68(22):9323-30. doi: 10.1158/0008-5472.CAN-08-2873.


Fatty acid synthase activity in tumor cells.

Little JL, Kridel SJ.

Subcell Biochem. 2008;49:169-94. doi: 10.1007/978-1-4020-8831-5_7. Review.


1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer.

Vāvere AL, Kridel SJ, Wheeler FB, Lewis JS.

J Nucl Med. 2008 Feb;49(2):327-34. doi: 10.2967/jnumed.107.046672. Epub 2008 Jan 16.


Fatty acid synthase inhibitors: new directions for oncology.

Kridel SJ, Lowther WT, Pemble CW 4th.

Expert Opin Investig Drugs. 2007 Nov;16(11):1817-29. Review.


Dietary fat-gene interactions in cancer.

Chen YQ, Edwards IJ, Kridel SJ, Thornburg T, Berquin IM.

Cancer Metastasis Rev. 2007 Dec;26(3-4):535-51. Review.


Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat.

Pemble CW 4th, Johnson LC, Kridel SJ, Lowther WT.

Nat Struct Mol Biol. 2007 Aug;14(8):704-9. Epub 2007 Jul 8.


Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.

Little JL, Wheeler FB, Fels DR, Koumenis C, Kridel SJ.

Cancer Res. 2007 Feb 1;67(3):1262-9.


Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity.

Kridel SJ, Axelrod F, Rozenkrantz N, Smith JW.

Cancer Res. 2004 Mar 15;64(6):2070-5.


S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death.

Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, Lipton SA.

Science. 2002 Aug 16;297(5584):1186-90.


A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases.

Kridel SJ, Sawai H, Ratnikov BI, Chen EI, Li W, Godzik A, Strongin AY, Smith JW.

J Biol Chem. 2002 Jun 28;277(26):23788-93. Epub 2002 Apr 16.


A unique substrate recognition profile for matrix metalloproteinase-2.

Chen EI, Kridel SJ, Howard EW, Li W, Godzik A, Smith JW.

J Biol Chem. 2002 Feb 8;277(6):4485-91. Epub 2001 Nov 2.


A substrate phage enzyme-linked immunosorbent assay to profile panels of proteases.

Kridel SJ, Chen E, Smith JW.

Anal Biochem. 2001 Jul 15;294(2):176-84.


Substrate hydrolysis by matrix metalloproteinase-9.

Kridel SJ, Chen E, Kotra LP, Howard EW, Mobashery S, Smith JW.

J Biol Chem. 2001 Jun 8;276(23):20572-8. Epub 2001 Mar 14.


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