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Items: 20

1.

Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain.

Marcinkowski P, Kreuchwig A, Mendieta S, Hoyer I, Witte F, Furkert J, Rutz C, Lentz D, Krause G, Schülein R.

Mol Pharmacol. 2019 Oct;96(4):452-462. doi: 10.1124/mol.119.116947. Epub 2019 Aug 9.

PMID:
31399504
2.

The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis.

Lozza L, Moura-Alves P, Domaszewska T, Lage Crespo C, Streata I, Kreuchwig A, Puyskens A, Bechtle M, Klemm M, Zedler U, Silviu Ungureanu B, Guhlich-Bornhof U, Koehler AB, Stäber M, Mollenkopf HJ, Hurwitz R, Furkert J, Krause G, Weiner J 3rd, Jacinto A, Mihai I, Leite-de-Moraes M, Siebenhaar F, Maurer M, Kaufmann SHE.

Sci Rep. 2019 Jul 26;9(1):10878. doi: 10.1038/s41598-019-47350-x.

3.

GPCR-SSFE 2.0-a fragment-based molecular modeling web tool for Class A G-protein coupled receptors.

Worth CL, Kreuchwig F, Tiemann JKS, Kreuchwig A, Ritschel M, Kleinau G, Hildebrand PW, Krause G.

Nucleic Acids Res. 2017 Jul 3;45(W1):W408-W415. doi: 10.1093/nar/gkx399.

4.

Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work.

Kleinau G, Worth CL, Kreuchwig A, Biebermann H, Marcinkowski P, Scheerer P, Krause G.

Front Endocrinol (Lausanne). 2017 Apr 24;8:86. doi: 10.3389/fendo.2017.00086. eCollection 2017. Review.

5.

AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.

Götz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zühlke K, Kreuchwig A, Kennedy EJ, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E.

Biochem J. 2016 Jul 1;473(13):1881-94. doi: 10.1042/BCJ20160242. Epub 2016 Apr 21.

6.

Differences in Signal Activation by LH and hCG are Mediated by the LH/CG Receptor's Extracellular Hinge Region.

Grzesik P, Kreuchwig A, Rutz C, Furkert J, Wiesner B, Schuelein R, Kleinau G, Gromoll J, Krause G.

Front Endocrinol (Lausanne). 2015 Sep 22;6:140. doi: 10.3389/fendo.2015.00140. eCollection 2015.

7.

AhR sensing of bacterial pigments regulates antibacterial defence.

Moura-Alves P, Faé K, Houthuys E, Dorhoi A, Kreuchwig A, Furkert J, Barison N, Diehl A, Munder A, Constant P, Skrahina T, Guhlich-Bornhof U, Klemm M, Koehler AB, Bandermann S, Goosmann C, Mollenkopf HJ, Hurwitz R, Brinkmann V, Fillatreau S, Daffe M, Tümmler B, Kolbe M, Oschkinat H, Krause G, Kaufmann SH.

Nature. 2014 Aug 28;512(7515):387-92. doi: 10.1038/nature13684. Epub 2014 Aug 13.

PMID:
25119038
8.

Small-molecule inhibitors of AF6 PDZ-mediated protein-protein interactions.

Vargas C, Radziwill G, Krause G, Diehl A, Keller S, Kamdem N, Czekelius C, Kreuchwig A, Schmieder P, Doyle D, Moelling K, Hagen V, Schade M, Oschkinat H.

ChemMedChem. 2014 Jul;9(7):1458-62. doi: 10.1002/cmdc.201300553. Epub 2014 Mar 25.

PMID:
24668962
9.

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.

Schäfer G, Milić J, Eldahshan A, Götz F, Zühlke K, Schillinger C, Kreuchwig A, Elkins JM, Abdul Azeez KR, Oder A, Moutty MC, Masada N, Beerbaum M, Schlegel B, Niquet S, Schmieder P, Krause G, von Kries JP, Cooper DM, Knapp S, Rademann J, Rosenthal W, Klussmann E.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12187-91. doi: 10.1002/anie.201304686. Epub 2013 Sep 23. No abstract available.

10.

Research resource: novel structural insights bridge gaps in glycoprotein hormone receptor analyses.

Kreuchwig A, Kleinau G, Krause G.

Mol Endocrinol. 2013 Aug;27(8):1357-63. doi: 10.1210/me.2013-1115. Epub 2013 Jun 24.

11.

Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists.

Hoyer I, Haas AK, Kreuchwig A, Schülein R, Krause G.

Biochem Soc Trans. 2013 Feb 1;41(1):213-7. doi: 10.1042/BST20120319. Review.

12.

Extended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor.

Krause G, Kreuchwig A, Kleinau G.

PLoS One. 2012;7(12):e52920. doi: 10.1371/journal.pone.0052920. Epub 2012 Dec 27.

13.

Hierarchical representation of supersecondary structures using a graph-theoretical approach.

Koch I, Kreuchwig A, May P.

Methods Mol Biol. 2013;932:7-33. doi: 10.1007/978-1-62703-065-6_2.

PMID:
22987344
14.

The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization.

Teichmann A, Rutz C, Kreuchwig A, Krause G, Wiesner B, Schülein R.

J Biol Chem. 2012 Aug 3;287(32):27265-74. doi: 10.1074/jbc.M112.360594. Epub 2012 Jun 11.

15.

Using ortholog sequence data to predict the functional relevance of mutations in G-protein-coupled receptors.

Cöster M, Wittkopf D, Kreuchwig A, Kleinau G, Thor D, Krause G, Schöneberg T.

FASEB J. 2012 Aug;26(8):3273-81. doi: 10.1096/fj.12-203737. Epub 2012 May 18.

PMID:
22611087
16.

GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models.

Worth CL, Kreuchwig A, Kleinau G, Krause G.

BMC Bioinformatics. 2011 May 23;12:185. doi: 10.1186/1471-2105-12-185.

17.

From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).

Kleinau G, Hoyer I, Kreuchwig A, Haas AK, Rutz C, Furkert J, Worth CL, Krause G, Schülein R.

J Biol Chem. 2011 Jul 22;286(29):25859-71. doi: 10.1074/jbc.M110.196980. Epub 2011 May 17.

18.

Research resource: Update and extension of a glycoprotein hormone receptors web application.

Kreuchwig A, Kleinau G, Kreuchwig F, Worth CL, Krause G.

Mol Endocrinol. 2011 Apr;25(4):707-12. doi: 10.1210/me.2010-0510. Epub 2011 Feb 3.

19.
20.

PTGL: a database for secondary structure-based protein topologies.

May P, Kreuchwig A, Steinke T, Koch I.

Nucleic Acids Res. 2010 Jan;38(Database issue):D326-30. doi: 10.1093/nar/gkp980. Epub 2009 Nov 11.

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