Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 331

1.

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.

Gasparoni G, Bultmann S, Lutsik P, Kraus TFJ, Sordon S, Vlcek J, Dietinger V, Steinmaurer M, Haider M, Mulholland CB, Arzberger T, Roeber S, Riemenschneider M, Kretzschmar HA, Giese A, Leonhardt H, Walter J.

Epigenetics Chromatin. 2018 Jul 25;11(1):41. doi: 10.1186/s13072-018-0211-3.

2.

Altered Long Noncoding RNA Expression Precedes the Course of Parkinson's Disease-a Preliminary Report.

Kraus TFJ, Haider M, Spanner J, Steinmaurer M, Dietinger V, Kretzschmar HA.

Mol Neurobiol. 2017 May;54(4):2869-2877. doi: 10.1007/s12035-016-9854-x. Epub 2016 Mar 28.

PMID:
27021022
3.

Profiling of methylation and demethylation pathways during brain development and ageing.

Kraus TF, Kilinc S, Steinmaurer M, Stieglitz M, Guibourt V, Kretzschmar HA.

J Neural Transm (Vienna). 2016 Mar;123(3):189-203. doi: 10.1007/s00702-015-1469-2. Epub 2015 Oct 26.

PMID:
26497022
4.

Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.

Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M.

Acta Neuropathol. 2015 Nov;130(5):619-31. doi: 10.1007/s00401-015-1483-3. Epub 2015 Oct 6.

5.

Three novel presenilin 1 mutations marking the wide spectrum of age at onset and clinical patterns in familial Alzheimer's disease.

Roeber S, Müller-Sarnowski F, Kress J, Edbauer D, Kuhlmann T, Tüttelmann F, Schindler C, Winter P, Arzberger T, Müller U, Danek A, Kretzschmar HA.

J Neural Transm (Vienna). 2015 Dec;122(12):1715-9. doi: 10.1007/s00702-015-1450-0. Epub 2015 Sep 8.

PMID:
26350633
6.

Genetic Characterization of Ten-Eleven-Translocation Methylcytosine Dioxygenase Alterations in Human Glioma.

Kraus TF, Greiner A, Steinmaurer M, Dietinger V, Guibourt V, Kretzschmar HA.

J Cancer. 2015 Jul 15;6(9):832-42. doi: 10.7150/jca.12010. eCollection 2015.

7.

Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues.

Wagner M, Steinbacher J, Kraus TF, Michalakis S, Hackner B, Pfaffeneder T, Perera A, Müller M, Giese A, Kretzschmar HA, Carell T.

Angew Chem Int Ed Engl. 2015 Oct 12;54(42):12511-4. doi: 10.1002/anie.201502722. Epub 2015 Jul 3.

8.

Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.

Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NCA, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, Farlow MR, Grafman J, Huey ED, Ryung Han M, Beecher S, Geller ET, Kretzschmar HA, Roeber S, Gearing M, Juncos JL, Vonsattel JPG, Van Deerlin VM, Grossman M, Hurtig HI, Gross RG, Arnold SE, Trojanowski JQ, Lee VM, Wenning GK, White CL, Höglinger GU, Müller U, Devlin B, Golbe LI, Crook J, Parisi JE, Boeve BF, Josephs KA, Wszolek ZK, Uitti RJ, Graff-Radford NR, Litvan I, Younkin SG, Wang LS, Ertekin-Taner N, Rademakers R, Hakonarsen H, Schellenberg GD, Dickson DW.

Nat Commun. 2015 Jun 16;6:7247. doi: 10.1038/ncomms8247.

9.

Clinical findings and diagnosis in genetic prion diseases in Germany.

Krasnianski A, Heinemann U, Ponto C, Kortt J, Kallenberg K, Varges D, Schulz-Schaeffer WJ, Kretzschmar HA, Zerr I.

Eur J Epidemiol. 2016 Feb;31(2):187-96. doi: 10.1007/s10654-015-0049-y. Epub 2015 Jun 16.

PMID:
26076917
10.

Loss of 5-hydroxymethylcytosine and intratumoral heterogeneity as an epigenomic hallmark of glioblastoma.

Kraus TF, Kolck G, Greiner A, Schierl K, Guibourt V, Kretzschmar HA.

Tumour Biol. 2015 Nov;36(11):8439-46. doi: 10.1007/s13277-015-3606-9. Epub 2015 May 29.

PMID:
26022161
11.

Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease.

Schulte EC, Fukumori A, Mollenhauer B, Hor H, Arzberger T, Perneczky R, Kurz A, Diehl-Schmid J, Hüll M, Lichtner P, Eckstein G, Zimprich A, Haubenberger D, Pirker W, Brücke T, Bereznai B, Molnar MJ, Lorenzo-Betancor O, Pastor P, Peters A, Gieger C, Estivill X, Meitinger T, Kretzschmar HA, Trenkwalder C, Haass C, Winkelmann J.

Eur J Hum Genet. 2015 Oct;23(10):1328-33. doi: 10.1038/ejhg.2014.300. Epub 2015 Jan 21.

12.

Identification of Stably Expressed lncRNAs as Valid Endogenous Controls for Profiling of Human Glioma.

Kraus TF, Greiner A, Guibourt V, Lisec K, Kretzschmar HA.

J Cancer. 2015 Jan 1;6(2):111-9. doi: 10.7150/jca.10867. eCollection 2015.

13.

Long non-coding RNA normalisers in human brain tissue.

Kraus TF, Greiner A, Guibourt V, Kretzschmar HA.

J Neural Transm (Vienna). 2015 Jul;122(7):1045-54. doi: 10.1007/s00702-014-1352-6. Epub 2014 Dec 21.

PMID:
25528156
14.

5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing.

Kraus TF, Guibourt V, Kretzschmar HA.

J Neural Transm (Vienna). 2015 Jul;122(7):1035-43. doi: 10.1007/s00702-014-1346-4. Epub 2014 Dec 4.

PMID:
25471351
15.

First symptom and initial diagnosis in sporadic CJD patients in Germany.

Krasnianski A, Kaune J, Jung K, Kretzschmar HA, Zerr I.

J Neurol. 2014 Sep;261(9):1811-7. doi: 10.1007/s00415-014-7410-z. Epub 2014 Jul 15.

PMID:
25022936
16.

Diffuse leukoencephalopathy with spheroids: biopsy findings and a novel mutation.

Levin J, Tiedt S, Arzberger T, Biskup S, Schuberth M, Stenglein-Krapf G, Kreth FW, Högen T, la Fougère C, Linn J, van der Knaap MS, Giese A, Kretzschmar HA, Danek A.

Clin Neurol Neurosurg. 2014 Jul;122:113-5. doi: 10.1016/j.clineuro.2014.04.022. Epub 2014 May 4. No abstract available.

PMID:
24908228
17.

Analyses of the similarity and difference of global gene expression profiles in cortex regions of three neurodegenerative diseases: sporadic Creutzfeldt-Jakob disease (sCJD), fatal familial insomnia (FFI), and Alzheimer's disease (AD).

Tian C, Liu D, Xiang W, Kretzschmar HA, Sun QL, Gao C, Xu Y, Wang H, Fan XY, Meng G, Li W, Dong XP.

Mol Neurobiol. 2014 Oct;50(2):473-81. doi: 10.1007/s12035-014-8758-x. Epub 2014 Jun 7.

PMID:
24902808
18.

Molecular stereotactic biopsy technique improves diagnostic accuracy and enables personalized treatment strategies in glioma patients.

Eigenbrod S, Trabold R, Brucker D, Erös C, Egensperger R, La Fougere C, Göbel W, Rühm A, Kretzschmar HA, Tonn JC, Herms J, Giese A, Kreth FW.

Acta Neurochir (Wien). 2014 Aug;156(8):1427-40. doi: 10.1007/s00701-014-2073-1. Epub 2014 May 3.

PMID:
24792966
19.

[Hereditary diffuse leukencephalopathy with spheroids: a microgliopathy due to CSF1 receptor impairment].

Schuberth M, Levin J, Sawalhe D, Schwarzkopf R, von Baumgarten L, Ertl-Wagner B, Rominger A, Arzberger T, Kretzschmar HA, Froböse T, Diehl-Schmid J, Biskup S, Danek A.

Nervenarzt. 2014 Apr;85(4):465-70. doi: 10.1007/s00115-014-4052-4. German.

PMID:
24706185
20.

Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.

Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A.

Acta Neuropathol. 2014;127(6):845-60. doi: 10.1007/s00401-014-1262-6. Epub 2014 Mar 12.

PMID:
24619111
21.

Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo.

Leidel F, Eiden M, Geissen M, Hirschberger T, Tavan P, Giese A, Kretzschmar HA, Schätzl H, Groschup MH.

Biochem Biophys Res Commun. 2014 Feb 28;445(1):23-9. doi: 10.1016/j.bbrc.2014.01.122. Epub 2014 Feb 3.

PMID:
24502948
22.

Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrPSc in prion-infected tissues.

Shi S, Mitteregger-Kretzschmar G, Giese A, Kretzschmar HA.

Acta Neuropathol Commun. 2013 Aug 2;1:44. doi: 10.1186/2051-5960-1-44.

23.

A proposal of new diagnostic pathway for fatal familial insomnia.

Krasnianski A, Sanchez Juan P, Ponto C, Bartl M, Heinemann U, Varges D, Schulz-Schaeffer WJ, Kretzschmar HA, Zerr I.

J Neurol Neurosurg Psychiatry. 2014 Jun;85(6):654-9. doi: 10.1136/jnnp-2013-305978. Epub 2013 Nov 18.

24.

Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.

Mori K, Arzberger T, Grässer FA, Gijselinck I, May S, Rentzsch K, Weng SM, Schludi MH, van der Zee J, Cruts M, Van Broeckhoven C, Kremmer E, Kretzschmar HA, Haass C, Edbauer D.

Acta Neuropathol. 2013 Dec;126(6):881-93. doi: 10.1007/s00401-013-1189-3. Epub 2013 Oct 17.

PMID:
24132570
25.

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations.

Mackenzie IR, Arzberger T, Kremmer E, Troost D, Lorenzl S, Mori K, Weng SM, Haass C, Kretzschmar HA, Edbauer D, Neumann M.

Acta Neuropathol. 2013 Dec;126(6):859-79. doi: 10.1007/s00401-013-1181-y. Epub 2013 Oct 6.

PMID:
24096617
26.

[Molecular biological identification of fungal pathogens in FFPE tissue from cases of cephalic mycosis].

Bernhardt A, de Boni L, Kretzschmar HA, Tintelnot K.

Pathologe. 2013 Nov;34(6):540-7. doi: 10.1007/s00292-013-1833-7. Review. German.

PMID:
24043212
27.

Analyses of protease resistance and aggregation state of abnormal prion protein across the spectrum of human prions.

Saverioni D, Notari S, Capellari S, Poggiolini I, Giese A, Kretzschmar HA, Parchi P.

J Biol Chem. 2013 Sep 27;288(39):27972-85. doi: 10.1074/jbc.M113.477547. Epub 2013 Jul 29.

28.

Sox2 requirement in sonic hedgehog-associated medulloblastoma.

Ahlfeld J, Favaro R, Pagella P, Kretzschmar HA, Nicolis S, Schüller U.

Cancer Res. 2013 Jun 15;73(12):3796-807. doi: 10.1158/0008-5472.CAN-13-0238. Epub 2013 Apr 17.

29.

Influence of the blood-CSF-barrier function on S100B in neurodegenerative diseases.

Steinacker P, Weidehaas K, Cepek L, Feneberg E, Kretzschmar HA, Otto M.

Acta Neurol Scand. 2013 Oct;128(4):249-56. doi: 10.1111/ane.12113. Epub 2013 Mar 19.

PMID:
23510454
30.

Report about four novel mutations in the prion protein gene.

Schelzke G, Stoeck K, Eigenbrod S, Grasbon-Frodl E, Raddatz LM, Ponto C, Kretzschmar HA, Zerr I.

Dement Geriatr Cogn Disord. 2013;35(3-4):229-37. doi: 10.1159/000345991. Epub 2013 Mar 5.

PMID:
23467330
31.

Atypical parkinsonism due to a D202N Gerstmann-Sträussler-Scheinker prion protein mutation: first in vivo diagnosed case.

Plate A, Benninghoff J, Jansen GH, Wlasich E, Eigenbrod S, Drzezga A, Jansen NL, Kretzschmar HA, Bötzel K, Rujescu D, Danek A.

Mov Disord. 2013 Feb;28(2):241-4. doi: 10.1002/mds.25188.

PMID:
23436635
32.

Comparative analysis of gene expression profiles between cortex and thalamus in Chinese fatal familial insomnia patients.

Tian C, Liu D, Sun QL, Chen C, Xu Y, Wang H, Xiang W, Kretzschmar HA, Li W, Chen C, Shi Q, Gao C, Zhang J, Zhang BY, Han J, Dong XP.

Mol Neurobiol. 2013 Aug;48(1):36-48. doi: 10.1007/s12035-013-8426-6. Epub 2013 Feb 21.

PMID:
23430483
33.

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D.

Science. 2013 Mar 15;339(6125):1335-8. doi: 10.1126/science.1232927. Epub 2013 Feb 7.

34.

Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.

Schön C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Steinbach S, Seeliger MW, Arzberger T, Goedert M, Kretzschmar HA, Schmidt B, Herms J.

PLoS One. 2012;7(12):e53547. doi: 10.1371/journal.pone.0053547. Epub 2012 Dec 31.

35.

Constitutive activation of β-catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system.

Pöschl J, Grammel D, Dorostkar MM, Kretzschmar HA, Schüller U.

Dev Biol. 2013 Feb 15;374(2):319-32. doi: 10.1016/j.ydbio.2012.12.001. Epub 2012 Dec 10.

36.

Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia.

Jesse S, Lehnert S, Jahn O, Parnetti L, Soininen H, Herukka SK, Steinacker P, Tawfik S, Tumani H, von Arnim CA, Neumann M, Kretzschmar HA, Kulaksiz H, Lenter M, Wiltfang J, Ferger B, Hengerer B, Otto M.

PLoS One. 2012;7(11):e48783. doi: 10.1371/journal.pone.0048783. Epub 2012 Nov 8.

37.

Prediction of oligodendroglial histology and LOH 1p/19q using dynamic [(18)F]FET-PET imaging in intracranial WHO grade II and III gliomas.

Jansen NL, Schwartz C, Graute V, Eigenbrod S, Lutz J, Egensperger R, Pöpperl G, Kretzschmar HA, Cumming P, Bartenstein P, Tonn JC, Kreth FW, la Fougère C, Thon N.

Neuro Oncol. 2012 Dec;14(12):1473-80. doi: 10.1093/neuonc/nos259. Epub 2012 Oct 22.

38.

Recruitment of neural precursor cells from circumventricular organs of patients with cerebral ischaemia.

Sanin V, Heeß C, Kretzschmar HA, Schüller U.

Neuropathol Appl Neurobiol. 2013 Aug;39(5):510-8. doi: 10.1111/j.1365-2990.2012.01301.x.

PMID:
22985410
39.

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Neumann M, Valori CF, Ansorge O, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ishihara K, Ang LC, Bilbao JM, Mackenzie IR.

Acta Neuropathol. 2012 Nov;124(5):705-16. doi: 10.1007/s00401-012-1020-6. Epub 2012 Jul 28.

PMID:
22842875
40.

Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype.

Rutherford NJ, Heckman MG, Dejesus-Hernandez M, Baker MC, Soto-Ortolaza AI, Rayaprolu S, Stewart H, Finger E, Volkening K, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, Knopman DS, Kretzschmar HA, Neumann M, Caselli RJ, White CL 3rd, Mackenzie IR, Petersen RC, Strong MJ, Miller BL, Boeve BF, Uitti RJ, Boylan KB, Wszolek ZK, Graff-Radford NR, Dickson DW, Ross OA, Rademakers R.

Neurobiol Aging. 2012 Dec;33(12):2950.e5-7. doi: 10.1016/j.neurobiolaging.2012.07.005. Epub 2012 Jul 26.

41.

Synthesis of benzamide derivatives and their evaluation as antiprion agents.

Fiorino F, Eiden M, Giese A, Severino B, Esposito A, Groschup MH, Perissutti E, Magli E, Incisivo GM, Ciano A, Frecentese F, Kretzschmar HA, Wagner J, Santagada V, Caliendo G.

Bioorg Med Chem. 2012 Aug 15;20(16):5001-11. doi: 10.1016/j.bmc.2012.06.026. Epub 2012 Jun 20.

PMID:
22795751
42.

Consensus classification of human prion disease histotypes allows reliable identification of molecular subtypes: an inter-rater study among surveillance centres in Europe and USA.

Parchi P, de Boni L, Saverioni D, Cohen ML, Ferrer I, Gambetti P, Gelpi E, Giaccone G, Hauw JJ, Höftberger R, Ironside JW, Jansen C, Kovacs GG, Rozemuller A, Seilhean D, Tagliavini F, Giese A, Kretzschmar HA.

Acta Neuropathol. 2012 Oct;124(4):517-29. doi: 10.1007/s00401-012-1002-8. Epub 2012 Jun 30.

43.

ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients.

Adam SA, Schnell O, Pöschl J, Eigenbrod S, Kretzschmar HA, Tonn JC, Schüller U.

Brain Pathol. 2012 Nov;22(6):788-97. doi: 10.1111/j.1750-3639.2012.00592.x. Epub 2012 Apr 19.

PMID:
22417385
44.

CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis.

Oeckl P, Steinacker P, Lehnert S, Jesse S, Kretzschmar HA, Ludolph AC, Otto M, Ferger B.

PLoS One. 2012;7(3):e32664. doi: 10.1371/journal.pone.0032664. Epub 2012 Mar 2.

45.

Clinical aspects of common genetic Creutzfeldt-Jakob disease.

Schelzke G, Kretzschmar HA, Zerr I.

Eur J Epidemiol. 2012 Feb;27(2):147-9. doi: 10.1007/s10654-012-9660-3. Epub 2012 Mar 2. No abstract available.

46.

Proper cerebellar development requires expression of β1-integrin in Bergmann glia, but not in granule neurons.

Frick A, Grammel D, Schmidt F, Pöschl J, Priller M, Pagella P, von Bueren AO, Peraud A, Tonn JC, Herms J, Rutkowski S, Kretzschmar HA, Schüller U.

Glia. 2012 May;60(5):820-32. doi: 10.1002/glia.22314. Epub 2012 Feb 28.

PMID:
22374686
47.

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem.

Grammel D, Warmuth-Metz M, von Bueren AO, Kool M, Pietsch T, Kretzschmar HA, Rowitch DH, Rutkowski S, Pfister SM, Schüller U.

Acta Neuropathol. 2012 Apr;123(4):601-14. doi: 10.1007/s00401-012-0961-0. Epub 2012 Feb 21.

PMID:
22349907
48.

Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors.

Kraus TF, Globisch D, Wagner M, Eigenbrod S, Widmann D, Münzel M, Müller M, Pfaffeneder T, Hackner B, Feiden W, Schüller U, Carell T, Kretzschmar HA.

Int J Cancer. 2012 Oct 1;131(7):1577-90. doi: 10.1002/ijc.27429. Epub 2012 Mar 2.

49.

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids.

Rademakers R, Baker M, Nicholson AM, Rutherford NJ, Finch N, Soto-Ortolaza A, Lash J, Wider C, Wojtas A, DeJesus-Hernandez M, Adamson J, Kouri N, Sundal C, Shuster EA, Aasly J, MacKenzie J, Roeber S, Kretzschmar HA, Boeve BF, Knopman DS, Petersen RC, Cairns NJ, Ghetti B, Spina S, Garbern J, Tselis AC, Uitti R, Das P, Van Gerpen JA, Meschia JF, Levy S, Broderick DF, Graff-Radford N, Ross OA, Miller BB, Swerdlow RH, Dickson DW, Wszolek ZK.

Nat Genet. 2011 Dec 25;44(2):200-5. doi: 10.1038/ng.1027.

50.

Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk.

Sanchez-Juan P, Bishop MT, Aulchenko YS, Brandel JP, Rivadeneira F, Struchalin M, Lambert JC, Amouyel P, Combarros O, Sainz J, Carracedo A, Uitterlinden AG, Hofman A, Zerr I, Kretzschmar HA, Laplanche JL, Knight RS, Will RG, van Duijn CM.

Neurobiol Aging. 2012 Jul;33(7):1487.e21-8. doi: 10.1016/j.neurobiolaging.2011.10.011. Epub 2011 Dec 2.

PMID:
22137330

Supplemental Content

Loading ...
Support Center