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Items: 1 to 50 of 113

1.

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.

Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB.

J Am Soc Nephrol. 2018 Dec 5. pii: ASN.2018070736. doi: 10.1681/ASN.2018070736. [Epub ahead of print]

PMID:
30518531
2.

The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia.

Rommel C, Rösner S, Lother A, Barg M, Schwaderer M, Gilsbach R, Bömicke T, Schnick T, Mayer S, Doll S, Hesse M, Kretz O, Stiller B, Neumann FJ, Mann M, Krane M, Fleischmann BK, Ravens U, Hein L.

Circ Res. 2018 Aug 17;123(5):550-563. doi: 10.1161/CIRCRESAHA.118.313036.

PMID:
29930145
3.

Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney.

Viau A, Bienaimé F, Lukas K, Todkar AP, Knoll M, Yakulov TA, Hofherr A, Kretz O, Helmstädter M, Reichardt W, Braeg S, Aschman T, Merkle A, Pfeifer D, Dumit VI, Gubler MC, Nitschke R, Huber TB, Terzi F, Dengjel J, Grahammer F, Köttgen M, Busch H, Boerries M, Walz G, Triantafyllopoulou A, Kuehn EW.

EMBO J. 2018 Aug 1;37(15). pii: e98615. doi: 10.15252/embj.201798615. Epub 2018 Jun 19.

4.

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB.

Cell Rep. 2018 May 22;23(8):2495-2508. doi: 10.1016/j.celrep.2018.04.059.

5.

Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.

Gradzka S, Thomas OS, Kretz O, Haimovici A, Vasilikos L, Wong WW, Häcker G, Gentle IE.

Cell Death Dis. 2018 May 1;9(5):529. doi: 10.1038/s41419-018-0508-y.

6.

Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated Negr1 Gene.

Singh K, Loreth D, Pöttker B, Hefti K, Innos J, Schwald K, Hengstler H, Menzel L, Sommer CJ, Radyushkin K, Kretz O, Philips MA, Haas CA, Frauenknecht K, Lilleväli K, Heimrich B, Vasar E, Schäfer MKE.

Front Mol Neurosci. 2018 Feb 9;11:30. doi: 10.3389/fnmol.2018.00030. eCollection 2018.

7.

The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.

Rogg M, Yasuda-Yamahara M, Abed A, Dinse P, Helmstädter M, Conzelmann AC, Frimmel J, Sellung D, Biniossek ML, Kretz O, Grahammer F, Schilling O, Huber TB, Schell C.

Sci Rep. 2017 Nov 21;7(1):15910. doi: 10.1038/s41598-017-15844-1.

8.

Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects.

Rujano MA, Cannata Serio M, Panasyuk G, Péanne R, Reunert J, Rymen D, Hauser V, Park JH, Freisinger P, Souche E, Guida MC, Maier EM, Wada Y, Jäger S, Krogan NJ, Kretz O, Nobre S, Garcia P, Quelhas D, Bird TD, Raskind WH, Schwake M, Duvet S, Foulquier F, Matthijs G, Marquardt T, Simons M.

J Exp Med. 2017 Dec 4;214(12):3707-3729. doi: 10.1084/jem.20170453. Epub 2017 Nov 10.

9.

Purification and Identification of Membrane Proteins from Urinary Extracellular Vesicles using Triton X-114 Phase Partitioning.

Hu S, Musante L, Tataruch D, Xu X, Kretz O, Henry M, Meleady P, Luo H, Zou H, Jiang Y, Holthofer H.

J Proteome Res. 2018 Jan 5;17(1):86-96. doi: 10.1021/acs.jproteome.7b00386. Epub 2017 Nov 20.

PMID:
29090927
10.

Mitochondrial Priming by CD28.

Klein Geltink RI, O'Sullivan D, Corrado M, Bremser A, Buck MD, Buescher JM, Firat E, Zhu X, Niedermann G, Caputa G, Kelly B, Warthorst U, Rensing-Ehl A, Kyle RL, Vandersarren L, Curtis JD, Patterson AE, Lawless S, Grzes K, Qiu J, Sanin DE, Kretz O, Huber TB, Janssens S, Lambrecht BN, Rambold AS, Pearce EJ, Pearce EL.

Cell. 2017 Oct 5;171(2):385-397.e11. doi: 10.1016/j.cell.2017.08.018. Epub 2017 Sep 14.

11.

Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis.

Mellows B, Mitchell R, Antonioli M, Kretz O, Chambers D, Zeuner MT, Denecke B, Musante L, Ramachandra DL, Debacq-Chainiaux F, Holthofer H, Joch B, Ray S, Widera D, David AL, Huber TB, Dengjel J, De Coppi P, Patel K.

Stem Cells Dev. 2017 Sep 15;26(18):1316-1333. doi: 10.1089/scd.2017.0089. Epub 2017 Aug 22.

PMID:
28679310
12.

The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.

Schell C, Rogg M, Suhm M, Helmstädter M, Sellung D, Yasuda-Yamahara M, Kretz O, Küttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, Huber TB.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4621-E4630. doi: 10.1073/pnas.1617004114. Epub 2017 May 23.

13.

TIR-domain-containing adapter-inducing interferon-β (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy.

Gentle IE, McHenry KT, Weber A, Metz A, Kretz O, Porter D, Häcker G.

FEBS J. 2017 Jul;284(13):1987-2003. doi: 10.1111/febs.14091. Epub 2017 May 19.

14.

YAP-mediated mechanotransduction determines the podocyte's response to damage.

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Gandhirajan RK, Krüger M, Brinkkoetter PT, Huber TB, Kann M, Wickström SA, Benzing T, Schermer B.

Sci Signal. 2017 Apr 11;10(474). pii: eaaf8165. doi: 10.1126/scisignal.aaf8165.

PMID:
28400537
15.

Targeting mTOR Signaling Can Prevent the Progression of FSGS.

Zschiedrich S, Bork T, Liang W, Wanner N, Eulenbruch K, Munder S, Hartleben B, Kretz O, Gerber S, Simons M, Viau A, Burtin M, Wei C, Reiser J, Herbach N, Rastaldi MP, Cohen CD, Tharaux PL, Terzi F, Walz G, Gödel M, Huber TB.

J Am Soc Nephrol. 2017 Jul;28(7):2144-2157. doi: 10.1681/ASN.2016050519. Epub 2017 Mar 7.

16.

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.

Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, Müller AL, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ, Lienkamp SS.

Nat Cell Biol. 2016 Dec;18(12):1269-1280. doi: 10.1038/ncb3437. Epub 2016 Nov 7.

PMID:
27820600
17.

MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.

Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Mårtensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A.

Cell. 2016 Oct 20;167(3):722-738.e23. doi: 10.1016/j.cell.2016.09.052.

18.

The flexibility of a generic LC-MS/MS method for the quantitative analysis of therapeutic proteins based on human immunoglobulin G and related constructs in animal studies.

Lanshoeft C, Wolf T, Walles M, Barteau S, Picard F, Kretz O, Cianférani S, Heudi O.

J Pharm Biomed Anal. 2016 Nov 30;131:214-222. doi: 10.1016/j.jpba.2016.08.039. Epub 2016 Aug 31.

PMID:
27599352
19.

Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres.

Omairi S, Matsakas A, Degens H, Kretz O, Hansson KA, Solbrå AV, Bruusgaard JC, Joch B, Sartori R, Giallourou N, Mitchell R, Collins-Hooper H, Foster K, Pasternack A, Ritvos O, Sandri M, Narkar V, Swann JR, Huber TB, Patel K.

Elife. 2016 Aug 5;5. pii: e16940. doi: 10.7554/eLife.16940.

20.

Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury.

Pedigo CE, Ducasa GM, Leclercq F, Sloan A, Mitrofanova A, Hashmi T, Molina-David J, Ge M, Lassenius MI, Forsblom C, Lehto M, Groop PH, Kretzler M, Eddy S, Martini S, Reich H, Wahl P, Ghiggeri G, Faul C, Burke GW 3rd, Kretz O, Huber TB, Mendez AJ, Merscher S, Fornoni A.

J Clin Invest. 2016 Sep 1;126(9):3336-50. doi: 10.1172/JCI85939. Epub 2016 Aug 2.

21.

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.

Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB.

JCI Insight. 2016 Jun 16;1(9). pii: e86177.

22.

Urinary extracellular vesicles for RNA extraction: optimization of a protocol devoid of prokaryote contamination.

Tataruch-Weinert D, Musante L, Kretz O, Holthofer H.

J Extracell Vesicles. 2016 Jun 24;5:30281. doi: 10.3402/jev.v5.30281. eCollection 2016.

23.

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells.

Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kühne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F.

J Am Soc Nephrol. 2017 Jan;28(1):230-241. doi: 10.1681/ASN.2015111224. Epub 2016 Jun 13.

24.

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.

Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL.

Cell. 2016 Jun 30;166(1):63-76. doi: 10.1016/j.cell.2016.05.035. Epub 2016 Jun 9.

25.

Quantitative analysis of hIgG1 in monkey serum by LC-MS/MS using mass spectrometric immunoassay.

Lanshoeft C, Heudi O, Cianférani S, Warren AP, Picard F, Kretz O.

Bioanalysis. 2016 May;8(10):1035-49. doi: 10.4155/bio.16.32. Epub 2016 Apr 20.

PMID:
27095045
26.

Synaptic Remodeling of Entorhinal Input Contributes to an Aberrant Hippocampal Network in Temporal Lobe Epilepsy.

Janz P, Savanthrapadian S, Häussler U, Kilias A, Nestel S, Kretz O, Kirsch M, Bartos M, Egert U, Haas CA.

Cereb Cortex. 2017 Mar 1;27(3):2348-2364. doi: 10.1093/cercor/bhw093.

PMID:
27073230
27.

Analysis of small molecule antibody-drug conjugate catabolites in rat liver and tumor tissue by liquid extraction surface analysis micro-capillary liquid chromatography/tandem mass spectrometry.

Lanshoeft C, Stutz G, Elbast W, Wolf T, Walles M, Stoeckli M, Picard F, Kretz O.

Rapid Commun Mass Spectrom. 2016 Apr 15;30(7):823-32. doi: 10.1002/rcm.7511.

PMID:
26969923
28.

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.

Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Saez I, Schermer B, Höhne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Müller RU, Krüger M, Benzing T.

Hum Mol Genet. 2016 Apr 1;25(7):1328-44. doi: 10.1093/hmg/ddw016. Epub 2016 Jan 19.

29.
30.

The use of generic surrogate peptides for the quantitative analysis of human immunoglobulin G1 in pre-clinical species with high-resolution mass spectrometry.

Lanshoeft C, Wolf T, Heudi O, Cianférani S, Barteau S, Walles M, Picard F, Kretz O.

Anal Bioanal Chem. 2016 Feb;408(6):1687-99. doi: 10.1007/s00216-015-9286-x. Epub 2016 Jan 12.

PMID:
26758601
31.

The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility.

Schell C, Kretz O, Liang W, Kiefer B, Schneider S, Sellung D, Bork T, Leiber C, Rüegg MA, Mallidis C, Schlatt S, Mayerhofer A, Huber TB, Grahammer F.

Am J Pathol. 2016 Feb;186(2):324-36. doi: 10.1016/j.ajpath.2015.10.012. Epub 2015 Dec 10.

PMID:
26683665
32.

The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells.

Yasunaga T, Hoff S, Schell C, Helmstädter M, Kretz O, Kuechlin S, Yakulov TA, Engel C, Müller B, Bensch R, Ronneberger O, Huber TB, Lienkamp SS, Walz G.

J Cell Biol. 2015 Dec 7;211(5):963-73. doi: 10.1083/jcb.201502043.

33.

Microtubule Associated Protein 1b (MAP1B) Is a Marker of the Microtubular Cytoskeleton in Podocytes but Is Not Essential for the Function of the Kidney Filtration Barrier in Mice.

Gödel M, Temerinac D, Grahammer F, Hartleben B, Kretz O, Riederer BM, Propst F, Kohl S, Huber TB.

PLoS One. 2015 Oct 8;10(10):e0140116. doi: 10.1371/journal.pone.0140116. eCollection 2015.

34.

MOF maintains transcriptional programs regulating cellular stress response.

Sheikh BN, Bechtel-Walz W, Lucci J, Karpiuk O, Hild I, Hartleben B, Vornweg J, Helmstädter M, Sahyoun AH, Bhardwaj V, Stehle T, Diehl S, Kretz O, Voss AK, Thomas T, Manke T, Huber TB, Akhtar A.

Oncogene. 2016 May;35(21):2698-710. doi: 10.1038/onc.2015.335. Epub 2015 Sep 21.

35.

Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure.

Mayer SC, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle H, Bugger H, Rühle F, Schrepper A, Schwarzer M, Heilmann C, Bönisch U, Gupta SK, Wilpert J, Kretz O, von Elverfeldt D, Orth J, Aktories K, Beyersdorf F, Bode C, Stiller B, Krüger M, Thum T, Doenst T, Stoll M, Hein L.

Circ Res. 2015 Sep 11;117(7):622-33. doi: 10.1161/CIRCRESAHA.115.306721. Epub 2015 Jul 20.

36.

The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function.

Albert GI, Schell C, Kirschner KM, Schäfer S, Naumann R, Müller A, Kretz O, Kuropka B, Girbig M, Hübner N, Krause E, Scholz H, Huber TB, Knobeloch KP, Freund C.

J Mol Cell Biol. 2015 Oct;7(5):402-14. doi: 10.1093/jmcb/mjv039. Epub 2015 Jun 16.

PMID:
26082520
37.

Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response.

Schell C, Kretz O, Bregenzer A, Rogg M, Helmstädter M, Lisewski U, Gotthardt M, Tharaux PL, Huber TB, Grahammer F.

PLoS One. 2015 Jun 15;10(6):e0129424. doi: 10.1371/journal.pone.0129424. eCollection 2015.

38.

Ultrafast quantitative MS-based method for ceritinib analysis in human plasma samples from clinical trial.

Lanshoeft C, Heudi O, Raccuglia M, Leuthold LA, Picard F, Kretz O.

Bioanalysis. 2015;7(4):425-35. doi: 10.4155/bio.14.292.

PMID:
25747762
39.

New microfluidic-based sampling procedure for overcoming the hematocrit problem associated with dried blood spot analysis.

Leuthold LA, Heudi O, Déglon J, Raccuglia M, Augsburger M, Picard F, Kretz O, Thomas A.

Anal Chem. 2015 Feb 17;87(4):2068-71. doi: 10.1021/ac503931g. Epub 2015 Jan 30.

PMID:
25607538
40.

Designer amphiphilic proteins as building blocks for the intracellular formation of organelle-like compartments.

Huber MC, Schreiber A, von Olshausen P, Varga BR, Kretz O, Joch B, Barnert S, Schubert R, Eimer S, Kele P, Schiller SM.

Nat Mater. 2015 Jan;14(1):125-32. doi: 10.1038/nmat4118. Epub 2014 Nov 2.

PMID:
25362355
41.

Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.

Manevski N, Swart P, Balavenkatraman KK, Bertschi B, Camenisch G, Kretz O, Schiller H, Walles M, Ling B, Wettstein R, Schaefer DJ, Itin P, Ashton-Chess J, Pognan F, Wolf A, Litherland K.

Drug Metab Dispos. 2015 Jan;43(1):126-39. doi: 10.1124/dmd.114.060350. Epub 2014 Oct 22.

42.

Liquid chromatography tandem mass spectrometry method for the quantitative analysis of ceritinib in human plasma and its application to pharmacokinetic studies.

Heudi O, Vogel D, Lau YY, Picard F, Kretz O.

Anal Bioanal Chem. 2014 Nov;406(28):7389-96. doi: 10.1007/s00216-014-8125-9. Epub 2014 Sep 26.

PMID:
25258279
43.

Aldehyde oxidase activity in fresh human skin.

Manevski N, Balavenkatraman KK, Bertschi B, Swart P, Walles M, Camenisch G, Schiller H, Kretz O, Ling B, Wettstein R, Schaefer DJ, Pognan F, Wolf A, Litherland K.

Drug Metab Dispos. 2014 Dec;42(12):2049-57. doi: 10.1124/dmd.114.060368. Epub 2014 Sep 23.

44.

Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation.

Mossmann D, Vögtle FN, Taskin AA, Teixeira PF, Ring J, Burkhart JM, Burger N, Pinho CM, Tadic J, Loreth D, Graff C, Metzger F, Sickmann A, Kretz O, Wiedemann N, Zahedi RP, Madeo F, Glaser E, Meisinger C.

Cell Metab. 2014 Oct 7;20(4):662-9. doi: 10.1016/j.cmet.2014.07.024. Epub 2014 Aug 28.

45.

Golgi fragmentation and sphingomyelin transport to Chlamydia trachomatis during penicillin-induced persistence do not depend on the cytosolic presence of the chlamydial protease CPAF.

Dille S, Herbst K, Volceanov L, Nölke T, Kretz O, Häcker G.

PLoS One. 2014 Jul 28;9(7):e103220. doi: 10.1371/journal.pone.0103220. eCollection 2014.

46.

Laser diode thermal desorption atmospheric pressure chemical ionization tandem mass spectrometry applied for the ultra-fast quantitative analysis of BKM120 in human plasma.

Lanshoeft C, Heudi O, Leuthold LA, Schlotterbeck G, Elbast W, Picard F, Kretz O.

Anal Bioanal Chem. 2014 Sep;406(22):5413-23. doi: 10.1007/s00216-014-7966-6. Epub 2014 Jun 24.

PMID:
24958346
47.

V-ATPase/mTOR signaling regulates megalin-mediated apical endocytosis.

Gleixner EM, Canaud G, Hermle T, Guida MC, Kretz O, Helmstädter M, Huber TB, Eimer S, Terzi F, Simons M.

Cell Rep. 2014 Jul 10;8(1):10-9. doi: 10.1016/j.celrep.2014.05.035. Epub 2014 Jun 19.

48.

Application of a deuterium replacement strategy to modulate the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a novel CRF1 antagonist.

Stringer RA, Williams G, Picard F, Sohal B, Kretz O, McKenna J, Krauser JA.

Drug Metab Dispos. 2014 May;42(5):954-62. doi: 10.1124/dmd.114.057265. Epub 2014 Mar 10.

49.

Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis.

Bechtel W, Helmstädter M, Balica J, Hartleben B, Kiefer B, Hrnjic F, Schell C, Kretz O, Liu S, Geist F, Kerjaschki D, Walz G, Huber TB.

J Am Soc Nephrol. 2013 Apr;24(5):727-43. doi: 10.1681/ASN.2012070700. Epub 2013 Mar 14.

50.

A fast and reliable reversed phase high performance liquid chromatography method for simultaneous determination of selected anti-retroviral and lumefantrine in human plasma.

Maganda B, Heudi O, Cortinovis A, Picard F, Kretz O, Minzi O.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Mar 1;919-920:52-60. doi: 10.1016/j.jchromb.2013.01.009. Epub 2013 Jan 19.

PMID:
23411019

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