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Items: 1 to 50 of 141

1.

New hybrid trifluoromethylquinolines as antiplasmodium agents.

da Silva RMRJ, Gandi MO, Mendonça JS, Carvalho AS, Coutinho JP, Aguiar ACC, Krettli AU, Boechat N.

Bioorg Med Chem. 2019 Mar 15;27(6):1002-1008. doi: 10.1016/j.bmc.2019.01.044. Epub 2019 Feb 2.

PMID:
30737133
2.

Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity.

Ceravolo IP, Zani CL, Figueiredo FJB, Kohlhoff M, Santana AEG, Krettli AU.

Malar J. 2018 Nov 26;17(1):436. doi: 10.1186/s12936-018-2568-y.

3.

Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity.

Aguiar ACC, Murce E, Cortopassi WA, Pimentel AS, Almeida MMFS, Barros DCS, Guedes JS, Meneghetti MR, Krettli AU.

Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):459-464. doi: 10.1016/j.ijpddr.2018.10.002. Epub 2018 Oct 13.

4.

A systems biology approach to antimalarial drug discovery.

Cortopassi WA, Celmar Costa Franca T, Krettli AU.

Expert Opin Drug Discov. 2018 Jul;13(7):617-626. doi: 10.1080/17460441.2018.1471056. Epub 2018 May 8. Review.

PMID:
29737894
5.

Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance.

Amolegbe SA, Hirano Y, Adebayo JO, Ademowo OG, Balogun EA, Obaleye JA, Krettli AU, Yu C, Hayami S.

Sci Rep. 2018 Feb 15;8(1):3078. doi: 10.1038/s41598-018-21351-8.

6.

Cysteine-stabilised peptide extract of Morinda lucida (Benth) leaf exhibits antimalarial activity and augments antioxidant defense system in P. berghei-infected mice.

Adebayo JO, Adewole KE, Krettli AU.

J Ethnopharmacol. 2017 Jul 31;207:118-128. doi: 10.1016/j.jep.2017.06.026. Epub 2017 Jun 20.

PMID:
28645782
7.

Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms.

Aguiar AC, Figueiredo FJ, Neuenfeldt PD, Katsuragawa TH, Drawanz BB, Cunico W, Sinnis P, Zavala F, Krettli AU.

Malar J. 2017 Mar 9;16(1):110. doi: 10.1186/s12936-017-1755-6.

8.

Synthesis, antimalarial activity in vitro, and docking studies of novel neolignan derivatives.

Pereira GAN, Souza GC, Santos LS, Barata LES, Meneses CCF, Krettli AU, Daniel-Ribeiro CT, Alves CN.

Chem Biol Drug Des. 2017 Sep;90(3):464-472. doi: 10.1111/cbdd.12968. Epub 2017 Apr 6.

PMID:
28245094
9.

Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors.

Azeredo LFSP, Coutinho JP, Jabor VAP, Feliciano PR, Nonato MC, Kaiser CR, Menezes CMS, Hammes ASO, Caffarena ER, Hoelz LVB, de Souza NB, Pereira GAN, Cerávolo IP, Krettli AU, Boechat N.

Eur J Med Chem. 2017 Jan 27;126:72-83. doi: 10.1016/j.ejmech.2016.09.073. Epub 2016 Sep 30.

PMID:
27744189
10.

New pentasubstituted pyrrole hybrid atorvastatin-quinoline derivatives with antiplasmodial activity.

Carvalho RC, Martins WA, Silva TP, Kaiser CR, Bastos MM, Pinheiro LC, Krettli AU, Boechat N.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):1881-4. doi: 10.1016/j.bmcl.2016.03.027. Epub 2016 Mar 9.

PMID:
26988303
11.

Transmission-Blocking Potential of MEFAS, a Hybrid Compound Derived from Artesunate and Mefloquine.

Penna-Coutinho J, Almela MJ, Miguel-Blanco C, Herreros E, Sá PM, Boechat N, Krettli AU.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):3145-7. doi: 10.1128/AAC.02216-15. Print 2016 May.

12.

In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.

Lima RB, Rocha e Silva LF, Melo MR, Costa JS, Picanço NS, Lima ES, Vasconcellos MC, Boleti AP, Santos JM, Amorim RC, Chaves FC, Coutinho JP, Tadei WP, Krettli AU, Pohlit AM.

Malar J. 2015 Dec 18;14:508. doi: 10.1186/s12936-015-0999-2.

13.

Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites.

Souza NB, Aguiar AC, Oliveira AC, Top S, Pigeon P, Jaouen G, Goulart MO, Krettli AU.

Mem Inst Oswaldo Cruz. 2015 Dec;110(8):981-8. doi: 10.1590/0074-02760150163. Epub 2015 Nov 24.

14.

Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part II: experimental studies withAspidosperma ramiflorum in vivo and in vitro.

Aguiar AC, Cunha AC, Ceravolo IP, Gonçalves RA, Oliveira AJ, Krettli AU.

Mem Inst Oswaldo Cruz. 2015 Nov;110(7):906-13. doi: 10.1590/0074-02760150188.

15.

BbMP-1, a new metalloproteinase isolated from Bothrops brazili snake venom with in vitro antiplasmodial properties.

Kayano AM, Simões-Silva R, Medeiros PS, Maltarollo VG, Honorio KM, Oliveira E, Albericio F, da Silva SL, Aguiar AC, Krettli AU, Fernandes CF, Zuliani JP, Calderon LA, Stábeli RG, Soares AM.

Toxicon. 2015 Nov;106:30-41. doi: 10.1016/j.toxicon.2015.09.005. Epub 2015 Sep 10.

16.

Ethnopharmacological evaluation of medicinal plants used against malaria by quilombola communities from Oriximiná, Brazil.

Oliveira DR, Krettli AU, Aguiar AC, Leitão GG, Vieira MN, Martins KS, Leitão SG.

J Ethnopharmacol. 2015 Sep 15;173:424-34. doi: 10.1016/j.jep.2015.07.035. Epub 2015 Jul 29.

17.

Anti-Plasmodium falciparum activity of quinoline-sulfonamide hybrids.

Pinheiro LC, Boechat N, Ferreira Mde L, Júnior CC, Jesus AM, Leite MM, Souza NB, Krettli AU.

Bioorg Med Chem. 2015 Sep 1;23(17):5979-84. doi: 10.1016/j.bmc.2015.06.056. Epub 2015 Jul 2.

PMID:
26190461
18.

In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives.

Rocha e Silva LF, Nogueira KL, Pinto AC, Katzin AM, Sussmann RA, Muniz MP, de Andrade Neto VF, Chaves FC, Coutinho JP, Lima ES, Krettli AU, Tadei WP, Pohlit AM.

Antimicrob Agents Chemother. 2015;59(6):3271-80. doi: 10.1128/AAC.05012-14. Epub 2015 Mar 23.

19.

Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug action.

de Souza NB, Carmo AM, da Silva AD, França TC, Krettli AU.

Malar J. 2014 Dec 2;13:469. doi: 10.1186/1475-2875-13-469.

20.

Evaluation of antimalarial activity and toxicity of a new primaquine prodrug.

Davanço MG, Aguiar AC, Dos Santos LA, Padilha EC, Campos ML, de Andrade CR, da Fonseca LM, Dos Santos JL, Chin CM, Krettli AU, Peccinini RG.

PLoS One. 2014 Aug 18;9(8):e105217. doi: 10.1371/journal.pone.0105217. eCollection 2014.

21.

Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies.

de Souza NB, de Andrade IM, Carneiro PF, Jardim GA, de Melo IM, da Silva Júnior EN, Krettli AU.

Mem Inst Oswaldo Cruz. 2014 Aug;109(5):546-52. Epub 2014 Aug 5.

22.

The use of an integrated molecular-, chemical- and biological-based approach for promoting the better use and conservation of medicinal species: a case study of Brazilian quinas.

Palhares RM, Drummond MG, Brasil BS, Krettli AU, Oliveira GC, Brandão MG.

J Ethnopharmacol. 2014 Aug 8;155(1):815-22. doi: 10.1016/j.jep.2014.06.040. Epub 2014 Jun 24.

PMID:
24971797
23.

New compounds hybrids 1h-1,2,3-triazole-quinoline against Plasmodium falciparum.

Boechat N, Ferreira Mde L, Pinheiro LC, Jesus AM, Leite MM, Júnior CC, Aguiar AC, de Andrade IM, Krettli AU.

Chem Biol Drug Des. 2014 Sep;84(3):325-32. doi: 10.1111/cbdd.12321. Epub 2014 Jun 5.

PMID:
24803084
24.

Anti-malarial activity of indole alkaloids isolated from Aspidosperma olivaceum.

Chierrito TP, Aguiar AC, de Andrade IM, Ceravolo IP, Gonçalves RA, de Oliveira AJ, Krettli AU.

Malar J. 2014 Apr 14;13:142. doi: 10.1186/1475-2875-13-142.

25.

Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum.

Cortopassi WA, Penna-Coutinho J, Aguiar AC, Pimentel AS, Buarque CD, Costa PR, Alves BR, França TC, Krettli AU.

PLoS One. 2014 Mar 20;9(3):e91191. doi: 10.1371/journal.pone.0091191. eCollection 2014.

26.

Plasmodium vivax and Plasmodium falciparum ex vivo susceptibility to anti-malarials and gene characterization in Rondônia, West Amazon, Brazil.

Aguiar AC, Pereira DB, Amaral NS, De Marco L, Krettli AU.

Malar J. 2014 Feb 28;13:73. doi: 10.1186/1475-2875-13-73.

27.

Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part I: Aspidosperma nitidum (Benth) used as a remedy to treat fever and malaria in the Amazon.

Coutinho JP, Aguiar AC, dos Santos PA, Lima JC, Rocha MG, Zani CL, Alves TM, Santana AE, Pereira Mde M, Krettli AU.

Mem Inst Oswaldo Cruz. 2013 Dec;108(8):974-82. doi: 10.1590/0074-0276130246.

28.

Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies.

Adebayo JO, Balogun EA, Malomo SO, Soladoye AO, Olatunji LA, Kolawole OM, Oguntoye OS, Babatunde AS, Akinola OB, Aguiar AC, Andrade IM, Souza NB, Krettli AU.

Evid Based Complement Alternat Med. 2013;2013:742476. doi: 10.1155/2013/742476. Epub 2013 Jul 30.

29.

4,5-seco-guaiane and a nine-membered sesquiterpene lactone from Holostylis reniformis.

Pereira MD, da Silva T, Lopes LM, Krettli AU, Madureira LS, Zukerman-Schpector J.

Molecules. 2012 Nov 27;17(12):14046-57. doi: 10.3390/molecules171214046.

30.

New approaches in antimalarial drug discovery and development: a review.

Aguiar AC, Rocha EM, Souza NB, França TC, Krettli AU.

Mem Inst Oswaldo Cruz. 2012 Nov;107(7):831-45. Review.

31.

New trifluoromethyl triazolopyrimidines as anti-Plasmodium falciparum agents.

Boechat N, Pinheiro LC, Silva TS, Aguiar AC, Carvalho AS, Bastos MM, Costa CC, Pinheiro S, Pinto AC, Mendonça JS, Dutra KD, Valverde AL, Santos-Filho OA, Ceravolo IP, Krettli AU.

Molecules. 2012 Jul 10;17(7):8285-302. doi: 10.3390/molecules17078285.

32.

Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites.

Aguiar AC, Santos Rde M, Figueiredo FJ, Cortopassi WA, Pimentel AS, França TC, Meneghetti MR, Krettli AU.

PLoS One. 2012;7(5):e37259. doi: 10.1371/journal.pone.0037259. Epub 2012 May 23.

33.

Evaluation of the antiplasmodial and cytotoxicity potentials of husk fiber extracts from Cocos nucifera, a medicinal plant used in Nigeria to treat human malaria.

Adebayo JO, Santana AE, Krettli AU.

Hum Exp Toxicol. 2012 Mar;31(3):244-9. doi: 10.1177/0960327111424298. Epub 2012 Jan 12.

PMID:
22241625
34.

Synthesis and antimalarial activity of thioetherhydroxyethylsulfonamides, potential aspartyl protease inhibitors, Part 3.

Vellasco Junior WT, Guedes GP, Vasconcelos TR, Vaz MG, de Souza MV, Krettli AU, Krettli LG, Aguiar AC, Gomes CR, Cunico W.

Eur J Med Chem. 2011 Nov;46(11):5688-93. doi: 10.1016/j.ejmech.2011.09.025. Epub 2011 Sep 22.

PMID:
21982338
35.

Antimalarial activity of physalins B, D, F, and G.

Sá MS, de Menezes MN, Krettli AU, Ribeiro IM, Tomassini TC, Ribeiro dos Santos R, de Azevedo WF Jr, Soares MB.

J Nat Prod. 2011 Oct 28;74(10):2269-72. doi: 10.1021/np200260f. Epub 2011 Sep 28.

PMID:
21954931
36.

Breakthroughs towards a malaria vaccine.

Nussenzweig RS, Krettli AU.

Hist Cienc Saude Manguinhos. 2011 Jun 1;18(2):559-64.

37.

Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies.

Penna-Coutinho J, Cortopassi WA, Oliveira AA, França TC, Krettli AU.

PLoS One. 2011;6(7):e21237. doi: 10.1371/journal.pone.0021237. Epub 2011 Jul 14.

38.

Novel 1,2,3-triazole derivatives for use against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain.

Boechat N, Ferreira VF, Ferreira SB, de Lourdes G Ferreira M, de C da Silva F, Bastos MM, Dos S Costa M, Lourenço MC, Pinto AC, Krettli AU, Aguiar AC, Teixeira BM, da Silva NV, Martins PR, Bezerra FA, Camilo AL, da Silva GP, Costa CC.

J Med Chem. 2011 Sep 8;54(17):5988-99. doi: 10.1021/jm2003624. Epub 2011 Aug 15.

PMID:
21776985
39.

Docking studies on the binding of quinoline derivatives and hematin to Plasmodium falciparum lactate dehydrogenase.

Cortopassi WA, Oliveira AA, Guimarães AP, Rennó MN, Krettli AU, França TC.

J Biomol Struct Dyn. 2011 Aug;29(1):207-18.

PMID:
21696234
40.

Potential antimalarials from Nigerian plants: a review.

Adebayo JO, Krettli AU.

J Ethnopharmacol. 2011 Jan 27;133(2):289-302. doi: 10.1016/j.jep.2010.11.024. Epub 2010 Nov 18. Review.

42.

Synthesis, antimalarial evaluation and molecular modeling studies of hydroxyethylpiperazines, potential aspartyl protease inhibitors, part 2.

Cunico W, Gomes CR, Facchinetti V, Moreth M, Penido C, Henriques MG, Varotti FP, Krettli LG, Krettli AU, da Silva FS, Caffarena ER, de Magalhães CS.

Eur J Med Chem. 2009 Sep;44(9):3816-20. doi: 10.1016/j.ejmech.2009.03.041. Epub 2009 Apr 8.

PMID:
19403210
43.

Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice.

de Sá MS, Costa JF, Krettli AU, Zalis MG, Maia GL, Sette IM, Câmara Cde A, Filho JM, Giulietti-Harley AM, Ribeiro Dos Santos R, Soares MB.

Parasitol Res. 2009 Jul;105(1):275-9. doi: 10.1007/s00436-009-1394-0. Epub 2009 Apr 15.

PMID:
19367418
44.

Testing of natural products and synthetic molecules aiming at new antimalarials.

Krettli AU, Adebayo JO, Krettli LG.

Curr Drug Targets. 2009 Mar;10(3):261-70. Review.

PMID:
19275562
45.

Antimalarial drug discovery: screening of Brazilian medicinal plants and purified compounds.

Krettli AU.

Expert Opin Drug Discov. 2009 Feb;4(2):95-108. doi: 10.1517/17530050802678127.

PMID:
23480511
46.

Synthesis, antimalarial activity, and intracellular targets of MEFAS, a new hybrid compound derived from mefloquine and artesunate.

de Pilla Varotti F, Botelho AC, Andrade AA, de Paula RC, Fagundes EM, Valverde A, Mayer LM, Mendonça JS, de Souza MV, Boechat N, Krettli AU.

Antimicrob Agents Chemother. 2008 Nov;52(11):3868-74. doi: 10.1128/AAC.00510-08. Epub 2008 Aug 18.

47.

Ampelozyziphus amazonicus Ducke (Rhamnaceae), a medicinal plant used to prevent malaria in the Amazon Region, hampers the development of Plasmodium berghei sporozoites.

Andrade-Neto VF, Brandão MG, Nogueira F, Rosário VE, Krettli AU.

Int J Parasitol. 2008 Nov;38(13):1505-11. doi: 10.1016/j.ijpara.2008.05.007. Epub 2008 May 27.

PMID:
18599059
48.

Malaria vectors in areas of Plasmodium falciparum epidemic transmission in the Amazon region, Brazil.

da Rocha JA, de Oliveira SB, Póvoa MM, Moreira LA, Krettli AU.

Am J Trop Med Hyg. 2008 Jun;78(6):872-7.

PMID:
18541762
49.

Synthesis and antimalarial activity of hydroxyethylpiperazine derivatives.

Cunico W, Gomes CR, Moreth M, Manhanini DP, Figueiredo IH, Penido C, Henriques MG, Varotti FP, Krettli AU.

Eur J Med Chem. 2009 Mar;44(3):1363-8. doi: 10.1016/j.ejmech.2008.04.009. Epub 2008 Apr 29.

PMID:
18514971
50.

Inhibitory properties of the antibody response to Plasmodium vivax Duffy binding protein in an area with unstable malaria transmission.

Ceravolo IP, Souza-Silva FA, Fontes CJ, Braga EM, Madureira AP, Krettli AU, Souza JM, Brito CF, Adams JH, Carvalho LH.

Scand J Immunol. 2008 Mar;67(3):270-8. doi: 10.1111/j.1365-3083.2007.02059.x. Epub 2008 Jan 22.

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