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Identification of suitable controls for miRNA quantification in T-cells and whole blood cells in sepsis.

Hirschberger S, Hübner M, Strauß G, Effinger D, Bauer M, Weis S, Giamarellos-Bourboulis EJ, Kreth S.

Sci Rep. 2019 Oct 31;9(1):15735. doi: 10.1038/s41598-019-51782-w.


Myeloid-Derived Suppressor Cells Mediate Immunosuppression After Cardiopulmonary Bypass.

Hübner M, Tomasi R, Effinger D, Wu T, Klein G, Bender M, Kilger E, Juchem G, Schwedhelm E, Kreth S.

Crit Care Med. 2019 Aug;47(8):e700-e709. doi: 10.1097/CCM.0000000000003820.


Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis.

Heun Y, Pircher J, Czermak T, Bluem P, Hupel G, Bohmer M, Kraemer BF, Pogoda K, Pfeifer A, Woernle M, Ribeiro A, Hübner M, Kreth S, Claus RA, Weis S, Ungelenk L, Krötz F, Pohl U, Mannell H.

EBioMedicine. 2019 Apr;42:120-132. doi: 10.1016/j.ebiom.2019.03.034. Epub 2019 Mar 21.


Intronic miR-744 Inhibits Glioblastoma Migration by Functionally Antagonizing Its Host Gene MAP2K4.

Hübner M, Hinske CL, Effinger D, Wu T, Thon N, Kreth FW, Kreth S.

Cancers (Basel). 2018 Oct 25;10(11). pii: E400. doi: 10.3390/cancers10110400.


MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis.

Möhnle P, Hirschberger S, Hinske LC, Briegel J, Hübner M, Weis S, Dimopoulos G, Bauer M, Giamarellos-Bourboulis EJ, Kreth S.

Mol Med. 2018 Oct 17;24(1):54. doi: 10.1186/s10020-018-0056-z.


Dynamic 18F-FET PET is a powerful imaging biomarker in gadolinium-negative gliomas.

Kunz M, Albert NL, Unterrainer M, la Fougere C, Egensperger R, Schüller U, Lutz J, Kreth S, Tonn JC, Kreth FW, Thon N.

Neuro Oncol. 2019 Feb 14;21(2):274-284. doi: 10.1093/neuonc/noy098.


MiRNAs: dynamic regulators of immune cell functions in inflammation and cancer.

Hirschberger S, Hinske LC, Kreth S.

Cancer Lett. 2018 Sep 1;431:11-21. doi: 10.1016/j.canlet.2018.05.020. Epub 2018 May 22. Review.


Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury.

Koeppen M, Lee JW, Seo SW, Brodsky KS, Kreth S, Yang IV, Buttrick PM, Eckle T, Eltzschig HK.

Nat Commun. 2018 Feb 26;9(1):816. doi: 10.1038/s41467-018-03105-2.


Identification and Validation of Potential Differential miRNA Regulation via Alternative Polyadenylation.

Hübner M, Galante PAF, Kreth S, Hinske LC.

Methods Mol Biol. 2018;1733:87-92. doi: 10.1007/978-1-4939-7601-0_7.


MiRIAD update: using alternative polyadenylation, protein interaction network analysis and additional species to enhance exploration of the role of intragenic miRNAs and their host genes.

Hinske LC, Dos Santos FRC, Ohara DT, Ohno-Machado L, Kreth S, Galante PAF.

Database (Oxford). 2017 Jan 1;2017. doi: 10.1093/database/bax053.


Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice.

Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaah5360. doi: 10.1126/scitranslmed.aah5360.


MicroRNAs as Clinical Biomarkers and Therapeutic Tools in Perioperative Medicine.

Kreth S, Hübner M, Hinske LC.

Anesth Analg. 2018 Feb;126(2):670-681. doi: 10.1213/ANE.0000000000002444. Review.


Intronic miRNA-641 controls its host Gene's pathway PI3K/AKT and this relationship is dysfunctional in glioblastoma multiforme.

Hinske LC, Heyn J, Hübner M, Rink J, Hirschberger S, Kreth S.

Biochem Biophys Res Commun. 2017 Aug 5;489(4):477-483. doi: 10.1016/j.bbrc.2017.05.175. Epub 2017 May 30.


Soluble intercellular adhesion molecule-1: a potential biomarker for pain intensity in chronic pain patients.

Luchting B, Hinske LC, Rachinger-Adam B, Celi LA, Kreth S, Azad SC.

Biomark Med. 2017 Mar;11(3):265-276. doi: 10.2217/bmm-2016-0246. Epub 2017 Feb 16.


Outcome in unresectable glioblastoma: MGMT promoter methylation makes the difference.

Thon N, Thorsteinsdottir J, Eigenbrod S, Schüller U, Lutz J, Kreth S, Belka C, Tonn JC, Niyazi M, Kreth FW.

J Neurol. 2017 Feb;264(2):350-358. doi: 10.1007/s00415-016-8355-1. Epub 2016 Dec 5.


miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain.

Heyn J, Luchting B, Hinske LC, Hübner M, Azad SC, Kreth S.

J Neuroinflammation. 2016 Sep 20;13(1):248. doi: 10.1186/s12974-016-0712-6.


Differential expression of P2X7 receptor and IL-1β in nociceptive and neuropathic pain.

Luchting B, Heyn J, Woehrle T, Rachinger-Adam B, Kreth S, Hinske LC, Azad SC.

J Neuroinflammation. 2016 May 4;13(1):100. doi: 10.1186/s12974-016-0565-z.


Down-regulation of MicroRNA-31 in CD4+ T Cells Contributes to Immunosuppression in Human Sepsis by Promoting TH2 Skewing.

van der Heide V, Möhnle P, Rink J, Briegel J, Kreth S.

Anesthesiology. 2016 Apr;124(4):908-22. doi: 10.1097/ALN.0000000000001031.


Emerging Roles for MicroRNAs in Perioperative Medicine.

Neudecker V, Brodsky KS, Kreth S, Ginde AA, Eltzschig HK.

Anesthesiology. 2016 Feb;124(2):489-506. doi: 10.1097/ALN.0000000000000969. Review.


Alternative polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR.

Hinske LC, Galante PA, Limbeck E, Möhnle P, Parmigiani RB, Ohno-Machado L, Camargo AA, Kreth S.

PLoS One. 2015 Mar 23;10(3):e0121507. doi: 10.1371/journal.pone.0121507. eCollection 2015.


Anti-inflammatory T-cell shift in neuropathic pain.

Luchting B, Rachinger-Adam B, Heyn J, Hinske LC, Kreth S, Azad SC.

J Neuroinflammation. 2015 Jan 21;12:12. doi: 10.1186/s12974-014-0225-0.


Dynamic 18F-FET PET in suspected WHO grade II gliomas defines distinct biological subgroups with different clinical courses.

Thon N, Kunz M, Lemke L, Jansen NL, Eigenbrod S, Kreth S, Lutz J, Egensperger R, Giese A, Herms J, Weller M, Kretzschmar H, Tonn JC, la Fougère C, Kreth FW.

Int J Cancer. 2015 May 1;136(9):2132-45. doi: 10.1002/ijc.29259. Epub 2014 Nov 3.


MicroRNA-146a controls Th1-cell differentiation of human CD4+ T lymphocytes by targeting PRKCε.

Möhnle P, Schütz SV, van der Heide V, Hübner M, Luchting B, Sedlbauer J, Limbeck E, Hinske LC, Briegel J, Kreth S.

Eur J Immunol. 2015 Jan;45(1):260-72. doi: 10.1002/eji.201444667. Epub 2014 Nov 27.


miRIAD-integrating microRNA inter- and intragenic data.

Hinske LC, França GS, Torres HA, Ohara DT, Lopes-Ramos CM, Heyn J, Reis LF, Ohno-Machado L, Kreth S, Galante PA.

Database (Oxford). 2014 Oct 6;2014. pii: bau099. doi: 10.1093/database/bau099. Print 2014.


Disrupted TH17/Treg balance in patients with chronic low back pain.

Luchting B, Rachinger-Adam B, Zeitler J, Egenberger L, Möhnle P, Kreth S, Azad SC.

PLoS One. 2014 Aug 14;9(8):e104883. doi: 10.1371/journal.pone.0104883. eCollection 2014.


MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure.

Möhnle P, Schütz SV, Schmidt M, Hinske C, Hübner M, Heyn J, Beiras-Fernandez A, Kreth S.

Biochem Biophys Res Commun. 2014 Sep 5;451(4):516-21. doi: 10.1016/j.bbrc.2014.08.008. Epub 2014 Aug 9.


Local expression of myocardial galectin-3 does not correlate with its serum levels in patients undergoing heart transplantation.

Beiras-Fernandez A, Weis F, Rothkopf J, Kaczmarek I, Ledderose C, Dick A, Keller T, Beiras A, Kreth S.

Ann Transplant. 2013 Nov 22;18:643-50. doi: 10.12659/AOT.889396.


MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure.

Kreth S, Ledderose C, Schütz S, Beiras A, Heyn J, Weis F, Beiras-Fernandez A.

J Heart Lung Transplant. 2014 Mar;33(3):252-60. doi: 10.1016/j.healun.2013.10.014. Epub 2013 Oct 12.


Personalized treatment strategies in glioblastoma: MGMT promoter methylation status.

Thon N, Kreth S, Kreth FW.

Onco Targets Ther. 2013 Sep 27;6:1363-72. doi: 10.2147/OTT.S50208. Review.


Polymerization of novel methacrylated anthraquinone dyes.

Dollendorf C, Kreth SK, Choi SW, Ritter H.

Beilstein J Org Chem. 2013;9:453-9. doi: 10.3762/bjoc.9.48. Epub 2013 Feb 28.


In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing.

Kreth S, Limbeck E, Hinske LC, Schütz SV, Thon N, Hoefig K, Egensperger R, Kreth FW.

Acta Neuropathol. 2013 May;125(5):671-81. doi: 10.1007/s00401-013-1081-1. Epub 2013 Jan 23.


Experimental miRNA target validation.

Heyn J, Hinske LC, Ledderose C, Limbeck E, Kreth S.

Methods Mol Biol. 2013;936:83-90.


Setting up an intronic miRNA database.

Hinske LC, Heyn J, Galante PA, Ohno-Machado L, Kreth S.

Methods Mol Biol. 2013;936:69-76.


Corticosteroid resistance in sepsis is influenced by microRNA-124--induced downregulation of glucocorticoid receptor-α.

Ledderose C, Möhnle P, Limbeck E, Schütz S, Weis F, Rink J, Briegel J, Kreth S.

Crit Care Med. 2012 Oct;40(10):2745-53.


Epigenetics in human gliomas.

Kreth S, Thon N, Kreth FW.

Cancer Lett. 2014 Jan 28;342(2):185-92. doi: 10.1016/j.canlet.2012.04.008. Epub 2012 Apr 21. Review.


Adenosine A2A receptor upregulation in human PMNs is controlled by miRNA-214, miRNA-15, and miRNA-16.

Heyn J, Ledderose C, Hinske LC, Limbeck E, Möhnle P, Lindner HA, Kreth S.

Shock. 2012 Feb;37(2):156-63. doi: 10.1097/SHK.0b013e31823f16bc.


Ghrelin, a novel peptide hormone in the regulation of energy balance and cardiovascular function.

Ledderose C, Kreth S, Beiras-Fernandez A.

Recent Pat Endocr Metab Immune Drug Discov. 2011 Jan;5(1):1-6. Review.


Selection of reliable reference genes for quantitative real-time PCR in human T cells and neutrophils.

Ledderose C, Heyn J, Limbeck E, Kreth S.

BMC Res Notes. 2011 Oct 20;4:427. doi: 10.1186/1756-0500-4-427.


Hyperbranched polyethylenimine bearing cyclodextrin moieties showing temperature and pH controlled dye release.

Böhm I, Kreth SK, Ritter H.

Beilstein J Org Chem. 2011;7:1130-1134. doi: 10.3762/bjoc.7.130. Epub 2011 Aug 18.


IDH1 mutations in grade II astrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival.

Thon N, Eigenbrod S, Kreth S, Lutz J, Tonn JC, Kretzschmar H, Peraud A, Kreth FW.

Cancer. 2012 Jan 15;118(2):452-60. doi: 10.1002/cncr.26298. Epub 2011 Jun 29.


MicroRNAs as potential therapeutic agents in the treatment of myocardial infarction.

Heyn J, Hinske C, Möhnle P, Luchting B, Beiras-Fernandez A, Kreth S.

Curr Vasc Pharmacol. 2011 Nov;9(6):733-40. Review.


O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation.

Kreth S, Thon N, Eigenbrod S, Lutz J, Ledderose C, Egensperger R, Tonn JC, Kretzschmar HA, Hinske LC, Kreth FW.

PLoS One. 2011 Feb 18;6(2):e17156. doi: 10.1371/journal.pone.0017156.


Hot spots in dynamic (18)FET-PET delineate malignant tumor parts within suspected WHO grade II gliomas.

Kunz M, Thon N, Eigenbrod S, Hartmann C, Egensperger R, Herms J, Geisler J, la Fougere C, Lutz J, Linn J, Kreth S, von Deimling A, Tonn JC, Kretzschmar HA, Pöpperl G, Kreth FW.

Neuro Oncol. 2011 Mar;13(3):307-16. doi: 10.1093/neuonc/noq196. Epub 2011 Feb 3.


Predominant influence of MGMT methylation in non-resectable glioblastoma after radiotherapy plus temozolomide.

Thon N, Eigenbrod S, Grasbon-Frodl EM, Lutz J, Kreth S, Popperl G, Belka C, Kretzschmar HA, Tonn JC, Kreth FW.

J Neurol Neurosurg Psychiatry. 2011 Apr;82(4):441-6. doi: 10.1136/jnnp.2010.214593. Epub 2010 Sep 22.


Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure.

Beiras-Fernandez A, Kreth S, Weis F, Ledderose C, Pöttinger T, Dieguez C, Beiras A, Reichart B.

Peptides. 2010 Dec;31(12):2222-8. doi: 10.1016/j.peptides.2010.08.019. Epub 2010 Sep 8.


Effect of anaesthesia and cardiopulmonary bypass on blood endocannabinoid concentrations during cardiac surgery.

Weis F, Beiras-Fernandez A, Hauer D, Hornuss C, Sodian R, Kreth S, Briegel J, Schelling G.

Br J Anaesth. 2010 Aug;105(2):139-44. doi: 10.1093/bja/aeq117. Epub 2010 Jun 4.


Identification of valid endogenous control genes for determining gene expression in human glioma.

Kreth S, Heyn J, Grau S, Kretzschmar HA, Egensperger R, Kreth FW.

Neuro Oncol. 2010 Jun;12(6):570-9. doi: 10.1093/neuonc/nop072. Epub 2010 Feb 5.


Motion sickness, stress and the endocannabinoid system.

Choukèr A, Kaufmann I, Kreth S, Hauer D, Feuerecker M, Thieme D, Vogeser M, Thiel M, Schelling G.

PLoS One. 2010 May 21;5(5):e10752. doi: 10.1371/journal.pone.0010752.


Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways.

Kreth S, Ledderose C, Luchting B, Weis F, Thiel M.

Shock. 2010 Jul;34(1):10-6. doi: 10.1097/SHK.0b013e3181cdc3e2.


Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure.

Weis F, Beiras-Fernandez A, Sodian R, Kaczmarek I, Reichart B, Beiras A, Schelling G, Kreth S.

J Mol Cell Cardiol. 2010 Jun;48(6):1187-93. doi: 10.1016/j.yjmcc.2009.10.025. Epub 2009 Nov 26.


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