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Items: 43

1.

The emerging role of activins in renal disease.

Mehta N, Krepinsky JC.

Curr Opin Nephrol Hypertens. 2019 Nov 9. doi: 10.1097/MNH.0000000000000560. [Epub ahead of print]

PMID:
31714286
2.

The caveolin-1 regulated protein follistatin protects against diabetic kidney disease.

Zhang D, Gava AL, Van Krieken R, Mehta N, Li R, Gao B, Desjardins EM, Steinberg GR, Hawke T, Krepinsky JC.

Kidney Int. 2019 Nov;96(5):1134-1149. doi: 10.1016/j.kint.2019.05.032. Epub 2019 Jun 17.

PMID:
31492508
3.

GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury.

Platko K, Lebeau PF, Byun JH, Poon SV, Day EA, MacDonald ME, Holzapfel N, Mejia-Benitez A, Maclean KN, Krepinsky JC, Austin RC.

Mol Metab. 2019 Sep;27:62-74. doi: 10.1016/j.molmet.2019.06.021. Epub 2019 Jun 28.

4.

Follistatin Protects Against Glomerular Mesangial Cell Apoptosis and Oxidative Stress to Ameliorate Chronic Kidney Disease.

Mehta N, Gava AL, Zhang D, Gao B, Krepinsky JC.

Antioxid Redox Signal. 2019 Sep 10;31(8):551-571. doi: 10.1089/ars.2018.7684. Epub 2019 Jul 3.

PMID:
31184201
5.

Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells.

Mehta N, Zhang D, Li R, Wang T, Gava A, Parthasarathy P, Gao B, Krepinsky JC.

Cell Commun Signal. 2019 Apr 17;17(1):37. doi: 10.1186/s12964-019-0351-5.

6.

Parathyroid hormone-related protein induces fibronectin up-regulation in rat mesangial cells through reactive oxygen species/Src/EGFR signaling.

Chen HM, Dai JJ, Zhu R, Peng FF, Wu SZ, Yu H, Krepinsky JC, Zhang BF.

Biosci Rep. 2019 Apr 26;39(4). pii: BSR20182293. doi: 10.1042/BSR20182293. Print 2019 Apr 30.

7.

Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy.

Van Krieken R, Mehta N, Wang T, Zheng M, Li R, Gao B, Ayaub E, Ask K, Paton JC, Paton AW, Austin RC, Krepinsky JC.

J Biol Chem. 2019 May 10;294(19):7755-7768. doi: 10.1074/jbc.RA118.006939. Epub 2019 Mar 26.

PMID:
30914477
8.

Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions.

Crane ED, Al-Hashimi AA, Chen J, Lynn EG, Won KD, Lhoták Š, Naeim M, Platko K, Lebeau P, Byun JH, Shayegan B, Krepinsky JC, Rayner KJ, Marchiò S, Pasqualini R, Arap W, Austin RC.

JCI Insight. 2018 Dec 20;3(24). pii: 99363. doi: 10.1172/jci.insight.99363.

9.

Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice.

Van Krieken R, Marway M, Parthasarathy P, Mehta N, Ingram AJ, Gao B, Krepinsky JC.

Endocrinology. 2018 Mar 1;159(3):1479-1495. doi: 10.1210/en.2018-00093.

PMID:
29420703
10.

Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK.

Li R, Wang T, Walia K, Gao B, Krepinsky JC.

J Cell Sci. 2018 Feb 20;131(4). pii: jcs208629. doi: 10.1242/jcs.208629.

11.

Dual roles of parathyroid hormone related protein in TGF-β1 signaling and fibronectin up-regulation in mesangial cells.

Wu SZ, Yang SJ, Chen HM, Peng FF, Yu H, Krepinsky JC, Zhang BF.

Biosci Rep. 2017 Oct 27;37(5). pii: BSR20171061. doi: 10.1042/BSR20171061. Print 2017 Oct 31.

12.

Caveolin-1 in the Pathogenesis of Diabetic Nephropathy: Potential Therapeutic Target?

Van Krieken R, Krepinsky JC.

Curr Diab Rep. 2017 Mar;17(3):19. doi: 10.1007/s11892-017-0844-9. Review.

PMID:
28283950
13.

Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.

Mohammed-Ali Z, Lu C, Marway MK, Carlisle RE, Ask K, Lukic D, Krepinsky JC, Dickhout JG.

Sci Rep. 2017 Feb 2;7:41572. doi: 10.1038/srep41572.

14.

Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion.

Van Krieken R, Chen G, Gao B, Read J, Al Saleh HA, Li R, Al-Nedawi K, Krepinsky JC.

Cell Signal. 2017 Jan;29:158-167. doi: 10.1016/j.cellsig.2016.11.004. Epub 2016 Nov 5.

PMID:
27826032
15.

SREBP inhibition ameliorates renal injury after unilateral ureteral obstruction.

Mustafa M, Wang TN, Chen X, Gao B, Krepinsky JC.

Am J Physiol Renal Physiol. 2016 Sep 1;311(3):F614-25. doi: 10.1152/ajprenal.00140.2016. Epub 2016 Jul 6.

16.

High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells.

Li R, Uttarwar L, Gao B, Charbonneau M, Shi Y, Chan JS, Dubois CM, Krepinsky JC.

J Biol Chem. 2015 Aug 28;290(35):21603-14. doi: 10.1074/jbc.M115.651604. Epub 2015 Jul 14.

17.

SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis.

Wang TN, Chen X, Li R, Gao B, Mohammed-Ali Z, Lu C, Yum V, Dickhout JG, Krepinsky JC.

J Am Soc Nephrol. 2015 Aug;26(8):1839-54. doi: 10.1681/ASN.2013121332. Epub 2014 Nov 14.

18.

SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells.

Chen G, Wang T, Uttarwar L, vanKrieken R, Li R, Chen X, Gao B, Ghayur A, Margetts P, Krepinsky JC.

J Mol Cell Biol. 2014 Dec;6(6):516-30. doi: 10.1093/jmcb/mju041. Epub 2014 Oct 26.

PMID:
25348957
19.

Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease.

Guan T, Gao B, Chen G, Chen X, Janssen M, Uttarwar L, Ingram AJ, Krepinsky JC.

Am J Physiol Renal Physiol. 2013 Nov 15;305(10):F1466-76. doi: 10.1152/ajprenal.00057.2013. Epub 2013 Aug 14.

20.

Caveolin-1 deficiency protects against mesangial matrix expansion in a mouse model of type 1 diabetic nephropathy.

Guan TH, Chen G, Gao B, Janssen MR, Uttarwar L, Ingram AJ, Krepinsky JC.

Diabetologia. 2013 Sep;56(9):2068-77. doi: 10.1007/s00125-013-2968-z. Epub 2013 Jun 21.

PMID:
23793581
21.

TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells.

Chen G, Chen X, Sukumar A, Gao B, Curley J, Schnaper HW, Ingram AJ, Krepinsky JC.

J Cell Sci. 2013 Aug 15;126(Pt 16):3697-712. doi: 10.1242/jcs.126714. Epub 2013 Jun 18.

22.

Pantoprazole-induced acute interstitial nephritis.

Klassen S, Krepinsky JC, Prebtani AP.

CMAJ. 2013 Jan 8;185(1):56-9. doi: 10.1503/cmaj.120954. Epub 2012 Oct 29. No abstract available.

23.

SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells.

Uttarwar L, Gao B, Ingram AJ, Krepinsky JC.

Am J Physiol Renal Physiol. 2012 Feb 1;302(3):F329-41. doi: 10.1152/ajprenal.00136.2011. Epub 2011 Oct 26.

24.

High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generation.

Zhang Y, Peng F, Gao B, Ingram AJ, Krepinsky JC.

Am J Physiol Renal Physiol. 2012 Jan 1;302(1):F159-72. doi: 10.1152/ajprenal.00749.2010. Epub 2011 Oct 5.

25.

Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression.

Samarakoon R, Chitnis SS, Higgins SP, Higgins CE, Krepinsky JC, Higgins PJ.

PLoS One. 2011;6(7):e22896. doi: 10.1371/journal.pone.0022896. Epub 2011 Jul 28.

26.

HB-EGF release mediates glucose-induced activation of the epidermal growth factor receptor in mesangial cells.

Uttarwar L, Peng F, Wu D, Kumar S, Gao B, Ingram AJ, Krepinsky JC.

Am J Physiol Renal Physiol. 2011 Apr;300(4):F921-31. doi: 10.1152/ajprenal.00436.2010. Epub 2011 Feb 2.

27.

Mechanical strain-induced RhoA activation requires NADPH oxidase-mediated ROS generation in caveolae.

Zhang Y, Peng F, Gao B, Ingram AJ, Krepinsky JC.

Antioxid Redox Signal. 2010 Oct 1;13(7):959-73. doi: 10.1089/ars.2009.2908.

PMID:
20380579
28.

Mechanical stretch-induced RhoA activation is mediated by the RhoGEF Vav2 in mesangial cells.

Peng F, Zhang B, Ingram AJ, Gao B, Zhang Y, Krepinsky JC.

Cell Signal. 2010 Jan;22(1):34-40. doi: 10.1016/j.cellsig.2009.09.003. Epub 2009 Sep 13.

PMID:
19755152
29.

EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells.

Wu D, Peng F, Zhang B, Ingram AJ, Kelly DJ, Gilbert RE, Gao B, Kumar S, Krepinsky JC.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F822-34. doi: 10.1152/ajprenal.00054.2009. Epub 2009 Jul 15.

30.

Endoplasmic reticulum stress and renal disease.

Dickhout JG, Krepinsky JC.

Antioxid Redox Signal. 2009 Sep;11(9):2341-52. doi: 10.1089/ARS.2009.2705. Review.

PMID:
19508129
31.

PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells.

Wu D, Peng F, Zhang B, Ingram AJ, Kelly DJ, Gilbert RE, Gao B, Krepinsky JC.

J Am Soc Nephrol. 2009 Mar;20(3):554-66. doi: 10.1681/ASN.2008040445. Epub 2009 Feb 11.

32.

TGFbeta-induced RhoA activation and fibronectin production in mesangial cells require caveolae.

Peng F, Zhang B, Wu D, Ingram AJ, Gao B, Krepinsky JC.

Am J Physiol Renal Physiol. 2008 Jul;295(1):F153-64. doi: 10.1152/ajprenal.00419.2007. Epub 2008 Apr 23.

33.

RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease.

Peng F, Wu D, Gao B, Ingram AJ, Zhang B, Chorneyko K, McKenzie R, Krepinsky JC.

Diabetes. 2008 Jun;57(6):1683-92. doi: 10.2337/db07-1149. Epub 2008 Mar 20.

34.
35.

Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells.

Wu D, Peng F, Zhang B, Ingram AJ, Gao B, Krepinsky JC.

Diabetologia. 2007 Sep;50(9):2008-2018. doi: 10.1007/s00125-007-0721-1. Epub 2007 Jul 11.

PMID:
17622510
36.

Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells.

Zhang B, Peng F, Wu D, Ingram AJ, Gao B, Krepinsky JC.

Cell Signal. 2007 Aug;19(8):1690-700. Epub 2007 Mar 19.

PMID:
17446044
37.

RhoA activation in mesangial cells by mechanical strain depends on caveolae and caveolin-1 interaction.

Peng F, Wu D, Ingram AJ, Zhang B, Gao B, Krepinsky JC.

J Am Soc Nephrol. 2007 Jan;18(1):189-98. Epub 2006 Nov 22.

38.

Association study between fibronectin and coronary heart disease.

Zhang Y, Zhou X, Krepinsky JC, Wang C, Segbo J, Zheng F.

Clin Chem Lab Med. 2006;44(1):37-42.

PMID:
16375583
39.

Detecting the polymorphisms of paraoxonase (PON) cluster in Chinese Han population based on a rapid method.

Zhang Y, Zheng F, Du H, Krepinsky JC, Segbo JA, Zhou X.

Clin Chim Acta. 2006 Mar;365(1-2):98-103. Epub 2005 Sep 26.

PMID:
16185677
40.

Akt mediates mechanical strain-induced collagen production by mesangial cells.

Krepinsky JC, Li Y, Chang Y, Liu L, Peng F, Wu D, Tang D, Scholey J, Ingram AJ.

J Am Soc Nephrol. 2005 Jun;16(6):1661-72. Epub 2005 Apr 6.

41.

Stretch-induced Raf-1 activation in mesangial cells requires actin cytoskeletal integrity.

Krepinsky JC, Li Y, Tang D, Liu L, Scholey J, Ingram AJ.

Cell Signal. 2005 Mar;17(3):311-20.

PMID:
15567062
42.

Activation of mesangial cell MAPK in response to homocysteine.

Ingram AJ, Krepinsky JC, James L, Austin RC, Tang D, Salapatek AM, Thai K, Scholey JW.

Kidney Int. 2004 Aug;66(2):733-45.

43.

Nitric oxide inhibits stretch-induced MAPK activation in mesangial cells through RhoA inactivation.

Krepinsky JC, Ingram AJ, Tang D, Wu D, Liu L, Scholey JW.

J Am Soc Nephrol. 2003 Nov;14(11):2790-800.

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