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KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8.

Zhang W, Hong S, Maniar KP, Cheng S, Jie C, Rademaker AW, Krensky AM, Clayberger C.

Oncogene. 2016 Oct 20;35(42):5565-5575. doi: 10.1038/onc.2016.97. Epub 2016 Apr 4.


Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes.

Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J.

Cell. 2015 May 21;161(5):1229. doi: 10.1016/j.cell.2015.05.021. Epub 2015 May 21. No abstract available.


Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.

Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J.

Cell. 2014 Jun 5;157(6):1309-23. doi: 10.1016/j.cell.2014.03.062. Erratum in: Cell. 2015 May 21;161(5):1229.


The reproductive phenotype of mice null for transcription factor Krüppel-like factor 13 suggests compensatory function of family member Krüppel-like factor 9 in the peri-implantation uterus.

Heard ME, Pabona JM, Clayberger C, Krensky AM, Simmen FA, Simmen RC.

Biol Reprod. 2012 Nov 16;87(5):115. doi: 10.1095/biolreprod.112.102251. Print 2012 Nov.


Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.

Kim DS, Zhang W, Millman SE, Hwang BJ, Kwon SJ, Clayberger C, Pagano M, Krensky AM.

Blood. 2012 Aug 23;120(8):1658-67. doi: 10.1182/blood-2012-03-415968. Epub 2012 Jul 13.


15 kDa granulysin causes differentiation of monocytes to dendritic cells but lacks cytotoxic activity.

Clayberger C, Finn MW, Wang T, Saini R, Wilson C, Barr VA, Sabatino M, Castiello L, Stroncek D, Krensky AM.

J Immunol. 2012 Jun 15;188(12):6119-26. doi: 10.4049/jimmunol.1200570. Epub 2012 May 14.


15 kDa Granulysin versus GM-CSF for monocytes differentiation: analogies and differences at the transcriptome level.

Castiello L, Stroncek DF, Finn MW, Wang E, Marincola FM, Clayberger C, Krensky AM, Sabatino M.

J Transl Med. 2011 Apr 18;9:41. doi: 10.1186/1479-5876-9-41.


KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells.

Lai D, Zhu J, Wang T, Hu-Li J, Terabe M, Berzofsky JA, Clayberger C, Krensky AM.

J Exp Med. 2011 May 9;208(5):1093-103. doi: 10.1084/jem.20101527. Epub 2011 Apr 11.


Granulysin delivered by cytotoxic cells damages endoplasmic reticulum and activates caspase-7 in target cells.

Saini RV, Wilson C, Finn MW, Wang T, Krensky AM, Clayberger C.

J Immunol. 2011 Mar 15;186(6):3497-504. doi: 10.4049/jimmunol.1003409. Epub 2011 Feb 4.


Monocyte-derived DC maturation strategies and related pathways: a transcriptional view.

Castiello L, Sabatino M, Jin P, Clayberger C, Marincola FM, Krensky AM, Stroncek DF.

Cancer Immunol Immunother. 2011 Apr;60(4):457-66. doi: 10.1007/s00262-010-0954-6. Epub 2011 Jan 22. Review.


Induction of granulysin and perforin cytolytic mediator expression in 10-week-old infants vaccinated with BCG at birth.

Semple PL, Watkins M, Davids V, Krensky AM, Hanekom WA, Kaplan G, Ress S.

Clin Dev Immunol. 2011;2011:438463. doi: 10.1155/2011/438463. Epub 2010 Dec 28.


Granulysin production and anticryptococcal activity is dependent upon a far upstream enhancer that binds STAT5 in human peripheral blood CD4+ T cells.

Xing J, Wu F, Wang S, Krensky AM, Mody CH, Zheng C.

J Immunol. 2010 Nov 1;185(9):5074-81. doi: 10.4049/jimmunol.1001725. Epub 2010 Oct 1.


Expression and purification of 15 kDa granulysin utilizing an insect cell secretion system.

Finn MW, Clayberger C, Krensky AM.

Protein Expr Purif. 2011 Jan;75(1):70-4. doi: 10.1016/j.pep.2010.07.009. Epub 2010 Jul 30.


Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin.

Tewary P, Yang D, de la Rosa G, Li Y, Finn MW, Krensky AM, Clayberger C, Oppenheim JJ.

Blood. 2010 Nov 4;116(18):3465-74. doi: 10.1182/blood-2010-03-273953. Epub 2010 Jul 21.


Ten years of the Immune Tolerance Network: an integrated clinical research organization.

Bluestone JA, Krensky AM, Turka LA, Rotrosen D, Matthews JB.

Sci Transl Med. 2010 Feb 17;2(19):19cm7. doi: 10.1126/scitranslmed.3000672.


A human T cell-specific molecule is a member of a new gene family. 1988.

Schall TJ, Jongstra J, Dyer BJ, Jorgensen J, Clayberger C, Davis MM, Krensky AM.

J Immunol. 2009 Apr 1;182(7):3947-54. No abstract available.


Biology and clinical relevance of granulysin.

Krensky AM, Clayberger C.

Tissue Antigens. 2009 Mar;73(3):193-8. doi: 10.1111/j.1399-0039.2008.01218.x. Review.


XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma.

Nguyen KD, Fohner A, Booker JD, Dong C, Krensky AM, Nadeau KC.

J Immunol. 2008 Oct 15;181(8):5386-95.


Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients.

Zheng CF, Jones GJ, Shi M, Wiseman JC, Marr KJ, Berenger BM, Huston SM, Gill MJ, Krensky AM, Kubes P, Mody CH.

J Immunol. 2008 Jun 1;180(11):7221-9.


Visiting a forest, but not a city, increases human natural killer activity and expression of anti-cancer proteins.

Li Q, Morimoto K, Kobayashi M, Inagaki H, Katsumata M, Hirata Y, Hirata K, Suzuki H, Li YJ, Wakayama Y, Kawada T, Park BJ, Ohira T, Matsui N, Kagawa T, Miyazaki Y, Krensky AM.

Int J Immunopathol Pharmacol. 2008 Jan-Mar;21(1):117-27.


In vitro and in vivo antimicrobial activity of granulysin-derived peptides against Vibrio cholerae.

da Silva AP, Unks D, Lyu SC, Ma J, Zbozien-Pacamaj R, Chen X, Krensky AM, Clayberger C.

J Antimicrob Chemother. 2008 May;61(5):1103-9. doi: 10.1093/jac/dkn058. Epub 2008 Feb 29.


IL-24 modulates IFN-gamma expression in patients with tuberculosis.

Wu B, Huang C, Kato-Maeda M, Hopewell PC, Daley CL, Krensky AM, Clayberger C.

Immunol Lett. 2008 Apr 15;117(1):57-62. doi: 10.1016/j.imlet.2007.11.018. Epub 2007 Dec 26.


IL-9 is associated with an impaired Th1 immune response in patients with tuberculosis.

Wu B, Huang C, Kato-Maeda M, Hopewell PC, Daley CL, Krensky AM, Clayberger C.

Clin Immunol. 2008 Feb;126(2):202-10. Epub 2007 Nov 26.


Forest bathing enhances human natural killer activity and expression of anti-cancer proteins.

Li Q, Morimoto K, Nakadai A, Inagaki H, Katsumata M, Shimizu T, Hirata Y, Hirata K, Suzuki H, Miyazaki Y, Kagawa T, Koyama Y, Ohira T, Takayama N, Krensky AM, Kawada T.

Int J Immunopathol Pharmacol. 2007 Apr-Jun;20(2 Suppl 2):3-8.


Altered phosphorylated signal transducer and activator of transcription profile of CD4+CD161+ T cells in asthma: modulation by allergic status and oral corticosteroids.

Gernez Y, Tirouvanziam R, Nguyen KD, Herzenberg LA, Krensky AM, Nadeau KC.

J Allergy Clin Immunol. 2007 Dec;120(6):1441-8. Epub 2007 Oct 24.


CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia.

Hosen N, Park CY, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M, Krensky AM, Weissman IL.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11008-13. Epub 2007 Jun 18.


Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins.

Chen X, Howe J, Andrä J, Rössle M, Richter W, da Silva AP, Krensky AM, Clayberger C, Brandenburg K.

Biochim Biophys Acta. 2007 Oct;1768(10):2421-31. Epub 2007 May 22.


Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.

Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM.

J Immunol. 2007 Jun 1;178(11):7081-7.


Unique gene expression profiles in infants vaccinated with different strains of Mycobacterium bovis bacille Calmette-Guerin.

Wu B, Huang C, Garcia L, Ponce de Leon A, Osornio JS, Bobadilla-del-Valle M, Ferreira L, Canizales S, Small P, Kato-Maeda M, Krensky AM, Clayberger C.

Infect Immun. 2007 Jul;75(7):3658-64. Epub 2007 May 14.


Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo.

Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM.

J Immunol. 2007 May 1;178(9):5496-504.


Decreased serum granulysin levels in childhood tuberculosis which reverse after therapy.

Di Liberto D, Buccheri S, Caccamo N, Meraviglia S, Romano A, Di Carlo P, Titone L, Dieli F, Krensky AM, Salerno A.

Tuberculosis (Edinb). 2007 Jul;87(4):322-8. Epub 2007 Mar 26.


Messenger RNA expression of IL-8, FOXP3, and IL-12beta differentiates latent tuberculosis infection from disease.

Wu B, Huang C, Kato-Maeda M, Hopewell PC, Daley CL, Krensky AM, Clayberger C.

J Immunol. 2007 Mar 15;178(6):3688-94.


Mechanisms of disease: regulation of RANTES (CCL5) in renal disease.

Krensky AM, Ahn YT.

Nat Clin Pract Nephrol. 2007 Mar;3(3):164-70. Review.


Granulysin-mediated tumor rejection in transgenic mice.

Huang LP, Lyu SC, Clayberger C, Krensky AM.

J Immunol. 2007 Jan 1;178(1):77-84.


Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes.

Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM.

Mol Cell Biol. 2007 Jan;27(1):253-66. Epub 2006 Oct 30.


Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients.

Zheng CF, Ma LL, Jones GJ, Gill MJ, Krensky AM, Kubes P, Mody CH.

Blood. 2007 Mar 1;109(5):2049-57. Epub 2006 Oct 12.


Healthy lifestyles are associated with higher levels of perforin, granulysin and granzymes A/B-expressing cells in peripheral blood lymphocytes.

Li Q, Morimoto K, Nakadai A, Qu T, Matsushima H, Katsumata M, Shimizu T, Inagaki H, Hirata Y, Hirata K, Kawada T, Lu Y, Nakayama K, Krensky AM.

Prev Med. 2007 Feb;44(2):117-23. Epub 2006 Oct 9.


Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency.

Cohen AC, Nadeau KC, Tu W, Hwa V, Dionis K, Bezrodnik L, Teper A, Gaillard M, Heinrich J, Krensky AM, Rosenfeld RG, Lewis DB.

J Immunol. 2006 Sep 1;177(5):2770-4.


Phytoncides (wood essential oils) induce human natural killer cell activity.

Li Q, Nakadai A, Matsushima H, Miyazaki Y, Krensky AM, Kawada T, Morimoto K.

Immunopharmacol Immunotoxicol. 2006;28(2):319-33.


Cell selectivity correlates with membrane-specific interactions: a case study on the antimicrobial peptide G15 derived from granulysin.

Ramamoorthy A, Thennarasu S, Tan A, Lee DK, Clayberger C, Krensky AM.

Biochim Biophys Acta. 2006 Feb;1758(2):154-63. Epub 2006 Mar 10.


Coordinate expression of CC chemokine ligand 5, granulysin, and perforin in CD8+ T cells provides a host defense mechanism against Mycobacterium tuberculosis.

Stegelmann F, Bastian M, Swoboda K, Bhat R, Kiessler V, Krensky AM, Roellinghoff M, Modlin RL, Stenger S.

J Immunol. 2005 Dec 1;175(11):7474-83.


Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme A and granulysin in human NK-92CI cell line.

Li Q, Nakadai A, Ishizaki M, Morimoto K, Ueda A, Krensky AM, Kawada T.

Toxicology. 2005 Sep 15;213(1-2):107-16.


Granulysin: a novel host defense molecule.

Krensky AM, Clayberger C.

Am J Transplant. 2005 Aug;5(8):1789-92. Review.


Glycosylated recombinant human XCL1/lymphotactin exhibits enhanced biologic activity.

Dong C, Chua A, Ganguly B, Krensky AM, Clayberger C.

J Immunol Methods. 2005 Jul;302(1-2):136-44.


Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammatory activator.

Deng A, Chen S, Li Q, Lyu SC, Clayberger C, Krensky AM.

J Immunol. 2005 May 1;174(9):5243-8.


Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin.

Li Q, Dong C, Deng A, Katsumata M, Nakadai A, Kawada T, Okada S, Clayberger C, Krensky AM.

Antimicrob Agents Chemother. 2005 Jan;49(1):388-97.


Transactivation of the CCL5/RANTES gene by Epstein-Barr virus latent membrane protein 1.

Uchihara JN, Krensky AM, Matsuda T, Kawakami H, Okudaira T, Masuda M, Ohta T, Takasu N, Mori N.

Int J Cancer. 2005 May 1;114(5):747-55. Retraction in: Int J Cancer. 2011 Dec 1;129(11):2762-3.


Lesional T cells and dermal dendrocytes in psoriasis plaque express increased levels of granulysin.

Raychaudhuri SP, Jiang WY, Raychaudhuri SK, Krensky AM.

J Am Acad Dermatol. 2004 Dec;51(6):1006-8.


A novel apoptosis pathway activated by the carboxyl terminus of p21.

Dong C, Li Q, Lyu SC, Krensky AM, Clayberger C.

Blood. 2005 Feb 1;105(3):1187-94. Epub 2004 Oct 5.


NK cells use perforin rather than granulysin for anticryptococcal activity.

Ma LL, Wang CL, Neely GG, Epelman S, Krensky AM, Mody CH.

J Immunol. 2004 Sep 1;173(5):3357-65.

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