Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 81

1.

The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology.

Mao C, Cook WJ, Zhou M, Koszalka GW, Krenitsky TA, Ealick SE.

Structure. 1997 Oct 15;5(10):1373-83.

2.

1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity.

Daluge SM, Good SS, Faletto MB, Miller WH, St Clair MH, Boone LR, Tisdale M, Parry NR, Reardon JE, Dornsife RE, Averett DR, Krenitsky TA.

Antimicrob Agents Chemother. 1997 May;41(5):1082-93.

3.

Metabolism and pharmacokinetics of a double prodrug of ganciclovir in the rat and monkey.

Krasny HC, Beauchamp L, Krenitsky TA, de Miranda P.

Drug Metab Dispos. 1995 Nov;23(11):1242-7.

PMID:
8591725
4.

2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies.

Lambe CU, Averett DR, Paff MT, Reardon JE, Wilson JG, Krenitsky TA.

Cancer Res. 1995 Aug 1;55(15):3352-6.

5.

Varicella-zoster virus thymidine kinase. Characterization and substrate specificity.

Roberts GB, Fyfe JA, McKee SA, Rahim SG, Daluge SM, Almond MR, Rideout JL, Koszalka GW, Krenitsky TA.

Biochem Pharmacol. 1993 Dec 14;46(12):2209-18.

PMID:
8274154
6.

Novel 6-alkoxypurine 2',3'-dideoxynucleosides as inhibitors of the cytopathic effect of the human immunodeficiency virus.

Burns CL, St Clair MH, Frick LW, Spector T, Averett DR, English ML, Holmes TJ, Krenitsky TA, Koszalka GW.

J Med Chem. 1993 Feb 5;36(3):378-84.

PMID:
8426365
7.

Purine 2'-deoxy-2'-fluororibosides as antiinfluenza virus agents.

Tuttle JV, Tisdale M, Krenitsky TA.

J Med Chem. 1993 Jan 8;36(1):119-25.

PMID:
8421277
8.

6-Dimethylamino-9-(beta-D-arabinofuranosyl)-9H-purine: pharmacokinetics and antiviral activity in simian varicella virus-infected monkeys.

Soike KF, Huang JL, Lambe CU, Nelson DJ, Ellis MN, Krenitsky TA, Koszalka GW.

Antiviral Res. 1993 Jan;20(1):13-20.

PMID:
8457145
9.

Review of research leading to new anti-herpesvirus agents in clinical development: valaciclovir hydrochloride (256U, the L-valyl ester of acyclovir) and 882C, a specific agent for varicella zoster virus.

Purifoy DJ, Beauchamp LM, de Miranda P, Ertl P, Lacey S, Roberts G, Rahim SG, Darby G, Krenitsky TA, Powell KL.

J Med Virol. 1993;Suppl 1:139-45. Review.

PMID:
8245881
10.

A novel human phosphotransferase highly specific for adenosine.

Garvey EP, Krenitsky TA.

Arch Biochem Biophys. 1992 Jul;296(1):161-9.

PMID:
1605627
11.

Di- and triester prodrugs of the varicella-zoster antiviral agent 6-methoxypurine arabinoside.

Jones LA, Moorman AR, Chamberlain SD, de Miranda P, Reynolds DJ, Burns CL, Krenitsky TA.

J Med Chem. 1992 Jan;35(1):56-63.

PMID:
1732533
12.

Selective anabolism of 6-methoxypurine arabinoside in varicella-zoster virus-infected cells.

Biron KK, de Miranda P, Burnette TC, Krenitsky TA.

Antimicrob Agents Chemother. 1991 Oct;35(10):2116-20.

13.

Anabolic pathway of 6-methoxypurine arabinoside in cells infected with varicella-zoster virus.

de Miranda P, Burnette TC, Biron KK, Miller RL, Averett DR, Krenitsky TA.

Antimicrob Agents Chemother. 1991 Oct;35(10):2121-4.

14.

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy.

Huber BE, Richards CA, Krenitsky TA.

Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):8039-43.

15.

beta-deuterium kinetic isotope effects in the purine nucleoside phosphorylase reaction.

Guo XM, Ashwell M, Sinnott ML, Krenitsky TA.

Biochem J. 1991 Sep 1;278 ( Pt 2):487-91.

16.

6-N-substituted derivatives of adenine arabinoside as selective inhibitors of varicella-zoster virus.

Koszalka GW, Averett DR, Fyfe JA, Roberts GB, Spector T, Biron K, Krenitsky TA.

Antimicrob Agents Chemother. 1991 Jul;35(7):1437-43.

17.

Metabolic disposition and pharmacokinetics of the antiviral agent 6-methoxypurine arabinoside in rats and monkeys.

Burnette TC, Koszalka GW, Krenitsky TA, De Miranda P.

Antimicrob Agents Chemother. 1991 Jun;35(6):1165-73.

18.

6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus.

Averett DR, Koszalka GW, Fyfe JA, Roberts GB, Purifoy DJ, Krenitsky TA.

Antimicrob Agents Chemother. 1991 May;35(5):851-7.

19.

Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution.

Walter MR, Cook WJ, Cole LB, Short SA, Koszalka GW, Krenitsky TA, Ealick SE.

J Biol Chem. 1990 Aug 15;265(23):14016-22.

20.

Nucleotide analogue inhibitors of purine nucleoside phosphorylase.

Krenitsky TA, Tuttle JV, Miller WH, Moorman AR, Orr GF, Beauchamp L.

J Biol Chem. 1990 Feb 25;265(6):3066-9.

22.

Inhibition of xanthine oxidase by 4-hydroxy-6-mercaptopyrazolo[3,4-d]pyrimidine.

Spector T, Hall WW, Porter DJ, Lambe CU, Nelson DJ, Krenitsky TA.

Biochem Pharmacol. 1989 Dec 1;38(23):4315-20.

PMID:
2557043
23.

Nucleosides of azathioprine and thiamiprine as antiarthritics.

Krenitsky TA, Hall WW, Selph JL, Truax JF, Vinegar R.

J Med Chem. 1989 Jul;32(7):1471-5.

PMID:
2738881
25.

Effects of 3'-azido-3'-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells.

Frick LW, Nelson DJ, St Clair MH, Furman PA, Krenitsky TA.

Biochem Biophys Res Commun. 1988 Jul 15;154(1):124-9.

PMID:
3164996
26.

Antigiardial activity of guanine arabinoside. Mechanism studies.

Miller RL, Nelson DJ, LaFon SW, Miller WH, Krenitsky TA.

Biochem Pharmacol. 1987 Aug 1;36(15):2519-25.

PMID:
2440445
27.

Trypanosoma cruzi adenine nucleoside phosphorylase. Purification and substrate specificity.

Miller RL, Sabourin CL, Krenitsky TA.

Biochem Pharmacol. 1987 Feb 15;36(4):553-60.

PMID:
3103626
28.

Allopurinol as an inhibitor of the in vivo formation of acyclovir from desciclovir.

Krasny HC, Krenitsky TA.

Biochem Pharmacol. 1986 Dec 1;35(23):4339-40. No abstract available.

PMID:
3790156
29.

Aldehyde oxidase from rabbit liver: specificity toward purines and their analogs.

Hall WW, Krenitsky TA.

Arch Biochem Biophys. 1986 Nov 15;251(1):36-46.

PMID:
3789740
30.

Inhibition of uridine phosphorylase from Escherichia coli by benzylacyclouridines.

Park KS, el Kouni MH, Krenitsky TA, Chu SH, Cha S.

Biochem Pharmacol. 1986 Nov 1;35(21):3853-5.

PMID:
3535805
31.

Human and bovine xanthine oxidases. Inhibition studies with oxipurinol.

Spector T, Hall WW, Krenitsky TA.

Biochem Pharmacol. 1986 Sep 15;35(18):3109-14.

PMID:
3755906
32.

Xanthine oxidase from human liver: purification and characterization.

Krenitsky TA, Spector T, Hall WW.

Arch Biochem Biophys. 1986 May 15;247(1):108-19.

PMID:
3010873
33.

Imidazo[4,5-c]pyridines (3-deazapurines) and their nucleosides as immunosuppressive and antiinflammatory agents.

Krenitsky TA, Rideout JL, Chao EY, Koszalka GW, Gurney F, Crouch RC, Cohn NK, Wolberg G, Vinegar R.

J Med Chem. 1986 Jan;29(1):138-43.

PMID:
3941408
34.

5'-Methylthioadenosine (MTA) phosphorylase from promastigotes of Leishmania donovani.

Koszalka GW, Krenitsky TA.

Adv Exp Med Biol. 1986;195 Pt B:559-63. No abstract available.

PMID:
3094329
35.

Crystallization and preliminary x-ray investigation of purine-nucleoside phosphorylase from Escherichia coli.

Cook WJ, Ealick SE, Krenitsky TA, Stoeckler JD, Helliwell JR, Bugg CE.

J Biol Chem. 1985 Oct 25;260(24):12968-9.

36.

6-Deoxyacyclovir: a xanthine oxidase-activated prodrug of acyclovir.

Krenitsky TA, Hall WW, de Miranda P, Beauchamp LM, Schaeffer HJ, Whiteman PD.

Proc Natl Acad Sci U S A. 1984 May;81(10):3209-13.

37.

Nucleoside hydrolases from Trypanosoma cruzi.

Miller RL, Sabourin CL, Krenitsky TA, Berens RL, Marr JJ.

J Biol Chem. 1984 Apr 25;259(8):5073-7.

38.

Effects of acyclovir and its metabolites on purine nucleoside phosphorylase.

Tuttle JV, Krenitsky TA.

J Biol Chem. 1984 Apr 10;259(7):4065-9.

39.

Purine salvage enzymes in Leishmania donovani and Trichomonas vaginalis.

Krenitsky TA, Miller RL.

Adv Exp Med Biol. 1984;165 Pt A:215-8. No abstract available.

PMID:
6426255
40.

Effects of acyclovir and its metabolites on hypoxanthine-guanine phosphoribosyltransferase.

Tuttle JV, Krenitsky TA, Elion GB.

Biochem Pharmacol. 1983 Oct 15;32(20):3011-5.

PMID:
6639669
41.

Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 3. Synthesis and activity of some nucleosides of 4-[(arylalkenyl)thio]pyrazolo[3,4-d]pyrimidines.

Rideout JL, Krenitsky TA, Chao EY, Elion GB, Williams RB, Latter VS.

J Med Chem. 1983 Oct;26(10):1489-94.

PMID:
6620308
42.

Antiviral agents.

Krenitsky TA, Beauchamp L.

Science. 1983 Jun 10;220(4602):1106. No abstract available.

PMID:
6857236
43.

3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.

Krenitsky TA, Freeman GA, Shaver SR, Beacham LM 3rd, Hurlbert S, Cohn NK, Elwell LP, Selway JW.

J Med Chem. 1983 Jun;26(6):891-5.

PMID:
6854592
44.

Purification, characterization, substrate and inhibitor specificity of adenosine kinase from several Eimeria species.

Miller RL, Adamczyk DL, Rideout JL, Krenitsky TA.

Mol Biochem Parasitol. 1982 Oct;6(4):209-23.

PMID:
6292713
45.

Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 2. Synthesis and activity of some nucleosides of 4-(alkylamino)-1H-pyrazolo[3, 4-d]pyrimidines.

Rideout JL, Krenitsky TA, Koszalka GW, Cohn NK, Chao EY, Elion GB, Latter VS, Williams RB.

J Med Chem. 1982 Sep;25(9):1040-4.

PMID:
7131482
46.

Correlation of substrate-stabilization patterns with proposed mechanisms for three nucleoside phosphorylases.

Krenitsky TA, Tuttle JV.

Biochim Biophys Acta. 1982 May 3;703(2):247-9.

PMID:
6805517
47.

Antileishmanial action of 4-thiopyrazolo (3.4-d) pyrimidine and its ribonucleoside. Biological effects and metabolism.

Marr JJ, Berens RL, Nelson DJ, Krenitsky TA, Spector T, LaFon SW, Elion GB.

Biochem Pharmacol. 1982 Jan 15;31(2):143-8.

PMID:
7073876
48.

Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 1. Synthesis and activity of some nucleosides of purines and 4-(alkylthio)pyrazolo[3,4-d]pyrimidines.

Krenitsky TA, Rideout JL, Koszalka GW, Inmon RB, Chao EY, Elion GB, Latter VS, Williams RB.

J Med Chem. 1982 Jan;25(1):32-5.

PMID:
7086819
49.

Purine nucleoside synthesis, an efficient method employing nucleoside phosphorylases.

Krenitsky TA, Koszalka GW, Tuttle JV.

Biochemistry. 1981 Jun 9;20(12):3615-21.

PMID:
6789872
50.

Purine phosphoribosyltransferases from Leishmania donovani.

Tuttle JV, Krenitsky TA.

J Biol Chem. 1980 Feb 10;255(3):909-16. No abstract available.

Supplemental Content

Loading ...
Support Center