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Items: 20


Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes.

Jones JR, Kong L, Hanna MG 4th, Hoffman B, Krencik R, Bradley R, Hagemann T, Choi J, Doers M, Dubovis M, Sherafat MA, Bhattacharyya A, Kendziorski C, Audhya A, Messing A, Zhang SC.

Cell Rep. 2018 Oct 23;25(4):947-958.e4. doi: 10.1016/j.celrep.2018.09.083.


Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells.

Cvetkovic C, Basu N, Krencik R.

J Vis Exp. 2018 Aug 16;(138). doi: 10.3791/58034.


Concepts toward directing human astroplasticity to promote neuroregeneration.

Patel R, Muir M, Cvetkovic C, Krencik R.

Dev Dyn. 2019 Jan;248(1):21-33. doi: 10.1002/dvdy.24655. Epub 2018 Sep 6. Review.


Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.

Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, Horner PJ, Rowitch DH, Ullian EM.

Stem Cell Reports. 2017 Dec 12;9(6):1745-1753. doi: 10.1016/j.stemcr.2017.10.026. Epub 2017 Nov 30.


Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.

Yeh E, Dao DQ, Wu ZY, Kandalam SM, Camacho FM, Tom C, Zhang W, Krencik R, Rauen KA, Ullian EM, Weiss LA.

Mol Psychiatry. 2018 Aug;23(8):1687-1698. doi: 10.1038/mp.2017.238. Epub 2017 Nov 21.


Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner.

Krejciova Z, Alibhai J, Zhao C, Krencik R, Rzechorzek NM, Ullian EM, Manson J, Ironside JW, Head MW, Chandran S.

J Exp Med. 2017 Dec 4;214(12):3481-3495. doi: 10.1084/jem.20161547. Epub 2017 Nov 15.


Zika virus cell tropism in the developing human brain and inhibition by azithromycin.

Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, Mancia Leon WR, Krencik R, Ullian EM, Spatazza J, Pollen AA, Mandel-Brehm C, Nowakowski TJ, Kriegstein AR, DeRisi JL.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14408-14413. Epub 2016 Nov 29.


Human astrocytes are distinct contributors to the complexity of synaptic function.

Krencik R, van Asperen JV, Ullian EM.

Brain Res Bull. 2017 Mar;129:66-73. doi: 10.1016/j.brainresbull.2016.08.012. Epub 2016 Aug 25. Review.


Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells.

Hu Y, Qu ZY, Cao SY, Li Q, Ma L, Krencik R, Xu M, Liu Y.

J Neurosci Methods. 2016 Jun 15;266:42-9. doi: 10.1016/j.jneumeth.2016.03.017. Epub 2016 Mar 29.


Efficient generation of region-specific forebrain neurons from human pluripotent stem cells under highly defined condition.

Yuan F, Fang KH, Cao SY, Qu ZY, Li Q, Krencik R, Xu M, Bhattacharyya A, Su YW, Zhu DY, Liu Y.

Sci Rep. 2015 Dec 16;5:18550. doi: 10.1038/srep18550.


Dysregulation of astrocyte extracellular signaling in Costello syndrome.

Krencik R, Hokanson KC, Narayan AR, Dvornik J, Rooney GE, Rauen KA, Weiss LA, Rowitch DH, Ullian EM.

Sci Transl Med. 2015 May 6;7(286):286ra66. doi: 10.1126/scitranslmed.aaa5645.


Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits.

Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang SC.

Nat Biotechnol. 2013 May;31(5):440-7. doi: 10.1038/nbt.2565. Epub 2013 Apr 21.


A cellular star atlas: using astrocytes from human pluripotent stem cells for disease studies.

Krencik R, Ullian EM.

Front Cell Neurosci. 2013 Mar 14;7:25. doi: 10.3389/fncel.2013.00025. eCollection 2013.


Astrocytes and disease: a neurodevelopmental perspective.

Molofsky AV, Krencik R, Ullian EM, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH.

Genes Dev. 2012 May 1;26(9):891-907. doi: 10.1101/gad.188326.112. Review. Erratum in: Genes Dev. 2012 Jul 1;26(13):1508. Krenick, Robert [corrected to Krencik, Robert]; Ullian, Erik [corrected to Ullian, Erik M].


Directed differentiation of functional astroglial subtypes from human pluripotent stem cells.

Krencik R, Zhang SC.

Nat Protoc. 2011 Oct 13;6(11):1710-7. doi: 10.1038/nprot.2011.405.


Specification of transplantable astroglial subtypes from human pluripotent stem cells.

Krencik R, Weick JP, Liu Y, Zhang ZJ, Zhang SC.

Nat Biotechnol. 2011 May 22;29(6):528-34. doi: 10.1038/nbt.1877.


The COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatin.

Bao X, Cai W, Deng H, Zhang W, Krencik R, Girton J, Johansen J, Johansen KM.

J Biol Chem. 2008 Nov 21;283(47):32741-50. doi: 10.1074/jbc.M806227200. Epub 2008 Sep 26.


Stem cell neural differentiation: A model for chemical biology.

Krencik R, Zhang SC.

Curr Opin Chem Biol. 2006 Dec;10(6):592-7. Epub 2006 Oct 13. Review.


The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells.

Bao X, Zhang W, Krencik R, Deng H, Wang Y, Girton J, Johansen J, Johansen KM.

J Cell Sci. 2005 Nov 1;118(Pt 21):5079-87.


Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells.

Kweon GR, Marks JD, Krencik R, Leung EH, Schumacker PT, Hyland K, Kang UJ.

J Biol Chem. 2004 Dec 10;279(50):51783-92. Epub 2004 Oct 6.

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