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Items: 23


Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity.

Marshall EE, Malouli D, Hansen SG, Gilbride RM, Hughes CM, Ventura AB, Ainslie E, Selseth AN, Ford JC, Burke D, Kreklywich CN, Womack J, Legasse AW, Axthelm MK, Kahl C, Streblow D, Edlefsen PT, Picker LJ, Früh K.

Sci Transl Med. 2019 Jul 17;11(501). pii: eaaw2603. doi: 10.1126/scitranslmed.aaw2603.


Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs.

Broeckel R, Sarkar S, May NA, Totonchy J, Kreklywich CN, Smith P, Graves L, DeFilippis VR, Heise MT, Morrison TE, Moorman N, Streblow DN.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02325-18. doi: 10.1128/AAC.02325-18. Print 2019 Apr.


Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology.

Hirsch AJ, Roberts VHJ, Grigsby PL, Haese N, Schabel MC, Wang X, Lo JO, Liu Z, Kroenke CD, Smith JL, Kelleher M, Broeckel R, Kreklywich CN, Parkins CJ, Denton M, Smith P, DeFilippis V, Messer W, Nelson JA, Hennebold JD, Grafe M, Colgin L, Lewis A, Ducore R, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Moses AV, Morgan TK, Frias AE, Streblow DN.

Nat Commun. 2018 Jan 17;9(1):263. doi: 10.1038/s41467-017-02499-9.


Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques.

Broeckel R, Fox JM, Haese N, Kreklywich CN, Sukulpovi-Petty S, Legasse A, Smith PP, Denton M, Corvey C, Krishnan S, Colgin LMA, Ducore RM, Lewis AD, Axthelm MK, Mandron M, Cortez P, Rothblatt J, Rao E, Focken I, Carter K, Sapparapau G, Crowe JE Jr, Diamond MS, Streblow DN.

PLoS Negl Trop Dis. 2017 Jun 19;11(6):e0005637. doi: 10.1371/journal.pntd.0005637. eCollection 2017 Jun.


Rat Cytomegalovirus Vaccine Prevents Accelerated Chronic Rejection in CMV-Naïve Recipients of Infected Donor Allograft Hearts.

Streblow DN, Hwee YK, Kreklywich CN, Andoh T, Denton M, Smith P, Hart E, Broekel R, Pallett C, Rogers K, Streblow AD, Chuop M, Perry A, Slifka M, Messaoudi I, Orloff SL.

Am J Transplant. 2015 Jul;15(7):1805-16. doi: 10.1111/ajt.13188. Epub 2015 Mar 12.


Fluorescence-based laser capture microscopy technology facilitates identification of critical in vivo cytomegalovirus transcriptional programs.

Kreklywich CN, Smith PP, Jones CB, Cornea A, Orloff SL, Streblow DN.

Methods Mol Biol. 2014;1119:217-37. doi: 10.1007/978-1-62703-788-4_13.


Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity.

Messaoudi I, Vomaske J, Totonchy T, Kreklywich CN, Haberthur K, Springgay L, Brien JD, Diamond MS, Defilippis VR, Streblow DN.

PLoS Negl Trop Dis. 2013 Jul 25;7(7):e2343. doi: 10.1371/journal.pntd.0002343. Print 2013.


A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection.

Umashankar M, Petrucelli A, Cicchini L, Caposio P, Kreklywich CN, Rak M, Bughio F, Goldman DC, Hamlin KL, Nelson JA, Fleming WH, Streblow DN, Goodrum F.

PLoS Pathog. 2011 Dec;7(12):e1002444. doi: 10.1371/journal.ppat.1002444. Epub 2011 Dec 29.


Cytomegalovirus microRNA expression is tissue specific and is associated with persistence.

Meyer C, Grey F, Kreklywich CN, Andoh TF, Tirabassi RS, Orloff SL, Streblow DN.

J Virol. 2011 Jan;85(1):378-89. doi: 10.1128/JVI.01900-10. Epub 2010 Oct 27.


IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin.

Botto S, Streblow DN, DeFilippis V, White L, Kreklywich CN, Smith PP, Caposio P.

Blood. 2011 Jan 6;117(1):352-61. doi: 10.1182/blood-2010-06-291245. Epub 2010 Oct 7.


Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model.

Smith MS, Goldman DC, Bailey AS, Pfaffle DL, Kreklywich CN, Spencer DB, Othieno FA, Streblow DN, Garcia JV, Fleming WH, Nelson JA.

Cell Host Microbe. 2010 Sep 16;8(3):284-91. doi: 10.1016/j.chom.2010.08.001.


Rat cytomegalovirus infection depletes MHC II in bone marrow derived dendritic cells.

Baca Jones CC, Kreklywich CN, Messaoudi I, Vomaske J, McCartney E, Orloff SL, Nelson JA, Streblow DN.

Virology. 2009 May 25;388(1):78-90. doi: 10.1016/j.virol.2009.02.050. Epub 2009 Apr 5.


Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing.

Dumortier J, Streblow DN, Moses AV, Jacobs JM, Kreklywich CN, Camp D, Smith RD, Orloff SL, Nelson JA.

J Virol. 2008 Jul;82(13):6524-35. doi: 10.1128/JVI.00502-08. Epub 2008 Apr 30.


The role of angiogenic and wound repair factors during CMV-accelerated transplant vascular sclerosis in rat cardiac transplants.

Streblow DN, Kreklywich CN, Andoh T, Moses AV, Dumortier J, Smith PP, Defilippis V, Fruh K, Nelson JA, Orloff SL.

Am J Transplant. 2008 Feb;8(2):277-87. Epub 2007 Dec 18.


Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro.

Streblow DN, van Cleef KW, Kreklywich CN, Meyer C, Smith P, Defilippis V, Grey F, Früh K, Searles R, Bruggeman C, Vink C, Nelson JA, Orloff SL.

J Virol. 2007 Apr;81(8):3816-26. Epub 2007 Jan 24.


Cytomegalovirus accelerates chronic allograft nephropathy in a rat renal transplant model with associated provocative chemokine profiles.

Soule JL, Streblow DN, Andoh TF, Kreklywich CN, Orloff SL.

Transplant Proc. 2006 Dec;38(10):3214-20.


Mouse cytomegalovirus M33 is necessary and sufficient in virus-induced vascular smooth muscle cell migration.

Melnychuk RM, Smith P, Kreklywich CN, Ruchti F, Vomaske J, Hall L, Loh L, Nelson JA, Orloff SL, Streblow DN.

J Virol. 2005 Aug;79(16):10788-95.


Rat cytomegalovirus-accelerated transplant vascular sclerosis is reduced with mutation of the chemokine-receptor R33.

Streblow DN, Kreklywich CN, Smith P, Soule JL, Meyer C, Yin M, Beisser P, Vink C, Nelson JA, Orloff SL.

Am J Transplant. 2005 Mar;5(3):436-42.


Kinetics and development of CMV-accelerated transplant vascular sclerosis in rat cardiac allografts is linked to early increase in chemokine expression and presence of virus.

De La Melena VT, Kreklywich CN, Streblow DN, Yin Q, Cook JW, Soderberg-Naucler C, Bruggeman CA, Nelson JA, Orloff SL.

Transplant Proc. 2001 Feb-Mar;33(1-2):1822-3. No abstract available.


Linkage mapping detects two secondary microdeletions in cell hybrid HHW1064, used to isolate DNA probes from within 5q11.2-->q13.3.

Bernard LE, McPherson JD, Wasmuth JJ, Kreklywich CN, Brzustowicz LM, Wood S.

Cytogenet Cell Genet. 1993;64(1):46-8.


Dinucleotide repeat polymorphism at the D5S260 locus on chromosome 5q.

Bernard LE, Kreklywich CN, Wood S.

Nucleic Acids Res. 1991 Dec 25;19(24):6970. No abstract available.


Dinucleotide repeat polymorphisms at the D5S257 and D5S268 loci on chromosome 5p.

Bernard LE, Kreklywich CN, Wood S.

Nucleic Acids Res. 1991 Oct 25;19(20):5794. No abstract available.


A polymorphic DNA marker at the D8S131 locus.

Weber B, Riess O, Kreklywich CN, Wood S, Hayden MR.

Nucleic Acids Res. 1991 Apr 11;19(7):1725. No abstract available.

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