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Items: 50

1.

Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(-) Ketamine Concentrations.

Henthorn TK, Avram MJ, Dahan A, Gustafsson LL, Persson J, Krejcie TC, Olofsen E.

Anesthesiology. 2018 Aug;129(2):260-270. doi: 10.1097/ALN.0000000000002265.

PMID:
29771709
2.

Beta blockade increases pulmonary and systemic transit time heterogeneity: evaluation based on indocyanine green kinetics in healthy volunteers.

Weiss M, Krejcie TC, Avram MJ.

Clin Physiol Funct Imaging. 2017 May;37(3):270-275. doi: 10.1111/cpf.12295. Epub 2015 Aug 24.

PMID:
26303231
3.

Recirculatory pharmacokinetic modeling: what goes around, comes around.

Krejcie TC, Avram MJ.

Anesth Analg. 2012 Aug;115(2):223-6. doi: 10.1213/ANE.0b013e318240139b. No abstract available.

PMID:
22826520
4.

A physiologically based model of hepatic ICG clearance: interplay between sinusoidal uptake and biliary excretion.

Weiss M, Krejcie TC, Avram MJ.

Eur J Pharm Sci. 2011 Oct 9;44(3):359-65. doi: 10.1016/j.ejps.2011.08.018. Epub 2011 Aug 26.

PMID:
21893195
5.

When Duzitol does not do it all: the two sides of drug synergy.

Krejcie TC, Avram MJ.

Anesth Analg. 2011 Sep;113(3):441-3. doi: 10.1213/ANE.0b013e3182251509. No abstract available.

PMID:
21862600
6.

Early drug distribution: a generally neglected aspect of pharmacokinetics of particular relevance to intravenously administered anesthetic agents.

Henthorn TK, Krejcie TC, Avram MJ.

Clin Pharmacol Ther. 2008 Jul;84(1):18-22. doi: 10.1038/clpt.2008.107. Review.

PMID:
18563069
7.

Morphine bioavailability from a topical gel formulation in volunteers.

Paice JA, Von Roenn JH, Hudgins JC, Luong L, Krejcie TC, Avram MJ.

J Pain Symptom Manage. 2008 Mar;35(3):314-20. doi: 10.1016/j.jpainsymman.2007.04.016. Epub 2008 Jan 7.

8.

A minimal physiological model of thiopental distribution kinetics based on a multiple indicator approach.

Weiss M, Krejcie TC, Avram MJ.

Drug Metab Dispos. 2007 Sep;35(9):1525-32. Epub 2007 May 30.

PMID:
17537875
9.
10.

Recirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogs.

Avram MJ, Henthorn TK, Spyker DA, Krejcie TC, Lloyd PM, Cassella JV, Rabinowitz JD.

Drug Metab Dispos. 2007 Feb;35(2):262-7. Epub 2006 Nov 1.

PMID:
17079359
11.

Transit time dispersion in pulmonary and systemic circulation: effects of cardiac output and solute diffusivity.

Weiss M, Krejcie TC, Avram MJ.

Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H861-70. Epub 2006 Feb 24.

12.

Anesthesia management and perioperative mortality.

Avram MJ, Krejcie TC.

Anesthesiology. 2006 Jan;104(1):202-3; author reply 204-5, 205-6. No abstract available.

PMID:
16394709
13.

Beta-adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution.

Avram MJ, Krejcie TC, Henthorn TK, Niemann CU.

J Pharmacol Exp Ther. 2004 Nov;311(2):617-24. Epub 2004 Jun 14.

PMID:
15197245
14.

Using front-end kinetics to optimize target-controlled drug infusions.

Avram MJ, Krejcie TC.

Anesthesiology. 2003 Nov;99(5):1078-86.

PMID:
14576543
15.

Anesthesia-induced alterations in plasma tracer concentrations may have relevance for brain imaging studies.

Alkire MT, Krejcie TC, Avram MJ.

Anesthesiology. 2002 Jul;97(1):281-2; author reply 282. No abstract available.

PMID:
12131139
16.

The concordance of early antipyrine and thiopental distribution kinetics.

Avram MJ, Krejcie TC, Henthorn TK.

J Pharmacol Exp Ther. 2002 Aug;302(2):594-600.

PMID:
12130720
17.
18.

Facilitated uptake of fentanyl, but not alfentanil, by human pulmonary endothelial cells.

Waters CM, Krejcie TC, Avram MJ.

Anesthesiology. 2000 Sep;93(3):825-31.

PMID:
10969317
19.

Isoflurane alters the recirculatory pharmacokinetics of physiologic markers.

Avram MJ, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Henthorn TK.

Anesthesiology. 2000 Jun;92(6):1757-68.

PMID:
10839928
20.

Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol.

Niemann CU, Henthorn TK, Krejcie TC, Shanks CA, Enders-Klein C, Avram MJ.

Clin Pharmacol Ther. 2000 Apr;67(4):342-50.

PMID:
10801242
21.

Ketamine distribution described by a recirculatory pharmacokinetic model is not stereoselective.

Henthorn TK, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ.

Anesthesiology. 1999 Dec;91(6):1733-43.

PMID:
10598617
22.

Modifications of blood volume alter the disposition of markers of blood volume, extracellular fluid, and total body water.

Krejcie TC, Henthorn TK, Gentry WB, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ.

J Pharmacol Exp Ther. 1999 Dec;291(3):1308-16.

PMID:
10565856
23.

What determines anesthetic induction dose? It's the front-end kinetics, doctor!

Krejcie TC, Avram MJ.

Anesth Analg. 1999 Sep;89(3):541-4. Review. No abstract available.

PMID:
10475278
24.

Uptake of fentanyl in pulmonary endothelium.

Waters CM, Avram MJ, Krejcie TC, Henthorn TK.

J Pharmacol Exp Ther. 1999 Jan;288(1):157-63.

PMID:
9862766
25.

Transporter-mediated pulmonary endothelial uptake of fentanyl.

Henthorn TK, Krejcie TC, Avram MJ, Jensen TR, Waters CM.

Int J Clin Pharmacol Ther. 1998 Feb;36(2):74-5. No abstract available.

PMID:
9520148
26.

The effect of halothane on the recirculatory pharmacokinetics of physiologic markers.

Avram MJ, Krejcie TC, Niemann CU, Klein C, Gentry WB, Shanks CA, Henthorn TK.

Anesthesiology. 1997 Dec;87(6):1381-93.

PMID:
9416724
27.

A recirculatory model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs.

Krejcie TC, Avram MJ, Gentry WB, Niemann CU, Janowski MP, Henthorn TK.

J Pharmacokinet Biopharm. 1997 Apr;25(2):169-90.

PMID:
9408858
28.

Use of parallel Erlang density functions to analyze first-pass pulmonary uptake of multiple indicators in dogs.

Krejcie TC, Jacquez JA, Avram MJ, Niemann CU, Shanks CA, Henthorn TK.

J Pharmacokinet Biopharm. 1996 Dec;24(6):569-88.

29.

Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly.

Krejcie TC, Henthorn TK, Niemann CU, Klein C, Gupta DK, Gentry WB, Shanks CA, Avram MJ.

J Pharmacol Exp Ther. 1996 Sep;278(3):1050-7.

PMID:
8819485
30.

Induction and maintenance of anesthesia in dogs by intravenous administration of methohexital.

Gentry WB, Krejcie TC, Henthorn TK, Avram MJ.

Am J Vet Res. 1996 Jul;57(7):1044-9.

PMID:
8807019
31.

Calculation of an effect compartment rate constant using recovery indices obtained with an isolated arm technique.

Shanks CA, Avram MJ, Krejcie TC, Henthorn TK.

Br J Anaesth. 1995 Jul;75(1):109-12.

32.

Effect of infusion rate on thiopental dose-response relationships. Assessment of a pharmacokinetic-pharmacodynamic model.

Gentry WB, Krejcie TC, Henthorn TK, Shanks CA, Howard KA, Gupta DK, Avram MJ.

Anesthesiology. 1994 Aug;81(2):316-24; discussion 25A.

PMID:
8053580
33.

A recirculatory pharmacokinetic model describing the circulatory mixing, tissue distribution and elimination of antipyrine in dogs.

Krejcie TC, Henthorn TK, Shanks CA, Avram MJ.

J Pharmacol Exp Ther. 1994 May;269(2):609-16.

PMID:
8182527
34.

A pharmacokinetic-pharmacodynamic model for quantal responses with thiopental.

Shanks CA, Avram MJ, Krejcie TC, Henthorn TK, Gentry WB.

J Pharmacokinet Biopharm. 1993 Jun;21(3):309-21.

PMID:
8258770
35.

Determinants of thiopental induction dose requirements.

Avram MJ, Sanghvi R, Henthorn TK, Krejcie TC, Shanks CA, Fragen RJ, Howard KA, Kaczynski DA.

Anesth Analg. 1993 Jan;76(1):10-7.

PMID:
8418708
36.

Time-dependent distribution volume and kinetics of the pharmacodynamic effector site.

Henthorn TK, Krejcie TC, Shanks CA, Avram MJ.

J Pharm Sci. 1992 Nov;81(11):1136-8. No abstract available.

PMID:
1447720
37.

The relationship between alfentanil distribution kinetics and cardiac output.

Henthorn TK, Krejcie TC, Avram MJ.

Clin Pharmacol Ther. 1992 Aug;52(2):190-6.

PMID:
1505154
38.

Minimal compartmental model of circulatory mixing of indocyanine green.

Henthorn TK, Avram MJ, Krejcie TC, Shanks CA, Asada A, Kaczynski DA.

Am J Physiol. 1992 Mar;262(3 Pt 2):H903-10.

PMID:
1558199
39.

Cauda equina syndrome after continuous spinal anesthesia.

Rigler ML, Drasner K, Krejcie TC, Yelich SJ, Scholnick FT, DeFontes J, Bohner D.

Anesth Analg. 1991 Mar;72(3):275-81.

PMID:
1994754
40.

Using a microcomputer to convert percent response values to probits.

Krejcie TC.

Int J Clin Monit Comput. 1991;8(1):19-23.

PMID:
1919279
41.
42.

Alfentanil clearance is independent of the polymorphic debrisoquin hydroxylase.

Henthorn TK, Avram MJ, Krejcie TC.

Anesthesiology. 1989 Nov;71(5):635-9.

PMID:
2817455
43.

Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis.

Henthorn TK, Benitez J, Avram MJ, Martinez C, Llerena A, Cobaleda J, Krejcie TC, Gibbons RD.

Clin Pharmacol Ther. 1989 Mar;45(3):328-33.

PMID:
2920506
44.

Awake fibreoptic intubation in the patient at high risk of aspiration.

Ovassapian A, Krejcie TC, Yelich SJ, Dykes MH.

Br J Anaesth. 1989 Jan;62(1):13-6.

45.

Intravascular mixing and drug distribution: the concurrent disposition of thiopental and indocyanine green.

Henthorn TK, Avram MJ, Krejcie TC.

Clin Pharmacol Ther. 1989 Jan;45(1):56-65.

PMID:
2910638
47.

The initial rate of change in distribution volume is the sum of intercompartmental clearances.

Avram MJ, Henthorn TK, Shanks CA, Krejcie TC.

J Pharm Sci. 1986 Sep;75(9):919-20. No abstract available.

PMID:
3783465
48.

Assay for serum sufentanil level is not sensitive.

Avram MJ, Henthorn TK, Krejcie TC.

Anesthesiology. 1986 Jul;65(1):110-2. No abstract available.

PMID:
2942059
49.

Reduction in slow intercompartmental clearance of urea during dialysis.

Bowsher DJ, Krejcie TC, Avram MJ, Chow MJ, Del Greco F, Atkinson AJ Jr.

J Lab Clin Med. 1985 Apr;105(4):489-97.

PMID:
3884720
50.

Pulmonary artery balloon counterpulsation for right ventricular failure: I. Experimental results.

Opravil M, Gorman AJ, Krejcie TC, Michaelis LL, Moran JM.

Ann Thorac Surg. 1984 Sep;38(3):242-53.

PMID:
6476946

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