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A Combination of Approved Antibodies Overcomes Resistance of Lung Cancer to Osimertinib by Blocking Bypass Pathways.

Romaniello D, Mazzeo L, Mancini M, Marrocco I, Noronha A, Kreitman M, Srivastava S, Ghosh S, Lindzen M, Salame TM, Onn A, Bar J, Yarden Y.

Clin Cancer Res. 2018 Nov 15;24(22):5610-5621. doi: 10.1158/1078-0432.CCR-18-0450. Epub 2018 Jul 2.


Irreversible modifications of receptor tyrosine kinases.

Kreitman M, Noronha A, Yarden Y.

FEBS Lett. 2018 Jul;592(13):2199-2212. doi: 10.1002/1873-3468.13095. Epub 2018 May 28. Review.


Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations.

Jha AR, Zhou D, Brown CD, Kreitman M, Haddad GG, White KP.

Mol Biol Evol. 2016 Feb;33(2):501-17. doi: 10.1093/molbev/msv248. Epub 2015 Nov 17.


Natural variation of the expression pattern of the segmentation gene even-skipped in melanogaster.

Jiang P, Ludwig MZ, Kreitman M, Reinitz J.

Dev Biol. 2015 Sep 1;405(1):173-81. doi: 10.1016/j.ydbio.2015.06.019. Epub 2015 Jun 27.


Whole-Genome Resequencing of Experimental Populations Reveals Polygenic Basis of Egg-Size Variation in Drosophila melanogaster.

Jha AR, Miles CM, Lippert NR, Brown CD, White KP, Kreitman M.

Mol Biol Evol. 2015 Oct;32(10):2616-32. doi: 10.1093/molbev/msv136. Epub 2015 Jun 3.


Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure.

Lerch MT, López CJ, Yang Z, Kreitman MJ, Horwitz J, Hubbell WL.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2437-46. doi: 10.1073/pnas.1506505112. Epub 2015 Apr 27.


Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.

Palsson A, Wesolowska N, Reynisdóttir S, Ludwig MZ, Kreitman M.

PLoS One. 2014 May 1;9(5):e91924. doi: 10.1371/journal.pone.0091924. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e99548.


Ancestral resurrection of the Drosophila S2E enhancer reveals accessible evolutionary paths through compensatory change.

Martinez C, Rest JS, Kim AR, Ludwig M, Kreitman M, White K, Reinitz J.

Mol Biol Evol. 2014 Apr;31(4):903-16. doi: 10.1093/molbev/msu042. Epub 2014 Jan 9.


Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos.

Cheung D, Miles C, Kreitman M, Ma J.

Development. 2014 Jan;141(1):124-35. doi: 10.1242/dev.098640. Epub 2013 Nov 27.


Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin.

He BZ, Ludwig MZ, Dickerson DA, Barse L, Arun B, Vilhjálmsson BJ, Jiang P, Park SY, Tamarina NA, Selleck SB, Wittkopp PJ, Bell GI, Kreitman M.

Genetics. 2014 Feb;196(2):557-67. doi: 10.1534/genetics.113.157800. Epub 2013 Nov 26. Erratum in: Genetics. 2014 Apr;196(4):1357. Jiang, Pengyao [added].


Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.

Park SY, Ludwig MZ, Tamarina NA, He BZ, Carl SH, Dickerson DA, Barse L, Arun B, Williams CL, Miles CM, Philipson LH, Steiner DF, Bell GI, Kreitman M.

Genetics. 2014 Feb;196(2):539-55. doi: 10.1534/genetics.113.157602. Epub 2013 Nov 26. Erratum in: Genetics. 2014 Dec;198(4):1773.


Sex-specific pattern formation during early Drosophila development.

Manu, Ludwig MZ, Kreitman M.

Genetics. 2013 May;194(1):163-73. doi: 10.1534/genetics.112.148205. Epub 2013 Feb 14.


Enantiomeric natural products: occurrence and biogenesis.

Finefield JM, Sherman DH, Kreitman M, Williams RM.

Angew Chem Int Ed Engl. 2012 May 14;51(20):4802-36. doi: 10.1002/anie.201107204. Epub 2012 May 3. Review.


Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness.

Ludwig MZ, Manu, Kittler R, White KP, Kreitman M.

PLoS Genet. 2011 Nov;7(11):e1002364. doi: 10.1371/journal.pgen.1002364. Epub 2011 Nov 10.


Scaling of the Bicoid morphogen gradient by a volume-dependent production rate.

Cheung D, Miles C, Kreitman M, Ma J.

Development. 2011 Jul;138(13):2741-9. doi: 10.1242/dev.064402. Epub 2011 May 25.


Does positive selection drive transcription factor binding site turnover? A test with Drosophila cis-regulatory modules.

He BZ, Holloway AK, Maerkl SJ, Kreitman M.

PLoS Genet. 2011 Apr;7(4):e1002053. doi: 10.1371/journal.pgen.1002053. Epub 2011 Apr 28.


Effect of immunohistochemistry on molecular analysis of tissue samples: implications for microdissection technologies.

Tangrea MA, Mukherjee S, Gao B, Markey SP, Du Q, Armani M, Kreitman MS, Rosenberg AM, Wallis BS, Eberle FC, Duncan FC, Hanson JC, Chuaqui RF, Rodriguez-Canales J, Emmert-Buck MR.

J Histochem Cytochem. 2011 Jun;59(6):591-600. doi: 10.1369/0022155411404704. Epub 2011 Mar 23.


Evolution and inheritance of early embryonic patterning in Drosophila simulans and D. sechellia.

Lott SE, Ludwig MZ, Kreitman M.

Evolution. 2011 May;65(5):1388-99. doi: 10.1111/j.1558-5646.2010.01206.x. Epub 2010 Dec 24.


Artificial selection on egg size perturbs early pattern formation in Drosophila melanogaster.

Miles CM, Lott SE, Hendriks CL, Ludwig MZ, Manu, Williams CL, Kreitman M.

Evolution. 2011 Jan;65(1):33-42. doi: 10.1111/j.1558-5646.2010.01088.x.


Research on the origin of life. Introduction.

Di Giulio M, Kreitman M.

J Mol Evol. 2009 Nov;69(5):405. doi: 10.1007/s00239-009-9284-8. No abstract available.


Variation in the ratio of nucleotide substitution and indel rates across genomes in mammals and bacteria.

Chen JQ, Wu Y, Yang H, Bergelson J, Kreitman M, Tian D.

Mol Biol Evol. 2009 Jul;26(7):1523-31. doi: 10.1093/molbev/msp063. Epub 2009 Mar 27.


Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes.

Tian D, Wang Q, Zhang P, Araki H, Yang S, Kreitman M, Nagylaki T, Hudson R, Bergelson J, Chen JQ.

Nature. 2008 Sep 4;455(7209):105-8. doi: 10.1038/nature07175. Epub 2008 Jul 20.


Low levels of polymorphism in genes that control the activation of defense response in Arabidopsis thaliana.

Bakker EG, Traw MB, Toomajian C, Kreitman M, Bergelson J.

Genetics. 2008 Apr;178(4):2031-43. doi: 10.1534/genetics.107.083279. Epub 2008 Feb 1.


Molecular evolution of pathogenicity-island genes in Pseudomonas viridiflava.

Araki H, Innan H, Kreitman M, Bergelson J.

Genetics. 2007 Oct;177(2):1031-41. Epub 2007 Aug 24.


Canalization of segmentation and its evolution in Drosophila.

Lott SE, Kreitman M, Palsson A, Alekseeva E, Ludwig MZ.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10926-31. Epub 2007 Jun 14.


A genome-wide survey of R gene polymorphisms in Arabidopsis.

Bakker EG, Toomajian C, Kreitman M, Bergelson J.

Plant Cell. 2006 Aug;18(8):1803-18. Epub 2006 Jun 23.


Distribution of genetic variation within and among local populations of Arabidopsis thaliana over its species range.

Bakker EG, Stahl EA, Toomajian C, Nordborg M, Kreitman M, Bergelson J.

Mol Ecol. 2006 Apr;15(5):1405-18.


Presence/absence polymorphism for alternative pathogenicity islands in Pseudomonas viridiflava, a pathogen of Arabidopsis.

Araki H, Tian D, Goss EM, Jakob K, Halldorsdottir SS, Kreitman M, Bergelson J.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5887-92. Epub 2006 Mar 31.


The pattern of polymorphism in Arabidopsis thaliana.

Nordborg M, Hu TT, Ishino Y, Jhaveri J, Toomajian C, Zheng H, Bakker E, Calabrese P, Gladstone J, Goyal R, Jakobsson M, Kim S, Morozov Y, Padhukasahasram B, Plagnol V, Rosenberg NA, Shah C, Wall JD, Wang J, Zhao K, Kalbfleisch T, Schulz V, Kreitman M, Bergelson J.

PLoS Biol. 2005 Jul;3(7):e196. Epub 2005 May 24.


Functional evolution of a cis-regulatory module.

Ludwig MZ, Palsson A, Alekseeva E, Bergman CM, Nathan J, Kreitman M.

PLoS Biol. 2005 Apr;3(4):e93. Epub 2005 Mar 15.


Intragenic spatial patterns of codon usage bias in prokaryotic and eukaryotic genomes.

Qin H, Wu WB, Comeron JM, Kreitman M, Li WH.

Genetics. 2004 Dec;168(4):2245-60.


Balancing claims for balancing selection.

Kreitman M, Di Rienzo A.

Trends Genet. 2004 Jul;20(7):300-4. Review. No abstract available. Erratum in: Trends Genet. 2005 Jan;21(1):36.


A method for detecting recent selection in the human genome from allele age estimates.

Toomajian C, Ajioka RS, Jorde LB, Kushner JP, Kreitman M.

Genetics. 2003 Sep;165(1):287-97.


Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana.

Tian D, Traw MB, Chen JQ, Kreitman M, Bergelson J.

Nature. 2003 May 1;423(6935):74-7.


Natural selection for polymorphism in the disease resistance gene Rps2 of Arabidopsis thaliana.

Mauricio R, Stahl EA, Korves T, Tian D, Kreitman M, Bergelson J.

Genetics. 2003 Feb;163(2):735-46.


Pseudomonas viridiflava and P. syringae--natural pathogens of Arabidopsis thaliana.

Jakob K, Goss EM, Araki H, Van T, Kreitman M, Bergelson J.

Mol Plant Microbe Interact. 2002 Dec;15(12):1195-203.


Sequence variation and haplotype structure at the human HFE locus.

Toomajian C, Kreitman M.

Genetics. 2002 Aug;161(4):1609-23.


Signature of balancing selection in Arabidopsis.

Tian D, Araki H, Stahl E, Bergelson J, Kreitman M.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11525-30. Epub 2002 Aug 9.


Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst(2)DDT locus.

Brandt A, Scharf M, Pedra JH, Holmes G, Dean A, Kreitman M, Pittendrigh BR.

Insect Mol Biol. 2002 Aug;11(4):337-41.


Population, evolutionary and genomic consequences of interference selection.

Comeron JM, Kreitman M.

Genetics. 2002 May;161(1):389-410.


Patterns of genetic variation at a chromosome 4 locus of Drosophila melanogaster and D. simulans.

Jensen MA, Charlesworth B, Kreitman M.

Genetics. 2002 Feb;160(2):493-507.


Zuckerkandl Prize.

Bernardi G, Gojobori T, Kreitman M.

J Mol Evol. 2002 Feb;54(2):143. No abstract available.


The extent of linkage disequilibrium in Arabidopsis thaliana.

Nordborg M, Borevitz JO, Bergelson J, Berry CC, Chory J, Hagenblad J, Kreitman M, Maloof JN, Noyes T, Oefner PJ, Stahl EA, Weigel D.

Nat Genet. 2002 Feb;30(2):190-3. Epub 2002 Jan 7.


Methods to detect selection in populations with applications to the human.

Kreitman M.

Annu Rev Genomics Hum Genet. 2000;1:539-59. Review.


Evolutionary dynamics of plant R-genes.

Bergelson J, Kreitman M, Stahl EA, Tian D.

Science. 2001 Jun 22;292(5525):2281-5. Review.


The population genetics of the origin and divergence of the Drosophila simulans complex species.

Kliman RM, Andolfatto P, Coyne JA, Depaulis F, Kreitman M, Berry AJ, McCarter J, Wakeley J, Hey J.

Genetics. 2000 Dec;156(4):1913-31.

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