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Genetic Vulnerability to Opioid Addiction.

Reed B, Kreek MJ.

Cold Spring Harb Perspect Med. 2020 Mar 23. pii: a039735. doi: 10.1101/cshperspect.a039735. [Epub ahead of print]


Bruce S. McEwen, Ph.D.

Kreek MJ.

Neuropsychopharmacology. 2020 Mar 10. doi: 10.1038/s41386-020-0645-8. [Epub ahead of print] No abstract available.


Neuroendocrine effects of naltrexone versus nalmefene in humans.

Butelman ER, Fry RS, Kimani R, Reed B, Kreek MJ.

Hum Psychopharmacol. 2020 Mar;35(2):e2726. doi: 10.1002/hup.2726. Epub 2020 Feb 12.


Effects of Kappa opioid receptor blockade by LY2444296 HCl, a selective short-acting antagonist, during chronic extended access cocaine self-administration and re-exposure in rat.

Valenza M, Windisch KA, Butelman ER, Reed B, Kreek MJ.

Psychopharmacology (Berl). 2020 Apr;237(4):1147-1160. doi: 10.1007/s00213-019-05444-4. Epub 2020 Jan 8.


Murine model of OPRM1 A118G alters oxycodone self-administration and locomotor activation, but not conditioned place preference.

Collins D, Zhang Y, Blendy J, Kreek MJ.

Neuropharmacology. 2020 May 1;167:107864. doi: 10.1016/j.neuropharm.2019.107864. Epub 2019 Nov 25.


Escalation of drug use in persons dually diagnosed with opioid and cocaine dependence: Gender comparison and dimensional predictors.

Butelman ER, Chen CY, Brown KG, Kreek MJ.

Drug Alcohol Depend. 2019 Dec 1;205:107657. doi: 10.1016/j.drugalcdep.2019.107657. Epub 2019 Oct 22.


A 3' UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction.

Levran O, Randesi M, Rotrosen J, Ott J, Adelson M, Kreek MJ.

PLoS One. 2019 Nov 5;14(11):e0224399. doi: 10.1371/journal.pone.0224399. eCollection 2019.


Kappa Opioid Receptors and Mu Opioid Receptors as Combined Targets for Medication Development for Alcoholism.

Zhou Y, Kreek MJ.

Biol Psychiatry. 2019 Dec 1;86(11):809-810. doi: 10.1016/j.biopsych.2019.08.011. No abstract available.


Current status of opioid addiction treatment and related preclinical research.

Kreek MJ, Reed B, Butelman ER.

Sci Adv. 2019 Oct 2;5(10):eaax9140. doi: 10.1126/sciadv.aax9140. eCollection 2019 Oct. Review.


Sex and chronic stress differentially alter phosphorylated mu and delta opioid receptor levels in the rat hippocampus following oxycodone conditioned place preference.

Bellamy JR, Rubin BR, Zverovich A, Zhou Y, Contoreggi NH, Gray JD, McEwen BS, Kreek MJ, Milner TA.

Neurosci Lett. 2019 Nov 20;713:134514. doi: 10.1016/j.neulet.2019.134514. Epub 2019 Sep 24.


Clinically utilized kappa-opioid receptor agonist nalfurafine combined with low-dose naltrexone prevents alcohol relapse-like drinking in male and female mice.

Zhou Y, Kreek MJ.

Brain Res. 2019 Dec 1;1724:146410. doi: 10.1016/j.brainres.2019.146410. Epub 2019 Aug 27.


Are trait impulsivity and exposure to cannabis or alcohol associated with the age of trajectory of cocaine use? A gender-specific dimensional analysis in humans with cocaine dependence diagnosis.

Butelman ER, Chen CY, Conybeare RA, Brown KG, Fry RS, Kimani R, Correa da Rosa J, Ott J, Kreek MJ.

Exp Clin Psychopharmacol. 2019 Aug 19. doi: 10.1037/pha0000314. [Epub ahead of print]


Nuclear transcriptional changes in hypothalamus of Pomc enhancer knockout mice after excessive alcohol drinking.

Zhou Y, Liang Y, Low MJ, Kreek MJ.

Genes Brain Behav. 2019 Nov;18(8):e12600. doi: 10.1111/gbb.12600. Epub 2019 Aug 8.


Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses.

Dunn AD, Reed B, Erazo J, Ben-Ezra A, Kreek MJ.

ACS Chem Neurosci. 2019 Aug 21;10(8):3590-3600. doi: 10.1021/acschemneuro.9b00195. Epub 2019 Jul 31.


Sex Differences in Neuroplasticity- and Stress-Related Gene Expression and Protein Levels in the Rat Hippocampus Following Oxycodone Conditioned Place Preference.

Randesi M, Contoreggi NH, Zhou Y, Rubin BR, Bellamy JR, Yu F, Gray JD, McEwen BS, Milner TA, Kreek MJ.

Neuroscience. 2019 Jul 1;410:274-292. doi: 10.1016/j.neuroscience.2019.04.047. Epub 2019 May 7.


Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice.

Zhou Y, Leri F, Low MJ, Kreek MJ.

Pharmacol Biochem Behav. 2019 Jun;181:28-36. doi: 10.1016/j.pbb.2019.04.004. Epub 2019 Apr 13.


VMAT2 gene (SLC18A2) variants associated with a greater risk for developing opioid dependence.

Randesi M, van den Brink W, Levran O, Blanken P, van Ree JM, Ott J, Kreek MJ.

Pharmacogenomics. 2019 Apr;20(5):331-341. doi: 10.2217/pgs-2018-0137. Epub 2019 Apr 15.


Impact of Pharmacological Manipulation of the κ-Opioid Receptor System on Self-grooming and Anhedonic-like Behaviors in Male Mice.

Butelman ER, McElroy BD, Prisinzano TE, Kreek MJ.

J Pharmacol Exp Ther. 2019 Jul;370(1):1-8. doi: 10.1124/jpet.119.256354. Epub 2019 Apr 11.


Association of variants of prodynorphin promoter 68-bp repeats in caucasians with opioid dependence diagnosis: Effect on age trajectory of heroin use.

Yuferov V, Randesi M, Butelman ER, van den Brink W, Blanken P, van Ree JM, Ott J, Kreek MJ.

Neurosci Lett. 2019 Jun 21;704:100-105. doi: 10.1016/j.neulet.2019.03.038. Epub 2019 Mar 29.


Combination of Clinically Utilized Kappa-Opioid Receptor Agonist Nalfurafine With Low-Dose Naltrexone Reduces Excessive Alcohol Drinking in Male and Female Mice.

Zhou Y, Kreek MJ.

Alcohol Clin Exp Res. 2019 Jun;43(6):1077-1090. doi: 10.1111/acer.14033. Epub 2019 May 2.


Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction.

Peles E, Levran O, Randesi M, Ott J, Kreek MJ, Adelson M.

J Addict Med. 2019 Nov/Dec;13(6):430-435. doi: 10.1097/ADM.0000000000000515.


Chronic immobilization stress primes the hippocampal opioid system for oxycodone-associated learning in female but not male rats.

Reich B, Zhou Y, Goldstein E, Srivats SS, Contoreggi NH, Kogan JF, McEwen BS, Kreek MJ, Milner TA, Gray JD.

Synapse. 2019 May;73(5):e22088. doi: 10.1002/syn.22088. Epub 2019 Jan 22.


Chronic Oxycodone Self-administration Altered Reward-related Genes in the Ventral and Dorsal Striatum of C57BL/6J Mice: An RNA-seq Analysis.

Zhang Y, Liang Y, Randesi M, Yuferov V, Zhao C, Kreek MJ.

Neuroscience. 2018 Nov 21;393:333-349. doi: 10.1016/j.neuroscience.2018.07.032. Epub 2018 Jul 29.


Naltrexone and nalmefene attenuate cocaine place preference in male mice.

Windisch KA, Reed B, Kreek MJ.

Neuropharmacology. 2018 Sep 15;140:174-183. doi: 10.1016/j.neuropharm.2018.07.025. Epub 2018 Jul 23.


Re-evaluation of the KMSK scales, rapid dimensional measures of self-exposure to specific drugs: Gender-specific features.

Butelman ER, Chen CY, Fry RS, Kimani R, Levran O, Ott J, Correa da Rosa J, Kreek MJ.

Drug Alcohol Depend. 2018 Sep 1;190:179-187. doi: 10.1016/j.drugalcdep.2018.05.028. Epub 2018 Jul 21.


Oprm1 A112G, a single nucleotide polymorphism, alters expression of stress-responsive genes in multiple brain regions in male and female mice.

Collins D, Randesi M, da Rosa JC, Zhang Y, Kreek MJ.

Psychopharmacology (Berl). 2018 Sep;235(9):2703-2711. doi: 10.1007/s00213-018-4965-x. Epub 2018 Jul 19.


Non-medical Cannabis Self-Exposure as a Dimensional Predictor of Opioid Dependence Diagnosis: A Propensity Score Matched Analysis.

Butelman ER, Maremmani AGI, Bacciardi S, Chen CY, Correa da Rosa J, Kreek MJ.

Front Psychiatry. 2018 Jun 27;9:283. doi: 10.3389/fpsyt.2018.00283. eCollection 2018.


A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction.

Levran O, Correa da Rosa J, Randesi M, Rotrosen J, Adelson M, Kreek MJ.

PLoS One. 2018 Jun 28;13(6):e0199951. doi: 10.1371/journal.pone.0199951. eCollection 2018.


Oxycodone Self-Administration Induces Alterations in Expression of Integrin, Semaphorin and Ephrin Genes in the Mouse Striatum.

Yuferov V, Zhang Y, Liang Y, Zhao C, Randesi M, Kreek MJ.

Front Psychiatry. 2018 Jun 12;9:257. doi: 10.3389/fpsyt.2018.00257. eCollection 2018.


Sex differences after chronic stress in the expression of opioid-, stress- and neuroplasticity-related genes in the rat hippocampus.

Randesi M, Zhou Y, Mazid S, Odell SC, Gray JD, Correa da Rosa J, McEwen BS, Milner TA, Kreek MJ.

Neurobiol Stress. 2018 Jan 11;8:33-41. doi: 10.1016/j.ynstr.2018.01.001. eCollection 2018 Feb.


Gender-specific association of functional prodynorphin 68 bp repeats with cannabis exposure in an African American cohort.

Yuferov V, Butelman ER, Kreek MJ.

Neuropsychiatr Dis Treat. 2018 Apr 16;14:1025-1034. doi: 10.2147/NDT.S159954. eCollection 2018.


Involvement of Activated Brain Stress Responsive Systems in Excessive and "Relapse" Alcohol Drinking in Rodent Models: Implications for Therapeutics.

Zhou Y, Kreek MJ.

J Pharmacol Exp Ther. 2018 Jul;366(1):9-20. doi: 10.1124/jpet.117.245621. Epub 2018 Apr 18. Review.


Structurally Related Kappa Opioid Receptor Agonists with Substantial Differential Signaling Bias: Neuroendocrine and Behavioral Effects in C57BL6 Mice.

Dunn AD, Reed B, Guariglia C, Dunn AM, Hillman JM, Kreek MJ.

Int J Neuropsychopharmacol. 2018 Sep 1;21(9):847-857. doi: 10.1093/ijnp/pyy034.


Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice.

Zhou Y, Crowley R, Prisinzano T, Kreek MJ.

Neurosci Lett. 2018 Apr 23;673:19-23. doi: 10.1016/j.neulet.2018.02.056. Epub 2018 Feb 26.


Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin.

Levran O, Peles E, Randesi M, Correa da Rosa J, Shen PH, Rotrosen J, Adelson M, Kreek MJ.

Pharmacogenomics. 2018 Mar;19(4):333-341. doi: 10.2217/pgs-2017-0179. Epub 2018 Feb 21.


Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and without Cocaine Dependence.

Reed B, Butelman ER, Fry RS, Kimani R, Kreek MJ.

Neuropsychopharmacology. 2018 Mar;43(4):928. doi: 10.1038/npp.2017.245.


Dopamine gene variants in opioid addiction: comparison of dependent patients, nondependent users and healthy controls.

Randesi M, van den Brink W, Levran O, Yuferov V, Blanken P, van Ree JM, Ott J, Kreek MJ.

Pharmacogenomics. 2018 Jan;19(2):95-104. doi: 10.2217/pgs-2017-0134. Epub 2017 Dec 6.


V1b Receptor Antagonist SSR149415 and Naltrexone Synergistically Decrease Excessive Alcohol Drinking in Male and Female Mice.

Zhou Y, Rubinstein M, Low MJ, Kreek MJ.

Alcohol Clin Exp Res. 2018 Jan;42(1):195-205. doi: 10.1111/acer.13544. Epub 2017 Nov 28.


Medications for substance use disorders (SUD): emerging approaches.

Butelman ER, Kreek MJ.

Expert Opin Emerg Drugs. 2017 Dec;22(4):301-315. doi: 10.1080/14728214.2017.1395855. Epub 2017 Oct 30. Review.


The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment.

Levran O, Peles E, Randesi M, da Rosa JC, Adelson M, Kreek MJ.

Pharmacogenomics. 2017 Oct;18(15):1387-1391. doi: 10.2217/pgs-2017-0092. Epub 2017 Oct 4.


Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and without Cocaine Dependence.

Reed B, Butelman ER, Fry RS, Kimani R, Kreek MJ.

Neuropsychopharmacology. 2018 Mar;43(4):739-750. doi: 10.1038/npp.2017.205. Epub 2017 Aug 31. Erratum in: Neuropsychopharmacology. 2018 Mar;43(4):928.


Blockade of alcohol escalation and "relapse" drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice.

Zhou Y, Schwartz BI, Giza J, Gross SS, Lee FS, Kreek MJ.

Psychopharmacology (Berl). 2017 Oct;234(19):2955-2970. doi: 10.1007/s00213-017-4691-9. Epub 2017 Jul 20.


Can a rapid measure of self-exposure to drugs of abuse provide dimensional information on depression comorbidity?

Butelman ER, Bacciardi S, Maremmani AGI, Darst-Campbell M, Correa da Rosa J, Kreek MJ.

Am J Addict. 2017 Sep;26(6):632-639. doi: 10.1111/ajad.12578. Epub 2017 Jun 27.


Alterations of expression of inflammation/immune-related genes in the dorsal and ventral striatum of adult C57BL/6J mice following chronic oxycodone self-administration: a RNA sequencing study.

Zhang Y, Liang Y, Levran O, Randesi M, Yuferov V, Zhao C, Kreek MJ.

Psychopharmacology (Berl). 2017 Aug;234(15):2259-2275. doi: 10.1007/s00213-017-4657-y. Epub 2017 Jun 26.


"Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats".

Valenza M, Butelman ER, Kreek MJ.

Psychopharmacology (Berl). 2017 Aug;234(15):2219-2231. doi: 10.1007/s00213-017-4647-0. Epub 2017 May 27.


Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury.

Randesi M, Levran O, Correa da Rosa J, Hankins J, Rule J, Kreek MJ, Lee WM; Acute Liver Failure Study Group.

Cell Mol Gastroenterol Hepatol. 2017 Jan 24;3(3):500-505. doi: 10.1016/j.jcmgh.2017.01.008. eCollection 2017 May.


Synergistic blockade of alcohol escalation drinking in mice by a combination of novel kappa opioid receptor agonist Mesyl Salvinorin B and naltrexone.

Zhou Y, Crowley RS, Ben K, Prisinzano TE, Kreek MJ.

Brain Res. 2017 May 1;1662:75-86. doi: 10.1016/j.brainres.2017.02.027. Epub 2017 Mar 2.


Hypothalamic-specific proopiomelanocortin deficiency reduces alcohol drinking in male and female mice.

Zhou Y, Rubinstein M, Low MJ, Kreek MJ.

Genes Brain Behav. 2017 Apr;16(4):449-461. doi: 10.1111/gbb.12362. Epub 2017 Jan 17.


Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence.

Randesi M, van den Brink W, Levran O, Blanken P, Butelman ER, Yuferov V, da Rosa JC, Ott J, van Ree JM, Kreek MJ.

Drug Alcohol Depend. 2016 Nov 1;168:164-169. doi: 10.1016/j.drugalcdep.2016.08.634. Epub 2016 Sep 5.


Adolescent oxycodone self administration alters subsequent oxycodone-induced conditioned place preference and anti-nociceptive effect in C57BL/6J mice in adulthood.

Zhang Y, Windisch K, Altschuler J, Rahm S, Butelman ER, Kreek MJ.

Neuropharmacology. 2016 Dec;111:314-322. doi: 10.1016/j.neuropharm.2016.09.005. Epub 2016 Sep 7.

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