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Acoustic Tweezing Cytometry Induces Rapid Initiation of Human Embryonic Stem Cell Differentiation.

Topal T, Hong X, Xue X, Fan Z, Kanetkar N, Nguyen JT, Fu J, Deng CX, Krebsbach PH.

Sci Rep. 2018 Aug 28;8(1):12977. doi: 10.1038/s41598-018-30939-z.


Rapamycin rescues BMP mediated midline craniosynostosis phenotype through reduction of mTOR signaling in a mouse model.

Kramer K, Yang J, Swanson WB, Hayano S, Toda M, Pan H, Kim JK, Krebsbach PH, Mishina Y.

Genesis. 2018 Jun;56(6-7):e23220. doi: 10.1002/dvg.23220.


Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.

Nguyen JT, Ray C, Fox AL, Mendonça DB, Kim JK, Krebsbach PH.

Sci Adv. 2018 May 9;4(5):eaao5838. doi: 10.1126/sciadv.aao5838. eCollection 2018 May.


3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures.

Jordahl JH, Solorio L, Sun H, Ramcharan S, Teeple CB, Haley HR, Lee KJ, Eyster TW, Luker GD, Krebsbach PH, Lahann J.

Adv Mater. 2018 Apr;30(14):e1707196. doi: 10.1002/adma.201707196. Epub 2018 Feb 27.


CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes.

Jung Y, Cackowski FC, Yumoto K, Decker AM, Wang J, Kim JK, Lee E, Wang Y, Chung JS, Gursky AM, Krebsbach PH, Pienta KJ, Morgan TM, Taichman RS.

Cancer Res. 2018 Apr 15;78(8):2026-2039. doi: 10.1158/0008-5472.CAN-17-2332. Epub 2018 Feb 5.


Nanotopography regulates motor neuron differentiation of human pluripotent stem cells.

Chen W, Han S, Qian W, Weng S, Yang H, Sun Y, Villa-Diaz LG, Krebsbach PH, Fu J.

Nanoscale. 2018 Feb 15;10(7):3556-3565. doi: 10.1039/c7nr05430k.


Integrin alpha V beta 3 targeted dendrimer-rapamycin conjugate reduces fibroblast-mediated prostate tumor progression and metastasis.

Hill EE, Kim JK, Jung Y, Neeley CK, Pienta KJ, Taichman RS, Nor JE, Baker JR Jr, Krebsbach PH.

J Cell Biochem. 2018 Nov;119(10):8074-8083. doi: 10.1002/jcb.26727. Epub 2018 Jun 22.


Research and Discovery Science and the Future of Dental Education and Practice.

Polverini PJ, Krebsbach PH.

J Dent Educ. 2017 Sep;81(9):eS97-eS107. doi: 10.21815/JDE.017.040.


The Role of Integrin α6 (CD49f) in Stem Cells: More than a Conserved Biomarker.

Krebsbach PH, Villa-Diaz LG.

Stem Cells Dev. 2017 Aug 1;26(15):1090-1099. doi: 10.1089/scd.2016.0319. Epub 2017 Jun 12. Review.


FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation by Enhancing Wnt Signaling.

Sun C, Yuan H, Wang L, Wei X, Williams L, Krebsbach PH, Guan JL, Liu F.

J Bone Miner Res. 2016 Dec;31(12):2227-2238. doi: 10.1002/jbmr.2908. Epub 2016 Oct 24.


Inhibition of Focal Adhesion Kinase Signaling by Integrin α6β1 Supports Human Pluripotent Stem Cell Self-Renewal.

Villa-Diaz LG, Kim JK, Laperle A, Palecek SP, Krebsbach PH.

Stem Cells. 2016 Jul;34(7):1753-64. doi: 10.1002/stem.2349. Epub 2016 Mar 27.


Engineered Human Stem Cell Microenvironments.

Jordahl JH, Villa-Diaz L, Krebsbach PH, Lahann J.

Curr Stem Cell Rep. 2016 Mar;2(1):73-84. doi: 10.1007/s40778-016-0035-7. Epub 2016 Feb 3.


DPPA5 Supports Pluripotency and Reprogramming by Regulating NANOG Turnover.

Qian X, Kim JK, Tong W, Villa-Diaz LG, Krebsbach PH.

Stem Cells. 2016 Mar;34(3):588-600. doi: 10.1002/stem.2252. Epub 2015 Dec 22.


Leading with a Consistency of Purpose.

Krebsbach PH.

J Dent Res. 2015 Jul;94(7):874. doi: 10.1177/0022034515588886. No abstract available.


Dual Delivery of EPO and BMP2 from a Novel Modular Poly-ɛ-Caprolactone Construct to Increase the Bone Formation in Prefabricated Bone Flaps.

Patel JJ, Modes JE, Flanagan CL, Krebsbach PH, Edwards SP, Hollister SJ.

Tissue Eng Part C Methods. 2015 Sep;21(9):889-97. doi: 10.1089/ten.TEC.2014.0643. Epub 2015 Jul 22.


Stem cells rejuvenate radiation-impaired vasculogenesis in murine distraction osteogenesis.

Deshpande SS, Gallagher KK, Donneys A, Nelson NS, Guys NP, Felice PA, Page EE, Sun H, Krebsbach PH, Buchman SR.

Plast Reconstr Surg. 2015 Mar;135(3):799-806. doi: 10.1097/PRS.0000000000001024.


Derivation and long-term culture of transgene-free human induced pluripotent stem cells on synthetic substrates.

Villa-Diaz LG, Kim JK, Lahann J, Krebsbach PH.

Stem Cells Transl Med. 2014 Dec;3(12):1410-7. doi: 10.5966/sctm.2014-0087. Epub 2014 Oct 13.


Treatment of heterotopic ossification through remote ATP hydrolysis.

Peterson JR, De La Rosa S, Eboda O, Cilwa KE, Agarwal S, Buchman SR, Cederna PS, Xi C, Morris MD, Herndon DN, Xiao W, Tompkins RG, Krebsbach PH, Wang SC, Levi B.

Sci Transl Med. 2014 Sep 24;6(255):255ra132. doi: 10.1126/scitranslmed.3008810.


Enhancement of the propagation of human embryonic stem cells by modifications in the gel architecture of PMEDSAH polymer coatings.

Qian X, Villa-Diaz LG, Kumar R, Lahann J, Krebsbach PH.

Biomaterials. 2014 Dec;35(36):9581-90. doi: 10.1016/j.biomaterials.2014.08.015. Epub 2014 Sep 2.


Human transgene-free amniotic-fluid-derived induced pluripotent stem cells for autologous cell therapy.

Jiang G, Di Bernardo J, Maiden MM, Villa-Diaz LG, Mabrouk OS, Krebsbach PH, O'Shea KS, Kunisaki SM.

Stem Cells Dev. 2014 Nov 1;23(21):2613-25. doi: 10.1089/scd.2014.0110. Epub 2014 Aug 18.


Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells.

Sun Y, Yong KM, Villa-Diaz LG, Zhang X, Chen W, Philson R, Weng S, Xu H, Krebsbach PH, Fu J.

Nat Mater. 2014 Jun;13(6):599-604. doi: 10.1038/nmat3945. Epub 2014 Apr 13.


Human and murine very small embryonic-like cells represent multipotent tissue progenitors, in vitro and in vivo.

Havens AM, Sun H, Shiozawa Y, Jung Y, Wang J, Mishra A, Jiang Y, O'Neill DW, Krebsbach PH, Rodgerson DO, Taichman RS.

Stem Cells Dev. 2014 Apr 1;23(7):689-701. doi: 10.1089/scd.2013.0362. Epub 2014 Feb 4.


Controlling stem cell-mediated bone regeneration through tailored mechanical properties of collagen scaffolds.

Sun H, Zhu F, Hu Q, Krebsbach PH.

Biomaterials. 2014 Jan;35(4):1176-84. doi: 10.1016/j.biomaterials.2013.10.054. Epub 2013 Nov 7.


TBK1 regulates prostate cancer dormancy through mTOR inhibition.

Kim JK, Jung Y, Wang J, Joseph J, Mishra A, Hill EE, Krebsbach PH, Pienta KJ, Shiozawa Y, Taichman RS.

Neoplasia. 2013 Sep;15(9):1064-74.


Advances in culture and manipulation of human pluripotent stem cells.

Qian X, Villa-Diaz LG, Krebsbach PH.

J Dent Res. 2013 Nov;92(11):956-62. doi: 10.1177/0022034513501286. Epub 2013 Aug 9.


Adenosine triphosphate hydrolysis reduces neutrophil infiltration and necrosis in partial-thickness scald burns in mice.

Bayliss J, Delarosa S, Wu J, Peterson JR, Eboda ON, Su GL, Hemmila M, Krebsbach PH, Cederna PS, Wang SC, Xi C, Levi B.

J Burn Care Res. 2014 Jan-Feb;35(1):54-61. doi: 10.1097/BCR.0b013e31829b36d6.


Virus immobilization on biomaterial scaffolds through biotin-avidin interaction for improving bone regeneration.

Hu WW, Wang Z, Krebsbach PH.

J Tissue Eng Regen Med. 2016 Feb;10(2):E63-72. doi: 10.1002/term.1774. Epub 2013 Jun 24.


Osteoblast-targeted suppression of PPARγ increases osteogenesis through activation of mTOR signaling.

Sun H, Kim JK, Mortensen R, Mutyaba LP, Hankenson KD, Krebsbach PH.

Stem Cells. 2013 Oct;31(10):2183-92. doi: 10.1002/stem.1455.


Burn injury enhances bone formation in heterotopic ossification model.

Peterson JR, De La Rosa S, Sun H, Eboda O, Cilwa KE, Donneys A, Morris M, Buchman SR, Cederna PS, Krebsbach PH, Wang SC, Levi B.

Ann Surg. 2014 May;259(5):993-8. doi: 10.1097/SLA.0b013e318291da85.


Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis.

Jung Y, Kim JK, Shiozawa Y, Wang J, Mishra A, Joseph J, Berry JE, McGee S, Lee E, Sun H, Wang J, Jin T, Zhang H, Dai J, Krebsbach PH, Keller ET, Pienta KJ, Taichman RS.

Nat Commun. 2013;4:1795. doi: 10.1038/ncomms2766.


Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation.

Liu F, Fang F, Yuan H, Yang D, Chen Y, Williams L, Goldstein SA, Krebsbach PH, Guan JL.

J Bone Miner Res. 2013 Nov;28(11):2414-30. doi: 10.1002/jbmr.1971.


Fat grafting for thermal injury: current state and future directions.

Ranganathan K, Wong VW, Krebsbach PH, Wang SC, Cederna PS, Levi B.

J Burn Care Res. 2013 Mar-Apr;34(2):219-26. doi: 10.1097/BCR.0b013e318280e2dd. Review. Erratum in: J Burn Care Res. 2014 Nov-Dec;35(6):533. Wong, Victor C [corrected to Wong, Victor W].


Stem cell therapy remediates reconstruction of the craniofacial skeleton after radiation therapy.

Deshpande SS, Gallagher KK, Donneys A, Tchanque-Fossuo CN, Sarhaddi D, Sun H, Krebsbach PH, Buchman SR.

Stem Cells Dev. 2013 Jun 1;22(11):1625-32. doi: 10.1089/scd.2012.0472. Epub 2013 Feb 19.


Concise review: The evolution of human pluripotent stem cell culture: from feeder cells to synthetic coatings.

Villa-Diaz LG, Ross AM, Lahann J, Krebsbach PH.

Stem Cells. 2013 Jan;31(1):1-7. doi: 10.1002/stem.1260. Review.


Human very small embryonic-like cells generate skeletal structures, in vivo.

Havens AM, Shiozawa Y, Jung Y, Sun H, Wang J, McGee S, Mishra A, Taichman LS, Danciu T, Jiang Y, Yavanian G, Leary E, Krebsbach PH, Rodgerson D, Taichman RS.

Stem Cells Dev. 2013 Feb 15;22(4):622-30. doi: 10.1089/scd.2012.0327. Epub 2012 Sep 28.


Cyclic-RGD peptides increase the adenoviral transduction of human mesenchymal stem cells.

King WJ, Krebsbach PH.

Stem Cells Dev. 2013 Feb 15;22(4):679-86. doi: 10.1089/scd.2012.0379. Epub 2012 Oct 17.


Molecular signature and in vivo behavior of bone marrow endosteal and subendosteal stromal cell populations and their relevance to hematopoiesis.

Balduino A, Mello-Coelho V, Wang Z, Taichman RS, Krebsbach PH, Weeraratna AT, Becker KG, de Mello W, Taub DD, Borojevic R.

Exp Cell Res. 2012 Nov 15;318(19):2427-37. doi: 10.1016/j.yexcr.2012.07.009. Epub 2012 Jul 27.


Erythropoietin modulates the structure of bone morphogenetic protein 2-engineered cranial bone.

Sun H, Jung Y, Shiozawa Y, Taichman RS, Krebsbach PH.

Tissue Eng Part A. 2012 Oct;18(19-20):2095-105. doi: 10.1089/ten.TEA.2011.0742. Epub 2012 Aug 10.


Heterotopic ossification following burn injury: the role of stem cells.

Nelson ER, Wong VW, Krebsbach PH, Wang SC, Levi B.

J Burn Care Res. 2012 Jul-Aug;33(4):463-70. doi: 10.1097/BCR.0b013e31825af547. Review.


Mechanics regulates fate decisions of human embryonic stem cells.

Sun Y, Villa-Diaz LG, Lam RH, Chen W, Krebsbach PH, Fu J.

PLoS One. 2012;7(5):e37178. doi: 10.1371/journal.pone.0037178. Epub 2012 May 16.


Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells.

Chen W, Villa-Diaz LG, Sun Y, Weng S, Kim JK, Lam RH, Han L, Fan R, Krebsbach PH, Fu J.

ACS Nano. 2012 May 22;6(5):4094-103. doi: 10.1021/nn3004923. Epub 2012 Apr 16.


Growth factor delivery: how surface interactions modulate release in vitro and in vivo.

King WJ, Krebsbach PH.

Adv Drug Deliv Rev. 2012 Sep;64(12):1239-56. doi: 10.1016/j.addr.2012.03.004. Epub 2012 Mar 10. Review.


Derivation of mesenchymal stem cells from human induced pluripotent stem cells cultured on synthetic substrates.

Villa-Diaz LG, Brown SE, Liu Y, Ross AM, Lahann J, Parent JM, Krebsbach PH.

Stem Cells. 2012 Jun;30(6):1174-81. doi: 10.1002/stem.1084.


Gene therapy: implications for craniofacial regeneration.

Scheller EL, Villa-Diaz LG, Krebsbach PH.

J Craniofac Surg. 2012 Jan;23(1):333-7. doi: 10.1097/SCS.0b013e318241dc11. Review.


A potential role for the myeloid lineage in leptin-regulated bone metabolism.

Scheller EL, Song J, Dishowitz MI, Hankenson KD, Krebsbach PH.

Horm Metab Res. 2012 Jan;44(1):1-5. doi: 10.1055/s-0031-1297971. Epub 2011 Dec 28.


Effects of designed PLLA and 50:50 PLGA scaffold architectures on bone formation in vivo.

Saito E, Liao EE, Hu WW, Krebsbach PH, Hollister SJ.

J Tissue Eng Regen Med. 2013 Feb;7(2):99-111. doi: 10.1002/term.497. Epub 2011 Dec 9.


Treatment effects of rhBMP-2 on invasiveness of oral carcinoma cell lines.

Kokorina NA, Zakharkin SO, Krebsbach PH, Nussenbaum B.

Laryngoscope. 2011 Sep;121(9):1876-80. doi: 10.1002/lary.21914. Epub 2011 Aug 16.


rhBMP-2 has adverse effects on human oral carcinoma cell lines in vivo.

Kokorina NA, Lewis JS Jr, Zakharkin SO, Krebsbach PH, Nussenbaum B.

Laryngoscope. 2012 Jan;122(1):95-102. doi: 10.1002/lary.22345. Epub 2011 Oct 13.


Erythropoietin mediated bone formation is regulated by mTOR signaling.

Kim J, Jung Y, Sun H, Joseph J, Mishra A, Shiozawa Y, Wang J, Krebsbach PH, Taichman RS.

J Cell Biochem. 2012 Jan;113(1):220-8. doi: 10.1002/jcb.23347.


Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production.

Scheller EL, Hankenson KD, Reuben JS, Krebsbach PH.

J Cell Biochem. 2011 Nov;112(11):3364-72. doi: 10.1002/jcb.23267.

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