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Items: 13

1.

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.

Thorneloe KS, Cheung M, Bao W, Alsaid H, Lenhard S, Jian MY, Costell M, Maniscalco-Hauk K, Krawiec JA, Olzinski A, Gordon E, Lozinskaya I, Elefante L, Qin P, Matasic DS, James C, Tunstead J, Donovan B, Kallal L, Waszkiewicz A, Vaidya K, Davenport EA, Larkin J, Burgert M, Casillas LN, Marquis RW, Ye G, Eidam HS, Goodman KB, Toomey JR, Roethke TJ, Jucker BM, Schnackenberg CG, Townsley MI, Lepore JJ, Willette RN.

Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276.

2.

The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages.

Marino JP Jr, Kallander LS, Ma C, Oh HJ, Lee D, Gaitanopoulos DE, Krawiec JA, Parks DJ, Webb CL, Ziegler K, Jaye M, Thompson SK.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5617-21. doi: 10.1016/j.bmcl.2009.08.036. Epub 2009 Aug 13.

PMID:
19717304
3.

Modified PAXgene method allows for isolation of high-integrity total RNA from microlitre volumes of mouse whole blood.

Krawiec JA, Chen H, Alom-Ruiz S, Jaye M.

Lab Anim. 2009 Oct;43(4):394-8. doi: 10.1258/la.2008.0070157. Epub 2009 Jun 5.

PMID:
19502296
4.

Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.

Goodman KB, Bury MJ, Cheung M, Cichy-Knight MA, Dowdell SE, Dunn AK, Lee D, Lieby JA, Moore ML, Scherzer DA, Sha D, Suarez DP, Murphy DJ, Harpel MR, Manas ES, McNulty DE, Annan RS, Matico RE, Schwartz BK, Trill JJ, Sweitzer TD, Wang DY, Keller PM, Krawiec JA, Jaye MC.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):27-30. doi: 10.1016/j.bmcl.2008.11.033. Epub 2008 Nov 14.

PMID:
19058966
5.

A high-throughput screen for endothelial lipase using HDL as substrate.

Keller PM, Rust T, Murphy DJ, Matico R, Trill JJ, Krawiec JA, Jurewicz A, Jaye M, Harpel M, Thrall S, Schwartz B.

J Biomol Screen. 2008 Jul;13(6):468-75. doi: 10.1177/1087057108319738. Epub 2008 Jun 19.

PMID:
18566479
6.

Poloxamer 407 (P-407)-mediated reduction in the gene expression of ATP-binding-cassette transporter A1 may contribute to increased cholesterol in peripheral tissues of P-407-treated rats.

Johnston TP, Jaye M, Webb CL, Krawiec JA, Alom-Ruiz SP, Sachs-Barrable K, Wasan KM.

Eur J Pharmacol. 2006 May 1;536(3):232-40. Epub 2006 Mar 20.

PMID:
16603153
7.

Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.

Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL.

J Med Chem. 2005 Aug 25;48(17):5419-22.

PMID:
16107141
8.

Synthetic LXR agonists increase LDL in CETP species.

Groot PH, Pearce NJ, Yates JW, Stocker C, Sauermelch C, Doe CP, Willette RN, Olzinski A, Peters T, d'Epagnier D, Morasco KO, Krawiec JA, Webb CL, Aravindhan K, Jucker B, Burgert M, Ma C, Marino JP, Collins JL, Macphee CH, Thompson SK, Jaye M.

J Lipid Res. 2005 Oct;46(10):2182-91. Epub 2005 Jul 16.

9.

Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells.

Bilder GE, Krawiec JA, McVety K, Gazit A, Gilon C, Lyall R, Zilberstein A, Levitzki A, Perrone MH, Schreiber AB.

Am J Physiol. 1991 Apr;260(4 Pt 1):C721-30.

PMID:
1850195
10.

Comparison of 18O exchange and pH stop-flow assays for carbonic anhydrase.

Dodgson SJ, Gros G, Krawiec JA, Lin L, Bitterman N, Forster RE.

J Appl Physiol (1985). 1990 Jun;68(6):2443-50.

PMID:
2117006
11.

The distribution of actin during chemotaxis in rabbit neutrophils.

Oliver JM, Krawiec JA, Becker EL.

J Reticuloendothel Soc. 1978 Dec;24(6):697-704. No abstract available.

PMID:
376832
12.

A carbamate herbicide causes microtubule and microfilament disruption and nuclear fragmentation in fibroblasts.

Oliver JM, Krawiec JA, Berlin RD.

Exp Cell Res. 1978 Oct 1;116(1):229-37. No abstract available.

PMID:
568071
13.

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