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Post-Passage rock inhibition induces cytoskeletal aberrations and apoptosis in Human embryonic stem cells.

Gao L, Nath SC, Jiao X, Zhou R, Nishikawa S, Krawetz R, Li X, Rancourt DE.

Stem Cell Res. 2019 Dec;41:101641. doi: 10.1016/j.scr.2019.101641. Epub 2019 Oct 28.


p21-/- Mice Exhibit Spontaneous Articular Cartilage Regeneration Post-Injury.

Jablonski CL, Besler BA, Ali J, Krawetz RJ.

Cartilage. 2019 Sep 26:1947603519876348. doi: 10.1177/1947603519876348. [Epub ahead of print]


CCL2 But Not CCR2 Is Required for Spontaneous Articular Cartilage Regeneration Post-Injury.

Jablonski CL, Leonard C, Salo P, Krawetz RJ.

J Orthop Res. 2019 Dec;37(12):2561-2574. doi: 10.1002/jor.24444. Epub 2019 Aug 30.


Recapitulating bone development events in a customised bioreactor through interplay of oxygen tension, medium pH, and systematic differentiation approaches.

Lee PS, Hess R, Friedrichs J, Haenchen V, Eckert H, Cuniberti G, Rancourt D, Krawetz R, Hintze V, Gelinsky M, Scharnweber D.

J Tissue Eng Regen Med. 2019 Sep;13(9):1672-1684. doi: 10.1002/term.2921. Epub 2019 Jul 15.


Elucidating the endogenous synovial fluid proteome and peptidome of inflammatory arthritis using label-free mass spectrometry.

Mahendran SM, Keystone EC, Krawetz RJ, Liang K, Diamandis EP, Chandran V.

Clin Proteomics. 2019 May 30;16:23. doi: 10.1186/s12014-019-9243-3. eCollection 2019.


Absence of Proteoglycan 4 (Prg4) Leads to Increased Subchondral Bone Porosity Which Can Be Mitigated Through Intra-Articular Injection of PRG4.

Abubacker S, Premnath P, Shonak A, Leonard C, Shah S, Zhu Y, Jay GD, Schmidt TA, Boyd S, Krawetz R.

J Orthop Res. 2019 Oct;37(10):2077-2088. doi: 10.1002/jor.24378. Epub 2019 Jun 26.


Isolation and Characterization of an Adult Stem Cell Population from Human Epidural Fat.

Al-Jezani N, Cho R, Masson AO, Lenehan B, Krawetz R, Lyons FG.

Stem Cells Int. 2019 Mar 17;2019:2175273. doi: 10.1155/2019/2175273. eCollection 2019.


Absence of p21(WAF1/CIP1/SDI1) protects against osteopenia and minimizes bone loss after ovariectomy in a mouse model.

Premnath P, Ferrie L, Louie D, Boyd S, Krawetz R.

PLoS One. 2019 Apr 10;14(4):e0215018. doi: 10.1371/journal.pone.0215018. eCollection 2019.


Multiple mesenchymal progenitor cell subtypes with distinct functional potential are present within the intimal layer of the hip synovium.

Affan A, Al-Jezani N, Railton P, Powell JN, Krawetz RJ.

BMC Musculoskelet Disord. 2019 Mar 25;20(1):125. doi: 10.1186/s12891-019-2495-2.


Resetting the clock on arthritis.

Krawetz RJ.

Arthritis Res Ther. 2019 Jan 29;21(1):37. doi: 10.1186/s13075-019-1832-z.


CCL22 is a biomarker of cartilage injury and plays a functional role in chondrocyte apoptosis.

Ren G, Whittaker JL, Leonard C, De Rantere D, Pang DSJ, Salo P, Fritzler M, Kapoor M, de Koning APJ, Jaremko JL, Emery CA, Krawetz RJ.

Cytokine. 2019 Mar;115:32-44. doi: 10.1016/j.cyto.2018.11.030. Epub 2019 Jan 7.


Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation: Does proteoglycan 4 have the ability to buffer the inflammatory response?

Das N, Schmidt TA, Krawetz RJ, Dufour A.

Bioessays. 2019 Jan;41(1):e1800166. doi: 10.1002/bies.201800166. Epub 2018 Nov 28. Review.


Biochemical Markers for the Early Identification of Osteoarthritis: Systematic Review and Meta-Analysis.

Ren G, Krawetz RJ.

Mol Diagn Ther. 2018 Dec;22(6):671-682. doi: 10.1007/s40291-018-0362-8.


Serum cartilage oligomeric matrix protein (COMP) expression in individuals who sustained a youth sport-related intra-articular knee injury 3-10 years previously and uninjured matched controls.

Laudon J, Whittaker JL, Ren G, Jaremko JL, Emery CA, Krawetz RJ.

Osteoarthritis Cartilage. 2019 Feb;27(2):286-293. doi: 10.1016/j.joca.2018.09.011. Epub 2018 Oct 11.


17-DMAG regulates p21 expression to induce chondrogenesis in vitro and in vivo.

Bertram KL, Narendran N, Tailor P, Jablonski C, Leonard C, Irvine E, Hess R, Masson AO, Abubacker S, Rinker K, Biernaskie J, Yates RM, Salo P, Narendran A, Krawetz RJ.

Dis Model Mech. 2018 Oct 8;11(10). pii: dmm033662. doi: 10.1242/dmm.033662.


microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints.

Nakamura A, Rampersaud YR, Nakamura S, Sharma A, Zeng F, Rossomacha E, Ali SA, Krawetz R, Haroon N, Perruccio AV, Mahomed NN, Gandhi R, Rockel JS, Kapoor M.

Ann Rheum Dis. 2019 Jan;78(1):111-121. doi: 10.1136/annrheumdis-2018-213629. Epub 2018 Oct 4.


Production of Adult Human Synovial Fluid-Derived Mesenchymal Stem Cells in Stirred-Suspension Culture.

Jorgenson KD, Hart DA, Krawetz R, Sen A.

Stem Cells Int. 2018 Mar 27;2018:8431053. doi: 10.1155/2018/8431053. eCollection 2018.


Serum and synovial fluid cytokine profiling in hip osteoarthritis: distinct from knee osteoarthritis and correlated with pain.

Ren G, Lutz I, Railton P, Wiley JP, McAllister J, Powell J, Krawetz RJ.

BMC Musculoskelet Disord. 2018 Feb 5;19(1):39. doi: 10.1186/s12891-018-1955-4.


Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide.

Hazenbiller O, Duncan NA, Krawetz RJ.

BMC Cell Biol. 2017 Nov 14;18(1):32. doi: 10.1186/s12860-017-0148-6.


p21-/- mice exhibit enhanced bone regeneration after injury.

Premnath P, Jorgenson B, Hess R, Tailor P, Louie D, Taiani J, Boyd S, Krawetz R.

BMC Musculoskelet Disord. 2017 Nov 9;18(1):435. doi: 10.1186/s12891-017-1790-z.


Effect of mechanical strain on the pluripotency of murine embryonic stem cells seeded in a collagen-I scaffold.

Hazenbiller O, Nasr S, Krawetz RJ, Duncan NA.

J Orthop Res. 2018 Feb;36(2):799-807. doi: 10.1002/jor.23749. Epub 2017 Nov 20.


Developing a Customized Perfusion Bioreactor Prototype with Controlled Positional Variability in Oxygen Partial Pressure for Bone and Cartilage Tissue Engineering.

Lee PS, Eckert H, Hess R, Gelinsky M, Rancourt D, Krawetz R, Cuniberti G, Scharnweber D.

Tissue Eng Part C Methods. 2017 May;23(5):286-297. doi: 10.1089/ten.TEC.2016.0244.


Enumeration and Localization of Mesenchymal Progenitor Cells and Macrophages in Synovium from Normal Individuals and Patients with Pre-Osteoarthritis or Clinically Diagnosed Osteoarthritis.

O'Brien K, Tailor P, Leonard C, DiFrancesco LM, Hart DA, Matyas JR, Frank CB, Krawetz RJ.

Int J Mol Sci. 2017 Apr 5;18(4). pii: E774. doi: 10.3390/ijms18040774.


Characterizing heterogeneity in the response of synovial mesenchymal progenitor cells to synovial macrophages in normal individuals and patients with osteoarthritis.

Fichadiya A, Bertram KL, Ren G, Yates RM, Krawetz RJ.

J Inflamm (Lond). 2016 Apr 6;13:12. doi: 10.1186/s12950-016-0120-9. eCollection 2016.


Intra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model.

Mak J, Jablonski CL, Leonard CA, Dunn JF, Raharjo E, Matyas JR, Biernaskie J, Krawetz RJ.

Sci Rep. 2016 Mar 17;6:23076. doi: 10.1038/srep23076.


Applying computation biology and "big data" to develop multiplex diagnostics for complex chronic diseases such as osteoarthritis.

Ren G, Krawetz R.

Biomarkers. 2015;20(8):533-9. doi: 10.3109/1354750X.2015.1105499. Epub 2016 Jan 26. Review.


Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro.

Iqbal SM, Leonard C, Regmi SC, De Rantere D, Tailor P, Ren G, Ishida H, Hsu C, Abubacker S, Pang DS, Salo PT, Vogel HJ, Hart DA, Waterhouse CC, Jay GD, Schmidt TA, Krawetz RJ.

Sci Rep. 2016 Jan 11;6:18910. doi: 10.1038/srep18910.


Ion channel expression and function in normal and osteoarthritic human synovial fluid progenitor cells.

Bertram KL, Banderali U, Tailor P, Krawetz RJ.

Channels (Austin). 2016;10(2):148-57. doi: 10.1080/19336950.2015.1116652. Epub 2015 Dec 2.


Allogeneic Bone Marrow Transplant from MRL/MpJ Super-Healer Mice Does Not Improve Articular Cartilage Repair in the C57Bl/6 Strain.

Leonard CA, Lee WY, Tailor P, Salo PT, Kubes P, Krawetz RJ.

PLoS One. 2015 Jun 29;10(6):e0131661. doi: 10.1371/journal.pone.0131661. eCollection 2015.


Increased levels of p21((CIP1/WAF1)) correlate with decreased chondrogenic differentiation potential in synovial membrane progenitor cells.

Masson AO, Hess R, O'Brien K, Bertram KL, Tailor P, Irvine E, Ren G, Krawetz RJ.

Mech Ageing Dev. 2015 Jul;149:31-40. doi: 10.1016/j.mad.2015.05.005. Epub 2015 May 15.


Evaluating endogenous repair of focal cartilage defects in C57BL/6 and MRL/MpJ mice using 9.4T magnetic resonance imaging: A pilot study.

Mak J, Leonard C, Foniok T, Rushforth D, Dunn JF, Krawetz R.

Magn Reson Imaging. 2015 Jun;33(5):690-4. doi: 10.1016/j.mri.2015.01.001. Epub 2015 Jan 15.


Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.

Lee WY, Sanz MJ, Wong CH, Hardy PO, Salman-Dilgimen A, Moriarty TJ, Chaconas G, Marques A, Krawetz R, Mody CH, Kubes P.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13936-41. doi: 10.1073/pnas.1404769111. Epub 2014 Sep 9.


A computational method to differentiate normal individuals, osteoarthritis and rheumatoid arthritis patients using serum biomarkers.

Heard BJ, Rosvold JM, Fritzler MJ, El-Gabalawy H, Wiley JP, Krawetz RJ.

J R Soc Interface. 2014 Aug 6;11(97):20140428. doi: 10.1098/rsif.2014.0428.


Embryonic stem cell therapy improves bone quality in a model of impaired fracture healing in the mouse; tracked temporally using in vivo micro-CT.

Taiani JT, Buie HR, Campbell GM, Manske SL, Krawetz RJ, Rancourt DE, Boyd SK, Matyas JR.

Bone. 2014 Jul;64:263-72. doi: 10.1016/j.bone.2014.04.019. Epub 2014 Apr 26.


Clonal analysis of synovial fluid stem cells to characterize and identify stable mesenchymal stromal cell/mesenchymal progenitor cell phenotypes in a porcine model: a cell source with enhanced commitment to the chondrogenic lineage.

Ando W, Kutcher JJ, Krawetz R, Sen A, Nakamura N, Frank CB, Hart DA.

Cytotherapy. 2014 Jun;16(6):776-88. doi: 10.1016/j.jcyt.2013.12.003. Epub 2014 Feb 12.


Monocyte chemotactic protein-1 inhibits chondrogenesis of synovial mesenchymal progenitor cells: an in vitro study.

Harris Q, Seto J, O'Brien K, Lee PS, Kondo C, Heard BJ, Hart DA, Krawetz RJ.

Stem Cells. 2013 Oct;31(10):2253-65. doi: 10.1002/stem.1477.


Intraarticular and systemic inflammatory profiles may identify patients with osteoarthritis.

Heard BJ, Fritzler MJ, Wiley JP, McAllister J, Martin L, El-Gabalawy H, Hart DA, Frank CB, Krawetz R.

J Rheumatol. 2013 Aug;40(8):1379-87. doi: 10.3899/jrheum.121204. Epub 2013 May 15.


Would the real human embryonic stem cell please stand up?

Zhang B, Krawetz R, Rancourt DE.

Bioessays. 2013 Jul;35(7):632-8. doi: 10.1002/bies.201200162. Epub 2013 May 7. Review.


Muscular loading of joints triggers cellular secretion of PRG4 into the joint fluid.

Abusara Z, Krawetz R, Steele B, DuVall M, Schmidt T, Herzog W.

J Biomech. 2013 Apr 26;46(7):1225-30. doi: 10.1016/j.jbiomech.2013.02.027. Epub 2013 Mar 15.


Embryonic stem cells incorporate into newly formed bone and do not form tumors in an immunocompetent mouse fracture model.

Taiani JT, Krawetz RJ, Yamashita A, Pauchard Y, Buie HR, Ponjevic D, Boyd SK, Rancourt DE, Matyas JR.

Cell Transplant. 2013;22(8):1453-62. doi: 10.3727/096368912X658755. Epub 2012 Oct 31.


Assessment of the efficacy of MRI for detection of changes in bone morphology in a mouse model of bone injury.

Taha MA, Manske SL, Kristensen E, Taiani JT, Krawetz R, Wu Y, Ponjevic D, Matyas JR, Boyd SK, Rancourt DE, Dunn JF.

J Magn Reson Imaging. 2013 Jul;38(1):231-7. doi: 10.1002/jmri.23876. Epub 2012 Nov 2.


Synovial fluid progenitors expressing CD90+ from normal but not osteoarthritic joints undergo chondrogenic differentiation without micro-mass culture.

Krawetz RJ, Wu YE, Martin L, Rattner JB, Matyas JR, Hart DA.

PLoS One. 2012;7(8):e43616. doi: 10.1371/journal.pone.0043616. Epub 2012 Aug 29. Erratum in: PLoS One. 2012;7(9). doi:10.1371/annotation/ace75296-7ec7-4193-ac91-5d68cfe5073e.


Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid.

Heard BJ, Martin L, Rattner JB, Frank CB, Hart DA, Krawetz R.

BMC Musculoskelet Disord. 2012 Jul 23;13:126. doi: 10.1186/1471-2474-13-126.


Effect of basic fibroblast growth factor in mouse embryonic stem cell culture and osteogenic differentiation.

Rose LC, Fitzsimmons R, Lee P, Krawetz R, Rancourt DE, Uluda─č H.

J Tissue Eng Regen Med. 2013 May;7(5):371-82. doi: 10.1002/term.532. Epub 2012 Jun 4.


Shear stress influences the pluripotency of murine embryonic stem cells in stirred suspension bioreactors.

Gareau T, Lara GG, Shepherd RD, Krawetz R, Rancourt DE, Rinker KD, Kallos MS.

J Tissue Eng Regen Med. 2014 Apr;8(4):268-78. doi: 10.1002/term.1518. Epub 2012 Jun 1.


Osmolarity regulates chondrogenic differentiation potential of synovial fluid derived mesenchymal progenitor cells.

Bertram KL, Krawetz RJ.

Biochem Biophys Res Commun. 2012 Jun 8;422(3):455-61. doi: 10.1016/j.bbrc.2012.05.015. Epub 2012 May 10.


Suspension bioreactor expansion of undifferentiated human embryonic stem cells.

Krawetz R, Rancourt DE.

Methods Mol Biol. 2012;873:227-35. doi: 10.1007/978-1-61779-794-1_14.


Derivation of iPSCs in stirred suspension bioreactors.

Shafa M, Day B, Yamashita A, Meng G, Liu S, Krawetz R, Rancourt DE.

Nat Methods. 2012 Apr 8;9(5):465-6. doi: 10.1038/nmeth.1973.


Impact of stirred suspension bioreactor culture on the differentiation of murine embryonic stem cells into cardiomyocytes.

Shafa M, Krawetz R, Zhang Y, Rattner JB, Godollei A, Duff HJ, Rancourt DE.

BMC Cell Biol. 2011 Dec 14;12:53. doi: 10.1186/1471-2121-12-53.


Collagen I scaffolds cross-linked with beta-glycerol phosphate induce osteogenic differentiation of embryonic stem cells in vitro and regulate their tumorigenic potential in vivo.

Krawetz RJ, Taiani JT, Wu YE, Liu S, Meng G, Matyas JR, Rancourt DE.

Tissue Eng Part A. 2012 May;18(9-10):1014-24. doi: 10.1089/ten.TEA.2011.0174. Epub 2012 Jan 26.


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