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Items: 34

1.

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells.

Ma EH, Verway MJ, Johnson RM, Roy DG, Steadman M, Hayes S, Williams KS, Sheldon RD, Samborska B, Kosinski PA, Kim H, Griss T, Faubert B, Condotta SA, Krawczyk CM, DeBerardinis RJ, Stewart KM, Richer MJ, Chubukov V, Roddy TP, Jones RG.

Immunity. 2019 Nov 19;51(5):856-870.e5. doi: 10.1016/j.immuni.2019.09.003. Epub 2019 Oct 10.

PMID:
31747582
2.

Chromatin Architecture as an Essential Determinant of Dendritic Cell Function.

Boukhaled GM, Corrado M, Guak H, Krawczyk CM.

Front Immunol. 2019 Jun 4;10:1119. doi: 10.3389/fimmu.2019.01119. eCollection 2019. Review.

3.

Characterization of the innate stimulatory capacity of plant-derived virus-like particles bearing influenza hemagglutinin.

Won SY, Hunt K, Guak H, Hasaj B, Charland N, Landry N, Ward BJ, Krawczyk CM.

Vaccine. 2018 Dec 18;36(52):8028-8038. doi: 10.1016/j.vaccine.2018.10.099. Epub 2018 Nov 14.

4.

Dynamic strain determination using fibre-optic cables allows imaging of seismological and structural features.

Jousset P, Reinsch T, Ryberg T, Blanck H, Clarke A, Aghayev R, Hersir GP, Henninges J, Weber M, Krawczyk CM.

Nat Commun. 2018 Jul 3;9(1):2509. doi: 10.1038/s41467-018-04860-y.

5.

Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration.

Guak H, Al Habyan S, Ma EH, Aldossary H, Al-Masri M, Won SY, Ying T, Fixman ED, Jones RG, McCaffrey LM, Krawczyk CM.

Nat Commun. 2018 Jun 25;9(1):2463. doi: 10.1038/s41467-018-04804-6.

6.

Morphological characterization of a plant-made virus-like particle vaccine bearing influenza virus hemagglutinins by electron microscopy.

Lindsay BJ, Bonar MM, Costas-Cancelas IN, Hunt K, Makarkov AI, Chierzi S, Krawczyk CM, Landry N, Ward BJ, Rouiller I.

Vaccine. 2018 Apr 12;36(16):2147-2154. doi: 10.1016/j.vaccine.2018.02.106. Epub 2018 Mar 14.

7.

Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity.

Smith LK, Boukhaled GM, Condotta SA, Mazouz S, Guthmiller JJ, Vijay R, Butler NS, Bruneau J, Shoukry NH, Krawczyk CM, Richer MJ.

Immunity. 2018 Feb 20;48(2):299-312.e5. doi: 10.1016/j.immuni.2018.01.006. Epub 2018 Jan 23.

8.

Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice.

Dimitrov V, Bouttier M, Boukhaled G, Salehi-Tabar R, Avramescu RG, Memari B, Hasaj B, Lukacs GL, Krawczyk CM, White JH.

J Biol Chem. 2017 Dec 15;292(50):20657-20668. doi: 10.1074/jbc.M117.793885. Epub 2017 Oct 23.

9.

The Summit for Cancer Immunotherapy (Summit4CI), June 26-29, 2016 Halifax, Canada.

Wouters MCA, Laumont CM, Chen B, Han SJ, Matuszewska K, Potts K, Boudreau JE, Krawczyk CM.

Cancer Immunol Immunother. 2017 Jun;66(6):811-818. doi: 10.1007/s00262-017-1996-9. Epub 2017 Apr 13. No abstract available.

PMID:
28409191
10.

Serine Is an Essential Metabolite for Effector T Cell Expansion.

Ma EH, Bantug G, Griss T, Condotta S, Johnson RM, Samborska B, Mainolfi N, Suri V, Guak H, Balmer ML, Verway MJ, Raissi TC, Tsui H, Boukhaled G, Henriques da Costa S, Frezza C, Krawczyk CM, Friedman A, Manfredi M, Richer MJ, Hess C, Jones RG.

Cell Metab. 2017 Feb 7;25(2):482. doi: 10.1016/j.cmet.2017.01.014. No abstract available.

11.

Serine Is an Essential Metabolite for Effector T Cell Expansion.

Ma EH, Bantug G, Griss T, Condotta S, Johnson RM, Samborska B, Mainolfi N, Suri V, Guak H, Balmer ML, Verway MJ, Raissi TC, Tsui H, Boukhaled G, Henriques da Costa S, Frezza C, Krawczyk CM, Friedman A, Manfredi M, Richer MJ, Hess C, Jones RG.

Cell Metab. 2017 Feb 7;25(2):345-357. doi: 10.1016/j.cmet.2016.12.011. Epub 2017 Jan 19. Erratum in: Cell Metab. 2017 Feb 7;25(2):482.

12.

Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2016 Nov 16;17(12):1479. doi: 10.1038/ni1216-1479c. No abstract available.

PMID:
27849203
13.

USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2017 Jan;18(1):54-63. doi: 10.1038/ni.3581. Epub 2016 Oct 10. Erratum in: Nat Immunol. 2016 Nov 16;17 (12 ):1479.

PMID:
27721430
14.

Detecting Secreted Analytes from Immune Cells: An Overview of Technologies.

Pike KA, Hui C, Krawczyk CM.

Methods Mol Biol. 2016;1458:111-24. doi: 10.1007/978-1-4939-3801-8_9.

PMID:
27581018
15.

The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.

Boukhaled GM, Cordeiro B, Deblois G, Dimitrov V, Bailey SD, Holowka T, Domi A, Guak H, Chiu HH, Everts B, Pearce EJ, Lupien M, White JH, Krawczyk CM.

Cell Rep. 2016 Aug 16;16(7):1829-37. doi: 10.1016/j.celrep.2016.07.026. Epub 2016 Aug 4.

16.

8th Annual Canadian Cancer Immunotherapy Consortium (CCIC) Symposium 2015--May 20-22, Vancouver, Canada.

Boudreau JE, Wouters MC, Krawczyk CM.

Cancer Immunol Immunother. 2016 Feb;65(2):235-41. doi: 10.1007/s00262-015-1785-2. Epub 2016 Jan 12. No abstract available.

PMID:
26759005
17.

Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis.

Van Den Ham KM, Shio MT, Rainone A, Fournier S, Krawczyk CM, Olivier M.

PLoS One. 2015 Mar 13;10(3):e0118451. doi: 10.1371/journal.pone.0118451. eCollection 2015.

18.

The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo.

Blagih J, Coulombe F, Vincent EE, Dupuy F, Galicia-Vázquez G, Yurchenko E, Raissi TC, van der Windt GJ, Viollet B, Pearce EL, Pelletier J, Piccirillo CA, Krawczyk CM, Divangahi M, Jones RG.

Immunity. 2015 Jan 20;42(1):41-54. doi: 10.1016/j.immuni.2014.12.030. Epub 2015 Jan 2.

19.

Impact of Leishmania mexicana infection on dendritic cell signaling and functions.

Contreras I, Estrada JA, Guak H, Martel C, Borjian A, Ralph B, Shio MT, Fournier S, Krawczyk CM, Olivier M.

PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3202. doi: 10.1371/journal.pntd.0003202. eCollection 2014 Sep.

20.

LKB1 and AMPK: central regulators of lymphocyte metabolism and function.

Blagih J, Krawczyk CM, Jones RG.

Immunol Rev. 2012 Sep;249(1):59-71. doi: 10.1111/j.1600-065X.2012.01157.x. Review.

PMID:
22889215
21.

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

Gallant M, Beaulieu C, Berthelette C, Colucci J, Crackower MA, Dalton C, Denis D, Ducharme Y, Friesen RW, Guay D, Gervais FG, Hamel M, Houle R, Krawczyk CM, Kosjek B, Lau S, Leblanc Y, Lee EE, Levesque JF, Mellon C, Molinaro C, Mullet W, O'Neill GP, O'Shea P, Sawyer N, Sillaots S, Simard D, Slipetz D, Stocco R, Sørensen D, Truong VL, Wong E, Wu J, Zaghdane H, Wang Z.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93. doi: 10.1016/j.bmcl.2010.11.015. Epub 2010 Nov 5.

PMID:
21106375
22.

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.

Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ.

Blood. 2010 Jun 10;115(23):4742-9. doi: 10.1182/blood-2009-10-249540. Epub 2010 Mar 29.

23.

Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression.

Taylor JJ, Krawczyk CM, Mohrs M, Pearce EJ.

J Clin Invest. 2009 Apr;119(4):1019-28. doi: 10.1172/JCI36534. Epub 2009 Mar 2.

24.

Th2 differentiation is unaffected by Jagged2 expression on dendritic cells.

Krawczyk CM, Sun J, Pearce EJ.

J Immunol. 2008 Jun 15;180(12):7931-7.

25.

The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis.

Jones RG, Bui T, White C, Madesh M, Krawczyk CM, Lindsten T, Hawkins BJ, Kubek S, Frauwirth KA, Wang YL, Conway SJ, Roderick HL, Bootman MD, Shen H, Foskett JK, Thompson CB.

Immunity. 2007 Aug;27(2):268-80. Epub 2007 Aug 9.

26.

Memory CD4 T cells enhance primary CD8 T-cell responses.

Krawczyk CM, Shen H, Pearce EJ.

Infect Immun. 2007 Jul;75(7):3556-60. Epub 2007 Apr 16.

27.

Functional plasticity in memory T helper cell responses.

Krawczyk CM, Shen H, Pearce EJ.

J Immunol. 2007 Apr 1;178(7):4080-8.

28.

NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo.

Jones RG, Saibil SD, Pun JM, Elford AR, Bonnard M, Pellegrini M, Arya S, Parsons ME, Krawczyk CM, Gerondakis S, Yeh WC, Woodgett JR, Boothby MR, Ohashi PS.

J Immunol. 2005 Sep 15;175(6):3790-9.

29.

Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b.

Krawczyk CM, Jones RG, Atfield A, Bachmaier K, Arya S, Odermatt B, Ohashi PS, Penninger JM.

J Immunol. 2005 Feb 1;174(3):1472-8.

30.

Control of effector CD8+ T cell function by the transcription factor Eomesodermin.

Pearce EL, Mullen AC, Martins GA, Krawczyk CM, Hutchins AS, Zediak VP, Banica M, DiCioccio CB, Gross DA, Mao CA, Shen H, Cereb N, Yang SY, Lindsten T, Rossant J, Hunter CA, Reiner SL.

Science. 2003 Nov 7;302(5647):1041-3.

31.

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

Jones RG, Elford AR, Parsons MJ, Wu L, Krawczyk CM, Yeh WC, Hakem R, Rottapel R, Woodgett JR, Ohashi PS.

J Exp Med. 2002 Aug 5;196(3):335-48.

32.

Thymic anti-tumor effectors in mice cured of lymphoma by cyclophosphamide plus TNF-alpha therapy: phenotypic and functional characterization up to 20 months after initial tumor inoculation.

Ehrke MJ, Verstovsek S, Pocchiari SK, Krawczyk CM, Ujházy P, Zaleskis G, Maccubbin DL, Meer JM, Mihich E.

Int J Cancer. 1998 May 18;76(4):579-86.

33.

Cyclophosphamide plus tumor necrosis factor-alpha chemoimmunotherapy cured mice: life-long immunity and rejection of re-implanted primary lymphoma.

Ehrke MJ, Verstovsek S, Krawczyk CM, Ujházy P, Zaleskis G, Maccubbin DL, Mihich E.

Int J Cancer. 1995 Nov 3;63(3):463-71.

PMID:
7591249
34.

Protective specific immunity induced by cyclophosphamide plus tumor necrosis factor alpha combination treatment of EL4-lymphoma-bearing C57BL/6 mice.

Krawczyk CM, Verstovsek S, Ujházy P, Maccubbin D, Ehrke MJ.

Cancer Immunol Immunother. 1995 Jun;40(6):347-57. Erratum in: Cancer Immunol Immunother 1997 Oct;45(1):60.

PMID:
7627991

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