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Items: 1 to 50 of 67

1.

Total Synthesis of (-)-Mitrephorone A.

Richter MJR, Schneider M, Brandstaetter M, Krautwald S, Carreira EM.

J Am Chem Soc. 2018 Nov 9. doi: 10.1021/jacs.8b09685. [Epub ahead of print]

PMID:
30412398
2.

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.

Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A, Jentzsch M, Falk-Paulsen M, Stengel ST, Welz L, Schwarzer R, Rabe B, Barchet W, Krautwald S, Hartmann G, Pasparakis M, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P.

J Exp Med. 2018 Nov 5;215(11):2868-2886. doi: 10.1084/jem.20171029. Epub 2018 Sep 25.

3.

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.

Van Opdenbosch N, Van Gorp H, Verdonckt M, Saavedra PHV, de Vasconcelos NM, Gonçalves A, Vande Walle L, Demon D, Matusiak M, Van Hauwermeiren F, D'Hont J, Hochepied T, Krautwald S, Kanneganti TD, Lamkanfi M.

Cell Rep. 2017 Dec 19;21(12):3427-3444. doi: 10.1016/j.celrep.2017.11.088.

4.

t-BuOOH induces ferroptosis in human and murine cell lines.

Wenz C, Faust D, Linz B, Turmann C, Nikolova T, Bertin J, Gough P, Wipf P, Schröder AS, Krautwald S, Dietrich C.

Arch Toxicol. 2018 Feb;92(2):759-775. doi: 10.1007/s00204-017-2066-y. Epub 2017 Oct 3.

PMID:
28975372
5.

Stereoselective Synthesis of Piperidines by Iridium-Catalyzed Cyclocondensation.

Sandmeier T, Krautwald S, Carreira EM.

Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11515-11519. doi: 10.1002/anie.201706374. Epub 2017 Aug 7.

PMID:
28731546
6.

Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure.

Müller T, Dewitz C, Schmitz J, Schröder AS, Bräsen JH, Stockwell BR, Murphy JM, Kunzendorf U, Krautwald S.

Cell Mol Life Sci. 2017 Oct;74(19):3631-3645. doi: 10.1007/s00018-017-2547-4. Epub 2017 May 27.

7.

Stereodivergence in Asymmetric Catalysis.

Krautwald S, Carreira EM.

J Am Chem Soc. 2017 Apr 26;139(16):5627-5639. doi: 10.1021/jacs.6b13340. Epub 2017 Apr 12.

PMID:
28384402
8.

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium.

Ros U, Peña-Blanco A, Hänggi K, Kunzendorf U, Krautwald S, Wong WW, García-Sáez AJ.

Cell Rep. 2017 Apr 4;19(1):175-187. doi: 10.1016/j.celrep.2017.03.024.

9.

Study of Intermediates in Iridium-(Phosphoramidite,Olefin)-Catalyzed Enantioselective Allylic Substitution.

Rössler SL, Krautwald S, Carreira EM.

J Am Chem Soc. 2017 Mar 15;139(10):3603-3606. doi: 10.1021/jacs.6b12421. Epub 2017 Mar 7.

PMID:
28267330
10.

Cobalt-Catalyzed 1,1-Diboration of Terminal Alkynes: Scope, Mechanism, and Synthetic Applications.

Krautwald S, Bezdek MJ, Chirik PJ.

J Am Chem Soc. 2017 Mar 15;139(10):3868-3875. doi: 10.1021/jacs.7b00445. Epub 2017 Mar 1.

11.
12.

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.

Günther C, He GW, Kremer AE, Murphy JM, Petrie EJ, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath MF, Becker C, Wirtz S.

J Clin Invest. 2016 Nov 1;126(11):4346-4360. doi: 10.1172/JCI87545. Epub 2016 Oct 17.

13.

Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis.

Ousingsawat J, Cabrita I, Wanitchakool P, Sirianant L, Krautwald S, Linkermann A, Schreiber R, Kunzelmann K.

Cell Mol Life Sci. 2017 Jan;74(1):173-181. doi: 10.1007/s00018-016-2338-3. Epub 2016 Aug 17.

PMID:
27535660
14.

The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance.

Gautheron J, Vucur M, Schneider AT, Severi I, Roderburg C, Roy S, Bartneck M, Schrammen P, Diaz MB, Ehling J, Gremse F, Heymann F, Koppe C, Lammers T, Kiessling F, Van Best N, Pabst O, Courtois G, Linkermann A, Krautwald S, Neumann UP, Tacke F, Trautwein C, Green DR, Longerich T, Frey N, Luedde M, Bluher M, Herzig S, Heikenwalder M, Luedde T.

Nat Commun. 2016 Jun 21;7:11869. doi: 10.1038/ncomms11869.

15.

Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure.

Corcelle-Termeau E, Vindeløv SD, Hämälistö S, Mograbi B, Keldsbo A, Bräsen JH, Favaro E, Adam D, Szyniarowski P, Hofman P, Krautwald S, Farkas T, Petersen NH, Rohde M, Linkermann A, Jäättelä M.

Autophagy. 2016 May 3;12(5):833-49. doi: 10.1080/15548627.2016.1159378. Epub 2016 Apr 12.

16.

Inhibition of regulated cell death by cell-penetrating peptides.

Krautwald S, Dewitz C, Fändrich F, Kunzendorf U.

Cell Mol Life Sci. 2016 Jun;73(11-12):2269-84. doi: 10.1007/s00018-016-2200-7. Epub 2016 Apr 5. Review.

17.

Bioisosteric Exchange of Csp3 -Chloro and Methyl Substituents: Synthesis and Initial Biological Studies of Atpenin A5 Analogues.

Krautwald S, Nilewski C, Mori M, Shiomi K, Ōmura S, Carreira EM.

Angew Chem Int Ed Engl. 2016 Mar 14;55(12):4049-53. doi: 10.1002/anie.201511672. Epub 2016 Feb 17.

PMID:
26891236
18.

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis.

Mulay SR, Desai J, Kumar SV, Eberhard JN, Thomasova D, Romoli S, Grigorescu M, Kulkarni OP, Popper B, Vielhauer V, Zuchtriegel G, Reichel C, Bräsen JH, Romagnani P, Bilyy R, Munoz LE, Herrmann M, Liapis H, Krautwald S, Linkermann A, Anders HJ.

Nat Commun. 2016 Jan 28;7:10274. doi: 10.1038/ncomms10274.

19.

Blockade of CCR7 leads to decreased dendritic cell migration to draining lymph nodes and promotes graft survival in low-risk corneal transplantation.

Hos D, Dörrie J, Schaft N, Bock F, Notara M, Kruse FE, Krautwald S, Cursiefen C, Bachmann BO.

Exp Eye Res. 2016 May;146:1-6. doi: 10.1016/j.exer.2015.12.004. Epub 2015 Dec 12.

PMID:
26689751
20.

PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling.

Desai J, Kumar SV, Mulay SR, Konrad L, Romoli S, Schauer C, Herrmann M, Bilyy R, Müller S, Popper B, Nakazawa D, Weidenbusch M, Thomasova D, Krautwald S, Linkermann A, Anders HJ.

Eur J Immunol. 2016 Jan;46(1):223-9. doi: 10.1002/eji.201545605. Epub 2015 Nov 30.

21.

Stereodivergent Dual Catalytic α-Allylation of Protected α-Amino- and α-Hydroxyacetaldehydes.

Sandmeier T, Krautwald S, Zipfel HF, Carreira EM.

Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14363-7. doi: 10.1002/anie.201506933. Epub 2015 Oct 2.

PMID:
26427612
22.

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.

Fauster A, Rebsamen M, Huber KV, Bigenzahn JW, Stukalov A, Lardeau CH, Scorzoni S, Bruckner M, Gridling M, Parapatics K, Colinge J, Bennett KL, Kubicek S, Krautwald S, Linkermann A, Superti-Furga G.

Cell Death Dis. 2015 May 21;6:e1767. doi: 10.1038/cddis.2015.130.

23.

Synchronized renal tubular cell death involves ferroptosis.

Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vanden Berghe T, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Bräsen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41. doi: 10.1073/pnas.1415518111. Epub 2014 Nov 10.

24.

Regulated cell death and inflammation: an auto-amplification loop causes organ failure.

Linkermann A, Stockwell BR, Krautwald S, Anders HJ.

Nat Rev Immunol. 2014 Nov;14(11):759-67. doi: 10.1038/nri3743. Epub 2014 Oct 17. Review.

PMID:
25324125
25.

Stereodivergent total synthesis of Δ9-tetrahydrocannabinols.

Schafroth MA, Zuccarello G, Krautwald S, Sarlah D, Carreira EM.

Angew Chem Int Ed Engl. 2014 Dec 8;53(50):13898-901. doi: 10.1002/anie.201408380. Epub 2014 Oct 10.

PMID:
25303495
26.

Regulated cell death in AKI.

Linkermann A, Chen G, Dong G, Kunzendorf U, Krautwald S, Dong Z.

J Am Soc Nephrol. 2014 Dec;25(12):2689-701. doi: 10.1681/ASN.2014030262. Epub 2014 Jun 12. Review.

27.

Molecular mechanisms of regulated necrosis.

Galluzzi L, Kepp O, Krautwald S, Kroemer G, Linkermann A.

Semin Cell Dev Biol. 2014 Nov;35:24-32. doi: 10.1016/j.semcdb.2014.02.006. Epub 2014 Feb 26. Review.

PMID:
24582829
28.

Stereodivergent α-allylation of linear aldehydes with dual iridium and amine catalysis.

Krautwald S, Schafroth MA, Sarlah D, Carreira EM.

J Am Chem Soc. 2014 Feb 26;136(8):3020-3. doi: 10.1021/ja5003247. Epub 2014 Feb 13.

PMID:
24506196
29.

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock.

Vanden Berghe T, Demon D, Bogaert P, Vandendriessche B, Goethals A, Depuydt B, Vuylsteke M, Roelandt R, Van Wonterghem E, Vandenbroecke J, Choi SM, Meyer E, Krautwald S, Declercq W, Takahashi N, Cauwels A, Vandenabeele P.

Am J Respir Crit Care Med. 2014 Feb 1;189(3):282-91. doi: 10.1164/rccm.201308-1535OC.

PMID:
24456467
30.

Phosphorylated MLKL causes plasma membrane rupture.

Linkermann A, Kunzendorf U, Krautwald S.

Mol Cell Oncol. 2014 Aug 13;1(1):e29915. doi: 10.4161/mco.29915. eCollection 2014. No abstract available.

31.

Widespread mitochondrial depletion via mitophagy does not compromise necroptosis.

Tait SW, Oberst A, Quarato G, Milasta S, Haller M, Wang R, Karvela M, Ichim G, Yatim N, Albert ML, Kidd G, Wakefield R, Frase S, Krautwald S, Linkermann A, Green DR.

Cell Rep. 2013 Nov 27;5(4):878-85. doi: 10.1016/j.celrep.2013.10.034. Epub 2013 Nov 21.

32.

The fire within: pyroptosis in the kidney.

Krautwald S, Linkermann A.

Am J Physiol Renal Physiol. 2014 Jan;306(2):F168-9. doi: 10.1152/ajprenal.00552.2013. Epub 2013 Nov 13. No abstract available.

33.

Necroptosis in immunity and ischemia-reperfusion injury.

Linkermann A, Hackl MJ, Kunzendorf U, Walczak H, Krautwald S, Jevnikar AM.

Am J Transplant. 2013 Nov;13(11):2797-804. doi: 10.1111/ajt.12448. Epub 2013 Sep 18. Review.

34.

The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice.

Linkermann A, Heller JO, Prókai A, Weinberg JM, De Zen F, Himmerkus N, Szabó AJ, Bräsen JH, Kunzendorf U, Krautwald S.

J Am Soc Nephrol. 2013 Oct;24(10):1545-57. doi: 10.1681/ASN.2012121169. Epub 2013 Jul 5. Erratum in: J Am Soc Nephrol. 2014 Dec;25(12):2942.

35.

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury.

Linkermann A, Bräsen JH, Darding M, Jin MK, Sanz AB, Heller JO, De Zen F, Weinlich R, Ortiz A, Walczak H, Weinberg JM, Green DR, Kunzendorf U, Krautwald S.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12024-9. doi: 10.1073/pnas.1305538110. Epub 2013 Jul 1.

36.

Enantio- and diastereodivergent dual catalysis: α-allylation of branched aldehydes.

Krautwald S, Sarlah D, Schafroth MA, Carreira EM.

Science. 2013 May 31;340(6136):1065-8. doi: 10.1126/science.1237068.

37.

Characteristics of Susac syndrome: a review of all reported cases.

Dörr J, Krautwald S, Wildemann B, Jarius S, Ringelstein M, Duning T, Aktas O, Ringelstein EB, Paul F, Kleffner I.

Nat Rev Neurol. 2013 Jun;9(6):307-16. doi: 10.1038/nrneurol.2013.82. Epub 2013 Apr 30. Review.

PMID:
23628737
38.

Photocatalytic synthesis of allylic trifluoromethyl substituted styrene derivatives in batch and flow.

Kreis LM, Krautwald S, Pfeiffer N, Martin RE, Carreira EM.

Org Lett. 2013 Apr 5;15(7):1634-7. doi: 10.1021/ol400410m. Epub 2013 Mar 21.

PMID:
23517196
39.

The authors reply.

Linkermann A, Kunzendorf U, Krautwald S.

Kidney Int. 2013 Mar;83(3):531. doi: 10.1038/ki.2012.471. No abstract available.

40.

The transcription factor Forkhead box P3 (FoxP3) is expressed in glioma cells and associated with increased apoptosis.

Held-Feindt J, Hattermann K, Sebens S, Krautwald S, Mehdorn HM, Mentlein R.

Exp Cell Res. 2013 Mar 10;319(5):731-9. doi: 10.1016/j.yexcr.2012.11.018. Epub 2012 Dec 1.

PMID:
23211717
41.

Iridium-catalyzed enantioselective polyene cyclization.

Schafroth MA, Sarlah D, Krautwald S, Carreira EM.

J Am Chem Soc. 2012 Dec 19;134(50):20276-8. doi: 10.1021/ja310386m. Epub 2012 Dec 11.

PMID:
23193947
42.

Programmed necrosis in acute kidney injury.

Linkermann A, De Zen F, Weinberg J, Kunzendorf U, Krautwald S.

Nephrol Dial Transplant. 2012 Sep;27(9):3412-9. doi: 10.1093/ndt/gfs373. Review.

PMID:
22942173
43.

Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock.

Linkermann A, Bräsen JH, De Zen F, Weinlich R, Schwendener RA, Green DR, Kunzendorf U, Krautwald S.

Mol Med. 2012 May 9;18:577-86. doi: 10.2119/molmed.2011.00423.

44.

Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury.

Linkermann A, Bräsen JH, Himmerkus N, Liu S, Huber TB, Kunzendorf U, Krautwald S.

Kidney Int. 2012 Apr;81(8):751-61. doi: 10.1038/ki.2011.450. Epub 2012 Jan 11.

45.

Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure.

Linkermann A, Himmerkus N, Rölver L, Keyser KA, Steen P, Bräsen JH, Bleich M, Kunzendorf U, Krautwald S.

Kidney Int. 2011 Jan;79(2):169-78. doi: 10.1038/ki.2010.317. Epub 2010 Sep 1.

46.

Effective blockage of both the extrinsic and intrinsic pathways of apoptosis in mice by TAT-crmA.

Krautwald S, Ziegler E, Rölver L, Linkermann A, Keyser KA, Steen P, Wollert KC, Korf-Klingebiel M, Kunzendorf U.

J Biol Chem. 2010 Jun 25;285(26):19997-20005. doi: 10.1074/jbc.M110.122127. Epub 2010 Apr 28.

47.

CCR7 signaling inhibits T cell proliferation.

Ziegler E, Oberbarnscheidt M, Bulfone-Paus S, Förster R, Kunzendorf U, Krautwald S.

J Immunol. 2007 Nov 15;179(10):6485-93.

48.

CCL19-IgG prevents allograft rejection by impairment of immune cell trafficking.

Ziegler E, Gueler F, Rong S, Mengel M, Witzke O, Kribben A, Haller H, Kunzendorf U, Krautwald S.

J Am Soc Nephrol. 2006 Sep;17(9):2521-32. Epub 2006 Aug 9.

49.

Virus-induced polyclonal B cell activation improves protective CTL memory via retained CD27 expression on memory CTL.

Matter M, Mumprecht S, Pinschewer DD, Pavelic V, Yagita H, Krautwald S, Borst J, Ochsenbein AF.

Eur J Immunol. 2005 Nov;35(11):3229-39.

50.

Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses.

Marsland BJ, Nembrini C, Schmitz N, Abel B, Krautwald S, Bachmann MF, Kopf M.

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14374-9. Epub 2005 Sep 26.

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