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Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis.

Zhang Y, Yan T, Sun D, Xie C, Wang T, Liu X, Wang J, Wang Q, Luo Y, Wang P, Yagai T, Krausz KW, Yang X, Gonzalez FJ.

Free Radic Biol Med. 2019 Dec 23;148:33-41. doi: 10.1016/j.freeradbiomed.2019.12.012. [Epub ahead of print]


Withaferin A Improves Nonalcoholic Steatohepatitis in Mice.

Patel DP, Yan T, Kim D, Dias HB, Krausz KW, Kimura S, Gonzalez FJ.

J Pharmacol Exp Ther. 2019 Nov;371(2):360-374. doi: 10.1124/jpet.119.256792. Epub 2019 Aug 16.


Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma.

Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2019 Oct;28(10):1704-1711. doi: 10.1158/1055-9965.EPI-19-0453. Epub 2019 Jul 29.


Glutathione deficiency-elicited reprogramming of hepatic metabolism protects against alcohol-induced steatosis.

Chen Y, Manna SK, Golla S, Krausz KW, Cai Y, Garcia-Milian R, Chakraborty T, Chakraborty J, Chatterjee R, Thompson DC, Gonzalez FJ, Vasiliou V.

Free Radic Biol Med. 2019 Nov 1;143:127-139. doi: 10.1016/j.freeradbiomed.2019.07.025. Epub 2019 Jul 24.


Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport.

Xie C, Takahashi S, Brocker CN, He S, Chen L, Xie G, Jang K, Gao X, Krausz KW, Qu A, Levi M, Gonzalez FJ.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1396-1411. doi: 10.1016/j.bbalip.2019.05.014. Epub 2019 Jun 10.


Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.

Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ.

Gastroenterology. 2019 Sep;157(3):744-759.e4. doi: 10.1053/j.gastro.2019.05.057. Epub 2019 May 30.


Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.

Takahashi S, Tanaka N, Fukami T, Xie C, Yagai T, Kim D, Velenosi TJ, Yan T, Krausz KW, Levi M, Gonzalez FJ.

Hepatol Commun. 2018 Oct 1;2(12):1567-1582. doi: 10.1002/hep4.1263. eCollection 2018 Dec.


Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.

Sun L, Xie C, Wang G, Wu Y, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X, Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu C, Krausz KW, Nichols RG, Cai J, Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C.

Nat Med. 2018 Dec;24(12):1919-1929. doi: 10.1038/s41591-018-0222-4. Epub 2018 Nov 5.


The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells.

Li S, Xu J, Yao Z, Hu L, Qin Z, Gao H, Krausz KW, Gonzalez FJ, Yao X.

Chem Biol Interact. 2018 Dec 25;296:45-56. doi: 10.1016/j.cbi.2018.09.001. Epub 2018 Sep 17.


Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice.

Brocker CN, Patel DP, Velenosi TJ, Kim D, Yan T, Yue J, Li G, Krausz KW, Gonzalez FJ.

J Lipid Res. 2018 Nov;59(11):2140-2152. doi: 10.1194/jlr.M088419. Epub 2018 Aug 29.


Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation.

Yan T, Wang H, Cao L, Wang Q, Takahashi S, Yagai T, Li G, Krausz KW, Wang G, Gonzalez FJ, Hao H.

Drug Metab Dispos. 2018 Sep;46(9):1310-1319. doi: 10.1124/dmd.118.082008. Epub 2018 Jun 29.


Metabolic alterations in triptolide-induced acute hepatotoxicity.

Zhao J, Xie C, Mu X, Krausz KW, Patel DP, Shi X, Gao X, Wang Q, Gonzalez FJ.

Biomed Chromatogr. 2018 Oct;32(10):e4299. doi: 10.1002/bmc.4299. Epub 2018 Jul 4.


Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation.

Haznadar M, Krausz KW, Margono E, Diehl CM, Bowman ED, Manna SK, Robles AI, Ryan BM, Gonzalez FJ, Harris CC.

Cancer Med. 2018 Jun;7(6):2764-2775. doi: 10.1002/cam4.1444. Epub 2018 May 3.


Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis.

Zhang Y, Yan T, Sun D, Xie C, Zheng Y, Zhang L, Yagai T, Krausz KW, Bisson WH, Yang X, Gonzalez FJ.

Drug Metab Dispos. 2018 Jul;46(7):1030-1040. doi: 10.1124/dmd.117.080176. Epub 2018 Apr 24. Erratum in: Drug Metab Dispos. 2018 Aug;46(8):1190.


Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.

Pathak P, Xie C, Nichols RG, Ferrell JM, Boehme S, Krausz KW, Patterson AD, Gonzalez FJ, Chiang JYL.

Hepatology. 2018 Oct;68(4):1574-1588. doi: 10.1002/hep.29857. Epub 2018 May 21.


Corrigendum to "Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha" [Mol Metab 7 (2018) 80-89].

Li G, Brocker CN, Yan T, Xie C, Krausz KW, Xiang R, Gonzalez FJ.

Mol Metab. 2018 Mar;9:217-219. doi: 10.1016/j.molmet.2018.01.008. Epub 2018 Feb 2. No abstract available.


Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In Vitro.

Xie C, Gao X, Sun D, Zhang Y, Krausz KW, Qin X, Gonzalez FJ.

Drug Metab Dispos. 2018 Apr;46(4):336-345. doi: 10.1124/dmd.117.079723. Epub 2018 Jan 23.


Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha.

Li G, Brocker CN, Yan T, Xie C, Krausz KW, Xiang R, Gonzalez FJ.

Mol Metab. 2018 Jan;7:80-89. doi: 10.1016/j.molmet.2017.10.011. Epub 2017 Nov 6. Erratum in: Mol Metab. 2018 Jan 23;:.


Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643.

Li G, Brocker CN, Xie C, Yan T, Noguchi A, Krausz KW, Xiang R, Gonzalez FJ.

J Gastroenterol Hepatol. 2018 May;33(5):1138-1145. doi: 10.1111/jgh.14046. Epub 2018 Feb 19.


Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ.

Cell Metab. 2017 Nov 7;26(5):801. doi: 10.1016/j.cmet.2017.10.007. No abstract available.


FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity.

Wang XX, Wang D, Luo Y, Myakala K, Dobrinskikh E, Rosenberg AZ, Levi J, Kopp JB, Field A, Hill A, Lucia S, Qiu L, Jiang T, Peng Y, Orlicky D, Garcia G, Herman-Edelstein M, D'Agati V, Henriksen K, Adorini L, Pruzanski M, Xie C, Krausz KW, Gonzalez FJ, Ranjit S, Dvornikov A, Gratton E, Levi M.

J Am Soc Nephrol. 2018 Jan;29(1):118-137. doi: 10.1681/ASN.2017020222. Epub 2017 Oct 31.


Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.

Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ.

Nat Med. 2017 Nov;23(11):1298-1308. doi: 10.1038/nm.4412. Epub 2017 Oct 9.


Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ.

Cell Metab. 2017 Oct 3;26(4):672-685.e4. doi: 10.1016/j.cmet.2017.08.019. Epub 2017 Sep 14. Erratum in: Cell Metab. 2017 Nov 7;26(5):801.


Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.

Tanaka N, Takahashi S, Hu X, Lu Y, Fujimori N, Golla S, Fang ZZ, Aoyama T, Krausz KW, Gonzalez FJ.

Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3170-3182. doi: 10.1016/j.bbadis.2017.08.017. Epub 2017 Aug 24.


Orthogonal Comparison of GC-MS and 1H NMR Spectroscopy for Short Chain Fatty Acid Quantitation.

Cai J, Zhang J, Tian Y, Zhang L, Hatzakis E, Krausz KW, Smith PB, Gonzalez FJ, Patterson AD.

Anal Chem. 2017 Aug 1;89(15):7900-7906. doi: 10.1021/acs.analchem.7b00848. Epub 2017 Jul 12.


Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption.

Wang H, Fang ZZ, Meng R, Cao YF, Tanaka N, Krausz KW, Gonzalez FJ.

Toxicology. 2017 Jul 1;386:133-142. doi: 10.1016/j.tox.2017.05.012. Epub 2017 May 24.


Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice.

Patel DP, Krausz KW, Xie C, Beyoğlu D, Gonzalez FJ, Idle JR.

PLoS One. 2017 May 16;12(5):e0177953. doi: 10.1371/journal.pone.0177953. eCollection 2017.


Editor's Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway.

Takahashi S, Tanaka N, Golla S, Fukami T, Krausz KW, Polunas MA, Weig BC, Masuo Y, Xie C, Jiang C, Gonzalez FJ.

Toxicol Sci. 2017 Aug 1;158(2):334-346. doi: 10.1093/toxsci/kfx094.


Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.

Pathak P, Liu H, Boehme S, Xie C, Krausz KW, Gonzalez F, Chiang JYL.

J Biol Chem. 2017 Jun 30;292(26):11055-11069. doi: 10.1074/jbc.M117.784322. Epub 2017 May 6.


Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure.

Golla S, Golla JP, Krausz KW, Manna SK, Simillion C, Beyoğlu D, Idle JR, Gonzalez FJ.

Radiat Res. 2017 May;187(5):612-629. doi: 10.1667/RR14592.1. Epub 2017 Mar 9.


Unique and Novel Urinary Metabolomic Features in Malignant versus Benign Adrenal Neoplasms.

Patel D, Thompson MD, Manna SK, Krausz KW, Zhang L, Nilubol N, Gonzalez FJ, Kebebew E.

Clin Cancer Res. 2017 Sep 1;23(17):5302-5310. doi: 10.1158/1078-0432.CCR-16-3156. Epub 2017 Apr 27.


An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice.

Xie C, Jiang C, Shi J, Gao X, Sun D, Sun L, Wang T, Takahashi S, Anitha M, Krausz KW, Patterson AD, Gonzalez FJ.

Diabetes. 2017 Mar;66(3):613-626. doi: 10.2337/db16-0663. Epub 2016 Nov 8.


Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.

Fang ZZ, Tanaka N, Lu D, Jiang CT, Zhang WH, Zhang C, Du Z, Fu ZW, Gao P, Cao YF, Sun HZ, Zhu ZT, Cai Y, Krausz KW, Yao Z, Gonzalez FJ.

Arch Toxicol. 2017 May;91(5):2235-2244. doi: 10.1007/s00204-016-1877-6. Epub 2016 Nov 16.


Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.

Takahashi S, Fukami T, Masuo Y, Brocker CN, Xie C, Krausz KW, Wolf CR, Henderson CJ, Gonzalez FJ.

J Lipid Res. 2016 Dec;57(12):2130-2137. Epub 2016 Sep 16.


The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4.

Gao X, Xie C, Wang Y, Luo Y, Yagai T, Sun D, Qin X, Krausz KW, Gonzalez FJ.

Biochem Pharmacol. 2016 Nov 1;119:93-104. doi: 10.1016/j.bcp.2016.08.021. Epub 2016 Aug 26.


Metabolism and Bioactivation of Fluorochloridone, a Novel Selective Herbicide, in Vivo and in Vitro.

Shi J, Xie C, Liu H, Krausz KW, Bewley CA, Zhang S, Tang L, Zhou Z, Gonzalez FJ.

Environ Sci Technol. 2016 Sep 6;50(17):9652-60. doi: 10.1021/acs.est.6b02113. Epub 2016 Aug 5.


Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells.

Yu T, Wang Y, Zhang H, Johnson CH, Jiang Y, Li X, Wu Z, Liu T, Krausz KW, Yu A, Gonzalez FJ, Huang M, Bi H.

Anal Bioanal Chem. 2016 Jun;408(16):4267-73. doi: 10.1007/s00216-016-9525-9. Epub 2016 Apr 13.


Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study.

Haznadar M, Cai Q, Krausz KW, Bowman ED, Margono E, Noro R, Thompson MD, Mathé EA, Munro HM, Steinwandel MD, Gonzalez FJ, Blot WJ, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2016 Jun;25(6):978-86. doi: 10.1158/1055-9965.EPI-15-1191. Epub 2016 Mar 24.


Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.

Yan T, Wang H, Zhao M, Yagai T, Chai Y, Krausz KW, Xie C, Cheng X, Zhang J, Che Y, Li F, Wu Y, Brocker CN, Gonzalez FJ, Wang G, Hao H.

Drug Metab Dispos. 2016 May;44(5):720-31. doi: 10.1124/dmd.116.069419. Epub 2016 Mar 10.


Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer.

Cook JA, Chandramouli GV, Anver MR, Sowers AL, Thetford A, Krausz KW, Gonzalez FJ, Mitchell JB, Patterson AD.

Cancer Res. 2016 Mar 15;76(6):1569-77. doi: 10.1158/0008-5472.CAN-15-2416. Epub 2016 Feb 15.


Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.

Jiang C, Xie C, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD, Gonzalez FJ.

Nat Commun. 2015 Dec 15;6:10166. doi: 10.1038/ncomms10166.


Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value.

Eldridge MA, Lerchner W, Saunders RC, Kaneko H, Krausz KW, Gonzalez FJ, Ji B, Higuchi M, Minamimoto T, Richmond BJ.

Nat Neurosci. 2016 Jan;19(1):37-9. doi: 10.1038/nn.4192. Epub 2015 Dec 14.


Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat.

Mak TD, Tyburski JB, Krausz KW, Kalinich JF, Gonzalez FJ, Fornace AJ Jr.

Metabolomics. 2015 Oct 1;11(5):1082-1094. Epub 2014 Dec 20.


Maternal bile acid transporter deficiency promotes neonatal demise.

Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD.

Nat Commun. 2015 Sep 29;6:8186. doi: 10.1038/ncomms9186.


Metabolic mapping of A3 adenosine receptor agonist MRS5980.

Fang ZZ, Tosh DK, Tanaka N, Wang H, Krausz KW, O'Connor R, Jacobson KA, Gonzalez FJ.

Biochem Pharmacol. 2015 Sep 15;97(2):215-23. doi: 10.1016/j.bcp.2015.07.007. Epub 2015 Jul 23.


St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling.

Manna SK, Golla S, Golla JP, Tanaka N, Cai Y, Takahashi S, Krausz KW, Matsubara T, Korboukh I, Gonzalez FJ.

Cancer Prev Res (Phila). 2015 Sep;8(9):786-95. doi: 10.1158/1940-6207.CAPR-14-0113. Epub 2015 Jun 11.


Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet.

Tanaka N, Takahashi S, Zhang Y, Krausz KW, Smith PB, Patterson AD, Gonzalez FJ.

Biochim Biophys Acta. 2015 Jul;1852(7):1242-52. doi: 10.1016/j.bbadis.2015.02.012. Epub 2015 Feb 28.


Modulation of colon cancer by nutmeg.

Li F, Yang XW, Krausz KW, Nichols RG, Xu W, Patterson AD, Gonzalez FJ.

J Proteome Res. 2015 Apr 3;14(4):1937-46. doi: 10.1021/pr5013152. Epub 2015 Mar 10.


Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism.

Teranishi Y, Matsubara T, Krausz KW, Le TT, Gonzalez FJ, Yoshizato K, Ikeda K, Kawada N.

Lab Invest. 2015 May;95(5):515-24. doi: 10.1038/labinvest.2015.29. Epub 2015 Feb 16.

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