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Items: 1 to 50 of 161

1.

Glycyrrhizin alleviates non-alcoholic steatohepatitis via modulating bile acids and meta-inflammation.

Yan T, Wang H, Cao L, Wang Q, Takahashi S, Yagai T, Li G, Krausz KW, Wang G, Gonzalez FJ, Hao H.

Drug Metab Dispos. 2018 Jun 29. pii: dmd.118.082008. doi: 10.1124/dmd.118.082008. [Epub ahead of print]

PMID:
29959134
2.

Metabolic alterations in triptolide-induced acute hepatotoxicity.

Zhao J, Xie C, Mu X, Krausz KW, Patel DP, Shi X, Gao X, Wang Q, Gonzalez FJ.

Biomed Chromatogr. 2018 May 25:e4299. doi: 10.1002/bmc.4299. [Epub ahead of print]

PMID:
29799631
3.

Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation.

Haznadar M, Krausz KW, Margono E, Diehl CM, Bowman ED, Manna SK, Robles AI, Ryan BM, Gonzalez FJ, Harris CC.

Cancer Med. 2018 Jun;7(6):2764-2775. doi: 10.1002/cam4.1444. Epub 2018 May 3.

4.

Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis.

Zhang Y, Yan T, Sun D, Xie C, Zheng Y, Zhang L, Yagai T, Krausz KW, Bisson WH, Yang X, Gonzalez FJ.

Drug Metab Dispos. 2018 Jul;46(7):1030-1040. doi: 10.1124/dmd.117.080176. Epub 2018 Apr 24. Erratum in: Drug Metab Dispos. 2018 Aug;46(8):1190.

5.

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.

Pathak P, Xie C, Nichols RG, Ferrell JM, Boehme S, Krausz KW, Patterson AD, Gonzalez FJ, Chiang JYL.

Hepatology. 2018 Feb 27. doi: 10.1002/hep.29857. [Epub ahead of print]

PMID:
29486523
6.

Corrigendum to "Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha" [Mol Metab 7 (2018) 80-89].

Li G, Brocker CN, Yan T, Xie C, Krausz KW, Xiang R, Gonzalez FJ.

Mol Metab. 2018 Mar;9:217-219. doi: 10.1016/j.molmet.2018.01.008. Epub 2018 Feb 2. No abstract available.

7.

Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In Vitro.

Xie C, Gao X, Sun D, Zhang Y, Krausz KW, Qin X, Gonzalez FJ.

Drug Metab Dispos. 2018 Apr;46(4):336-345. doi: 10.1124/dmd.117.079723. Epub 2018 Jan 23.

9.

Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha.

Li G, Brocker CN, Yan T, Xie C, Krausz KW, Xiang R, Gonzalez FJ.

Mol Metab. 2018 Jan;7:80-89. doi: 10.1016/j.molmet.2017.10.011. Epub 2017 Nov 6. Erratum in: Mol Metab. 2018 Jan 23;:.

10.

Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643.

Li G, Brocker CN, Xie C, Yan T, Noguchi A, Krausz KW, Xiang R, Gonzalez FJ.

J Gastroenterol Hepatol. 2018 May;33(5):1138-1145. doi: 10.1111/jgh.14046. Epub 2018 Feb 19.

PMID:
29141109
11.

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ.

Cell Metab. 2017 Nov 7;26(5):801. doi: 10.1016/j.cmet.2017.10.007. No abstract available.

12.

FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity.

Wang XX, Wang D, Luo Y, Myakala K, Dobrinskikh E, Rosenberg AZ, Levi J, Kopp JB, Field A, Hill A, Lucia S, Qiu L, Jiang T, Peng Y, Orlicky D, Garcia G, Herman-Edelstein M, D'Agati V, Henriksen K, Adorini L, Pruzanski M, Xie C, Krausz KW, Gonzalez FJ, Ranjit S, Dvornikov A, Gratton E, Levi M.

J Am Soc Nephrol. 2018 Jan;29(1):118-137. doi: 10.1681/ASN.2017020222. Epub 2017 Oct 31.

PMID:
29089371
13.

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.

Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ.

Nat Med. 2017 Nov;23(11):1298-1308. doi: 10.1038/nm.4412. Epub 2017 Oct 9.

PMID:
29035368
14.

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ.

Cell Metab. 2017 Oct 3;26(4):672-685.e4. doi: 10.1016/j.cmet.2017.08.019. Epub 2017 Sep 14.

PMID:
28918936
15.

Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.

Tanaka N, Takahashi S, Hu X, Lu Y, Fujimori N, Golla S, Fang ZZ, Aoyama T, Krausz KW, Gonzalez FJ.

Biochim Biophys Acta. 2017 Dec;1863(12):3170-3182. doi: 10.1016/j.bbadis.2017.08.017. Epub 2017 Aug 24.

PMID:
28844958
16.

Orthogonal Comparison of GC-MS and 1H NMR Spectroscopy for Short Chain Fatty Acid Quantitation.

Cai J, Zhang J, Tian Y, Zhang L, Hatzakis E, Krausz KW, Smith PB, Gonzalez FJ, Patterson AD.

Anal Chem. 2017 Aug 1;89(15):7900-7906. doi: 10.1021/acs.analchem.7b00848. Epub 2017 Jul 12.

PMID:
28650151
17.

Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption.

Wang H, Fang ZZ, Meng R, Cao YF, Tanaka N, Krausz KW, Gonzalez FJ.

Toxicology. 2017 Jul 1;386:133-142. doi: 10.1016/j.tox.2017.05.012. Epub 2017 May 24.

18.

Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice.

Patel DP, Krausz KW, Xie C, Beyoğlu D, Gonzalez FJ, Idle JR.

PLoS One. 2017 May 16;12(5):e0177953. doi: 10.1371/journal.pone.0177953. eCollection 2017.

19.

Editor's Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway.

Takahashi S, Tanaka N, Golla S, Fukami T, Krausz KW, Polunas MA, Weig BC, Masuo Y, Xie C, Jiang C, Gonzalez FJ.

Toxicol Sci. 2017 Aug 1;158(2):334-346. doi: 10.1093/toxsci/kfx094.

PMID:
28505368
20.

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.

Pathak P, Liu H, Boehme S, Xie C, Krausz KW, Gonzalez F, Chiang JYL.

J Biol Chem. 2017 Jun 30;292(26):11055-11069. doi: 10.1074/jbc.M117.784322. Epub 2017 May 6.

21.

Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure.

Golla S, Golla JP, Krausz KW, Manna SK, Simillion C, Beyoğlu D, Idle JR, Gonzalez FJ.

Radiat Res. 2017 May;187(5):612-629. doi: 10.1667/RR14592.1. Epub 2017 Mar 9.

22.

Unique and Novel Urinary Metabolomic Features in Malignant versus Benign Adrenal Neoplasms.

Patel D, Thompson MD, Manna SK, Krausz KW, Zhang L, Nilubol N, Gonzalez FJ, Kebebew E.

Clin Cancer Res. 2017 Sep 1;23(17):5302-5310. doi: 10.1158/1078-0432.CCR-16-3156. Epub 2017 Apr 27.

23.

An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice.

Xie C, Jiang C, Shi J, Gao X, Sun D, Sun L, Wang T, Takahashi S, Anitha M, Krausz KW, Patterson AD, Gonzalez FJ.

Diabetes. 2017 Mar;66(3):613-626. doi: 10.2337/db16-0663. Epub 2016 Nov 8.

24.

Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.

Fang ZZ, Tanaka N, Lu D, Jiang CT, Zhang WH, Zhang C, Du Z, Fu ZW, Gao P, Cao YF, Sun HZ, Zhu ZT, Cai Y, Krausz KW, Yao Z, Gonzalez FJ.

Arch Toxicol. 2017 May;91(5):2235-2244. doi: 10.1007/s00204-016-1877-6. Epub 2016 Nov 16.

PMID:
27853831
25.

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.

Takahashi S, Fukami T, Masuo Y, Brocker CN, Xie C, Krausz KW, Wolf CR, Henderson CJ, Gonzalez FJ.

J Lipid Res. 2016 Dec;57(12):2130-2137. Epub 2016 Sep 16.

26.

The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4.

Gao X, Xie C, Wang Y, Luo Y, Yagai T, Sun D, Qin X, Krausz KW, Gonzalez FJ.

Biochem Pharmacol. 2016 Nov 1;119:93-104. doi: 10.1016/j.bcp.2016.08.021. Epub 2016 Aug 26.

27.

Metabolism and Bioactivation of Fluorochloridone, a Novel Selective Herbicide, in Vivo and in Vitro.

Shi J, Xie C, Liu H, Krausz KW, Bewley CA, Zhang S, Tang L, Zhou Z, Gonzalez FJ.

Environ Sci Technol. 2016 Sep 6;50(17):9652-60. doi: 10.1021/acs.est.6b02113. Epub 2016 Aug 5.

PMID:
27443216
28.

Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells.

Yu T, Wang Y, Zhang H, Johnson CH, Jiang Y, Li X, Wu Z, Liu T, Krausz KW, Yu A, Gonzalez FJ, Huang M, Bi H.

Anal Bioanal Chem. 2016 Jun;408(16):4267-73. doi: 10.1007/s00216-016-9525-9. Epub 2016 Apr 13.

PMID:
27074779
29.

Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study.

Haznadar M, Cai Q, Krausz KW, Bowman ED, Margono E, Noro R, Thompson MD, Mathé EA, Munro HM, Steinwandel MD, Gonzalez FJ, Blot WJ, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2016 Jun;25(6):978-86. doi: 10.1158/1055-9965.EPI-15-1191. Epub 2016 Mar 24.

30.

Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.

Yan T, Wang H, Zhao M, Yagai T, Chai Y, Krausz KW, Xie C, Cheng X, Zhang J, Che Y, Li F, Wu Y, Brocker CN, Gonzalez FJ, Wang G, Hao H.

Drug Metab Dispos. 2016 May;44(5):720-31. doi: 10.1124/dmd.116.069419. Epub 2016 Mar 10.

31.

Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer.

Cook JA, Chandramouli GV, Anver MR, Sowers AL, Thetford A, Krausz KW, Gonzalez FJ, Mitchell JB, Patterson AD.

Cancer Res. 2016 Mar 15;76(6):1569-77. doi: 10.1158/0008-5472.CAN-15-2416. Epub 2016 Feb 15.

32.

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.

Jiang C, Xie C, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD, Gonzalez FJ.

Nat Commun. 2015 Dec 15;6:10166. doi: 10.1038/ncomms10166.

33.

Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value.

Eldridge MA, Lerchner W, Saunders RC, Kaneko H, Krausz KW, Gonzalez FJ, Ji B, Higuchi M, Minamimoto T, Richmond BJ.

Nat Neurosci. 2016 Jan;19(1):37-9. doi: 10.1038/nn.4192. Epub 2015 Dec 14.

34.

Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat.

Mak TD, Tyburski JB, Krausz KW, Kalinich JF, Gonzalez FJ, Fornace AJ Jr.

Metabolomics. 2015 Oct 1;11(5):1082-1094. Epub 2014 Dec 20.

35.

Maternal bile acid transporter deficiency promotes neonatal demise.

Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD.

Nat Commun. 2015 Sep 29;6:8186. doi: 10.1038/ncomms9186.

36.

Metabolic mapping of A3 adenosine receptor agonist MRS5980.

Fang ZZ, Tosh DK, Tanaka N, Wang H, Krausz KW, O'Connor R, Jacobson KA, Gonzalez FJ.

Biochem Pharmacol. 2015 Sep 15;97(2):215-23. doi: 10.1016/j.bcp.2015.07.007. Epub 2015 Jul 23.

37.

St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling.

Manna SK, Golla S, Golla JP, Tanaka N, Cai Y, Takahashi S, Krausz KW, Matsubara T, Korboukh I, Gonzalez FJ.

Cancer Prev Res (Phila). 2015 Sep;8(9):786-95. doi: 10.1158/1940-6207.CAPR-14-0113. Epub 2015 Jun 11.

38.

Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet.

Tanaka N, Takahashi S, Zhang Y, Krausz KW, Smith PB, Patterson AD, Gonzalez FJ.

Biochim Biophys Acta. 2015 Jul;1852(7):1242-52. doi: 10.1016/j.bbadis.2015.02.012. Epub 2015 Feb 28.

39.

Modulation of colon cancer by nutmeg.

Li F, Yang XW, Krausz KW, Nichols RG, Xu W, Patterson AD, Gonzalez FJ.

J Proteome Res. 2015 Apr 3;14(4):1937-46. doi: 10.1021/pr5013152. Epub 2015 Mar 10.

PMID:
25712450
40.

Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism.

Teranishi Y, Matsubara T, Krausz KW, Le TT, Gonzalez FJ, Yoshizato K, Ikeda K, Kawada N.

Lab Invest. 2015 May;95(5):515-24. doi: 10.1038/labinvest.2015.29. Epub 2015 Feb 16.

41.

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease.

Jiang C, Xie C, Li F, Zhang L, Nichols RG, Krausz KW, Cai J, Qi Y, Fang ZZ, Takahashi S, Tanaka N, Desai D, Amin SG, Albert I, Patterson AD, Gonzalez FJ.

J Clin Invest. 2015 Jan;125(1):386-402. doi: 10.1172/JCI76738. Epub 2014 Dec 15.

42.

Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling.

Liu A, Tanaka N, Sun L, Guo B, Kim JH, Krausz KW, Fang Z, Jiang C, Yang J, Gonzalez FJ.

Chem Biol Interact. 2014 Nov 5;223:80-6. doi: 10.1016/j.cbi.2014.09.012. Epub 2014 Sep 27.

43.

Disruption of tumor suppressor gene Hint1 leads to remodeling of the lipid metabolic phenotype of mouse liver.

Beyoğlu D, Krausz KW, Martin J, Maurhofer O, Dorow J, Ceglarek U, Gonzalez FJ, Dufour JF, Idle JR.

J Lipid Res. 2014 Nov;55(11):2309-19. doi: 10.1194/jlr.M050682. Epub 2014 Sep 5.

44.

PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis.

Zhou X, Cao L, Jiang C, Xie Y, Cheng X, Krausz KW, Qi Y, Sun L, Shah YM, Gonzalez FJ, Wang G, Hao H.

Nat Commun. 2014 Sep 3;5:4573. doi: 10.1038/ncomms5573.

45.

Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet.

Tanaka N, Takahashi S, Fang ZZ, Matsubara T, Krausz KW, Qu A, Gonzalez FJ.

Biochim Biophys Acta. 2014 Nov;1841(11):1596-607. doi: 10.1016/j.bbalip.2014.08.015. Epub 2014 Aug 29.

46.

N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis.

Bi HC, Pan YZ, Qiu JX, Krausz KW, Li F, Johnson CH, Jiang CT, Gonzalez FJ, Yu AM.

Carcinogenesis. 2014 Oct;35(10):2264-72. doi: 10.1093/carcin/bgu174. Epub 2014 Aug 12.

47.

PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate.

Qi Y, Jiang C, Tanaka N, Krausz KW, Brocker CN, Fang ZZ, Bredell BX, Shah YM, Gonzalez FJ.

Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G564-73. doi: 10.1152/ajpgi.00153.2014. Epub 2014 Jul 17.

48.

Metabolic profiling of praziquantel enantiomers.

Wang H, Fang ZZ, Zheng Y, Zhou K, Hu C, Krausz KW, Sun D, Idle JR, Gonzalez FJ.

Biochem Pharmacol. 2014 Jul 15;90(2):166-78. doi: 10.1016/j.bcp.2014.05.001. Epub 2014 May 10.

49.

Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.

Qi Y, Jiang C, Cheng J, Krausz KW, Li T, Ferrell JM, Gonzalez FJ, Chiang JY.

Biochim Biophys Acta. 2015 Jan;1851(1):19-29. doi: 10.1016/j.bbalip.2014.04.008. Epub 2014 May 4.

50.

Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer.

Mathé EA, Patterson AD, Haznadar M, Manna SK, Krausz KW, Bowman ED, Shields PG, Idle JR, Smith PB, Anami K, Kazandjian DG, Hatzakis E, Gonzalez FJ, Harris CC.

Cancer Res. 2014 Jun 15;74(12):3259-70. doi: 10.1158/0008-5472.CAN-14-0109. Epub 2014 Apr 15.

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