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Items: 15

1.

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.

Miragaia RJ, Gomes T, Chomka A, Jardine L, Riedel A, Hegazy AN, Whibley N, Tucci A, Chen X, Lindeman I, Emerton G, Krausgruber T, Shields J, Haniffa M, Powrie F, Teichmann SA.

Immunity. 2019 Feb 19;50(2):493-504.e7. doi: 10.1016/j.immuni.2019.01.001. Epub 2019 Feb 5.

2.

Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL.

Schmidl C, Vladimer GI, Rendeiro AF, Schnabl S, Krausgruber T, Taubert C, Krall N, Pemovska T, Araghi M, Snijder B, Hubmann R, Ringler A, Runggatscher K, Demirtas D, de la Fuente OL, Hilgarth M, Skrabs C, Porpaczy E, Gruber M, Hoermann G, Kubicek S, Staber PB, Shehata M, Superti-Furga G, Jäger U, Bock C.

Nat Chem Biol. 2019 Mar;15(3):232-240. doi: 10.1038/s41589-018-0205-2. Epub 2019 Jan 28.

PMID:
30692684
3.

Pooled CRISPR screening with single-cell transcriptome readout.

Datlinger P, Rendeiro AF, Schmidl C, Krausgruber T, Traxler P, Klughammer J, Schuster LC, Kuchler A, Alpar D, Bock C.

Nat Methods. 2017 Mar;14(3):297-301. doi: 10.1038/nmeth.4177. Epub 2017 Jan 18.

4.

T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.

Krausgruber T, Schiering C, Adelmann K, Harrison OJ, Chomka A, Pearson C, Ahern PP, Shale M, Oukka M, Powrie F.

Nat Commun. 2016 May 19;7:11627. doi: 10.1038/ncomms11627.

5.

Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling.

Ilott NE, Bollrath J, Danne C, Schiering C, Shale M, Adelmann K, Krausgruber T, Heger A, Sims D, Powrie F.

ISME J. 2016 Oct;10(10):2389-404. doi: 10.1038/ismej.2016.40. Epub 2016 Mar 22.

6.

Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.

Griseri T, Arnold IC, Pearson C, Krausgruber T, Schiering C, Franchini F, Schulthess J, McKenzie BS, Crocker PR, Powrie F.

Immunity. 2015 Jul 21;43(1):187-99. doi: 10.1016/j.immuni.2015.07.008.

7.

Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3⁺ Treg cell function in the intestine.

Harrison OJ, Srinivasan N, Pott J, Schiering C, Krausgruber T, Ilott NE, Maloy KJ.

Mucosal Immunol. 2015 Nov;8(6):1226-36. doi: 10.1038/mi.2015.13. Epub 2015 Mar 4.

8.

The alarmin IL-33 promotes regulatory T-cell function in the intestine.

Schiering C, Krausgruber T, Chomka A, Fröhlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BMJ, Löhning M, Belkaid Y, Fallon PG, Powrie F.

Nature. 2014 Sep 25;513(7519):564-568. doi: 10.1038/nature13577. Epub 2014 Jul 16.

9.

Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.

Verjee LS, Verhoekx JS, Chan JK, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood KS, Nanchahal J.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E928-37. doi: 10.1073/pnas.1301100110. Epub 2013 Feb 19.

10.

KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages.

Eames HL, Saliba DG, Krausgruber T, Lanfrancotti A, Ryzhakov G, Udalova IA.

Immunobiology. 2012 Dec;217(12):1315-24. doi: 10.1016/j.imbio.2012.07.026. Epub 2012 Aug 11.

PMID:
22995936
11.

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N, Hussell T, Feldmann M, Udalova IA.

Nat Immunol. 2011 Mar;12(3):231-8. doi: 10.1038/ni.1990. Epub 2011 Jan 16.

PMID:
21240265
12.

Beyond the enhanceosome: cluster of novel κB sites downstream of the human IFN-β gene is essential for lipopolysaccharide-induced gene activation.

Goh FG, Thomson SJ, Krausgruber T, Lanfrancotti A, Copley RR, Udalova IA.

Blood. 2010 Dec 16;116(25):5580-8. doi: 10.1182/blood-2010-05-282285. Epub 2010 Sep 20.

13.

IRF5 is required for late-phase TNF secretion by human dendritic cells.

Krausgruber T, Saliba D, Ryzhakov G, Lanfrancotti A, Blazek K, Udalova IA.

Blood. 2010 Jun 3;115(22):4421-30. doi: 10.1182/blood-2010-01-263020. Epub 2010 Mar 17.

14.

Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation.

Goh FG, Piccinini AM, Krausgruber T, Udalova IA, Midwood KS.

J Immunol. 2010 Mar 1;184(5):2655-62. doi: 10.4049/jimmunol.0903359. Epub 2010 Jan 27.

15.

The role of transposable elements in the regulation of IFN-lambda1 gene expression.

Thomson SJ, Goh FG, Banks H, Krausgruber T, Kotenko SV, Foxwell BM, Udalova IA.

Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11564-9. doi: 10.1073/pnas.0904477106. Epub 2009 Jul 1.

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