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Items: 1 to 50 of 169

1.

Single nonfouling hydrogels with mechanical and chemical functionality gradients.

Carr LR, Krause JE, Ella-Menye JR, Jiang S.

Biomaterials. 2011 Nov;32(33):8456-61. doi: 10.1016/j.biomaterials.2011.07.062. Epub 2011 Sep 7.

PMID:
21903259
2.

Uniform zwitterionic polymer hydrogels with a nonfouling and functionalizable crosslinker using photopolymerization.

Carr LR, Zhou Y, Krause JE, Xue H, Jiang S.

Biomaterials. 2011 Oct;32(29):6893-9. doi: 10.1016/j.biomaterials.2011.06.006. Epub 2011 Jun 25.

PMID:
21704366
3.

Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.

Hodgetts KJ, Ge P, Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Kieltyka A, Horvath RF, Kehne JH, Krause JE, Maynard GD, Hoffman D, Lee Y, Fung L, Doller D.

J Med Chem. 2011 Jun 23;54(12):4187-206. doi: 10.1021/jm200365y. Epub 2011 May 27.

PMID:
21618986
4.

Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.

Hodgetts KJ, Blum CA, Caldwell T, Bakthavatchalam R, Zheng X, Capitosti S, Krause JE, Cortright D, Crandall M, Murphy BA, Boyce S, Brian Jones A, Chenard BL.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4359-63. doi: 10.1016/j.bmcl.2010.06.069. Epub 2010 Jun 17.

PMID:
20615696
5.

Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.

Blum CA, Caldwell T, Zheng X, Bakthavatchalam R, Capitosti S, Brielmann H, De Lombaert S, Kershaw MT, Matson D, Krause JE, Cortright D, Crandall M, Martin WJ, Murphy BA, Boyce S, Jones AB, Mason G, Rycroft W, Perrett H, Conley R, Burnaby-Davies N, Chenard BL, Hodgetts KJ.

J Med Chem. 2010 Apr 22;53(8):3330-48. doi: 10.1021/jm100051g.

PMID:
20307063
6.

De novo expression of the neurokinin 1 receptor in spinal lamina I pyramidal neurons in polyarthritis.

Almarestani L, Waters SM, Krause JE, Bennett GJ, Ribeiro-da-Silva A.

J Comp Neurol. 2009 May 20;514(3):284-95. doi: 10.1002/cne.22024.

PMID:
19296480
7.

C5a, but not C3a, increases VEGF secretion in ARPE-19 human retinal pigment epithelial cells.

Cortright DN, Meade R, Waters SM, Chenard BL, Krause JE.

Curr Eye Res. 2009 Jan;34(1):57-61. doi: 10.1080/02713680802546658.

PMID:
19172471
8.

Opportunities and challenges in the discovery of new central nervous system drugs.

Krause JE, Chenard BL.

Ann N Y Acad Sci. 2008 Nov;1144:243-50. doi: 10.1196/annals.1418.024.

PMID:
19076381
9.

Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation.

Broom DC, Matson DJ, Bradshaw E, Buck ME, Meade R, Coombs S, Matchett M, Ford KK, Yu W, Yuan J, Sun SH, Ochoa R, Krause JE, Wustrow DJ, Cortright DN.

J Pharmacol Exp Ther. 2008 Dec;327(3):620-33. doi: 10.1124/jpet.108.141853. Epub 2008 Sep 4.

PMID:
18772321
10.

Identification and characterization of NDT 9513727 [N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist.

Brodbeck RM, Cortright DN, Kieltyka AP, Yu J, Baltazar CO, Buck ME, Meade R, Maynard GD, Thurkauf A, Chien DS, Hutchison AJ, Krause JE.

J Pharmacol Exp Ther. 2008 Dec;327(3):898-909. doi: 10.1124/jpet.108.141572. Epub 2008 Aug 27.

PMID:
18753409
11.

1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.

Guo Q, Chandrasekhar J, Ihle D, Wustrow DJ, Chenard BL, Krause JE, Hutchison A, Alderman D, Cheng C, Cortright D, Broom D, Kershaw MT, Simmermacher-Mayer J, Peng Y, Hodgetts KJ.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5027-31. doi: 10.1016/j.bmcl.2008.08.014. Epub 2008 Aug 9.

PMID:
18752949
12.

2-Arylpyrimidines: novel CRF-1 receptor antagonists.

Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Krause JE, Hutchison A, Horvath RF, Ge P, Kehne J, Hoffman D, Chandrasekhar J, Doller D, Hodgetts KJ.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4486-90. doi: 10.1016/j.bmcl.2008.07.063. Epub 2008 Jul 18.

PMID:
18672365
13.

Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.

Blum CA, Zheng X, Brielmann H, Hodgetts KJ, Bakthavatchalam R, Chandrasekhar J, Krause JE, Cortright D, Matson D, Crandall M, Ngo CK, Fung L, Day M, Kershaw M, De Lombaert S, Chenard BL.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4573-7. doi: 10.1016/j.bmcl.2008.07.036. Epub 2008 Jul 15.

PMID:
18662872
14.

Aminopyrazine CB1 receptor inverse agonists.

Wustrow DJ, Maynard GD, Yuan J, Zhao H, Mao J, Guo Q, Kershaw M, Hammer J, Brodbeck RM, Near KE, Zhou D, Beers DS, Chenard BL, Krause JE, Hutchison AJ.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3376-81. doi: 10.1016/j.bmcl.2008.04.022. Epub 2008 Apr 13.

PMID:
18448340
15.

The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.

Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Chandrasekhar J, Horvath RF, Ge P, Kershaw MT, Krause JE, Kehne J, Hoffman D, Doller D, Hodgetts KJ.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):891-6. doi: 10.1016/j.bmcl.2007.12.050. Epub 2008 Jan 3.

PMID:
18180159
16.

Hunting for ion channel modulators with herpes simplex virus.

Cortright DN, Buck ME, Krause JE.

Nat Methods. 2007 Sep;4(9):692-3. No abstract available.

PMID:
17762875
17.

Morphological characterization of spinal cord dorsal horn lamina I neurons projecting to the parabrachial nucleus in the rat.

Almarestani L, Waters SM, Krause JE, Bennett GJ, Ribeiro-da-Silva A.

J Comp Neurol. 2007 Sep 20;504(3):287-97.

PMID:
17640051
18.

TRP channels and pain.

Cortright DN, Krause JE, Broom DC.

Biochim Biophys Acta. 2007 Aug;1772(8):978-88. Epub 2007 Mar 19. Review.

19.

Leukocyte effects of C5a-receptor blockade during simulated extracorporeal circulation.

Rinder CS, Smith MJ, Rinder HM, Cortright DN, Brodbeck RM, Krause JE, Smith BR.

Ann Thorac Surg. 2007 Jan;83(1):146-52.

PMID:
17184649
20.

Neurokinin A and neurokinin B in the human retina.

Schmid E, Leierer J, Kieselbach G, Teuchner B, Kralinger M, Fischer-Colbrie R, Krause JE, Nguyen QA, Haas G, Stemberger K, Troger J.

Peptides. 2006 Dec;27(12):3370-6. Epub 2006 Sep 7.

PMID:
16956695
21.

Letter re: melanin-concentrating hormone and energy balance.

Waters SM, Krause JE.

J Clin Endocrinol Metab. 2005 Nov;90(11):6337; author reply 6337. No abstract available.

PMID:
16275983
22.

Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction.

Waters SM, Brodbeck RM, Steflik J, Yu J, Baltazar C, Peck AE, Severance D, Zhang LY, Currie K, Chenard BL, Hutchison AJ, Maynard G, Krause JE.

J Biol Chem. 2005 Dec 9;280(49):40617-23. Epub 2005 Oct 17. Erratum in: J Biol Chem. 2006 Feb 10;281(6):3752.

23.

The P2X3 antagonist P1, P5-di[inosine-5'] pentaphosphate binds to the desensitized state of the receptor in rat dorsal root ganglion neurons.

Ford KK, Matchett M, Krause JE, Yu W.

J Pharmacol Exp Ther. 2005 Oct;315(1):405-13. Epub 2005 Jul 13.

PMID:
16014755
24.

Transient receptor potential ion channels as targets for the discovery of pain therapeutics.

Krause JE, Chenard BL, Cortright DN.

Curr Opin Investig Drugs. 2005 Jan;6(1):48-57. Review.

PMID:
15675603
25.
26.

C5L2, a nonsignaling C5A binding protein.

Okinaga S, Slattery D, Humbles A, Zsengeller Z, Morteau O, Kinrade MB, Brodbeck RM, Krause JE, Choe HR, Gerard NP, Gerard C.

Biochemistry. 2003 Aug 12;42(31):9406-15.

PMID:
12899627
27.

The distribution and regulation of vanilloid receptor VR1 and VR1 5' splice variant RNA expression in rat.

Sanchez JF, Krause JE, Cortright DN.

Neuroscience. 2001;107(3):373-81.

PMID:
11718993
28.

Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung.

Haley KJ, Sunday ME, Osathanondh R, Du J, Vathanaprida C, Karpitsky VV, Krause JE, Lilly CM.

Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1348-58.

29.

Photoaffinity labeling of mutant neurokinin-1 receptors reveals additional structural features of the substance P/NK-1 receptor complex.

Macdonald D, Mierke DF, Li H, Pellegrini M, Sachais B, Krause JE, Leeman SE, Boyd ND.

Biochemistry. 2001 Feb 27;40(8):2530-9.

PMID:
11327875
30.
31.

The tissue distribution and functional characterization of human VR1.

Cortright DN, Crandall M, Sanchez JF, Zou T, Krause JE, White G.

Biochem Biophys Res Commun. 2001 Mar;281(5):1183-9.

PMID:
11243859
32.

Immunohistochemical localization of the neuropeptide Y Y1 receptor in rat central nervous system.

Migita K, Loewy AD, Ramabhadran TV, Krause JE, Waters SM.

Brain Res. 2001 Jan 19;889(1-2):23-37.

PMID:
11166683
33.
34.

Substance P and its receptor neurokinin 1 expression in asthmatic airways.

Chu HW, Kraft M, Krause JE, Rex MD, Martin RJ.

J Allergy Clin Immunol. 2000 Oct;106(4):713-22.

PMID:
11031342
35.

Solution structures in SDS micelles and functional activity at the bullfrog substance P receptor of ranatachykinin peptides.

Perrine SA, Whitehead TL, Hicks RP, Szarek JL, Krause JE, Simmons MA.

J Med Chem. 2000 May 4;43(9):1741-53.

PMID:
10794691
36.

Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human.

Mezey E, Tóth ZE, Cortright DN, Arzubi MK, Krause JE, Elde R, Guo A, Blumberg PM, Szallasi A.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3655-60.

37.

Substance P and neurokinin-1 receptor expression by intrinsic airway neurons in the rat.

Fontán JJ, Cortright DN, Krause JE, Velloff CR, Karpitskyi VV, Carver TW Jr, Shapiro SD, Mora BN.

Am J Physiol Lung Cell Mol Physiol. 2000 Feb;278(2):L344-55.

38.

The distribution of neurokinin-1 and neurokinin-2 receptors in human central airways.

Mapp CE, Miotto D, Braccioni F, Saetta M, Turato G, Maestrelli P, Krause JE, Karpitskiy V, Boyd N, Geppetti P, Fabbri LM.

Am J Respir Crit Care Med. 2000 Jan;161(1):207-15.

PMID:
10619822
39.
40.

Substrate turnover by transporters curtails synaptic glutamate transients.

Mennerick S, Shen W, Xu W, Benz A, Tanaka K, Shimamoto K, Isenberg KE, Krause JE, Zorumski CF.

J Neurosci. 1999 Nov 1;19(21):9242-51.

41.

Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1.

Szallasi A, Szabó T, Bíró T, Modarres S, Blumberg PM, Krause JE, Cortright DN, Appendino G.

Br J Pharmacol. 1999 Sep;128(2):428-34.

42.

The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons.

Szallasi A, Blumberg PM, Annicelli LL, Krause JE, Cortright DN.

Mol Pharmacol. 1999 Sep;56(3):581-7.

PMID:
10462546
43.
44.

Neurokinin-3 receptor distribution in rat and human brain: an immunohistochemical study.

Mileusnic D, Lee JM, Magnuson DJ, Hejna MJ, Krause JE, Lorens JB, Lorens SA.

Neuroscience. 1999;89(4):1269-90.

PMID:
10362314
45.

Neurokinin B- and substance P-like immunoreactivity are co-localized in enteric nerves of rat ileum.

Yunker AM, Krause JE, Roth KA.

Regul Pept. 1999 Mar 17;80(1-2):67-74.

PMID:
10235636
46.

A non-pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptors.

Szallasi A, Bíró T, Szabó T, Modarres S, Petersen M, Klusch A, Blumberg PM, Krause JE, Sterner O.

Br J Pharmacol. 1999 Mar;126(6):1351-8.

47.

Effects of systemic resiniferatoxin treatment on substance P mRNA in rat dorsal root ganglia and substance P receptor mRNA in the spinal dorsal horn.

Szallasi A, Farkas-Szallasi T, Tucker JB, Lundberg JM, Hökfelt T, Krause JE.

Brain Res. 1999 Jan 9;815(2):177-84.

PMID:
9878727
48.

Preferential synaptic relationships between substance P-immunoreactive boutons and neurokinin 1 receptor sites in the rat spinal cord.

McLeod AL, Krause JE, Cuello AC, Ribeiro-da-Silva A.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15775-80.

49.
50.

Dialdehyde sesquiterpenes and other terpenoids as vanilloids.

Szallasi A, Bíró T, Modarres S, Garlaschelli L, Petersen M, Klusch A, Vidari G, Jonassohn M, De Rosa S, Sterner O, Blumberg PM, Krause JE.

Eur J Pharmacol. 1998 Aug 28;356(1):81-9.

PMID:
9761427

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